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The map label for this gene is hemN [H]

Identifier: 83593839

GI number: 83593839

Start: 2910313

End: 2911722

Strand: Direct

Name: hemN [H]

Synonym: Rru_A2504

Alternate gene names: 83593839

Gene position: 2910313-2911722 (Clockwise)

Preceding gene: 83593837

Following gene: 83593840

Centisome position: 66.86

GC content: 65.04

Gene sequence:

>1410_bases
ATGGACGGCGAGACGAACACCCTGCATCCCGAGGCGTCCCAGGCCAGTGCGATCAGCGCCAAGACCCAGGCCCTGGCGTC
GAAATACGATCTGCGTCTGCCCCGCTACACCTCCTATCCGACCGCCCCCCATTTCCATGGCGGCGTCGGGGCCGAGACCT
ATGGTCAATGGCTGGAAGCCCTGGAGCCGGGTTCGCCGGCCTCGCTGTATCTCCATGTCGCCTATTGCGCCGAGATGTGC
TGGTTCTGCGGCTGCCATACCCGGGTGACCAAGCGCTATGATCCGGTCGCCGATTACCTCGACGCCCTGCTGAGCGAAAG
CGCCATGGTGGCCAAGCGCCTGTCCGGGCCGCTGAAGGTCACCCATGTGCATTTCGGCGGCGGCACGCCCACCATCTTGA
CGGCCGATGATTTCGTCCGCACCATCGATACACTGCGCGCCGATTTCGGTCTGGCCGATGTCGCCGAGATCGCCGTGGAA
ATGGATCCGCGCACCGCGACCCTTGATTACGTCAAGGCGATGGCACGCGCCGGCGTCACCCGCGCCAGCATCGGCGTTCA
GGACTTCAAGGATGACGTTCAGAAGGCGATCAACCGCATCCAGCCCATCGAACTGGTCGCCCAGGTGATCGACTGGCTGC
GCGACAACGGCATCAGCGATATCAACATGGATCTGGTCTATGGCCTGCCCCATCAGACCACGTCGAGCGTCCTGCATACC
ATCGATCAGGCGATCGCCATGGCGCCGCGCCGGGTATCGCTGTTTGGCTATGCCCATGTGCCGTGGATGAAGAAGCACAT
GCGGCTGATCGACGAGGCCAGCCTGCCCGATGTGCCCGAGCGTTGGAGCCAGTATCTGGCGGCCACCGCCCACTTCCAGG
CCTTGGGCTATGTCGCCGTCGGCCTGGATCACTTCGCCGCCCCCGATGACGAGATGGCCCGCGCGCTCAGCGAAGGCATC
CTGCACCGCAATTTCCAAGGCTACACCACCGATACCGCCCCGGCGCTGATCGGCCTGGGCGCCTCGGGCATCGGCTATCT
GCCCCAGGGCTATGTCGCCAATGAGGGCGAAATCGGCGCCTATAAGGAGCTGATCCGCGGTGGATCCTTCGCCACCAAGC
GCGGCATCGCCGTCAGCACCGACGATATGGTCCGCCGCTCGGTCATCGAACGGCTGATGTGTGATCTGGCCGTCGATCTT
GGCGCCGTCGCCCGCGAATACGGCCTGCCCGACGACACCTTCGCCACGGAACTCGCCGCCATGGACTCGCTGGAAGGCGA
CGGCGTGCTGGTGCGCGAGGGCGGGGTCGTTCACATCACCGAACTGGGCCGGCCGCTGGTGCGCGCCGTCTGCGCCAAAT
TCGACCGCTACCTGAAAATGGGCGAGCAGCGCCATTCCCGCGCCGTCTGA

Upstream 100 bases:

>100_bases
AGCTTTGCCGCCGGATTCTAGCGAACGCGAAAGACTCTAGCGGTTGGCTAAACCGTTGACGAGGGCGCGCGAGACGCCCC
GACCAGGAGAGAGCGGCCCC

Downstream 100 bases:

