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The map label for this gene is hisG

Identifier: 84489006

GI number: 84489006

Start: 219503

End: 220372

Strand: Direct

Name: hisG

Synonym: Msp_0178

Alternate gene names: 84489006

Gene position: 219503-220372 (Clockwise)

Preceding gene: 84489002

Following gene: 84489007

Centisome position: 12.42

GC content: 32.07

Gene sequence:

>870_bases
ATGAAAGTTCGTATAGCCATACCTTCTAAGGGCAGAATTAGTGGACCTTCTGTATCCTTACTAGAAAAAGCAGGTATTGG
ATTAACAGATAATTCTAGTCGTAAATTATTTTCCAATACATTCGATCCTGAAATAAGTGTGATGTTTACACGTGCTGCAG
ATATTCCAGTATATGTGGCAGATGGGGCTGCAGACATAGGAATAACTGGTTTTGATTTAACACAAGAAAAAAATGTTGAT
GTTGAATTTCTTGATGATTTAAAATTTGGAGCAACACGTCTTGTTGTAGCAGCACCTGAAAATTCTGATTTTAATACAGT
TGATGATTTAAAAAATGTTAAAATTGTTGCAACAGAATTTCCACATTTAACACAGAAATACTTTGAAGAAAAAAATATAA
ATGCCACTATAATGCCATTAAGTGGAGCTACAGAGGTTGCACCACTAATTGGTGTTGCAGATGTTATTGCTGATTTAACA
AGTACTGGTACAACACTAAAAATGAATCATCTACATGAAATAGATACTATCATAAACAGTAGTGTTAGATTAATTGCAAA
CAAAGAAAGCTTAAAAACAAAGTATGAAAAGATAGAAGCTATTAGAACAGGTATTCTTGGCGTGCTCCATGCTGAACGTA
AAAAATTAATAATGGCAAATGTACATAAATCAAATCTTGATGATATAAAAAGTGCAATGCCTGGTATGAGTGGACCAACA
GTATCTGAGGTATATGGTGATGAAAATATGGTTGCAGTTCACTCTGTTATCTCAGAAACAGAAGTTTTTGAAACTATAAA
TAAATTACGTAAAATTGGTGCAAAGGATTTACTAGTACTACCAATTGAAAGAATATTAGAAAATAAATAG

Upstream 100 bases:

>100_bases
TTATCTTATTAAACATACATATTAATAATTTATATCAAATAAATTTATTAAGAATTTATAAAACTTACTAATATCTATAT
TATTTGGAGGAAATAAAAAT

Downstream 100 bases:

>100_bases
GATATTAACAACTACGATTAATATGAAATATATTAGATATATGGCTTCCAACAAAGAACATGTTGGAATAATAAAAGATG
ATATTATATATGATTTAGAT

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MKVRIAIPSKGRISGPSVSLLEKAGIGLTDNSSRKLFSNTFDPEISVMFTRAADIPVYVADGAADIGITGFDLTQEKNVD
VEFLDDLKFGATRLVVAAPENSDFNTVDDLKNVKIVATEFPHLTQKYFEEKNINATIMPLSGATEVAPLIGVADVIADLT
STGTTLKMNHLHEIDTIINSSVRLIANKESLKTKYEKIEAIRTGILGVLHAERKKLIMANVHKSNLDDIKSAMPGMSGPT
VSEVYGDENMVAVHSVISETEVFETINKLRKIGAKDLLVLPIERILENK

Sequences:

>Translated_289_residues
MKVRIAIPSKGRISGPSVSLLEKAGIGLTDNSSRKLFSNTFDPEISVMFTRAADIPVYVADGAADIGITGFDLTQEKNVD
VEFLDDLKFGATRLVVAAPENSDFNTVDDLKNVKIVATEFPHLTQKYFEEKNINATIMPLSGATEVAPLIGVADVIADLT
STGTTLKMNHLHEIDTIINSSVRLIANKESLKTKYEKIEAIRTGILGVLHAERKKLIMANVHKSNLDDIKSAMPGMSGPT
VSEVYGDENMVAVHSVISETEVFETINKLRKIGAKDLLVLPIERILENK
>Mature_289_residues
MKVRIAIPSKGRISGPSVSLLEKAGIGLTDNSSRKLFSNTFDPEISVMFTRAADIPVYVADGAADIGITGFDLTQEKNVD
VEFLDDLKFGATRLVVAAPENSDFNTVDDLKNVKIVATEFPHLTQKYFEEKNINATIMPLSGATEVAPLIGVADVIADLT
STGTTLKMNHLHEIDTIINSSVRLIANKESLKTKYEKIEAIRTGILGVLHAERKKLIMANVHKSNLDDIKSAMPGMSGPT
VSEVYGDENMVAVHSVISETEVFETINKLRKIGAKDLLVLPIERILENK

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=296, Percent_Identity=36.8243243243243, Blast_Score=179, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6320896, Length=287, Percent_Identity=33.1010452961672, Blast_Score=149, Evalue=4e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867 [H]

Pfam domain/function: PF01634 HisG; PF08029 HisG_C [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 31519; Mature: 31519

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVRIAIPSKGRISGPSVSLLEKAGIGLTDNSSRKLFSNTFDPEISVMFTRAADIPVYVA
CEEEEECCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHCCCCCCCEEEEEEECCCCEEEEE
DGAADIGITGFDLTQEKNVDVEFLDDLKFGATRLVVAAPENSDFNTVDDLKNVKIVATEF
CCCCCCCEECCCCCCCCCCCHHHHCCCCCCCEEEEEECCCCCCCCCHHHCCCCEEEEECC
PHLTQKYFEEKNINATIMPLSGATEVAPLIGVADVIADLTSTGTTLKMNHLHEIDTIINS
CHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHCC
SVRLIANKESLKTKYEKIEAIRTGILGVLHAERKKLIMANVHKSNLDDIKSAMPGMSGPT
CEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHCCCCCCCC
VSEVYGDENMVAVHSVISETEVFETINKLRKIGAKDLLVLPIERILENK
HHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHCCC
>Mature Secondary Structure
MKVRIAIPSKGRISGPSVSLLEKAGIGLTDNSSRKLFSNTFDPEISVMFTRAADIPVYVA
CEEEEECCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHCCCCCCCEEEEEEECCCCEEEEE
DGAADIGITGFDLTQEKNVDVEFLDDLKFGATRLVVAAPENSDFNTVDDLKNVKIVATEF
CCCCCCCEECCCCCCCCCCCHHHHCCCCCCCEEEEEECCCCCCCCCHHHCCCCEEEEECC
PHLTQKYFEEKNINATIMPLSGATEVAPLIGVADVIADLTSTGTTLKMNHLHEIDTIINS
CHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHCC
SVRLIANKESLKTKYEKIEAIRTGILGVLHAERKKLIMANVHKSNLDDIKSAMPGMSGPT
CEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHCCCCCCCC
VSEVYGDENMVAVHSVISETEVFETINKLRKIGAKDLLVLPIERILENK
HHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]