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The map label for this gene is gmk [H]

Identifier: 83719185

GI number: 83719185

Start: 1785775

End: 1786458

Strand: Direct

Name: gmk [H]

Synonym: BTH_I1586

Alternate gene names: 83719185

Gene position: 1785775-1786458 (Clockwise)

Preceding gene: 83719925

Following gene: 83720583

Centisome position: 46.88

GC content: 64.77

Gene sequence:

>684_bases
ATGACCGATTCGAACCGCGGCGGCGCGGCAGCCCATTCGCTGCACGCCGGCGTCTATCCCGGCAATCTCTTCATGGTCGT
CGCGCCGTCGGGCGCGGGCAAGTCGACGCTCGTCAACGCGCTGCTGTCGAAGGATCCGGAGATCTGTCTGTCGATTTCGT
ACACGACGCGCAAGCCGCGTTCCGGCGAGCAGGACGGCCAGCACTATCACTTCACGACCGTCGAGGATTTCCGCGCGCGC
CACGCGAGCCACGAGTTTCTGGAGAGCGCGGAGGTGCACGGCAACTACTACGGCACGTCGCGCGTGTGGATCGAAGAGCA
GATGAAGAGCGGCCACGATGTGCTGCTCGAAATCGATTGGCAGGGCGCGCAGCAAGTGAAGAAGCAGTTTCGCAACGCGG
TCGGCATCTTCATTCTGCCGCCGTCGCTCGCGGCGCTCGAGGAGCGGCTGAAAAAGCGCGGGCAGGACGAGCCGAACGTG
ATCACGCGGCGCCTGCTCGCCGCAGGCAGCGAGATCGCGCACGCGGCCGAAGCGGAGTACGTCGTGATCAACGAGACCTT
CGAGCACGCGCTTGCCGAGCTCGAATGCATCGTCGCCGCGACGCGCCTGCGCTTCACGTCGCAATATGCGCGGCATGCCG
AACTATTCGTCGAGCTCGGCATTCATCTGCCGCATGCGGAGTGA

Upstream 100 bases:

>100_bases
CTCGAAGGCGGCCGCGAAGGAACTCGCGGACGCGTCGATGGCGCTCAAGCTGCTGATCGAGCAGATGCGCGAGCAAGTGC
AAAACCTGGAGTAACGCAAC

Downstream 100 bases:

>100_bases
CGGCGGCGAACGAGGCACATAAGGTAGAATAAGCAACATATTCAGAAGGAACGACCCAACATGGCTCGCATTACCGTTGA
AGACTGCCTGAAGCAGATTC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 227; Mature: 226

Protein sequence:

>227_residues
MTDSNRGGAAAHSLHAGVYPGNLFMVVAPSGAGKSTLVNALLSKDPEICLSISYTTRKPRSGEQDGQHYHFTTVEDFRAR
HASHEFLESAEVHGNYYGTSRVWIEEQMKSGHDVLLEIDWQGAQQVKKQFRNAVGIFILPPSLAALEERLKKRGQDEPNV
ITRRLLAAGSEIAHAAEAEYVVINETFEHALAELECIVAATRLRFTSQYARHAELFVELGIHLPHAE

Sequences:

>Translated_227_residues
MTDSNRGGAAAHSLHAGVYPGNLFMVVAPSGAGKSTLVNALLSKDPEICLSISYTTRKPRSGEQDGQHYHFTTVEDFRAR
HASHEFLESAEVHGNYYGTSRVWIEEQMKSGHDVLLEIDWQGAQQVKKQFRNAVGIFILPPSLAALEERLKKRGQDEPNV
ITRRLLAAGSEIAHAAEAEYVVINETFEHALAELECIVAATRLRFTSQYARHAELFVELGIHLPHAE
>Mature_226_residues
TDSNRGGAAAHSLHAGVYPGNLFMVVAPSGAGKSTLVNALLSKDPEICLSISYTTRKPRSGEQDGQHYHFTTVEDFRARH
ASHEFLESAEVHGNYYGTSRVWIEEQMKSGHDVLLEIDWQGAQQVKKQFRNAVGIFILPPSLAALEERLKKRGQDEPNVI
TRRLLAAGSEIAHAAEAEYVVINETFEHALAELECIVAATRLRFTSQYARHAELFVELGIHLPHAE

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874831, Length=172, Percent_Identity=37.7906976744186, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI226874833, Length=175, Percent_Identity=37.1428571428571, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI4504221, Length=175, Percent_Identity=37.1428571428571, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI262118259, Length=134, Percent_Identity=32.089552238806, Blast_Score=78, Evalue=5e-15,
Organism=Homo sapiens, GI4505237, Length=134, Percent_Identity=32.089552238806, Blast_Score=78, Evalue=5e-15,
Organism=Homo sapiens, GI262118255, Length=134, Percent_Identity=32.089552238806, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI262118263, Length=134, Percent_Identity=32.089552238806, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI21361598, Length=198, Percent_Identity=24.2424242424242, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI38570142, Length=174, Percent_Identity=26.4367816091954, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1790080, Length=201, Percent_Identity=48.2587064676617, Blast_Score=199, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI193203132, Length=180, Percent_Identity=35, Blast_Score=113, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17508835, Length=180, Percent_Identity=35, Blast_Score=113, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI71988041, Length=183, Percent_Identity=25.6830601092896, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71988048, Length=171, Percent_Identity=26.9005847953216, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=182, Percent_Identity=37.9120879120879, Blast_Score=132, Evalue=7e-32,
Organism=Drosophila melanogaster, GI21356141, Length=153, Percent_Identity=41.1764705882353, Blast_Score=121, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 25186; Mature: 25054

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDSNRGGAAAHSLHAGVYPGNLFMVVAPSGAGKSTLVNALLSKDPEICLSISYTTRKPR
CCCCCCCCCHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCEEEEEEECCCCCC
SGEQDGQHYHFTTVEDFRARHASHEFLESAEVHGNYYGTSRVWIEEQMKSGHDVLLEIDW
CCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHCCCEECCEEEEHHHHHCCCCEEEEEECC
QGAQQVKKQFRNAVGIFILPPSLAALEERLKKRGQDEPNVITRRLLAAGSEIAHAAEAEY
CCHHHHHHHHHHCCEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHCCCCE
VVINETFEHALAELECIVAATRLRFTSQYARHAELFVELGIHLPHAE
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TDSNRGGAAAHSLHAGVYPGNLFMVVAPSGAGKSTLVNALLSKDPEICLSISYTTRKPR
CCCCCCCCHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCEEEEEEECCCCCC
SGEQDGQHYHFTTVEDFRARHASHEFLESAEVHGNYYGTSRVWIEEQMKSGHDVLLEIDW
CCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHCCCEECCEEEEHHHHHCCCCEEEEEECC
QGAQQVKKQFRNAVGIFILPPSLAALEERLKKRGQDEPNVITRRLLAAGSEIAHAAEAEY
CCHHHHHHHHHHCCEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHCCCCE
VVINETFEHALAELECIVAATRLRFTSQYARHAELFVELGIHLPHAE
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA