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The map label for this gene is hemA [H]

Identifier: 83593843

GI number: 83593843

Start: 2915085

End: 2916299

Strand: Direct

Name: hemA [H]

Synonym: Rru_A2508

Alternate gene names: 83593843

Gene position: 2915085-2916299 (Clockwise)

Preceding gene: 83593842

Following gene: 83593844

Centisome position: 66.97

GC content: 63.21

Gene sequence:

>1215_bases
ATGGATTATGAGGGCTATTTCGCCGAGCGACTTCACAGTCTGAAGCGGGAAGGGCGCTATCGCGTCTTCGCCGATCTCGA
ACGACAGGTGGGCCGGTTCCCCTTGGCGCGCAATTACCGCGACGGAGAGGTTCACGAAGTCACCATCTGGTGTTCGAACG
ATTACCTGGGAATGGGCATCCATCCCGTCGTCCTCGAAGCCACGAACGAAGCTTTGTACACCTGCGGCGCCGGCGCCGGG
GGCACGCGCAACATCAGCGGCACCAATCACTACCACGTGCTGCTCGAGCGCGAACTGGCCGATTGGTACAAGAAGGACGA
AGCCCTGCTGTTCACCAGCGGCTATGTCGCCAATATCACCACGCTGATGACCCTGGGCGCCCAGATCCCCGATCTGGTGA
TCTTCTCGGATTCCGATAATCACAATTCGATGATCGAGGGGATCCGCCACTCGCGCGCGCCCAAGGAGATCTTCCGCCAC
AACGATCTCGCCCATCTCGAAGAGCTGCTGCGCAAGTATCCCAAGGATCGCGCCAAGCTGATCGCCTTCGAATCCGTCTA
TTCGATGGATGGCGATATCGCCCCGATCGCCGAGATTTGCGATCTCGCCGATAAATACGGCGCCATGACCTTCCTTGATG
AAGTCCATGCCGTTGGCATGTATGGCGAGACCGGATCGGGCGTGGCCGAGCGCGATGGCGTGCGCGAGCGCCTGACCATC
ATCCAGGCGACCATGGGCAAGGCCATCGGCTGCGTCGGCGGCTTCATCTGCGCCTCCGCCTCGCTGATCGATTTCGTCCG
CAGCTTCGGGGCCGGCTTCATCTTCACCACCTCGCTGCCGCCGACCATCGCCGCTGGCGCCCTGGCCAGCGTGCGCTACC
TCAAAGAGCACAACGAGCTTCGCGTCCGCCACCAGGAGCGGGCCGCCACCACCAAGTGGCGCCTGCGCGAGGCCGGGCTG
CCGGTGATGCCCTCGGTCAGCCATATCATCCCGCTCGCCGTCGGCGACGCCTCGCTGTGCAAGCAGGCTTCGGACATGCT
GCTCAGCCTGCATGACATCTATGTGCAGCCGATCAACTTCCCGACCGTTCCGCGCGGCACCGAACGGCTGCGCCTGACCG
CCACGCCGCTGCACACCGACGAGCATCTCGACCATCTGGTCCATGCCCTGTCCGACGTGTGGCGTCGCCTGGGGATTGGT
CGTCAGGCCGCCTGA

Upstream 100 bases:

>100_bases
CCAACCTGCGGGTTTGAGGGCGCCCTAGTCCCTTCTGCCCAAAGAAATTCGCCGACGGCTTGGCGCCGGCAGGGGAACTG
TGATCAGGAGAGACCGATCA

Downstream 100 bases:

>100_bases
TCGCGCCCGACACCCTACTCTCCCCGATCATCCCGCTTGCCAAGCACCCCCTCCTCCCCTTGTGGGAGGAGGGGTTTTTC
TTTGCCTGGACGGACCGGTC

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MDYEGYFAERLHSLKREGRYRVFADLERQVGRFPLARNYRDGEVHEVTIWCSNDYLGMGIHPVVLEATNEALYTCGAGAG
GTRNISGTNHYHVLLERELADWYKKDEALLFTSGYVANITTLMTLGAQIPDLVIFSDSDNHNSMIEGIRHSRAPKEIFRH
NDLAHLEELLRKYPKDRAKLIAFESVYSMDGDIAPIAEICDLADKYGAMTFLDEVHAVGMYGETGSGVAERDGVRERLTI
IQATMGKAIGCVGGFICASASLIDFVRSFGAGFIFTTSLPPTIAAGALASVRYLKEHNELRVRHQERAATTKWRLREAGL
PVMPSVSHIIPLAVGDASLCKQASDMLLSLHDIYVQPINFPTVPRGTERLRLTATPLHTDEHLDHLVHALSDVWRRLGIG
RQAA

Sequences:

>Translated_404_residues
MDYEGYFAERLHSLKREGRYRVFADLERQVGRFPLARNYRDGEVHEVTIWCSNDYLGMGIHPVVLEATNEALYTCGAGAG
GTRNISGTNHYHVLLERELADWYKKDEALLFTSGYVANITTLMTLGAQIPDLVIFSDSDNHNSMIEGIRHSRAPKEIFRH
NDLAHLEELLRKYPKDRAKLIAFESVYSMDGDIAPIAEICDLADKYGAMTFLDEVHAVGMYGETGSGVAERDGVRERLTI
IQATMGKAIGCVGGFICASASLIDFVRSFGAGFIFTTSLPPTIAAGALASVRYLKEHNELRVRHQERAATTKWRLREAGL
PVMPSVSHIIPLAVGDASLCKQASDMLLSLHDIYVQPINFPTVPRGTERLRLTATPLHTDEHLDHLVHALSDVWRRLGIG
RQAA
>Mature_404_residues
MDYEGYFAERLHSLKREGRYRVFADLERQVGRFPLARNYRDGEVHEVTIWCSNDYLGMGIHPVVLEATNEALYTCGAGAG
GTRNISGTNHYHVLLERELADWYKKDEALLFTSGYVANITTLMTLGAQIPDLVIFSDSDNHNSMIEGIRHSRAPKEIFRH
NDLAHLEELLRKYPKDRAKLIAFESVYSMDGDIAPIAEICDLADKYGAMTFLDEVHAVGMYGETGSGVAERDGVRERLTI
IQATMGKAIGCVGGFICASASLIDFVRSFGAGFIFTTSLPPTIAAGALASVRYLKEHNELRVRHQERAATTKWRLREAGL
PVMPSVSHIIPLAVGDASLCKQASDMLLSLHDIYVQPINFPTVPRGTERLRLTATPLHTDEHLDHLVHALSDVWRRLGIG
RQAA

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=406, Percent_Identity=50.7389162561576, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI83977440, Length=406, Percent_Identity=50.7389162561576, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI83977444, Length=406, Percent_Identity=50.7389162561576, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI4502025, Length=403, Percent_Identity=51.8610421836228, Blast_Score=414, Evalue=1e-116,
Organism=Homo sapiens, GI40316939, Length=403, Percent_Identity=51.8610421836228, Blast_Score=414, Evalue=1e-116,
Organism=Homo sapiens, GI7657118, Length=356, Percent_Identity=35.9550561797753, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI284448556, Length=347, Percent_Identity=36.3112391930836, Blast_Score=232, Evalue=6e-61,
Organism=Homo sapiens, GI4758668, Length=419, Percent_Identity=28.1622911694511, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI119220554, Length=418, Percent_Identity=27.2727272727273, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI5454084, Length=247, Percent_Identity=33.6032388663968, Blast_Score=128, Evalue=8e-30,
Organism=Escherichia coli, GI1790046, Length=389, Percent_Identity=33.1619537275064, Blast_Score=202, Evalue=3e-53,
Organism=Escherichia coli, GI1786993, Length=341, Percent_Identity=34.6041055718475, Blast_Score=169, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI71994529, Length=363, Percent_Identity=35.2617079889807, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI32566772, Length=380, Percent_Identity=29.2105263157895, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17560914, Length=314, Percent_Identity=28.6624203821656, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17560912, Length=314, Percent_Identity=28.6624203821656, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI71982617, Length=261, Percent_Identity=29.5019157088123, Blast_Score=121, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI71982625, Length=261, Percent_Identity=29.5019157088123, Blast_Score=120, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6320438, Length=423, Percent_Identity=50.5910165484634, Blast_Score=419, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6320267, Length=376, Percent_Identity=27.6595744680851, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6323954, Length=277, Percent_Identity=25.6317689530686, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17137420, Length=401, Percent_Identity=49.1271820448878, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24662918, Length=360, Percent_Identity=36.3888888888889, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI17136286, Length=368, Percent_Identity=28.804347826087, Blast_Score=135, Evalue=7e-32,
Organism=Drosophila melanogaster, GI24653280, Length=282, Percent_Identity=29.4326241134752, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24653276, Length=282, Percent_Identity=29.4326241134752, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24653278, Length=282, Percent_Identity=29.4326241134752, Blast_Score=119, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 44935; Mature: 44935

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYEGYFAERLHSLKREGRYRVFADLERQVGRFPLARNYRDGEVHEVTIWCSNDYLGMGI
CCCCHHHHHHHHHHHHCCCEEEEHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCEECCCC
HPVVLEATNEALYTCGAGAGGTRNISGTNHYHVLLERELADWYKKDEALLFTSGYVANIT
CEEEEEECCCEEEEECCCCCCCCCCCCCCCEEEEEEHHHHHHHCCCCEEEEECCHHHHHH
TLMTLGAQIPDLVIFSDSDNHNSMIEGIRHSRAPKEIFRHNDLAHLEELLRKYPKDRAKL
HHHHHCCCCCCEEEECCCCCCHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHCCCHHHHE
IAFESVYSMDGDIAPIAEICDLADKYGAMTFLDEVHAVGMYGETGSGVAERDGVRERLTI
EEHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCHHHHHHH
IQATMGKAIGCVGGFICASASLIDFVRSFGAGFIFTTSLPPTIAAGALASVRYLKEHNEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHH
RVRHQERAATTKWRLREAGLPVMPSVSHIIPLAVGDASLCKQASDMLLSLHDIYVQPINF
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHEEECCCHHHHHHHHHHHHHHHHHEEECCCC
PTVPRGTERLRLTATPLHTDEHLDHLVHALSDVWRRLGIGRQAA
CCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDYEGYFAERLHSLKREGRYRVFADLERQVGRFPLARNYRDGEVHEVTIWCSNDYLGMGI
CCCCHHHHHHHHHHHHCCCEEEEHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCEECCCC
HPVVLEATNEALYTCGAGAGGTRNISGTNHYHVLLERELADWYKKDEALLFTSGYVANIT
CEEEEEECCCEEEEECCCCCCCCCCCCCCCEEEEEEHHHHHHHCCCCEEEEECCHHHHHH
TLMTLGAQIPDLVIFSDSDNHNSMIEGIRHSRAPKEIFRHNDLAHLEELLRKYPKDRAKL
HHHHHCCCCCCEEEECCCCCCHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHCCCHHHHE
IAFESVYSMDGDIAPIAEICDLADKYGAMTFLDEVHAVGMYGETGSGVAERDGVRERLTI
EEHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCHHHHHHH
IQATMGKAIGCVGGFICASASLIDFVRSFGAGFIFTTSLPPTIAAGALASVRYLKEHNEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHH
RVRHQERAATTKWRLREAGLPVMPSVSHIIPLAVGDASLCKQASDMLLSLHDIYVQPINF
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHEEECCCHHHHHHHHHHHHHHHHHEEECCCC
PTVPRGTERLRLTATPLHTDEHLDHLVHALSDVWRRLGIGRQAA
CCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2034217 [H]