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The map label for this gene is sdhA

Identifier: 84489008

GI number: 84489008

Start: 221193

End: 222866

Strand: Direct

Name: sdhA

Synonym: Msp_0180

Alternate gene names: 84489008

Gene position: 221193-222866 (Clockwise)

Preceding gene: 84489007

Following gene: 84489010

Centisome position: 12.52

GC content: 33.81

Gene sequence:

>1674_bases
ATGGAAATTAAAGAGTATACATGTGATGTGTTAGTAATAGGTTCTGGCGGTGCTGGATGTAAATGTGGAATTGTAGCAAG
TAAAGAGGGTCAGGATGTAATCATTGTATCTAAAGGTTTAACATTTAAATCTGGTTGTACAATGCTTGCAGAAGGAGGTT
ACAATGCAGTATTTGGGTATGTTGATGATGAAGATTCACTTCAACTACATATTCAAGACACACTTAAGGGTGGAGCATTT
CTCAATGACTTAAAACTCGTATATAAATTAGTTACTGAATCACCAAAAAGACTTGTTGAACTTGAATCATATGGTTCATT
ATTTGACAGACAAGAAGATGGTCGTTTAAATCAAAGAGCATTTGGAGGACAATCCTATCGTAGAACTTGTTTTAAAGGGG
ATCAAACTGGTCATGAAATGATGGTTGGACTTAAAGAAGAAGTTATACGTGAAGGTGTAGAAACACATGGAGAAATAATG
ATTACAAAATTATTATTTGATAAAAATCATACAAAAATTGTTGGAGCAATGGGTTTTTCACTACAGGATAGTTCAATAGT
AATATATCATTCAAAGACTACTGTTATTGCTTCTGGTGGATGTGGATGGTTATATCCTGTTACATCAAATGCTTTACAAA
AAACTGGTGATGGTATTATGATGGCATATGATGTTGGAGCAGATGTTATGGATATGGAAATGGTACAATTCCATCCAACA
GGTATGTTGTCTCCAAAATCCAGAAGAGGTGTTTTAATTACTGAGGCTGTTCGTGGTGAAGGGGGTTATTTAATTAACAC
TAATAATGAACGTTTCATGATAAATTATGATCCACGTCAGGAACTTGCAACTAGGGATATTGTTGCAAGATCTATCTATA
CTGAAATTCAGGAAGGTCGTGGAACTAATGATGGGGGAGTATATTTATCTGTAACACACCTACCAGATAGTCAGGTTCAT
AAGAAATTACAAACTATGGTTCAGCAATTTAAGGATGTTGGCGTGGATATTACAAAAGAACCAATGGAAGTAGCACCTAC
TGCTCATCATTTTATGGGTGGTGTTAGAATTAACACCGACTGTGAAACAAATATTGAAAACTTGTATGCTGCAGGTGAAG
CATCTTCTGGTGTGCATGGAGCAAATAGGTTAGGTGGTAATGCATTGGCTGATACTCAAGTATTTGGTCATATTGCTGGT
TTAAGTTCTGCAAAACAGGCACAAAATACCAAACTTGAAACTCCAGATGAAGATATGATTTCTTCTGAAATTTCACGTAT
TGAAGCTATATGTTCTGAAGGAAAATATCGTCCACAAGATATTAAGACTAAAATACAAGAAATAATGTGGAAGCATGTTG
CAATTGTTCGTGATGAAACAGGTTTAAAACAAGCAGAAATTGAATTAAATAAACTTGAAGAAATGACTTCTAACATGAAT
GTTTCTAAAATAAGAGAATACAACGATGATTTAGTAGTAGCTCTAGAAGTTATAAGTATGATAAAACTCGCTAAATTAAT
AGTAAAATCAGCTCTACTACGTAAAGAGAGTAGAGGAGCACATTATCGTATAGATTATCCTGAACGTAACGATAAAGAAT
ATCTTAAAAGCTTCATATTAAATAAAAATGGAGAAATTAAAACAGTAGAAAGAGGTCTATTTACAGATTATTAA

Upstream 100 bases:

>100_bases
TCACTTGGATGTGGGAGATACTGTTGTTGTTGAAATTGATGAAATGGGAAGTTTAGTTAATATTGTTAAATAAAAAAAAA
TTAAATATAGGGGTTATTTA

Downstream 100 bases:

>100_bases
ATAGTAATCTCTAACTTAATCTTCTTTTTATTTATTTAATGAATATTCTAATTTTGATTTTACAATATGATTTATTACTT
AAGATTAATTCATAACCTCA

Product: succinate dehydrogenase flavoprotein subunit

Products: fumarate; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 557; Mature: 557

Protein sequence:

>557_residues
MEIKEYTCDVLVIGSGGAGCKCGIVASKEGQDVIIVSKGLTFKSGCTMLAEGGYNAVFGYVDDEDSLQLHIQDTLKGGAF
LNDLKLVYKLVTESPKRLVELESYGSLFDRQEDGRLNQRAFGGQSYRRTCFKGDQTGHEMMVGLKEEVIREGVETHGEIM
ITKLLFDKNHTKIVGAMGFSLQDSSIVIYHSKTTVIASGGCGWLYPVTSNALQKTGDGIMMAYDVGADVMDMEMVQFHPT
GMLSPKSRRGVLITEAVRGEGGYLINTNNERFMINYDPRQELATRDIVARSIYTEIQEGRGTNDGGVYLSVTHLPDSQVH
KKLQTMVQQFKDVGVDITKEPMEVAPTAHHFMGGVRINTDCETNIENLYAAGEASSGVHGANRLGGNALADTQVFGHIAG
LSSAKQAQNTKLETPDEDMISSEISRIEAICSEGKYRPQDIKTKIQEIMWKHVAIVRDETGLKQAEIELNKLEEMTSNMN
VSKIREYNDDLVVALEVISMIKLAKLIVKSALLRKESRGAHYRIDYPERNDKEYLKSFILNKNGEIKTVERGLFTDY

Sequences:

>Translated_557_residues
MEIKEYTCDVLVIGSGGAGCKCGIVASKEGQDVIIVSKGLTFKSGCTMLAEGGYNAVFGYVDDEDSLQLHIQDTLKGGAF
LNDLKLVYKLVTESPKRLVELESYGSLFDRQEDGRLNQRAFGGQSYRRTCFKGDQTGHEMMVGLKEEVIREGVETHGEIM
ITKLLFDKNHTKIVGAMGFSLQDSSIVIYHSKTTVIASGGCGWLYPVTSNALQKTGDGIMMAYDVGADVMDMEMVQFHPT
GMLSPKSRRGVLITEAVRGEGGYLINTNNERFMINYDPRQELATRDIVARSIYTEIQEGRGTNDGGVYLSVTHLPDSQVH
KKLQTMVQQFKDVGVDITKEPMEVAPTAHHFMGGVRINTDCETNIENLYAAGEASSGVHGANRLGGNALADTQVFGHIAG
LSSAKQAQNTKLETPDEDMISSEISRIEAICSEGKYRPQDIKTKIQEIMWKHVAIVRDETGLKQAEIELNKLEEMTSNMN
VSKIREYNDDLVVALEVISMIKLAKLIVKSALLRKESRGAHYRIDYPERNDKEYLKSFILNKNGEIKTVERGLFTDY
>Mature_557_residues
MEIKEYTCDVLVIGSGGAGCKCGIVASKEGQDVIIVSKGLTFKSGCTMLAEGGYNAVFGYVDDEDSLQLHIQDTLKGGAF
LNDLKLVYKLVTESPKRLVELESYGSLFDRQEDGRLNQRAFGGQSYRRTCFKGDQTGHEMMVGLKEEVIREGVETHGEIM
ITKLLFDKNHTKIVGAMGFSLQDSSIVIYHSKTTVIASGGCGWLYPVTSNALQKTGDGIMMAYDVGADVMDMEMVQFHPT
GMLSPKSRRGVLITEAVRGEGGYLINTNNERFMINYDPRQELATRDIVARSIYTEIQEGRGTNDGGVYLSVTHLPDSQVH
KKLQTMVQQFKDVGVDITKEPMEVAPTAHHFMGGVRINTDCETNIENLYAAGEASSGVHGANRLGGNALADTQVFGHIAG
LSSAKQAQNTKLETPDEDMISSEISRIEAICSEGKYRPQDIKTKIQEIMWKHVAIVRDETGLKQAEIELNKLEEMTSNMN
VSKIREYNDDLVVALEVISMIKLAKLIVKSALLRKESRGAHYRIDYPERNDKEYLKSFILNKNGEIKTVERGLFTDY

Specific function: Catalyzes The Oxidation Of L-Aspartate To Iminoaspartate. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=535, Percent_Identity=35.7009345794393, Blast_Score=287, Evalue=2e-77,
Organism=Escherichia coli, GI1788928, Length=559, Percent_Identity=32.3792486583184, Blast_Score=274, Evalue=1e-74,
Organism=Escherichia coli, GI1786942, Length=565, Percent_Identity=34.3362831858407, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1790597, Length=552, Percent_Identity=33.5144927536232, Blast_Score=273, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI17550100, Length=529, Percent_Identity=35.1606805293006, Blast_Score=281, Evalue=6e-76,
Organism=Caenorhabditis elegans, GI17505833, Length=539, Percent_Identity=34.6938775510204, Blast_Score=281, Evalue=7e-76,
Organism=Caenorhabditis elegans, GI71986328, Length=445, Percent_Identity=26.7415730337079, Blast_Score=101, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6322701, Length=559, Percent_Identity=35.2415026833631, Blast_Score=293, Evalue=5e-80,
Organism=Saccharomyces cerevisiae, GI6322416, Length=531, Percent_Identity=35.7815442561205, Blast_Score=288, Evalue=1e-78,
Organism=Saccharomyces cerevisiae, GI6320788, Length=481, Percent_Identity=28.8981288981289, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6322511, Length=478, Percent_Identity=28.2426778242678, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI17137288, Length=567, Percent_Identity=35.2733686067019, Blast_Score=304, Evalue=1e-82,
Organism=Drosophila melanogaster, GI24655642, Length=567, Percent_Identity=35.2733686067019, Blast_Score=304, Evalue=1e-82,
Organism=Drosophila melanogaster, GI24655647, Length=567, Percent_Identity=35.2733686067019, Blast_Score=304, Evalue=1e-82,
Organism=Drosophila melanogaster, GI24663005, Length=536, Percent_Identity=33.7686567164179, Blast_Score=270, Evalue=3e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR015939
- InterPro:   IPR004112 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: 1.3.99.1

Molecular weight: Translated: 61737; Mature: 61737

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIKEYTCDVLVIGSGGAGCKCGIVASKEGQDVIIVSKGLTFKSGCTMLAEGGYNAVFGY
CCCCCEEEEEEEECCCCCCCEEEEEECCCCCEEEEEECCCEECCCCCEEECCCCCEEEEE
VDDEDSLQLHIQDTLKGGAFLNDLKLVYKLVTESPKRLVELESYGSLFDRQEDGRLNQRA
ECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHHH
FGGQSYRRTCFKGDQTGHEMMVGLKEEVIREGVETHGEIMITKLLFDKNHTKIVGAMGFS
CCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEEECCE
LQDSSIVIYHSKTTVIASGGCGWLYPVTSNALQKTGDGIMMAYDVGADVMDMEMVQFHPT
ECCCEEEEEECCEEEEECCCCCEEEECCCHHHHHCCCCEEEEEECCCCCEECHHEEECCC
GMLSPKSRRGVLITEAVRGEGGYLINTNNERFMINYDPRQELATRDIVARSIYTEIQEGR
CCCCCCCCCCEEEEEEECCCCCEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCC
GTNDGGVYLSVTHLPDSQVHKKLQTMVQQFKDVGVDITKEPMEVAPTAHHFMGGVRINTD
CCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCHHHHHCCEEECCC
CETNIENLYAAGEASSGVHGANRLGGNALADTQVFGHIAGLSSAKQAQNTKLETPDEDMI
CCCCHHHHEECCCCCCCCCCCHHCCCCCHHHHHHHHHHHCCCHHHHHCCCCCCCCCHHHH
SSEISRIEAICSEGKYRPQDIKTKIQEIMWKHVAIVRDETGLKQAEIELNKLEEMTSNMN
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHCCC
VSKIREYNDDLVVALEVISMIKLAKLIVKSALLRKESRGAHYRIDYPERNDKEYLKSFIL
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHH
NKNGEIKTVERGLFTDY
CCCCCEEEEECCCCCCC
>Mature Secondary Structure
MEIKEYTCDVLVIGSGGAGCKCGIVASKEGQDVIIVSKGLTFKSGCTMLAEGGYNAVFGY
CCCCCEEEEEEEECCCCCCCEEEEEECCCCCEEEEEECCCEECCCCCEEECCCCCEEEEE
VDDEDSLQLHIQDTLKGGAFLNDLKLVYKLVTESPKRLVELESYGSLFDRQEDGRLNQRA
ECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHHH
FGGQSYRRTCFKGDQTGHEMMVGLKEEVIREGVETHGEIMITKLLFDKNHTKIVGAMGFS
CCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEEECCE
LQDSSIVIYHSKTTVIASGGCGWLYPVTSNALQKTGDGIMMAYDVGADVMDMEMVQFHPT
ECCCEEEEEECCEEEEECCCCCEEEECCCHHHHHCCCCEEEEEECCCCCEECHHEEECCC
GMLSPKSRRGVLITEAVRGEGGYLINTNNERFMINYDPRQELATRDIVARSIYTEIQEGR
CCCCCCCCCCEEEEEEECCCCCEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCC
GTNDGGVYLSVTHLPDSQVHKKLQTMVQQFKDVGVDITKEPMEVAPTAHHFMGGVRINTD
CCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCHHHHHCCEEECCC
CETNIENLYAAGEASSGVHGANRLGGNALADTQVFGHIAGLSSAKQAQNTKLETPDEDMI
CCCCHHHHEECCCCCCCCCCCHHCCCCCHHHHHHHHHHHCCCHHHHHCCCCCCCCCHHHH
SSEISRIEAICSEGKYRPQDIKTKIQEIMWKHVAIVRDETGLKQAEIELNKLEEMTSNMN
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHCCC
VSKIREYNDDLVVALEVISMIKLAKLIVKSALLRKESRGAHYRIDYPERNDKEYLKSFIL
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHH
NKNGEIKTVERGLFTDY
CCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: succinate; acceptor

Specific reaction: succinate + acceptor = fumarate + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]