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The map label for this gene is tmk

Identifier: 84489171

GI number: 84489171

Start: 420666

End: 421253

Strand: Direct

Name: tmk

Synonym: Msp_0357

Alternate gene names: 84489171

Gene position: 420666-421253 (Clockwise)

Preceding gene: 84489169

Following gene: 84489177

Centisome position: 23.8

GC content: 27.89

Gene sequence:

>588_bases
ATGTACATAGTATTAGAAGGAATAGATGGAGTAGGAAAAACAACACAAACAGAAAAACTAAAAGAATGGTTAGAAAAACG
TGGATTTAGTGTAAAAACAATAGTAGAACCAACAGATTCAGATATAGGTAAAATAATACGGGAAGAACTATTAAAACCAG
AAGCAACATCTGATACAAATCAACAAATGTTAGCACTACTATTTGCAGCCGATAGATTAACTCTAAAAGATGAGATAAAT
CAAGTAAAAAATAATCAACAAAAAATATTAATAAGTGACAGATCATTCTACTCCAGTATAACCTACCAAAATTCCACAAC
AATAGAACCTGAATGGATTTATAAGATAAACAAACATACACCACGACCAGATTTAACAATAATATTAGATATTGATGAAG
ATGAAGCTTTAAAACGTTGTGATAAAATAGATACGTTTGAAAACAAGGAATTTCTTGAAAAAACAAGGGAGAACTATTTA
AAATTAGTAAAAACTGAGAAAAATATTGTAAAAATAGATGCAACACCTACAGAAGATGTAGTTCAAGATGAAATCCGTAA
TCAAATCATAAAATATTTAAAATTATGA

Upstream 100 bases:

>100_bases
AAAACATCTTTACTTTATTATCTTTTTATTTAATTATATAAAATAAATTAAGATGAAAAAATAAACATATTGATATAATA
AAATTCTTTGGAGAAAATAT

Downstream 100 bases:

>100_bases
TATTTTTTTTTAATAAAAAGAAAAAAGGAGTAATTCTCCTTTACATATTTAAACGTTCCTTCATAATATCTACAAGATAA
TTAATAGCATCGTTTATATC

Product: putative thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MYIVLEGIDGVGKTTQTEKLKEWLEKRGFSVKTIVEPTDSDIGKIIREELLKPEATSDTNQQMLALLFAADRLTLKDEIN
QVKNNQQKILISDRSFYSSITYQNSTTIEPEWIYKINKHTPRPDLTIILDIDEDEALKRCDKIDTFENKEFLEKTRENYL
KLVKTEKNIVKIDATPTEDVVQDEIRNQIIKYLKL

Sequences:

>Translated_195_residues
MYIVLEGIDGVGKTTQTEKLKEWLEKRGFSVKTIVEPTDSDIGKIIREELLKPEATSDTNQQMLALLFAADRLTLKDEIN
QVKNNQQKILISDRSFYSSITYQNSTTIEPEWIYKINKHTPRPDLTIILDIDEDEALKRCDKIDTFENKEFLEKTRENYL
KLVKTEKNIVKIDATPTEDVVQDEIRNQIIKYLKL
>Mature_195_residues
MYIVLEGIDGVGKTTQTEKLKEWLEKRGFSVKTIVEPTDSDIGKIIREELLKPEATSDTNQQMLALLFAADRLTLKDEIN
QVKNNQQKILISDRSFYSSITYQNSTTIEPEWIYKINKHTPRPDLTIILDIDEDEALKRCDKIDTFENKEFLEKTRENYL
KLVKTEKNIVKIDATPTEDVVQDEIRNQIIKYLKL

Specific function: Phosphorylation Of Dtmp To Form Dtdp In Both De Novo And Salvage Pathways Of Dttp Synthesis. [C]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Homo sapiens, GI42544174, Length=188, Percent_Identity=30.8510638297872, Blast_Score=75, Evalue=5e-14,
Organism=Escherichia coli, GI1787340, Length=208, Percent_Identity=29.8076923076923, Blast_Score=76, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_METST (Q2NHE3)

Other databases:

- EMBL:   CP000102
- RefSeq:   YP_447403.1
- HSSP:   P65248
- ProteinModelPortal:   Q2NHE3
- SMR:   Q2NHE3
- STRING:   Q2NHE3
- GeneID:   3856120
- GenomeReviews:   CP000102_GR
- KEGG:   mst:Msp_0357
- NMPDR:   fig|339860.6.peg.341
- eggNOG:   arNOG06813
- HOGENOM:   HBG626009
- OMA:   SSLAYQW
- PhylomeDB:   Q2NHE3
- ProtClustDB:   CLSK798266
- BioCyc:   MSTA339860:MSP_0357-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 22738; Mature: 22738

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYIVLEGIDGVGKTTQTEKLKEWLEKRGFSVKTIVEPTDSDIGKIIREELLKPEATSDTN
CEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCHH
QQMLALLFAADRLTLKDEINQVKNNQQKILISDRSFYSSITYQNSTTIEPEWIYKINKHT
HHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEECCHHHHHEEECCCCCCCHHHEEEECCCC
PRPDLTIILDIDEDEALKRCDKIDTFENKEFLEKTRENYLKLVKTEKNIVKIDATPTEDV
CCCCEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHH
VQDEIRNQIIKYLKL
HHHHHHHHHHHHHCC
>Mature Secondary Structure
MYIVLEGIDGVGKTTQTEKLKEWLEKRGFSVKTIVEPTDSDIGKIIREELLKPEATSDTN
CEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCHH
QQMLALLFAADRLTLKDEINQVKNNQQKILISDRSFYSSITYQNSTTIEPEWIYKINKHT
HHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEECCHHHHHEEECCCCCCCHHHEEEECCCC
PRPDLTIILDIDEDEALKRCDKIDTFENKEFLEKTRENYLKLVKTEKNIVKIDATPTEDV
CCCCEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHH
VQDEIRNQIIKYLKL
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA