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The map label for this gene is gdhA [H]

Identifier: 83718927

GI number: 83718927

Start: 1372922

End: 1374226

Strand: Direct

Name: gdhA [H]

Synonym: BTH_I1224

Alternate gene names: 83718927

Gene position: 1372922-1374226 (Clockwise)

Preceding gene: 83719876

Following gene: 83718416

Centisome position: 36.04

GC content: 66.05

Gene sequence:

>1305_bases
ATGTCTTCGCAATCGCAGTCCCCGTCCGTCGCGCAGTCCATTCCGTCGTACCTGCACGCGGACGATCTCGGCCCCTGGGG
CAACTACCTGCAGCAAGTCGATCGCGTCGCGCCGTACCTCGGCTCCCTGTCGCGCTGGATCGAGACGCTGAAGCGCCCGA
AGCGCATCCTGATCGTCGATGTGCCGATCGAGCTGGACAACGGCACCGTTGCGCATTTCGAGGGCTATCGCGTGCAGCAC
AACGTGTCGCGCGGCCCGGGCAAGGGCGGCGTGCGTTACCACCAGGACGTGACGCTGTCCGAGGTGATGGCGCTGTCCGC
CTGGATGTCGGTGAAGAACGCGGCCGTGAACGTGCCGTACGGCGGCGCGAAGGGCGGCATCCGCGTCGATCCGCGCAAGC
TCTCACGTGGCGAGCTCGAGCGCGTAACGCGTCGCTACACCAGCGAAATCGGCATCATCATCGGCCCGAACACCGATATT
CCCGCGCCTGACGTCAACACGAACGAGCAGATCATGGCGTGGATGATGGACACTTACTCGATGAACCAGGGCCAGACGGC
CACGGGCGTCGTGACCGGCAAGCCGATCTCGCTCGGCGGCTCGCTCGGCCGCAAGGAAGCGACTGGCCGCGGCGTGTTCG
TCGTCGGCTGCGAGGCGGCGAAGAAGAAGGGTGTCGAGATCGAAGGCGCGCGCATCGCGGTGCAGGGTTTCGGCAACGTC
GGCGGGATCGCCGCGAAGCTGTTCCAGGAAGCGGGCGCGAAGGTGATCGCGGTGCAGGATCACACGGGCACGATCCACCA
GCCGGCTGGCGTCGACACGGCCAAGCTGCTCGACCACGTCGGCCGCACGGGCGGCGTCGCGGGCTTCGAAGGCGCGGAAC
CGATGCCGAACGACGAGTTCTGGACCGTCGAGACCGAGATCCTGATTCCGGCCGCGCTGGAAAACCAGATCACCGAGAAG
AACGCGTCGAAGATCCGCACGAAGATCATCGTCGAAGGCGCGAACGGCCCGACGACGACGGCCGCGGACGACATCCTGAG
CGCGAACGGCGTGCTCGTGATCCCCGACGTGATCGCGAACGCGGGCGGCGTGACCGTGTCGTACTTCGAGTGGGTGCAGG
ATTTCTCGAGCTTCTTCTGGACCGAAGACGAGATCAACCACCGTCTCGAGCGCGTGATGCGCGAGGCGTTTGCCGGCGTG
TGGGCGGTGGCCGAAGAGCACAAGGTGTCGGTGCGCACGGCGGCGTTCATCGTCGCGTGCAAACGCATCCTGATGGCGCG
CGAAATGCGCGGTCTGTACCCCTGA

Upstream 100 bases:

>100_bases
CCGATCATGCACGAAACGCATAATCGAATAAGCAAACGGCATTGGATTTCGAAATTCGCTTTTTCGACAATGTGCGCATT
CTTCGACCGTTGGAGATTCC

Downstream 100 bases:

>100_bases
TCGACGGGTTGGAGCGATCGGCGACGCGCAGGTTGGAGGCCGCGTCGTGATTCACTCGCGGGCGGCACCGGCTCCGGTGC
CGCCCGCGTGCGCATCCGGG

Product: glutamate dehydrogenase

Products: NA

Alternate protein names: GDH [H]

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MSSQSQSPSVAQSIPSYLHADDLGPWGNYLQQVDRVAPYLGSLSRWIETLKRPKRILIVDVPIELDNGTVAHFEGYRVQH
NVSRGPGKGGVRYHQDVTLSEVMALSAWMSVKNAAVNVPYGGAKGGIRVDPRKLSRGELERVTRRYTSEIGIIIGPNTDI
PAPDVNTNEQIMAWMMDTYSMNQGQTATGVVTGKPISLGGSLGRKEATGRGVFVVGCEAAKKKGVEIEGARIAVQGFGNV
GGIAAKLFQEAGAKVIAVQDHTGTIHQPAGVDTAKLLDHVGRTGGVAGFEGAEPMPNDEFWTVETEILIPAALENQITEK
NASKIRTKIIVEGANGPTTTAADDILSANGVLVIPDVIANAGGVTVSYFEWVQDFSSFFWTEDEINHRLERVMREAFAGV
WAVAEEHKVSVRTAAFIVACKRILMAREMRGLYP

Sequences:

>Translated_434_residues
MSSQSQSPSVAQSIPSYLHADDLGPWGNYLQQVDRVAPYLGSLSRWIETLKRPKRILIVDVPIELDNGTVAHFEGYRVQH
NVSRGPGKGGVRYHQDVTLSEVMALSAWMSVKNAAVNVPYGGAKGGIRVDPRKLSRGELERVTRRYTSEIGIIIGPNTDI
PAPDVNTNEQIMAWMMDTYSMNQGQTATGVVTGKPISLGGSLGRKEATGRGVFVVGCEAAKKKGVEIEGARIAVQGFGNV
GGIAAKLFQEAGAKVIAVQDHTGTIHQPAGVDTAKLLDHVGRTGGVAGFEGAEPMPNDEFWTVETEILIPAALENQITEK
NASKIRTKIIVEGANGPTTTAADDILSANGVLVIPDVIANAGGVTVSYFEWVQDFSSFFWTEDEINHRLERVMREAFAGV
WAVAEEHKVSVRTAAFIVACKRILMAREMRGLYP
>Mature_433_residues
SSQSQSPSVAQSIPSYLHADDLGPWGNYLQQVDRVAPYLGSLSRWIETLKRPKRILIVDVPIELDNGTVAHFEGYRVQHN
VSRGPGKGGVRYHQDVTLSEVMALSAWMSVKNAAVNVPYGGAKGGIRVDPRKLSRGELERVTRRYTSEIGIIIGPNTDIP
APDVNTNEQIMAWMMDTYSMNQGQTATGVVTGKPISLGGSLGRKEATGRGVFVVGCEAAKKKGVEIEGARIAVQGFGNVG
GIAAKLFQEAGAKVIAVQDHTGTIHQPAGVDTAKLLDHVGRTGGVAGFEGAEPMPNDEFWTVETEILIPAALENQITEKN
ASKIRTKIIVEGANGPTTTAADDILSANGVLVIPDVIANAGGVTVSYFEWVQDFSSFFWTEDEINHRLERVMREAFAGVW
AVAEEHKVSVRTAAFIVACKRILMAREMRGLYP

Specific function: Unknown

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI31377775, Length=371, Percent_Identity=42.8571428571429, Blast_Score=282, Evalue=5e-76,
Organism=Homo sapiens, GI4885281, Length=371, Percent_Identity=42.0485175202156, Blast_Score=275, Evalue=6e-74,
Organism=Escherichia coli, GI1788059, Length=366, Percent_Identity=34.4262295081967, Blast_Score=182, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17544676, Length=392, Percent_Identity=40.0510204081633, Blast_Score=269, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6319256, Length=396, Percent_Identity=29.5454545454545, Blast_Score=139, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6324951, Length=377, Percent_Identity=29.7082228116711, Blast_Score=139, Evalue=1e-33,
Organism=Drosophila melanogaster, GI45553475, Length=362, Percent_Identity=42.2651933701657, Blast_Score=280, Evalue=2e-75,
Organism=Drosophila melanogaster, GI45549226, Length=354, Percent_Identity=42.9378531073446, Blast_Score=278, Evalue=4e-75,
Organism=Drosophila melanogaster, GI24649283, Length=388, Percent_Identity=40.7216494845361, Blast_Score=268, Evalue=6e-72,
Organism=Drosophila melanogaster, GI24649460, Length=301, Percent_Identity=43.1893687707641, Blast_Score=234, Evalue=9e-62,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 9362 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR014362
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.3 [H]

Molecular weight: Translated: 46865; Mature: 46734

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00074 GLFV_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSQSQSPSVAQSIPSYLHADDLGPWGNYLQQVDRVAPYLGSLSRWIETLKRPKRILIVD
CCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
VPIELDNGTVAHFEGYRVQHNVSRGPGKGGVRYHQDVTLSEVMALSAWMSVKNAAVNVPY
EEEEECCCEEEEEECEEEEECCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCEEECCC
GGAKGGIRVDPRKLSRGELERVTRRYTSEIGIIIGPNTDIPAPDVNTNEQIMAWMMDTYS
CCCCCCCEECHHHCCHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHC
MNQGQTATGVVTGKPISLGGSLGRKEATGRGVFVVGCEAAKKKGVEIEGARIAVQGFGNV
CCCCCCEEEEEECCCEECCCCCCCCCCCCCEEEEEECHHHHHCCCEECCCEEEEEECCCC
GGIAAKLFQEAGAKVIAVQDHTGTIHQPAGVDTAKLLDHVGRTGGVAGFEGAEPMPNDEF
HHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCE
WTVETEILIPAALENQITEKNASKIRTKIIVEGANGPTTTAADDILSANGVLVIPDVIAN
EEEEEEEEECHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCHHHHHCCCCEEEECHHHCC
AGGVTVSYFEWVQDFSSFFWTEDEINHRLERVMREAFAGVWAVAEEHKVSVRTAAFIVAC
CCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
KRILMAREMRGLYP
HHHHHHHHHHCCCC
>Mature Secondary Structure 
SSQSQSPSVAQSIPSYLHADDLGPWGNYLQQVDRVAPYLGSLSRWIETLKRPKRILIVD
CCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
VPIELDNGTVAHFEGYRVQHNVSRGPGKGGVRYHQDVTLSEVMALSAWMSVKNAAVNVPY
EEEEECCCEEEEEECEEEEECCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCEEECCC
GGAKGGIRVDPRKLSRGELERVTRRYTSEIGIIIGPNTDIPAPDVNTNEQIMAWMMDTYS
CCCCCCCEECHHHCCHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHC
MNQGQTATGVVTGKPISLGGSLGRKEATGRGVFVVGCEAAKKKGVEIEGARIAVQGFGNV
CCCCCCEEEEEECCCEECCCCCCCCCCCCCEEEEEECHHHHHCCCEECCCEEEEEECCCC
GGIAAKLFQEAGAKVIAVQDHTGTIHQPAGVDTAKLLDHVGRTGGVAGFEGAEPMPNDEF
HHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCE
WTVETEILIPAALENQITEKNASKIRTKIIVEGANGPTTTAADDILSANGVLVIPDVIAN
EEEEEEEEECHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCHHHHHCCCCEEEECHHHCC
AGGVTVSYFEWVQDFSSFFWTEDEINHRLERVMREAFAGVWAVAEEHKVSVRTAAFIVAC
CCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
KRILMAREMRGLYP
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9680336; 10360571; 9135121; 9654452; 10366510 [H]