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The map label for this gene is murC [H]

Identifier: 84625260

GI number: 84625260

Start: 4076172

End: 4077605

Strand: Reverse

Name: murC [H]

Synonym: XOO_3603

Alternate gene names: 84625260

Gene position: 4077605-4076172 (Counterclockwise)

Preceding gene: 84625261

Following gene: 84625259

Centisome position: 82.54

GC content: 66.11

Gene sequence:

>1434_bases
TTGATCCGCCGTCTGCAGGACAGTGGCGATCTGGTGCGCGCGTTTCCGCGCGTGCATTTCGTCGGCATCGGCGGCACCGG
CATGAGCGGCATTGCCGAGGTGATGTTGACGCTGGGCTATGAAGTCTCCGGCTCGGATAACTCGGATAACGTGGCCACGC
GTCGCTTGGCCAAGCTGGGTGCGCGCGTGATGCGCGGCCACTCGGCCGCCAATGTGTTGGGCACCGATTGCGTGGTGGTC
TCCAGCGCCATTCGCGATGACAACCCCGAGCTGATGGAAGCGCGCAGCCAGCGCATTCCGATCATGCCGCGTGCCGCGAT
GCTGGCCGAGTTGATGCGCTTCCGCCGCGGCATCGCGGTGGCCGGCACGCATGGCAAGACCACCACCACCAGCCTGGCTG
CAGCGGTGCTGAGCGAAGGCGGGTTGGACCCGACGTTCGTCATCGGCGGCCAGCTGCTGGCCGCAGGCGCCAACGCAAAA
CTCGGTGGCGGCCAATGGCTGGTCGCCGAGGCCGACGAGAGCGATGGCAGCTTCCTGCGCCTGAATCCGTTGATGGCCGT
CATCACCAACATCGATGCGGATCACCTGGAAAATTACGGCAACGATTTCGCGCGTATCCAGGCCGCATTCGCCGAATTCC
TGCAGCGCCTGCCGTTCTATGGCCTGTCACTGCTGTGCATCGACGACCCGGAAGTCGCTGCGCTGGCCGGCAGGACGCCG
CGCCACGTGATGAGCTACGGCATGAGCGAAAACGCCGACGTGCGCGCCGAAGATGTGGTGCAGGACGGTCCGCGCATGCG
CTTCACGCTGCGTCTGCCGGAAGGCACCACCACGCCAGTGACATTGGCGCTGCCGGGGCGTCACAACGTGCTCAATGCAC
TGGCGGCTGCCGCAATCGGCTGGCAGCTCGGCGTGGCTCCGGGCACCATTGCACGCGCGCTGGAAAACTTCGCCGGCATC
GGCCGTCGTTTCAACGATCTGGGCGAAGTCACCACCAGCACCGGCGCGCGCGTGCGCGTGGTCGACGATTACGGCCACCA
TCCACGCGAGCTCGAAGCCGTGTTCGCTGCGGCGCGTGGTGGCTGGCCGGACAAGCGCCTGGTCGTCGCATTCCAGCCAC
ACCGCTATAGCCGCACCCGCGATCAGTTCGACGCCTTCGCCGCGGTGCTCAGCACGGTCGACGCATTGGTGTTGAGCGAG
GTCTACCCGGCAGGCGAAGCGCCGATTCCGGGCGCCGATTCGCGTGCACTAGCGCGCGCCATCCGTGCGCGCGGCCGCAG
CGAACCGGTGGTCGTCGGCCAGATCGCCAGCCTTGCCGAAGTGTTGCCGGACGTGCTGCAAGACGGTGACCTGCTGTTGA
TGATGGGCGCCGGCGATATCGGTTATGTGGCACAGCACATCATCAACAACGGGTTTGTCGGAGAGCCGGCATGA

Upstream 100 bases:

>100_bases
GGCGATCGACCGCCGCCGTTGCCAATCTCCAATGCCGCTCGCTCTTCGACAGCCACAGGCTGGCCATCCTCACTCCCGGC
ACCTTCGCAGGGGGTGCAGC

Downstream 100 bases:

>100_bases
GCGCGGTCATCGCCAATGCCCGCACCAGCGATCCGGCCATCTTTGGCCGCGTCGCCGTGTTGCTCGGCGGCACTTCGTCC
GAGCGCGAGGTGTCCTTGAA

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MIRRLQDSGDLVRAFPRVHFVGIGGTGMSGIAEVMLTLGYEVSGSDNSDNVATRRLAKLGARVMRGHSAANVLGTDCVVV
SSAIRDDNPELMEARSQRIPIMPRAAMLAELMRFRRGIAVAGTHGKTTTTSLAAAVLSEGGLDPTFVIGGQLLAAGANAK
LGGGQWLVAEADESDGSFLRLNPLMAVITNIDADHLENYGNDFARIQAAFAEFLQRLPFYGLSLLCIDDPEVAALAGRTP
RHVMSYGMSENADVRAEDVVQDGPRMRFTLRLPEGTTTPVTLALPGRHNVLNALAAAAIGWQLGVAPGTIARALENFAGI
GRRFNDLGEVTTSTGARVRVVDDYGHHPRELEAVFAAARGGWPDKRLVVAFQPHRYSRTRDQFDAFAAVLSTVDALVLSE
VYPAGEAPIPGADSRALARAIRARGRSEPVVVGQIASLAEVLPDVLQDGDLLLMMGAGDIGYVAQHIINNGFVGEPA

Sequences:

