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The map label for this gene is xapA [C]

Identifier: 84489451

GI number: 84489451

Start: 750562

End: 751323

Strand: Direct

Name: xapA [C]

Synonym: Msp_0642

Alternate gene names: 84489451

Gene position: 750562-751323 (Clockwise)

Preceding gene: 84489450

Following gene: 84489452

Centisome position: 42.47

GC content: 30.58

Gene sequence:

>762_bases
ATGATTGGTATTATTGGTGGAACAGGAACAAAAGCATTACTTGAAACATACTCTATTGTAGATAAAAAAGATGTTAAGAC
AGAGTATGGACAGGCTCCACAAATCACTATATTGGATATTAATAATAAAGAAGTAGCATATATTCCAAGACATAGTCAAG
GACATAGTGTACCTCCACATAAAATTAATTATAGAGCAAATATTGAAGCATTAAAAACAATTGGTGTAAATCAAGTTTAT
GCAACTAACTCTGTGGGTTCTTTAGATACAAATATAGAACCTGGAAGTATATTAATACCAGATAACTTCATAGATTTTAC
ACATAATCGTGTTTCAACATTCTTTGATAATGAAGTTGTACATATTGATTGTACAAATCCTTACTGTGAAACACTTAGAA
CTAATTTAATAACTGGTAATGATGTACATCCCTATGGAATATACATTGCTACAGAAGGTCCACGATTTGAAACTGGTGCT
GAAATACAGTTTTATAAGTTAATAGGTGGAAAAGTTGTGGGTATGACAGGAGTTCCAGAAGTTGTTCTTGCAAAGGAAAA
ACAGATGTGTTATAGTAGTATTTGTGCAGTAACAAATTATGCGGCAGCTATATCACCAAATAAACTAACAATTACAGAAG
TTATTGATGCTATGAAGGATTGTGAAGAAAAATTAATTAAACTTATTACAAAAACCATTAAAAACACTGTTGTTAGTAGA
GATTGTGGATGTCAGCATATATTAGATGATGCAATTATTTAA

Upstream 100 bases:

>100_bases
ATAAAGATGTTGATTCAGTTGTAAAAACTGCTGATAAAACAGGTATAAGTAAACTTGTTGCTCAAATGAAACCATTAGGT
GTAATTAAGGGGTAAACTTA

Downstream 100 bases:

>100_bases
ATAATATTAAATATAACAAGAGTTATATTTTAAATAAAGAGTATAATAATAAGGGGTTTATATATGACTAATGAGATTAT
AAGAGAAATTGAAGAATTAA

Product: purine nucleoside phosphorylase

Products: ribose-1-phosphate; xanthine [C]

Alternate protein names: NA

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MIGIIGGTGTKALLETYSIVDKKDVKTEYGQAPQITILDINNKEVAYIPRHSQGHSVPPHKINYRANIEALKTIGVNQVY
ATNSVGSLDTNIEPGSILIPDNFIDFTHNRVSTFFDNEVVHIDCTNPYCETLRTNLITGNDVHPYGIYIATEGPRFETGA
EIQFYKLIGGKVVGMTGVPEVVLAKEKQMCYSSICAVTNYAAAISPNKLTITEVIDAMKDCEEKLIKLITKTIKNTVVSR
DCGCQHILDDAII

Sequences:

>Translated_253_residues
MIGIIGGTGTKALLETYSIVDKKDVKTEYGQAPQITILDINNKEVAYIPRHSQGHSVPPHKINYRANIEALKTIGVNQVY
ATNSVGSLDTNIEPGSILIPDNFIDFTHNRVSTFFDNEVVHIDCTNPYCETLRTNLITGNDVHPYGIYIATEGPRFETGA
EIQFYKLIGGKVVGMTGVPEVVLAKEKQMCYSSICAVTNYAAAISPNKLTITEVIDAMKDCEEKLIKLITKTIKNTVVSR
DCGCQHILDDAII
>Mature_253_residues
MIGIIGGTGTKALLETYSIVDKKDVKTEYGQAPQITILDINNKEVAYIPRHSQGHSVPPHKINYRANIEALKTIGVNQVY
ATNSVGSLDTNIEPGSILIPDNFIDFTHNRVSTFFDNEVVHIDCTNPYCETLRTNLITGNDVHPYGIYIATEGPRFETGA
EIQFYKLIGGKVVGMTGVPEVVLAKEKQMCYSSICAVTNYAAAISPNKLTITEVIDAMKDCEEKLIKLITKTIKNTVVSR
DCGCQHILDDAII

Specific function: The Nucleoside Phosphorylases Catalyze The Phosphorolytic Breakdown Of The N-Glycosidic Bond In The Nucleoside Molecule, With The Formation Of The Corresponding Free Bases And Pentose-1-Phosphate. This Protein Can Degrade All Purine Nucleosides Except Ade

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=248, Percent_Identity=37.5, Blast_Score=144, Evalue=1e-34,
Organism=Escherichia coli, GI1788746, Length=250, Percent_Identity=24.4, Blast_Score=74, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI71980569, Length=248, Percent_Identity=34.6774193548387, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6323045, Length=223, Percent_Identity=31.390134529148, Blast_Score=106, Evalue=3e-24,
Organism=Drosophila melanogaster, GI20130079, Length=214, Percent_Identity=33.6448598130841, Blast_Score=127, Evalue=9e-30,
Organism=Drosophila melanogaster, GI221459247, Length=226, Percent_Identity=32.7433628318584, Blast_Score=119, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: 2.4.2.- [C]

Molecular weight: Translated: 27809; Mature: 27809

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGIIGGTGTKALLETYSIVDKKDVKTEYGQAPQITILDINNKEVAYIPRHSQGHSVPPH
CEEEECCCCHHHHHHHHHHHCCHHHHHHCCCCCEEEEEEECCCEEEEECCCCCCCCCCCC
KINYRANIEALKTIGVNQVYATNSVGSLDTNIEPGSILIPDNFIDFTHNRVSTFFDNEVV
EEEEEECHHHHHHCCCCEEEECCCCCCCCCCCCCCEEECCCCCCCCCCCHHHHHCCCCEE
HIDCTNPYCETLRTNLITGNDVHPYGIYIATEGPRFETGAEIQFYKLIGGKVVGMTGVPE
EEECCCHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCEEEEEEECCEEEECCCCCH
VVLAKEKQMCYSSICAVTNYAAAISPNKLTITEVIDAMKDCEEKLIKLITKTIKNTVVSR
HHHHHHHHHHHHHHHHHHHHHEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DCGCQHILDDAII
CCCHHHHHHHCCC
>Mature Secondary Structure
MIGIIGGTGTKALLETYSIVDKKDVKTEYGQAPQITILDINNKEVAYIPRHSQGHSVPPH
CEEEECCCCHHHHHHHHHHHCCHHHHHHCCCCCEEEEEEECCCEEEEECCCCCCCCCCCC
KINYRANIEALKTIGVNQVYATNSVGSLDTNIEPGSILIPDNFIDFTHNRVSTFFDNEVV
EEEEEECHHHHHHCCCCEEEECCCCCCCCCCCCCCEEECCCCCCCCCCCHHHHHCCCCEE
HIDCTNPYCETLRTNLITGNDVHPYGIYIATEGPRFETGAEIQFYKLIGGKVVGMTGVPE
EEECCCHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCEEEEEEECCEEEECCCCCH
VVLAKEKQMCYSSICAVTNYAAAISPNKLTITEVIDAMKDCEEKLIKLITKTIKNTVVSR
HHHHHHHHHHHHHHHHHHHHHEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DCGCQHILDDAII
CCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: xanthosine; phosphate [C]

Specific reaction: xanthosine + phosphate = ribose-1-phosphate + xanthine [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]