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The map label for this gene is coaBC [H]

Identifier: 84622120

GI number: 84622120

Start: 501666

End: 502940

Strand: Direct

Name: coaBC [H]

Synonym: XOO_0463

Alternate gene names: 84622120

Gene position: 501666-502940 (Clockwise)

Preceding gene: 84622114

Following gene: 84622121

Centisome position: 10.15

GC content: 68.08

Gene sequence:

>1275_bases
GTGATCGGCTCAACTCAGGCCCGCCCCCTGGACGGACAGCGTTTGCTGCTGTGCGTCGGCGGAGGCATTGCCGCTTACAA
ATCGCTCGAACTGGTCCGTCGCCTGCGCGACGCCGGTGCGCAGGTGCAGGTCGCCATGACCAGCGGCGCGCAACAATTCG
TCACCCCGCTCAGCTTCCAGGCACTGTCCGGGCAACCGACCCGCACCACGTTATGGGACAGCGCTGCCGAGCAGGCGATG
GGCCACATCGAACTGGCGCGCTGGGCCGAGCGGGTAATCGTTGCCCCGGCGACCGCCGACCTGTTGGCGCGTCTGGCGCA
TGGTCTGGCCGACGATCTGGTCACAACCCTGTGCCTGGCGACCACCGCGCCGCTGACCGTGGCGCCGGCGATGAACCACC
GCATGTGGCTGCATCCAGCCACCCAGGCCAATATCGCCACCTTGCGCACGCGCGGGGTGAAGGTGGTGGGCCCCGACGAT
GGCCCGCTGGCCGAGGGCGAATCCGGCCCCGGGCGGCTGGCCGAGCCGGCGGCGATCATCGCCGCGCTGGTCGACGGCAT
TGCTGTCGCAAGCGCTGCACCGGCCGGTGCCAAGAGCACCGCTGCGCCGATGTTCGTGTCCAGCAGTGCACAGCTGGACG
GCCTGCGCATTGTGATCAGCGCCGGCCCCACCTTCGAAGACCTGGATCCGGTGCGCTACGTCGGCAACCGCAGCAGCGGC
AAGATGGGCTACGCCCTGGCCGCCGCCGCTGCCCGCCAGGGCGCCGACGTGGTGCTGGTGAGCGGGCCGGTGCATCAGAC
CACCCCGGCCGGCGTCCAGCGCATCGACGTGCGCTCGGCCGCGCAGATGCGTGATGCGGTGCTCGGCGCCTTCCCGGCCG
ACATTTACATCGGGGCCGCTGCCGTGGCCGATTACACGCCCAAGCGGGTGGTGTCGCAGAAGATCAAGAAGACCGGCGAA
ACGCTGACCCTGGAACTGGTGCGCACCCCGGACATCCTGGCCGAGGTTGCCGCGCAGACTGGCGCATTGAAACTGGTGGT
CGGTTTTGCTGCCGAAACGCACGACGTGGAGCATTACGCGCGTGGCAAGCTGGCGGCCAAGCGGCTGGATCTGATCATCG
CCAATCAGGTGGGGATCGAAGGCGGCGGCTTCGAAAGCGACAACAACGCGGCCACTGCCTATTGGCCGGGCGGCGAGCGC
GCGTTTCCCAGTAGCAGCAAGACTGAATTGGCCGACCAACTACTGGCCTTGATTGCGGAGAGATTGCAGGCATGA

Upstream 100 bases:

>100_bases
GCATATGGCGAGATTGCCGGTGCTCATCGCCGACGCCCATCAGGCCAAGCGAGGGCATCGGCTAATCTAGTTGTCCTTGT
AACCGTAGGACGACTCCGAC

Downstream 100 bases:

>100_bases
GCACCCCGACCCAGTCCTTGCAGGTGAAGTTGCTCGACCCGCGCTTCGGCGATCTGTGGCCGTTGCCGGCCTATGCCACC
GAATCCAGTGCAGGCATGGA

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MIGSTQARPLDGQRLLLCVGGGIAAYKSLELVRRLRDAGAQVQVAMTSGAQQFVTPLSFQALSGQPTRTTLWDSAAEQAM
GHIELARWAERVIVAPATADLLARLAHGLADDLVTTLCLATTAPLTVAPAMNHRMWLHPATQANIATLRTRGVKVVGPDD
GPLAEGESGPGRLAEPAAIIAALVDGIAVASAAPAGAKSTAAPMFVSSSAQLDGLRIVISAGPTFEDLDPVRYVGNRSSG
KMGYALAAAAARQGADVVLVSGPVHQTTPAGVQRIDVRSAAQMRDAVLGAFPADIYIGAAAVADYTPKRVVSQKIKKTGE
TLTLELVRTPDILAEVAAQTGALKLVVGFAAETHDVEHYARGKLAAKRLDLIIANQVGIEGGGFESDNNAATAYWPGGER
AFPSSSKTELADQLLALIAERLQA

Sequences:

>Translated_424_residues
MIGSTQARPLDGQRLLLCVGGGIAAYKSLELVRRLRDAGAQVQVAMTSGAQQFVTPLSFQALSGQPTRTTLWDSAAEQAM
GHIELARWAERVIVAPATADLLARLAHGLADDLVTTLCLATTAPLTVAPAMNHRMWLHPATQANIATLRTRGVKVVGPDD
GPLAEGESGPGRLAEPAAIIAALVDGIAVASAAPAGAKSTAAPMFVSSSAQLDGLRIVISAGPTFEDLDPVRYVGNRSSG
KMGYALAAAAARQGADVVLVSGPVHQTTPAGVQRIDVRSAAQMRDAVLGAFPADIYIGAAAVADYTPKRVVSQKIKKTGE
TLTLELVRTPDILAEVAAQTGALKLVVGFAAETHDVEHYARGKLAAKRLDLIIANQVGIEGGGFESDNNAATAYWPGGER
AFPSSSKTELADQLLALIAERLQA
>Mature_424_residues
MIGSTQARPLDGQRLLLCVGGGIAAYKSLELVRRLRDAGAQVQVAMTSGAQQFVTPLSFQALSGQPTRTTLWDSAAEQAM
GHIELARWAERVIVAPATADLLARLAHGLADDLVTTLCLATTAPLTVAPAMNHRMWLHPATQANIATLRTRGVKVVGPDD
GPLAEGESGPGRLAEPAAIIAALVDGIAVASAAPAGAKSTAAPMFVSSSAQLDGLRIVISAGPTFEDLDPVRYVGNRSSG
KMGYALAAAAARQGADVVLVSGPVHQTTPAGVQRIDVRSAAQMRDAVLGAFPADIYIGAAAVADYTPKRVVSQKIKKTGE
TLTLELVRTPDILAEVAAQTGALKLVVGFAAETHDVEHYARGKLAAKRLDLIIANQVGIEGGGFESDNNAATAYWPGGER
AFPSSSKTELADQLLALIAERLQA

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=180, Percent_Identity=33.3333333333333, Blast_Score=83, Evalue=5e-16,
Organism=Escherichia coli, GI87082301, Length=416, Percent_Identity=51.6826923076923, Blast_Score=367, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17560194, Length=185, Percent_Identity=30.8108108108108, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24657262, Length=182, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 44025; Mature: 44025

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGSTQARPLDGQRLLLCVGGGIAAYKSLELVRRLRDAGAQVQVAMTSGAQQFVTPLSFQ
CCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHCCHHHH
ALSGQPTRTTLWDSAAEQAMGHIELARWAERVIVAPATADLLARLAHGLADDLVTTLCLA
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHH
TTAPLTVAPAMNHRMWLHPATQANIATLRTRGVKVVGPDDGPLAEGESGPGRLAEPAAII
HCCCEEEECCCCCEEEECCCCCCCHHEEEECCEEEECCCCCCCCCCCCCCCCCCCHHHHH
AALVDGIAVASAAPAGAKSTAAPMFVSSSAQLDGLRIVISAGPTFEDLDPVRYVGNRSSG
HHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCEEEEEECCCCCCCCCHHHHHCCCCCC
KMGYALAAAAARQGADVVLVSGPVHQTTPAGVQRIDVRSAAQMRDAVLGAFPADIYIGAA
CCHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCHH
AVADYTPKRVVSQKIKKTGETLTLELVRTPDILAEVAAQTGALKLVVGFAAETHDVEHYA
HHHCCCHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHCCCCEEEEEEECCCHHHHHHHH
RGKLAAKRLDLIIANQVGIEGGGFESDNNAATAYWPGGERAFPSSSKTELADQLLALIAE
HHHHHHHHHHEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
RLQA
HHCC
>Mature Secondary Structure
MIGSTQARPLDGQRLLLCVGGGIAAYKSLELVRRLRDAGAQVQVAMTSGAQQFVTPLSFQ
CCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHCCHHHH
ALSGQPTRTTLWDSAAEQAMGHIELARWAERVIVAPATADLLARLAHGLADDLVTTLCLA
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHH
TTAPLTVAPAMNHRMWLHPATQANIATLRTRGVKVVGPDDGPLAEGESGPGRLAEPAAII
HCCCEEEECCCCCEEEECCCCCCCHHEEEECCEEEECCCCCCCCCCCCCCCCCCCHHHHH
AALVDGIAVASAAPAGAKSTAAPMFVSSSAQLDGLRIVISAGPTFEDLDPVRYVGNRSSG
HHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCEEEEEECCCCCCCCCHHHHHCCCCCC
KMGYALAAAAARQGADVVLVSGPVHQTTPAGVQRIDVRSAAQMRDAVLGAFPADIYIGAA
CCHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCHH
AVADYTPKRVVSQKIKKTGETLTLELVRTPDILAEVAAQTGALKLVVGFAAETHDVEHYA
HHHCCCHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHCCCCEEEEEEECCCHHHHHHHH
RGKLAAKRLDLIIANQVGIEGGGFESDNNAATAYWPGGERAFPSSSKTELADQLLALIAE
HHHHHHHHHHEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
RLQA
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]