>Translated_477_residues
MIRRLQDSGDLVRAFPRVHFVGIGGTGMSGIAEVMLTLGYEVSGSDNSDNVATRRLAKLGARVMRGHSAANVLGTDCVVV
SSAIRDDNPELMEARSQRIPIMPRAAMLAELMRFRRGIAVAGTHGKTTTTSLAAAVLSEGGLDPTFVIGGQLLAAGANAK
LGGGQWLVAEADESDGSFLRLNPLMAVITNIDADHLENYGNDFARIQAAFAEFLQRLPFYGLSLLCIDDPEVAALAGRTP
RHVMSYGMSENADVRAEDVVQDGPRMRFTLRLPEGTTTPVTLALPGRHNVLNALAAAAIGWQLGVAPGTIARALENFAGI
GRRFNDLGEVTTSTGARVRVVDDYGHHPRELEAVFAAARGGWPDKRLVVAFQPHRYSRTRDQFDAFAAVLSTVDALVLSE
VYPAGEAPIPGADSRALARAIRARGRSEPVVVGQIASLAEVLPDVLQDGDLLLMMGAGDIGYVAQHIINNGFVGEPA
>Mature_477_residues
MIRRLQDSGDLVRAFPRVHFVGIGGTGMSGIAEVMLTLGYEVSGSDNSDNVATRRLAKLGARVMRGHSAANVLGTDCVVV
SSAIRDDNPELMEARSQRIPIMPRAAMLAELMRFRRGIAVAGTHGKTTTTSLAAAVLSEGGLDPTFVIGGQLLAAGANAK
LGGGQWLVAEADESDGSFLRLNPLMAVITNIDADHLENYGNDFARIQAAFAEFLQRLPFYGLSLLCIDDPEVAALAGRTP
RHVMSYGMSENADVRAEDVVQDGPRMRFTLRLPEGTTTPVTLALPGRHNVLNALAAAAIGWQLGVAPGTIARALENFAGI
GRRFNDLGEVTTSTGARVRVVDDYGHHPRELEAVFAAARGGWPDKRLVVAFQPHRYSRTRDQFDAFAAVLSTVDALVLSE
VYPAGEAPIPGADSRALARAIRARGRSEPVVVGQIASLAEVLPDVLQDGDLLLMMGAGDIGYVAQHIINNGFVGEPA

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=461, Percent_Identity=53.5791757049892, Blast_Score=441, Evalue=1e-125,
Organism=Escherichia coli, GI1790680, Length=468, Percent_Identity=28.8461538461538, Blast_Score=150, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 50706; Mature: 50706

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRRLQDSGDLVRAFPRVHFVGIGGTGMSGIAEVMLTLGYEVSGSDNSDNVATRRLAKLG
CCCCCCCCCHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCEECCCCCCCHHHHHHHHHHH
ARVMRGHSAANVLGTDCVVVSSAIRDDNPELMEARSQRIPIMPRAAMLAELMRFRRGIAV
HHHHHCCCHHHHHCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCEEE
AGTHGKTTTTSLAAAVLSEGGLDPTFVIGGQLLAAGANAKLGGGQWLVAEADESDGSFLR
ECCCCCCHHHHHHHHHHHCCCCCCEEEECCEEEECCCCCCCCCCEEEEEECCCCCCCEEE
LNPLMAVITNIDADHLENYGNDFARIQAAFAEFLQRLPFYGLSLLCIDDPEVAALAGRTP
ECHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHCCCCH
RHVMSYGMSENADVRAEDVVQDGPRMRFTLRLPEGTTTPVTLALPGRHNVLNALAAAAIG
HHHHHCCCCCCCCCCHHHHHCCCCCEEEEEECCCCCCCCEEEEECCCHHHHHHHHHHHHH
WQLGVAPGTIARALENFAGIGRRFNDLGEVTTSTGARVRVVDDYGHHPRELEAVFAAARG
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHC
GWPDKRLVVAFQPHRYSRTRDQFDAFAAVLSTVDALVLSEVYPAGEAPIPGADSRALARA
CCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
IRARGRSEPVVVGQIASLAEVLPDVLQDGDLLLMMGAGDIGYVAQHIINNGFVGEPA
HHHCCCCCCEEHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MIRRLQDSGDLVRAFPRVHFVGIGGTGMSGIAEVMLTLGYEVSGSDNSDNVATRRLAKLG
CCCCCCCCCHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCEECCCCCCCHHHHHHHHHHH
ARVMRGHSAANVLGTDCVVVSSAIRDDNPELMEARSQRIPIMPRAAMLAELMRFRRGIAV
HHHHHCCCHHHHHCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCEEE
AGTHGKTTTTSLAAAVLSEGGLDPTFVIGGQLLAAGANAKLGGGQWLVAEADESDGSFLR
ECCCCCCHHHHHHHHHHHCCCCCCEEEECCEEEECCCCCCCCCCEEEEEECCCCCCCEEE
LNPLMAVITNIDADHLENYGNDFARIQAAFAEFLQRLPFYGLSLLCIDDPEVAALAGRTP
ECHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHCCCCH
RHVMSYGMSENADVRAEDVVQDGPRMRFTLRLPEGTTTPVTLALPGRHNVLNALAAAAIG
HHHHHCCCCCCCCCCHHHHHCCCCCEEEEEECCCCCCCCEEEEECCCHHHHHHHHHHHHH
WQLGVAPGTIARALENFAGIGRRFNDLGEVTTSTGARVRVVDDYGHHPRELEAVFAAARG
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHC
GWPDKRLVVAFQPHRYSRTRDQFDAFAAVLSTVDALVLSEVYPAGEAPIPGADSRALARA
CCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
IRARGRSEPVVVGQIASLAEVLPDVLQDGDLLLMMGAGDIGYVAQHIINNGFVGEPA
HHHCCCCCCEEHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]