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The map label for this gene is frmA [H]

Identifier: 84625304

GI number: 84625304

Start: 4124064

End: 4125173

Strand: Reverse

Name: frmA [H]

Synonym: XOO_3647

Alternate gene names: 84625304

Gene position: 4125173-4124064 (Counterclockwise)

Preceding gene: 84625305

Following gene: 84625303

Centisome position: 83.5

GC content: 63.33

Gene sequence:

>1110_bases
ATGAAATCCCGTGCAGCAGTTGCATTCGGACCCGGCAAGCCGCTGGAAATGGTCGAAATCGACGTCGCACCGCCAAAGGC
TGGCGAAGTGCTGGTGCGCATCACGCACACCGGCGTGTGCCACACCGATGCGTTCACGCTGTCCGGCGACGACCCGGAAG
GCATCTTCCCGTCGGTGCTTGGGCATGAAGGCGGCGGCATCGTCGAACAGGTCGGCGAAGGCGTGACCAGCGTCAAGGTG
GGCGATCACGTGATCCCGCTGTACACCGCCGAATGCCGCAAGTGCAAATTCTGTCTGTCCGGCAAGACCAACCTGTGCCA
GGCCGTGCGCGCCACCCAGGGCAAGGGCTTGATGCCCGATGGCACCACGCGCTTCTCGTATAACGGCGAGCCGATCTATC
ACTACATGGGCTGCAGCACCTTCAGCGAATACACCGTGGTGCCGGAGATTTCGCTGGCCGTGGTCAACCCGGAGGCGCCG
CTGGAAAAGGTCTGTCTGCTCGGTTGCGGCGTCACCACCGGCATCGGTGCGGTGCACAACACCGCCAAGGTCAAGCCGGG
CGAAAGCGTGGCGGTGTTCGGCCTGGGCGGCATTGGGCTGGCGGTGATCCAGGGCGCGGTGCAGGCCAAGGCCGGGCGCA
TCCTGGCAATCGACACCAACCCTGGCAAGTTCGATCTGGCACGCAGCATGGGCGCCACCGACTGCATCAACCCGAAGGAC
TACGACAAGCCGATCCAGGAGGTCATCGTCGAGTTGACCGATGGCGGCGTGGACTTCAGCTTCGAGTGCATCGGCAACGT
CAATGTCATGCGTTCGGCGCTGGAGTGTTGCCACAAGGGCTGGGGCGAGAGCGTCATCATCGGGGTGGCCGGTGCCGGCC
AGGAAATCAGCACGCGCCCGTTCCAGCTGGTCACCGGGCGCGTGTGGCGCGGCTCGGCCTTTGGCGGCGTCAAGGGGCGG
ACCCAATTGCCTGGCATGGTGGAGCAATCGATGAAGGGCGAGATCGATCTGGATCCGTTCATCACCCACACCATGCCGCT
GGAAGAGATCAACGAAGCCTTCCACCTGATGCATGAAGGCAAGTCGATCCGGACCGTGATTCATTTCTGA

Upstream 100 bases:

>100_bases
GATCTGCTCGGCCTGGTCCGGTCCTACCTCAAATAAATCTCCCACCGGGCCGGTGCTTGCCGTGCCCGTTCTCGAACCGC
ATCGTCAGGAGCGTCATCCC

Downstream 100 bases:

>100_bases
CCGTACGGCCAGGAGCGGCGCGTGGCCGCTTCCGCGCACGTAGTACACAAGACTCCGGGAGGGGCGTCATGACGCATGTG
TCGATTCATTCTTCGGTAGA

Product: alcohol dehydrogenase C

Products: NA

Alternate protein names: Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH [H]

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MKSRAAVAFGPGKPLEMVEIDVAPPKAGEVLVRITHTGVCHTDAFTLSGDDPEGIFPSVLGHEGGGIVEQVGEGVTSVKV
GDHVIPLYTAECRKCKFCLSGKTNLCQAVRATQGKGLMPDGTTRFSYNGEPIYHYMGCSTFSEYTVVPEISLAVVNPEAP
LEKVCLLGCGVTTGIGAVHNTAKVKPGESVAVFGLGGIGLAVIQGAVQAKAGRILAIDTNPGKFDLARSMGATDCINPKD
YDKPIQEVIVELTDGGVDFSFECIGNVNVMRSALECCHKGWGESVIIGVAGAGQEISTRPFQLVTGRVWRGSAFGGVKGR
TQLPGMVEQSMKGEIDLDPFITHTMPLEEINEAFHLMHEGKSIRTVIHF

Sequences:

>Translated_369_residues
MKSRAAVAFGPGKPLEMVEIDVAPPKAGEVLVRITHTGVCHTDAFTLSGDDPEGIFPSVLGHEGGGIVEQVGEGVTSVKV
GDHVIPLYTAECRKCKFCLSGKTNLCQAVRATQGKGLMPDGTTRFSYNGEPIYHYMGCSTFSEYTVVPEISLAVVNPEAP
LEKVCLLGCGVTTGIGAVHNTAKVKPGESVAVFGLGGIGLAVIQGAVQAKAGRILAIDTNPGKFDLARSMGATDCINPKD
YDKPIQEVIVELTDGGVDFSFECIGNVNVMRSALECCHKGWGESVIIGVAGAGQEISTRPFQLVTGRVWRGSAFGGVKGR
TQLPGMVEQSMKGEIDLDPFITHTMPLEEINEAFHLMHEGKSIRTVIHF
>Mature_369_residues
MKSRAAVAFGPGKPLEMVEIDVAPPKAGEVLVRITHTGVCHTDAFTLSGDDPEGIFPSVLGHEGGGIVEQVGEGVTSVKV
GDHVIPLYTAECRKCKFCLSGKTNLCQAVRATQGKGLMPDGTTRFSYNGEPIYHYMGCSTFSEYTVVPEISLAVVNPEAP
LEKVCLLGCGVTTGIGAVHNTAKVKPGESVAVFGLGGIGLAVIQGAVQAKAGRILAIDTNPGKFDLARSMGATDCINPKD
YDKPIQEVIVELTDGGVDFSFECIGNVNVMRSALECCHKGWGESVIIGVAGAGQEISTRPFQLVTGRVWRGSAFGGVKGR
TQLPGMVEQSMKGEIDLDPFITHTMPLEEINEAFHLMHEGKSIRTVIHF

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=369, Percent_Identity=64.2276422764228, Blast_Score=487, Evalue=1e-138,
Organism=Homo sapiens, GI34577061, Length=369, Percent_Identity=50.6775067750677, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI71565152, Length=373, Percent_Identity=49.8659517426273, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI4501933, Length=369, Percent_Identity=49.8644986449864, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI4501929, Length=369, Percent_Identity=49.8644986449864, Blast_Score=381, Evalue=1e-106,
Organism=Homo sapiens, GI156523966, Length=367, Percent_Identity=46.5940054495913, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI71743840, Length=369, Percent_Identity=47.9674796747967, Blast_Score=359, Evalue=2e-99,
Organism=Homo sapiens, GI262073058, Length=369, Percent_Identity=47.9674796747967, Blast_Score=359, Evalue=2e-99,
Organism=Homo sapiens, GI4501939, Length=361, Percent_Identity=46.814404432133, Blast_Score=356, Evalue=2e-98,
Organism=Homo sapiens, GI156627571, Length=368, Percent_Identity=24.1847826086957, Blast_Score=75, Evalue=9e-14,
Organism=Escherichia coli, GI1786552, Length=369, Percent_Identity=81.3008130081301, Blast_Score=612, Evalue=1e-176,
Organism=Escherichia coli, GI1787863, Length=354, Percent_Identity=26.271186440678, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790045, Length=358, Percent_Identity=26.536312849162, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788073, Length=365, Percent_Identity=26.027397260274, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI87082125, Length=382, Percent_Identity=24.6073298429319, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87081918, Length=349, Percent_Identity=31.2320916905444, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1786825, Length=249, Percent_Identity=28.9156626506024, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI226510992, Length=368, Percent_Identity=24.7282608695652, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788407, Length=228, Percent_Identity=28.9473684210526, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790718, Length=330, Percent_Identity=25.1515151515152, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786518, Length=371, Percent_Identity=26.4150943396226, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI25146526, Length=373, Percent_Identity=58.7131367292225, Blast_Score=456, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI71997431, Length=375, Percent_Identity=58.4, Blast_Score=452, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17565904, Length=343, Percent_Identity=58.0174927113703, Blast_Score=419, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17562584, Length=363, Percent_Identity=27.8236914600551, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71988145, Length=372, Percent_Identity=26.6129032258064, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17562582, Length=372, Percent_Identity=25.8064516129032, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320033, Length=371, Percent_Identity=61.7250673854447, Blast_Score=477, Evalue=1e-135,
Organism=Saccharomyces cerevisiae, GI6319621, Length=277, Percent_Identity=31.0469314079422, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6323961, Length=311, Percent_Identity=29.2604501607717, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324486, Length=348, Percent_Identity=28.448275862069, Blast_Score=95, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6323729, Length=254, Percent_Identity=30.3149606299213, Blast_Score=86, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6323099, Length=376, Percent_Identity=26.5957446808511, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17737895, Length=368, Percent_Identity=63.8586956521739, Blast_Score=489, Evalue=1e-139,
Organism=Drosophila melanogaster, GI17137530, Length=350, Percent_Identity=26.2857142857143, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284; =1.1.1.1 [H]

Molecular weight: Translated: 39101; Mature: 39101

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSRAAVAFGPGKPLEMVEIDVAPPKAGEVLVRITHTGVCHTDAFTLSGDDPEGIFPSVL
CCCCEEEEECCCCCCEEEEEECCCCCCCCEEEEEEECCEEECCEEEECCCCCCCCCHHHH
GHEGGGIVEQVGEGVTSVKVGDHVIPLYTAECRKCKFCLSGKTNLCQAVRATQGKGLMPD
CCCCCCHHHHHCCCCEEEEECCEEEEEEECCCHHEEEEECCCHHHHHHHHHCCCCCCCCC
GTTRFSYNGEPIYHYMGCSTFSEYTVVPEISLAVVNPEAPLEKVCLLGCGVTTGIGAVHN
CCEEEECCCCEEEEEECCCCCCCEEECCCEEEEEECCCCCHHHHHHHHCCHHHCCCHHCC
TAKVKPGESVAVFGLGGIGLAVIQGAVQAKAGRILAIDTNPGKFDLARSMGATDCINPKD
CCCCCCCCEEEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHCCCCCCCCCCC
YDKPIQEVIVELTDGGVDFSFECIGNVNVMRSALECCHKGWGESVIIGVAGAGQEISTRP
CHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCC
FQLVTGRVWRGSAFGGVKGRTQLPGMVEQSMKGEIDLDPFITHTMPLEEINEAFHLMHEG
EEEEECEEEECCCCCCCCCCCCCCCHHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHHCC
KSIRTVIHF
CCEEEEEEC
>Mature Secondary Structure
MKSRAAVAFGPGKPLEMVEIDVAPPKAGEVLVRITHTGVCHTDAFTLSGDDPEGIFPSVL
CCCCEEEEECCCCCCEEEEEECCCCCCCCEEEEEEECCEEECCEEEECCCCCCCCCHHHH
GHEGGGIVEQVGEGVTSVKVGDHVIPLYTAECRKCKFCLSGKTNLCQAVRATQGKGLMPD
CCCCCCHHHHHCCCCEEEEECCEEEEEEECCCHHEEEEECCCHHHHHHHHHCCCCCCCCC
GTTRFSYNGEPIYHYMGCSTFSEYTVVPEISLAVVNPEAPLEKVCLLGCGVTTGIGAVHN
CCEEEECCCCEEEEEECCCCCCCEEECCCEEEEEECCCCCHHHHHHHHCCHHHCCCHHCC
TAKVKPGESVAVFGLGGIGLAVIQGAVQAKAGRILAIDTNPGKFDLARSMGATDCINPKD
CCCCCCCCEEEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHCCCCCCCCCCC
YDKPIQEVIVELTDGGVDFSFECIGNVNVMRSALECCHKGWGESVIIGVAGAGQEISTRP
CHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCC
FQLVTGRVWRGSAFGGVKGRTQLPGMVEQSMKGEIDLDPFITHTMPLEEINEAFHLMHEG
EEEEECEEEECCCCCCCCCCCCCCCHHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHHCC
KSIRTVIHF
CCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]