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The map label for this gene is wecC [H]

Identifier: 84489042

GI number: 84489042

Start: 265043

End: 266293

Strand: Direct

Name: wecC [H]

Synonym: Msp_0214

Alternate gene names: 84489042

Gene position: 265043-266293 (Clockwise)

Preceding gene: 84489041

Following gene: 84489043

Centisome position: 15.0

GC content: 28.54

Gene sequence:

>1251_bases
ATGAAAATATGTGTTATAGGTCAAGGATATATAGGTATACCTACAGCAGCATTATTTGCATCCAATGGATGTGATGTGGT
AGGTGTAGATATTAATGAAGAAATAATAAGTAATTTAAATAATGGAGTTATGACAATAGAAGAACCAAAAATTAATGAAA
TTATGAATGCTTGTTTGGATAATGGAACATATCATGCAAGTTTAACTCCTGAAGAAGCTGATGTTTATATAATTACAGTT
CCAACACCATTTAAAAAAGAAGATTTATCCTGTGATTTAGGTTTTGTAATATCAGCATGTAAATCAATATTACCACTTAT
AAAAAAAGGAGATACTATCATAGTAGAATCAACAATAGCACCACTATCAACTGAAACAACAATAAAAGGTATCTTTGAAG
ATAGGGGATTTAATGTTGGTGAAGACATATACTTAGCACATTGTCCAGAAAGAGTTCTACCAGGTAACATGGTTGATGAA
TTAATACATAACAATAGAATAGTTGGTGGAATCAACAAAAGAAGTGCTAAAAAAGCTGCTGAAGTTTATAAAATATTTGT
TAAAGGTGAAGTTATAGAAACTGAAGCAAAAGTTGCTGAATTATCTAAGTGTATGGAAAATACATATAGGGATGTGAATA
TTGCACTAGCAAATGAATTAGCAAAGATTGGATCAAAACTAGGAATTAACATATTAGATGTTATTAAAATAGCAAATAAA
CATCCTCGTGTAAATATACTTTCACCAGGGCCAGGAGTAGGTGGACATTGTCTTGCAATAGATCCATACTTCATATATTC
ACTTATACCAGAGACTGCAAAAATCATAAAACTGGCTAGAGATACTAATAGAAGTATGCCAGATTTTGTTGTTGAAAATG
TTAGAAAAATTCTAAAAAATGAAGATAATCCAATAATATCAGTATTTGGTGTGGCATATAAAGGAAATTCTGATGATGAT
AGGGAAAGTCCATCTTATGAAATAATCAACAATCTTAAAGAAGATTATACTTTGAAAATATATGATCCTCATATAGAAAA
AATAGATCTAAGCTTTGATGAAGCAATAAAAGATTCATCATTAATATTAGTACTTACAAATCATGATGAATTCATGCATA
TGGACTTTGATAAAATAAAACAAGAAATGAAAAAGCCAGTAATATTTGATACAAGAAATATTATAGATAAACATTCAATT
CCAGATGATATTATATTATATAACTTTGGAAATTTATATGATGTAGAATAG

Upstream 100 bases:

>100_bases
TAATGATTATTTTTTTTATTTTAATATTATCAATTAATAATCATCTTGTTTGAATATGGATTTTAAAAATACCATTATCA
ATAATAATAAAAGTGATATA

Downstream 100 bases:

>100_bases
TGGTGACTTTTCAATGCATCCTTTTATTAGTGTAATTATACCTGTTTATAATGTTCAATTCACAATAGAAAGTTGTTTTC
TATCTTTAAAAAATCAAACT

Product: UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: UDP-ManNAc 6-dehydrogenase [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MKICVIGQGYIGIPTAALFASNGCDVVGVDINEEIISNLNNGVMTIEEPKINEIMNACLDNGTYHASLTPEEADVYIITV
PTPFKKEDLSCDLGFVISACKSILPLIKKGDTIIVESTIAPLSTETTIKGIFEDRGFNVGEDIYLAHCPERVLPGNMVDE
LIHNNRIVGGINKRSAKKAAEVYKIFVKGEVIETEAKVAELSKCMENTYRDVNIALANELAKIGSKLGINILDVIKIANK
HPRVNILSPGPGVGGHCLAIDPYFIYSLIPETAKIIKLARDTNRSMPDFVVENVRKILKNEDNPIISVFGVAYKGNSDDD
RESPSYEIINNLKEDYTLKIYDPHIEKIDLSFDEAIKDSSLILVLTNHDEFMHMDFDKIKQEMKKPVIFDTRNIIDKHSI
PDDIILYNFGNLYDVE

Sequences:

>Translated_416_residues
MKICVIGQGYIGIPTAALFASNGCDVVGVDINEEIISNLNNGVMTIEEPKINEIMNACLDNGTYHASLTPEEADVYIITV
PTPFKKEDLSCDLGFVISACKSILPLIKKGDTIIVESTIAPLSTETTIKGIFEDRGFNVGEDIYLAHCPERVLPGNMVDE
LIHNNRIVGGINKRSAKKAAEVYKIFVKGEVIETEAKVAELSKCMENTYRDVNIALANELAKIGSKLGINILDVIKIANK
HPRVNILSPGPGVGGHCLAIDPYFIYSLIPETAKIIKLARDTNRSMPDFVVENVRKILKNEDNPIISVFGVAYKGNSDDD
RESPSYEIINNLKEDYTLKIYDPHIEKIDLSFDEAIKDSSLILVLTNHDEFMHMDFDKIKQEMKKPVIFDTRNIIDKHSI
PDDIILYNFGNLYDVE
>Mature_416_residues
MKICVIGQGYIGIPTAALFASNGCDVVGVDINEEIISNLNNGVMTIEEPKINEIMNACLDNGTYHASLTPEEADVYIITV
PTPFKKEDLSCDLGFVISACKSILPLIKKGDTIIVESTIAPLSTETTIKGIFEDRGFNVGEDIYLAHCPERVLPGNMVDE
LIHNNRIVGGINKRSAKKAAEVYKIFVKGEVIETEAKVAELSKCMENTYRDVNIALANELAKIGSKLGINILDVIKIANK
HPRVNILSPGPGVGGHCLAIDPYFIYSLIPETAKIIKLARDTNRSMPDFVVENVRKILKNEDNPIISVFGVAYKGNSDDD
RESPSYEIINNLKEDYTLKIYDPHIEKIDLSFDEAIKDSSLILVLTNHDEFMHMDFDKIKQEMKKPVIFDTRNIIDKHSI
PDDIILYNFGNLYDVE

Specific function: Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA) [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=444, Percent_Identity=26.3513513513513, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI296040438, Length=346, Percent_Identity=24.5664739884393, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI296040443, Length=431, Percent_Identity=23.6658932714617, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI48994968, Length=406, Percent_Identity=41.1330049261084, Blast_Score=320, Evalue=1e-88,
Organism=Escherichia coli, GI1788340, Length=356, Percent_Identity=26.123595505618, Blast_Score=82, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17560350, Length=450, Percent_Identity=26.6666666666667, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI17136908, Length=452, Percent_Identity=25.6637168141593, Blast_Score=134, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 46278; Mature: 46278

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKICVIGQGYIGIPTAALFASNGCDVVGVDINEEIISNLNNGVMTIEEPKINEIMNACLD
CEEEEEECCCCCCCHHHHEECCCCCEEEECCCHHHHHCCCCCEEEECCCCHHHHHHHHHC
NGTYHASLTPEEADVYIITVPTPFKKEDLSCDLGFVISACKSILPLIKKGDTIIVESTIA
CCEEEEEECCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCC
PLSTETTIKGIFEDRGFNVGEDIYLAHCPERVLPGNMVDELIHNNRIVGGINKRSAKKAA
CCCCCHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHHHHHHCCEEEECCCHHHHHHHH
EVYKIFVKGEVIETEAKVAELSKCMENTYRDVNIALANELAKIGSKLGINILDVIKIANK
HHHEEEEECEEEEHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHCCCCHHHHHHHHCC
HPRVNILSPGPGVGGHCLAIDPYFIYSLIPETAKIIKLARDTNRSMPDFVVENVRKILKN
CCEEEEECCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCC
EDNPIISVFGVAYKGNSDDDRESPSYEIINNLKEDYTLKIYDPHIEKIDLSFDEAIKDSS
CCCCEEEEEEEEEECCCCCCCCCCCHHHHHCCCCCCEEEEECCCCEEECCCHHHHCCCCC
LILVLTNHDEFMHMDFDKIKQEMKKPVIFDTRNIIDKHSIPDDIILYNFGNLYDVE
EEEEEECCCCEEECCHHHHHHHHHCCEEEECHHHHHHCCCCCCEEEEECCCEEECC
>Mature Secondary Structure
MKICVIGQGYIGIPTAALFASNGCDVVGVDINEEIISNLNNGVMTIEEPKINEIMNACLD
CEEEEEECCCCCCCHHHHEECCCCCEEEECCCHHHHHCCCCCEEEECCCCHHHHHHHHHC
NGTYHASLTPEEADVYIITVPTPFKKEDLSCDLGFVISACKSILPLIKKGDTIIVESTIA
CCEEEEEECCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCC
PLSTETTIKGIFEDRGFNVGEDIYLAHCPERVLPGNMVDELIHNNRIVGGINKRSAKKAA
CCCCCHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHHHHHHCCEEEECCCHHHHHHHH
EVYKIFVKGEVIETEAKVAELSKCMENTYRDVNIALANELAKIGSKLGINILDVIKIANK
HHHEEEEECEEEEHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHCCCCHHHHHHHHCC
HPRVNILSPGPGVGGHCLAIDPYFIYSLIPETAKIIKLARDTNRSMPDFVVENVRKILKN
CCEEEEECCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCC
EDNPIISVFGVAYKGNSDDDRESPSYEIINNLKEDYTLKIYDPHIEKIDLSFDEAIKDSS
CCCCEEEEEEEEEECCCCCCCCCCCHHHHHCCCCCCEEEEECCCCEEECCCHHHHCCCCC
LILVLTNHDEFMHMDFDKIKQEMKKPVIFDTRNIIDKHSIPDDIILYNFGNLYDVE
EEEEEECCCCEEECCHHHHHHHHHCCEEEECHHHHHHCCCCCCEEEEECCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA