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The map label for this gene is pyrE [H]

Identifier: 83593842

GI number: 83593842

Start: 2913867

End: 2914550

Strand: Direct

Name: pyrE [H]

Synonym: Rru_A2507

Alternate gene names: 83593842

Gene position: 2913867-2914550 (Clockwise)

Preceding gene: 83593840

Following gene: 83593843

Centisome position: 66.94

GC content: 68.27

Gene sequence:

>684_bases
ATGGACCTTGATACCCTGGCCAACGCCGAGGCCGGCCGCACCGTCGCCAGCATCCTGTTGGAAATCGGCGCCGTCAATTT
CCGCCCCCAGCAGCCCTATACCTTGACCGCCGGATGGGCGAGCCCGGTCTATATCGACTGCCGCAAGATCATCAGCTATC
CGCGGGCGCGGCGGCGGATCATCGATCTCGCCACCCGCAAGATCGAACGCGCCATCGGCTTTGAAAGCCTCGACTCCGTG
GCCGGCGGCGAGACGGCGGGCATCCCTTACGCGGCGTGGCTGGCCGATTCCCTGGGTCTGCCCATGCAATACGTGCGCAA
GAAGCCCAAGGGCTTTGGCCGCATGGGCCAGATCGAAGGCGATCTCAGCGAAGGCCAGCGGGTGTTGCTGGTCGAAGACC
TCGCCAGCGACGGCGGCTCCAAGCTGGCCTTCGTCGACGCCCTGCGCCGGGCCGGGGCCCAGGTGAACGACACCTTCGTC
GTGTTCTTCTATGGCGCCTTCCCCGGCGCCACCGACGCCCTGGCCGCCGAGGGCATCACCCTGCATTGGCTGGCCACCTG
GCACGACGTGCTGGCCGTCGCCGAACGCACCGCCGCCTTCCCCGAAGACAGCATCGAGGGCGTGCGCGCCTTCCTTGCCG
ACCCCGTCGGCTGGTCGGCCGCCCATGGCGGCAAAGGCGCCTGA

Upstream 100 bases:

>100_bases
TGGTTTTACCGTTAAAAAGCGGTCATCGGAAGCTGGGGCGCATCCTCTGTCCGTCGCCACCCCTGCCCGTTCCCCGTCAA
CGGAAAGAAGGCCATGCGCA

Downstream 100 bases:

>100_bases
CCTCATGATGCGGCAAAGGCGCCCGAGCTAAAAGGGGTGAGGTAAAATAATCCGCTCCGCAAACCGGGCGACTCGGCGGC
GGCCGAGTCGCCGCCGCCCC

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MDLDTLANAEAGRTVASILLEIGAVNFRPQQPYTLTAGWASPVYIDCRKIISYPRARRRIIDLATRKIERAIGFESLDSV
AGGETAGIPYAAWLADSLGLPMQYVRKKPKGFGRMGQIEGDLSEGQRVLLVEDLASDGGSKLAFVDALRRAGAQVNDTFV
VFFYGAFPGATDALAAEGITLHWLATWHDVLAVAERTAAFPEDSIEGVRAFLADPVGWSAAHGGKGA

Sequences:

>Translated_227_residues
MDLDTLANAEAGRTVASILLEIGAVNFRPQQPYTLTAGWASPVYIDCRKIISYPRARRRIIDLATRKIERAIGFESLDSV
AGGETAGIPYAAWLADSLGLPMQYVRKKPKGFGRMGQIEGDLSEGQRVLLVEDLASDGGSKLAFVDALRRAGAQVNDTFV
VFFYGAFPGATDALAAEGITLHWLATWHDVLAVAERTAAFPEDSIEGVRAFLADPVGWSAAHGGKGA
>Mature_227_residues
MDLDTLANAEAGRTVASILLEIGAVNFRPQQPYTLTAGWASPVYIDCRKIISYPRARRRIIDLATRKIERAIGFESLDSV
AGGETAGIPYAAWLADSLGLPMQYVRKKPKGFGRMGQIEGDLSEGQRVLLVEDLASDGGSKLAFVDALRRAGAQVNDTFV
VFFYGAFPGATDALAAEGITLHWLATWHDVLAVAERTAAFPEDSIEGVRAFLADPVGWSAAHGGKGA

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=192, Percent_Identity=30.7291666666667, Blast_Score=104, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17508631, Length=189, Percent_Identity=31.7460317460317, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17554964, Length=184, Percent_Identity=29.8913043478261, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI17933654, Length=206, Percent_Identity=28.6407766990291, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 24324; Mature: 24324

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLDTLANAEAGRTVASILLEIGAVNFRPQQPYTLTAGWASPVYIDCRKIISYPRARRRI
CCCHHHCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHCCHHHHHHH
IDLATRKIERAIGFESLDSVAGGETAGIPYAAWLADSLGLPMQYVRKKPKGFGRMGQIEG
HHHHHHHHHHHHCHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCC
DLSEGQRVLLVEDLASDGGSKLAFVDALRRAGAQVNDTFVVFFYGAFPGATDALAAEGIT
CCCCCCEEEEEEEHHCCCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHCCCE
LHWLATWHDVLAVAERTAAFPEDSIEGVRAFLADPVGWSAAHGGKGA
EEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDLDTLANAEAGRTVASILLEIGAVNFRPQQPYTLTAGWASPVYIDCRKIISYPRARRRI
CCCHHHCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHCCHHHHHHH
IDLATRKIERAIGFESLDSVAGGETAGIPYAAWLADSLGLPMQYVRKKPKGFGRMGQIEG
HHHHHHHHHHHHCHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCC
DLSEGQRVLLVEDLASDGGSKLAFVDALRRAGAQVNDTFVVFFYGAFPGATDALAAEGIT
CCCCCCEEEEEEEHHCCCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHCCCE
LHWLATWHDVLAVAERTAAFPEDSIEGVRAFLADPVGWSAAHGGKGA
EEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA