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The map label for this gene is rnz

Identifier: 84489223

GI number: 84489223

Start: 472944

End: 473789

Strand: Direct

Name: rnz

Synonym: Msp_0411

Alternate gene names: 84489223

Gene position: 472944-473789 (Clockwise)

Preceding gene: 84489220

Following gene: 84489224

Centisome position: 26.76

GC content: 31.56

Gene sequence:

>846_bases
ATGATTCTCTTTGACTGTGGTGAAGCAACACAAAAACAAATTATGGAAGCTGGAATAAGTCCTATGAAGATAGATGATAT
ATACATAACACACTTACATGGTGATCATATTCTAGGTCTTCCAGGTATTGTTCAATCATTAGCATTTCGTGGAAGAACAA
GACCATTACATATTTATGGTCCAAGAGGAATAAATGAATTAATAGATCATATAAGACATATGGGCTTTTATACGATAGGA
TATGAATTAATAACCCATGAAATAGAAGATGATGGGATTCTATATCAACAAAATGATTTTAGAATATTATCTAGAAAAAT
GAAACATACTGTTGTTGATTATGCATATAAAATCGAGCAATTAAGACAACCTAAGTTTCTAAGACAGAAAGCTATTGAAT
TAGGCATACCTCCAGGTCCACTATTTGGAAAACTTCAAGCAGGAAAAGAAGTAACAGTAGATGGTAAGATAATAAAACCA
GAACAAGTGTTAGGACCACCACGTGAAGGTGTAAAAGTAGTATTTAGTGGGGATACAATTCCACAAGAATCTATGATAGA
CTTTGCAGAGAATGTTGATGTGTTGATACATGAGGCAACATTTACCAAGGACATTAAAGAAAAAGCATTTGAAAATGGAC
ATACTGTAGCAGAAGATGCAGCAGTAATTGCTAAAAAAGCTAATGTTGAACAATTAATATTAACACATTTATCAAATAGG
TACACATCCTCAAAACCATTACTTGATGAGGCAAAGACCATATTTGAAAATACTGTATATGCAGAGGATTTAATGGTTGT
TATTATAGAGAATAAAAAACCAGTACAAATAAATTTCAAAAAATAA

Upstream 100 bases:

>100_bases
GGTTATTAATATTATAGAATTAACTTTTTTAGGTACAGCATCAGCAATTCCTACAAGATCAAGAAATCATACATCAATAA
TAATTAAGATATCCAATAGA

Downstream 100 bases:

>100_bases
CATAATTTATAGATGATAGTTGTTAATTATTATTTCTTTAGAAAGATTTTTCTTAAGATAACTTTTAATTATTTATAGAA
ATATAACTATTATTACATAA

Product: putative ribonuclease Z

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MILFDCGEATQKQIMEAGISPMKIDDIYITHLHGDHILGLPGIVQSLAFRGRTRPLHIYGPRGINELIDHIRHMGFYTIG
YELITHEIEDDGILYQQNDFRILSRKMKHTVVDYAYKIEQLRQPKFLRQKAIELGIPPGPLFGKLQAGKEVTVDGKIIKP
EQVLGPPREGVKVVFSGDTIPQESMIDFAENVDVLIHEATFTKDIKEKAFENGHTVAEDAAVIAKKANVEQLILTHLSNR
YTSSKPLLDEAKTIFENTVYAEDLMVVIIENKKPVQINFKK

Sequences:

>Translated_281_residues
MILFDCGEATQKQIMEAGISPMKIDDIYITHLHGDHILGLPGIVQSLAFRGRTRPLHIYGPRGINELIDHIRHMGFYTIG
YELITHEIEDDGILYQQNDFRILSRKMKHTVVDYAYKIEQLRQPKFLRQKAIELGIPPGPLFGKLQAGKEVTVDGKIIKP
EQVLGPPREGVKVVFSGDTIPQESMIDFAENVDVLIHEATFTKDIKEKAFENGHTVAEDAAVIAKKANVEQLILTHLSNR
YTSSKPLLDEAKTIFENTVYAEDLMVVIIENKKPVQINFKK
>Mature_281_residues
MILFDCGEATQKQIMEAGISPMKIDDIYITHLHGDHILGLPGIVQSLAFRGRTRPLHIYGPRGINELIDHIRHMGFYTIG
YELITHEIEDDGILYQQNDFRILSRKMKHTVVDYAYKIEQLRQPKFLRQKAIELGIPPGPLFGKLQAGKEVTVDGKIIKP
EQVLGPPREGVKVVFSGDTIPQESMIDFAENVDVLIHEATFTKDIKEKAFENGHTVAEDAAVIAKKANVEQLILTHLSNR
YTSSKPLLDEAKTIFENTVYAEDLMVVIIENKKPVQINFKK

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA [H]

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family [H]

Homologues:

Organism=Homo sapiens, GI8922122, Length=333, Percent_Identity=29.1291291291291, Blast_Score=148, Evalue=6e-36,
Organism=Escherichia coli, GI87082078, Length=276, Percent_Identity=39.4927536231884, Blast_Score=196, Evalue=1e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR013471 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.1.26.11 [H]

Molecular weight: Translated: 31798; Mature: 31798

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILFDCGEATQKQIMEAGISPMKIDDIYITHLHGDHILGLPGIVQSLAFRGRTRPLHIYG
CEEEECCHHHHHHHHHHCCCCEEECEEEEEEECCCCEECCHHHHHHHHHCCCCCEEEEEC
PRGINELIDHIRHMGFYTIGYELITHEIEDDGILYQQNDFRILSRKMKHTVVDYAYKIEQ
CCCHHHHHHHHHHCCCHHEEHEEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHH
LRQPKFLRQKAIELGIPPGPLFGKLQAGKEVTVDGKIIKPEQVLGPPREGVKVVFSGDTI
HCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCEEECCHHHCCCCCCCEEEEECCCCC
PQESMIDFAENVDVLIHEATFTKDIKEKAFENGHTVAEDAAVIAKKANVEQLILTHLSNR
CHHHHHHHHCCCEEEEECHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHCC
YTSSKPLLDEAKTIFENTVYAEDLMVVIIENKKPVQINFKK
CCCCCCCHHHHHHHHHHCEEECCEEEEEECCCCCEEEEECC
>Mature Secondary Structure
MILFDCGEATQKQIMEAGISPMKIDDIYITHLHGDHILGLPGIVQSLAFRGRTRPLHIYG
CEEEECCHHHHHHHHHHCCCCEEECEEEEEEECCCCEECCHHHHHHHHHCCCCCEEEEEC
PRGINELIDHIRHMGFYTIGYELITHEIEDDGILYQQNDFRILSRKMKHTVVDYAYKIEQ
CCCHHHHHHHHHHCCCHHEEHEEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHH
LRQPKFLRQKAIELGIPPGPLFGKLQAGKEVTVDGKIIKPEQVLGPPREGVKVVFSGDTI
HCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCEEECCHHHCCCCCCCEEEEECCCCC
PQESMIDFAENVDVLIHEATFTKDIKEKAFENGHTVAEDAAVIAKKANVEQLILTHLSNR
CHHHHHHHHCCCEEEEECHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHCC
YTSSKPLLDEAKTIFENTVYAEDLMVVIIENKKPVQINFKK
CCCCCCCHHHHHHHHHHCEEECCEEEEEECCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]