Click here to switch to the map view.

The map label for this gene is algC [H]

Identifier: 84622122

GI number: 84622122

Start: 504363

End: 505766

Strand: Direct

Name: algC [H]

Synonym: XOO_0465

Alternate gene names: 84622122

Gene position: 504363-505766 (Clockwise)

Preceding gene: 84622121

Following gene: 84622132

Centisome position: 10.21

GC content: 64.67

Gene sequence:

>1404_bases
GTGCCGGCGGTGCAGATCGCCACCGAGATGTTCCGCGCCTACGACATCCGTGGTGTGGTCGGCAAAGACCTCAACCCCGG
CGTTGCCGCCTTGATCGGCCAGGCCATCGGCAGCGTGATGCAGGCGCAGGGCCTGCGCCATGTGGTGGTCGGCCGCGACG
GCCGGCTGTCCGGACCGGAGTTGACCAATGGCCTGATCGAAGGCCTGCGCCGCGCCGGCTGCAATGTCACCGACATCGGC
TTGGCGCCGACGCCGGTGGTGTACTTCGGCGCGTACGAGCTGCGTGCCGGCAGCTGCGTGGCGGTGACCGGCAGCCACAA
TCCGCCGGACTACAACGGCTTCAAGATCGTGATCGGCGGCGAGACCTTGTCCGGCACCACCATTGCCGAATTGCACCAGC
GCATCAACGAAGGCCGCCTGCATACCGCTGCCACGCCCGGCGAACTGGAGCAGCGCGACATCAGCGATGCCTACATCCAG
CGCATTGCCGACGACGTGCAGCTTGATCGCCCGATCAAGGTGGTGGTGGACGCCGGCAACGGCGTCGCCGGTGAGATCGC
GCCGCGCCTTCTGGAAGCGATCGGCGCCAAAGTGGTTCCGTTGTATTGCGATATCGACGGCACTTTTCCCAATCATCACC
CCGACCCGAGCGAGCCGCACAACCTCGACGATCTGGTGAGGATGGTGCAGCGTTTCGATGCGGATATCGGCGTGGCGTTC
GATGGCGACGCCGATCGCCTGGGCGTGGTCACCAAGGAAGGCACGGTGGTGTTCCCCGACCGCCTGCTGATGCTGTTCGC
CGCCGATGTGCTGCAGCGCAATCCCGGCGCGTTGGTCATCTACGACGTGAAATGCACCGGCAAGCTGTCCGACTACGTAT
TGCGCAATGGCGGCAGCCCGTTGATGTGGAAGACCGGGCATTCGCTGATCAAATCCAAGATGCGCGAGACCGACGCCGAA
CTGGCTGGCGAGATGAGCGGGCACTTCTTCTTCAAGGAGCGCTGGTACGGCTTCGACGACGGCATCTACGCCGCTGCACG
CTTGCTGGAAATTCTCGCCCAGAGCGAGCAGACCCCGTCCGAGGTATTGGACGCCTTGCCCGAAAGCGTCTCCACGCCGG
AGATCAAGGTGCCGGTGGAGGGCGATGTGCATGCGCTGGTCGCGCGTTTTGTCGAGCGTGCGCAGACCGGCGGAGAATCG
CCGTTCGAGTCGGCACGGCTGTCGACCATCGATGGCTTGAGGGCGGATTTCGTCGATGGCTGGGGCCTGATACGCGCTTC
CAACACCACGCCGATCCTGGTGCTGCGGTTCGAAGCCGACAGCGAGGCTGCATTGCAGCGGATTCGCACGCTGTTCCGCG
AGGAACTGCAGGCGTTGGTGCCTGCGCATCCCTTGGCGTTCTGA

Upstream 100 bases:

>100_bases
TGAACCCACCCTCAGTCAGAGCCTGCAGCAGGACGCCAGCATTGCCAGCGAAGCGCGCGCGCTGGACGTCGACGCCTCGC
CCACAGTGCCGCCGGTGCTG

Downstream 100 bases:

>100_bases
TTGCCAGATGCGCCGGGCGCCAGCTACGTTTCCTGTTAACAGGCAGCGCAGCTGGGCCGGCGCGGGGCGCACCTGGCGGC
CAGCCGAGACCGCCCCGCCG

Product: phosphomannomutase

Products: NA

Alternate protein names: PMM / PGM [H]

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MPAVQIATEMFRAYDIRGVVGKDLNPGVAALIGQAIGSVMQAQGLRHVVVGRDGRLSGPELTNGLIEGLRRAGCNVTDIG
LAPTPVVYFGAYELRAGSCVAVTGSHNPPDYNGFKIVIGGETLSGTTIAELHQRINEGRLHTAATPGELEQRDISDAYIQ
RIADDVQLDRPIKVVVDAGNGVAGEIAPRLLEAIGAKVVPLYCDIDGTFPNHHPDPSEPHNLDDLVRMVQRFDADIGVAF
DGDADRLGVVTKEGTVVFPDRLLMLFAADVLQRNPGALVIYDVKCTGKLSDYVLRNGGSPLMWKTGHSLIKSKMRETDAE
LAGEMSGHFFFKERWYGFDDGIYAAARLLEILAQSEQTPSEVLDALPESVSTPEIKVPVEGDVHALVARFVERAQTGGES
PFESARLSTIDGLRADFVDGWGLIRASNTTPILVLRFEADSEAALQRIRTLFREELQALVPAHPLAF

Sequences:

>Translated_467_residues
MPAVQIATEMFRAYDIRGVVGKDLNPGVAALIGQAIGSVMQAQGLRHVVVGRDGRLSGPELTNGLIEGLRRAGCNVTDIG
LAPTPVVYFGAYELRAGSCVAVTGSHNPPDYNGFKIVIGGETLSGTTIAELHQRINEGRLHTAATPGELEQRDISDAYIQ
RIADDVQLDRPIKVVVDAGNGVAGEIAPRLLEAIGAKVVPLYCDIDGTFPNHHPDPSEPHNLDDLVRMVQRFDADIGVAF
DGDADRLGVVTKEGTVVFPDRLLMLFAADVLQRNPGALVIYDVKCTGKLSDYVLRNGGSPLMWKTGHSLIKSKMRETDAE
LAGEMSGHFFFKERWYGFDDGIYAAARLLEILAQSEQTPSEVLDALPESVSTPEIKVPVEGDVHALVARFVERAQTGGES
PFESARLSTIDGLRADFVDGWGLIRASNTTPILVLRFEADSEAALQRIRTLFREELQALVPAHPLAF
>Mature_466_residues
PAVQIATEMFRAYDIRGVVGKDLNPGVAALIGQAIGSVMQAQGLRHVVVGRDGRLSGPELTNGLIEGLRRAGCNVTDIGL
APTPVVYFGAYELRAGSCVAVTGSHNPPDYNGFKIVIGGETLSGTTIAELHQRINEGRLHTAATPGELEQRDISDAYIQR
IADDVQLDRPIKVVVDAGNGVAGEIAPRLLEAIGAKVVPLYCDIDGTFPNHHPDPSEPHNLDDLVRMVQRFDADIGVAFD
GDADRLGVVTKEGTVVFPDRLLMLFAADVLQRNPGALVIYDVKCTGKLSDYVLRNGGSPLMWKTGHSLIKSKMRETDAEL
AGEMSGHFFFKERWYGFDDGIYAAARLLEILAQSEQTPSEVLDALPESVSTPEIKVPVEGDVHALVARFVERAQTGGESP
FESARLSTIDGLRADFVDGWGLIRASNTTPILVLRFEADSEAALQRIRTLFREELQALVPAHPLAF

Specific function: The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to it

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=453, Percent_Identity=33.9955849889625, Blast_Score=228, Evalue=5e-61,
Organism=Escherichia coli, GI1789566, Length=443, Percent_Identity=27.5395033860045, Blast_Score=108, Evalue=8e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2; =5.4.2.8 [H]

Molecular weight: Translated: 50511; Mature: 50380

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAVQIATEMFRAYDIRGVVGKDLNPGVAALIGQAIGSVMQAQGLRHVVVGRDGRLSGPE
CCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHH
LTNGLIEGLRRAGCNVTDIGLAPTPVVYFGAYELRAGSCVAVTGSHNPPDYNGFKIVIGG
HHHHHHHHHHHCCCCEEECCCCCCCEEEEECEEECCCCEEEEECCCCCCCCCCEEEEECC
ETLSGTTIAELHQRINEGRLHTAATPGELEQRDISDAYIQRIADDVQLDRPIKVVVDAGN
CCCCCCHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
GVAGEIAPRLLEAIGAKVVPLYCDIDGTFPNHHPDPSEPHNLDDLVRMVQRFDADIGVAF
CCCHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEE
DGDADRLGVVTKEGTVVFPDRLLMLFAADVLQRNPGALVIYDVKCTGKLSDYVLRNGGSP
CCCCCCEEEEECCCCEECHHHHHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHHCCCCC
LMWKTGHSLIKSKMRETDAELAGEMSGHFFFKERWYGFDDGIYAAARLLEILAQSEQTPS
EEECCCHHHHHHHHHHHHHHHHHHCCCCEEEEHHCCCCCCHHHHHHHHHHHHHHCCCCHH
EVLDALPESVSTPEIKVPVEGDVHALVARFVERAQTGGESPFESARLSTIDGLRADFVDG
HHHHHCHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHCC
WGLIRASNTTPILVLRFEADSEAALQRIRTLFREELQALVPAHPLAF
CEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PAVQIATEMFRAYDIRGVVGKDLNPGVAALIGQAIGSVMQAQGLRHVVVGRDGRLSGPE
CHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHH
LTNGLIEGLRRAGCNVTDIGLAPTPVVYFGAYELRAGSCVAVTGSHNPPDYNGFKIVIGG
HHHHHHHHHHHCCCCEEECCCCCCCEEEEECEEECCCCEEEEECCCCCCCCCCEEEEECC
ETLSGTTIAELHQRINEGRLHTAATPGELEQRDISDAYIQRIADDVQLDRPIKVVVDAGN
CCCCCCHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
GVAGEIAPRLLEAIGAKVVPLYCDIDGTFPNHHPDPSEPHNLDDLVRMVQRFDADIGVAF
CCCHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEE
DGDADRLGVVTKEGTVVFPDRLLMLFAADVLQRNPGALVIYDVKCTGKLSDYVLRNGGSP
CCCCCCEEEEECCCCEECHHHHHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHHCCCCC
LMWKTGHSLIKSKMRETDAELAGEMSGHFFFKERWYGFDDGIYAAARLLEILAQSEQTPS
EEECCCHHHHHHHHHHHHHHHHHHCCCCEEEEHHCCCCCCHHHHHHHHHHHHHHCCCCHH
EVLDALPESVSTPEIKVPVEGDVHALVARFVERAQTGGESPFESARLSTIDGLRADFVDG
HHHHHCHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHCC
WGLIRASNTTPILVLRFEADSEAALQRIRTLFREELQALVPAHPLAF
CEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1903398; 10984043; 7515870; 10481091; 8050998; 11716469; 11839312 [H]