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The map label for this gene is cadA [H]

Identifier: 84489487

GI number: 84489487

Start: 790493

End: 792427

Strand: Direct

Name: cadA [H]

Synonym: Msp_0678

Alternate gene names: 84489487

Gene position: 790493-792427 (Clockwise)

Preceding gene: 84489484

Following gene: 84489488

Centisome position: 44.73

GC content: 29.56

Gene sequence:

>1935_bases
ATGAATAAATTCGAGAAATTAATGGGTTTTCTCGAAGGTCTTAAAATGACCATAGTAGGAGGAATATTCCTATTAATAAG
TTTAATATTATTAATAACAAACACAACATTACCAATAGATCCTGCATGGGTAACTATTGTAATATGTGGACTTCCTCTTC
TATACCTAGCTTTAAGTAGATTAGTCTATGAACACTGGGTATCTTCAGCATTATTAATATGTATTGCAATGGTTGCATCA
TTAATGATTGGTGAAATATTTGCTGCAGGTGAAGTAGTATTTATAATGGCATTAGGAGCTCTTCTTGAAGACTACACTGT
AAGAAAATCAAAACAAGGATTAAGAGATTTAATAAATCTAAAACCACAAACTGGTAGATTACTAATTAAAGAAAATGGAG
ATATTGTAGAAAAAGAAATAAAAGTTCAGGAAATAAAAAAAGAAGATAAATTACGAGTACTTCCAGGAGAAGTAATTCCA
GTAGATGGAATTATAATCAGTGGAGATACATCTGTAGATCAATCTGTTATGACTGGTGAATCACTACCACTAGATAAAAC
AGTTAATGATGAAGTATATGCTGGTACTTTAAACTTATATGGTGCCATAGATATAATCTCAACAAAAATAGGTAAAGATT
CTTCACTAGAAAAATTAATTAGAATGGTTAAGGAAGCTGATGAAAAACAAGCACCAACACAAAGAATTGCAGATAAATGG
GCAACATGGTTAGTACCTGTTGCATTAGCTATTGCTATTATTACATACATACTAACATGGAATATTGAAAGAGCAGTAAC
AATACTAGTAGTATTCTGTCCATGTGCACTGATACTTGCTACACCAACAGCTATTATGGCTGCAATTGGTCAAGCTACAA
AACATGGTGTTCTTATAAAATCAGGTGAAGCTCTAGAGAAAATGGGTAATGTTAACTCCATAGCATTTGATAAAACAGGA
ACTTTAACCTATGGTAACCTAGAAGTATCTGATATAATACCATTGAAAGAAAATATTAGTAAAAAAATATTATTAAAATA
TGTAACAATTTCAGAGGTAAAATCAGAACATCCTATAGGTAAAGCCATAGTAAAATACAGTAAAAATGAATCTATCAATT
ATACTCAACCTGAAGAATTTAAAATGATTCCAGGAAAAGGAGTATCTGCAGTATATAATAATAAAAAAATACTATCTGGT
ACTATTAAATTCATGGAAGAAAATAATATTACAATAAATAGTGAATCTATTGAAAAATTAGACTTACTAAGAAATGAAGG
AAAAGCATCTATTGTAGTATCATATGATAATGAATTAGTTGGAATAATTGGGTTATCTGATGTGTTACGTGAAACTGCTC
CATATGTAGTTAATACTTTAATCAATGATTTAGATACTGATGTTGAATTATTAACTGGAGATAATCATAAAGCTGCAAAT
TACTTTGCAAGTAAAGTTGGTATAACAAATATCTATTCAGAACTGTTACCTGAAAACAAGGTTGAAATAATTGAACAATT
AAAATGTGATAAGAAAACAGTGTGTATGGTTGGTGATGGAATTAATGATGCTCCAGCACTAAAAACAGCAGATGTTAGTG
TTGCAATGGGTGGTATGGGTAGTGATATAGTTATTGATGCAGCAGATATTGCATTGCTAGGTGATGATATTGAAAATTTA
ACATATCTTAAAAAATTATCAAATGCAACTTTATTTACAATACATCTAAGTATAACAATATCTATGATAATAAATGCAGT
TGCTATTGTATGTTCAGTATTAGGACTATTAGATCCTATAAGTGGAGCATTAGTACATAATATAGGTTCATGTGCAGTTG
TAATGTTGGCAGCATCATTGTATGATAGAGATTTTTCTGATTATGCTCACAAATCTAAAGATAATATTACTATTAAAAAA
CCTATTACAAATTAA

Upstream 100 bases:

>100_bases
GGAGTAATACAAAAGTATTACTTTTTAGTAAATTCATTTATATACTAGTATTACAAAAGTATTAACTATAATATAAATAA
TATATAAAGGAGTAATACTT

Downstream 100 bases:

>100_bases
TTTTTTTTCTTTTTTTTCTATTTTTTCATGTTATTATTTAGTGAATAAATAGTTCTTATTTTGGGAACTTAATTTGATAT
TTATTCACTATATATGAACT

Product: cation transport ATPase

Products: NA

Alternate protein names: Cadmium efflux ATPase [H]

Number of amino acids: Translated: 644; Mature: 644

Protein sequence:

>644_residues
MNKFEKLMGFLEGLKMTIVGGIFLLISLILLITNTTLPIDPAWVTIVICGLPLLYLALSRLVYEHWVSSALLICIAMVAS
LMIGEIFAAGEVVFIMALGALLEDYTVRKSKQGLRDLINLKPQTGRLLIKENGDIVEKEIKVQEIKKEDKLRVLPGEVIP
VDGIIISGDTSVDQSVMTGESLPLDKTVNDEVYAGTLNLYGAIDIISTKIGKDSSLEKLIRMVKEADEKQAPTQRIADKW
ATWLVPVALAIAIITYILTWNIERAVTILVVFCPCALILATPTAIMAAIGQATKHGVLIKSGEALEKMGNVNSIAFDKTG
TLTYGNLEVSDIIPLKENISKKILLKYVTISEVKSEHPIGKAIVKYSKNESINYTQPEEFKMIPGKGVSAVYNNKKILSG
TIKFMEENNITINSESIEKLDLLRNEGKASIVVSYDNELVGIIGLSDVLRETAPYVVNTLINDLDTDVELLTGDNHKAAN
YFASKVGITNIYSELLPENKVEIIEQLKCDKKTVCMVGDGINDAPALKTADVSVAMGGMGSDIVIDAADIALLGDDIENL
TYLKKLSNATLFTIHLSITISMIINAVAIVCSVLGLLDPISGALVHNIGSCAVVMLAASLYDRDFSDYAHKSKDNITIKK
PITN

Sequences:

>Translated_644_residues
MNKFEKLMGFLEGLKMTIVGGIFLLISLILLITNTTLPIDPAWVTIVICGLPLLYLALSRLVYEHWVSSALLICIAMVAS
LMIGEIFAAGEVVFIMALGALLEDYTVRKSKQGLRDLINLKPQTGRLLIKENGDIVEKEIKVQEIKKEDKLRVLPGEVIP
VDGIIISGDTSVDQSVMTGESLPLDKTVNDEVYAGTLNLYGAIDIISTKIGKDSSLEKLIRMVKEADEKQAPTQRIADKW
ATWLVPVALAIAIITYILTWNIERAVTILVVFCPCALILATPTAIMAAIGQATKHGVLIKSGEALEKMGNVNSIAFDKTG
TLTYGNLEVSDIIPLKENISKKILLKYVTISEVKSEHPIGKAIVKYSKNESINYTQPEEFKMIPGKGVSAVYNNKKILSG
TIKFMEENNITINSESIEKLDLLRNEGKASIVVSYDNELVGIIGLSDVLRETAPYVVNTLINDLDTDVELLTGDNHKAAN
YFASKVGITNIYSELLPENKVEIIEQLKCDKKTVCMVGDGINDAPALKTADVSVAMGGMGSDIVIDAADIALLGDDIENL
TYLKKLSNATLFTIHLSITISMIINAVAIVCSVLGLLDPISGALVHNIGSCAVVMLAASLYDRDFSDYAHKSKDNITIKK
PITN
>Mature_644_residues
MNKFEKLMGFLEGLKMTIVGGIFLLISLILLITNTTLPIDPAWVTIVICGLPLLYLALSRLVYEHWVSSALLICIAMVAS
LMIGEIFAAGEVVFIMALGALLEDYTVRKSKQGLRDLINLKPQTGRLLIKENGDIVEKEIKVQEIKKEDKLRVLPGEVIP
VDGIIISGDTSVDQSVMTGESLPLDKTVNDEVYAGTLNLYGAIDIISTKIGKDSSLEKLIRMVKEADEKQAPTQRIADKW
ATWLVPVALAIAIITYILTWNIERAVTILVVFCPCALILATPTAIMAAIGQATKHGVLIKSGEALEKMGNVNSIAFDKTG
TLTYGNLEVSDIIPLKENISKKILLKYVTISEVKSEHPIGKAIVKYSKNESINYTQPEEFKMIPGKGVSAVYNNKKILSG
TIKFMEENNITINSESIEKLDLLRNEGKASIVVSYDNELVGIIGLSDVLRETAPYVVNTLINDLDTDVELLTGDNHKAAN
YFASKVGITNIYSELLPENKVEIIEQLKCDKKTVCMVGDGINDAPALKTADVSVAMGGMGSDIVIDAADIALLGDDIENL
TYLKKLSNATLFTIHLSITISMIINAVAIVCSVLGLLDPISGALVHNIGSCAVVMLAASLYDRDFSDYAHKSKDNITIKK
PITN

Specific function: This electroneutral antiporter ejects one cadmium ion while accumulating two protons by an energy-dependent efflux mechanism [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=581, Percent_Identity=30.9810671256454, Blast_Score=296, Evalue=3e-80,
Organism=Homo sapiens, GI115529486, Length=626, Percent_Identity=30.5111821086262, Blast_Score=296, Evalue=6e-80,
Organism=Homo sapiens, GI55743073, Length=535, Percent_Identity=31.0280373831776, Blast_Score=276, Evalue=4e-74,
Organism=Homo sapiens, GI48762685, Length=149, Percent_Identity=30.2013422818792, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI48762691, Length=149, Percent_Identity=30.2013422818792, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI48762689, Length=149, Percent_Identity=30.2013422818792, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI48762687, Length=149, Percent_Identity=30.2013422818792, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI118498343, Length=124, Percent_Identity=30.6451612903226, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI1789879, Length=567, Percent_Identity=30.6878306878307, Blast_Score=272, Evalue=4e-74,
Organism=Escherichia coli, GI1786691, Length=542, Percent_Identity=30.8118081180812, Blast_Score=261, Evalue=7e-71,
Organism=Escherichia coli, GI1786914, Length=556, Percent_Identity=27.6978417266187, Blast_Score=157, Evalue=3e-39,
Organism=Escherichia coli, GI2367363, Length=604, Percent_Identity=22.0198675496689, Blast_Score=87, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17556548, Length=590, Percent_Identity=31.6949152542373, Blast_Score=245, Evalue=4e-65,
Organism=Caenorhabditis elegans, GI71997262, Length=177, Percent_Identity=28.2485875706215, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71997275, Length=177, Percent_Identity=28.2485875706215, Blast_Score=73, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71997269, Length=177, Percent_Identity=28.2485875706215, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI32566766, Length=70, Percent_Identity=45.7142857142857, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17557770, Length=70, Percent_Identity=45.7142857142857, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17557486, Length=70, Percent_Identity=45.7142857142857, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320475, Length=514, Percent_Identity=31.7120622568093, Blast_Score=228, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6319772, Length=494, Percent_Identity=29.5546558704453, Blast_Score=203, Evalue=7e-53,
Organism=Saccharomyces cerevisiae, GI6321430, Length=571, Percent_Identity=23.292469352014, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6325221, Length=491, Percent_Identity=23.8289205702648, Blast_Score=97, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6321271, Length=154, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6321432, Length=210, Percent_Identity=30, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221329854, Length=344, Percent_Identity=32.8488372093023, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24668704, Length=147, Percent_Identity=29.2517006802721, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281366617, Length=147, Percent_Identity=29.2517006802721, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24668708, Length=147, Percent_Identity=29.2517006802721, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI161085803, Length=147, Percent_Identity=29.2517006802721, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24668696, Length=147, Percent_Identity=29.2517006802721, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.3 [H]

Molecular weight: Translated: 70056; Mature: 70056

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00154 ATPASE_E1_E2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKFEKLMGFLEGLKMTIVGGIFLLISLILLITNTTLPIDPAWVTIVICGLPLLYLALSR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
LVYEHWVSSALLICIAMVASLMIGEIFAAGEVVFIMALGALLEDYTVRKSKQGLRDLINL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KPQTGRLLIKENGDIVEKEIKVQEIKKEDKLRVLPGEVIPVDGIIISGDTSVDQSVMTGE
CCCCCEEEEECCCCHHHHHHHHHHHCCCCCEEECCCCEEEECCEEECCCCCCCHHHHCCC
SLPLDKTVNDEVYAGTLNLYGAIDIISTKIGKDSSLEKLIRMVKEADEKQAPTQRIADKW
CCCCCCCCCCCEEEEEEEHHEHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHH
ATWLVPVALAIAIITYILTWNIERAVTILVVFCPCALILATPTAIMAAIGQATKHGVLIK
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEE
SGEALEKMGNVNSIAFDKTGTLTYGNLEVSDIIPLKENISKKILLKYVTISEVKSEHPIG
CCHHHHHCCCCCEEEECCCCCEEECCEEHHHCCCCHHCCCHHHHHHHHHHHHHHCCCCHH
KAIVKYSKNESINYTQPEEFKMIPGKGVSAVYNNKKILSGTIKFMEENNITINSESIEKL
HHHHHCCCCCCCCCCCCHHEEECCCCCCCHHCCCCEEEEHHHHEEECCCEEECCHHHHHH
DLLRNEGKASIVVSYDNELVGIIGLSDVLRETAPYVVNTLINDLDTDVELLTGDNHKAAN
HHHHCCCCEEEEEEECCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHH
YFASKVGITNIYSELLPENKVEIIEQLKCDKKTVCMVGDGINDAPALKTADVSVAMGGMG
HHHHHCCHHHHHHHHCCCCHHHHHHHHCCCCCEEEEECCCCCCCCCCEECCCEEEECCCC
SDIVIDAADIALLGDDIENLTYLKKLSNATLFTIHLSITISMIINAVAIVCSVLGLLDPI
CCEEEECCHHEEECCCHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCC
SGALVHNIGSCAVVMLAASLYDRDFSDYAHKSKDNITIKKPITN
CHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEEECCCCC
>Mature Secondary Structure
MNKFEKLMGFLEGLKMTIVGGIFLLISLILLITNTTLPIDPAWVTIVICGLPLLYLALSR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
LVYEHWVSSALLICIAMVASLMIGEIFAAGEVVFIMALGALLEDYTVRKSKQGLRDLINL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KPQTGRLLIKENGDIVEKEIKVQEIKKEDKLRVLPGEVIPVDGIIISGDTSVDQSVMTGE
CCCCCEEEEECCCCHHHHHHHHHHHCCCCCEEECCCCEEEECCEEECCCCCCCHHHHCCC
SLPLDKTVNDEVYAGTLNLYGAIDIISTKIGKDSSLEKLIRMVKEADEKQAPTQRIADKW
CCCCCCCCCCCEEEEEEEHHEHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHH
ATWLVPVALAIAIITYILTWNIERAVTILVVFCPCALILATPTAIMAAIGQATKHGVLIK
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEE
SGEALEKMGNVNSIAFDKTGTLTYGNLEVSDIIPLKENISKKILLKYVTISEVKSEHPIG
CCHHHHHCCCCCEEEECCCCCEEECCEEHHHCCCCHHCCCHHHHHHHHHHHHHHCCCCHH
KAIVKYSKNESINYTQPEEFKMIPGKGVSAVYNNKKILSGTIKFMEENNITINSESIEKL
HHHHHCCCCCCCCCCCCHHEEECCCCCCCHHCCCCEEEEHHHHEEECCCEEECCHHHHHH
DLLRNEGKASIVVSYDNELVGIIGLSDVLRETAPYVVNTLINDLDTDVELLTGDNHKAAN
HHHHCCCCEEEEEEECCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHH
YFASKVGITNIYSELLPENKVEIIEQLKCDKKTVCMVGDGINDAPALKTADVSVAMGGMG
HHHHHCCHHHHHHHHCCCCHHHHHHHHCCCCCEEEEECCCCCCCCCCEECCCEEEECCCC
SDIVIDAADIALLGDDIENLTYLKKLSNATLFTIHLSITISMIINAVAIVCSVLGLLDPI
CCEEEECCHHEEECCCHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCC
SGALVHNIGSCAVVMLAASLYDRDFSDYAHKSKDNITIKKPITN
CHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1321115 [H]