>100_bases
TCCCTGATGCCCCTCGGCCCGGGAAACCGGGCCGAGGGAGCCGCGATCTATTTCTTTCGATATATACCTTTTTTTAATTT
TAGACCTTAGGCTACAATAG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MDGETNTLHPEASQASAISAKTQALASKYDLRLPRYTSYPTAPHFHGGVGAETYGQWLEALEPGSPASLYLHVAYCAEMC
WFCGCHTRVTKRYDPVADYLDALLSESAMVAKRLSGPLKVTHVHFGGGTPTILTADDFVRTIDTLRADFGLADVAEIAVE
MDPRTATLDYVKAMARAGVTRASIGVQDFKDDVQKAINRIQPIELVAQVIDWLRDNGISDINMDLVYGLPHQTTSSVLHT
IDQAIAMAPRRVSLFGYAHVPWMKKHMRLIDEASLPDVPERWSQYLAATAHFQALGYVAVGLDHFAAPDDEMARALSEGI
LHRNFQGYTTDTAPALIGLGASGIGYLPQGYVANEGEIGAYKELIRGGSFATKRGIAVSTDDMVRRSVIERLMCDLAVDL
GAVAREYGLPDDTFATELAAMDSLEGDGVLVREGGVVHITELGRPLVRAVCAKFDRYLKMGEQRHSRAV

Sequences:

>Translated_469_residues
MDGETNTLHPEASQASAISAKTQALASKYDLRLPRYTSYPTAPHFHGGVGAETYGQWLEALEPGSPASLYLHVAYCAEMC
WFCGCHTRVTKRYDPVADYLDALLSESAMVAKRLSGPLKVTHVHFGGGTPTILTADDFVRTIDTLRADFGLADVAEIAVE
MDPRTATLDYVKAMARAGVTRASIGVQDFKDDVQKAINRIQPIELVAQVIDWLRDNGISDINMDLVYGLPHQTTSSVLHT
IDQAIAMAPRRVSLFGYAHVPWMKKHMRLIDEASLPDVPERWSQYLAATAHFQALGYVAVGLDHFAAPDDEMARALSEGI
LHRNFQGYTTDTAPALIGLGASGIGYLPQGYVANEGEIGAYKELIRGGSFATKRGIAVSTDDMVRRSVIERLMCDLAVDL
GAVAREYGLPDDTFATELAAMDSLEGDGVLVREGGVVHITELGRPLVRAVCAKFDRYLKMGEQRHSRAV
>Mature_469_residues
MDGETNTLHPEASQASAISAKTQALASKYDLRLPRYTSYPTAPHFHGGVGAETYGQWLEALEPGSPASLYLHVAYCAEMC
WFCGCHTRVTKRYDPVADYLDALLSESAMVAKRLSGPLKVTHVHFGGGTPTILTADDFVRTIDTLRADFGLADVAEIAVE
MDPRTATLDYVKAMARAGVTRASIGVQDFKDDVQKAINRIQPIELVAQVIDWLRDNGISDINMDLVYGLPHQTTSSVLHT
IDQAIAMAPRRVSLFGYAHVPWMKKHMRLIDEASLPDVPERWSQYLAATAHFQALGYVAVGLDHFAAPDDEMARALSEGI
LHRNFQGYTTDTAPALIGLGASGIGYLPQGYVANEGEIGAYKELIRGGSFATKRGIAVSTDDMVRRSVIERLMCDLAVDL
GAVAREYGLPDDTFATELAAMDSLEGDGVLVREGGVVHITELGRPLVRAVCAKFDRYLKMGEQRHSRAV

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=195, Percent_Identity=26.6666666666667, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI87082341, Length=449, Percent_Identity=38.0846325167038, Blast_Score=323, Evalue=2e-89,
Organism=Escherichia coli, GI1789325, Length=392, Percent_Identity=26.2755102040816, Blast_Score=112, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 51145; Mature: 51145

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGETNTLHPEASQASAISAKTQALASKYDLRLPRYTSYPTAPHFHGGVGAETYGQWLEA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
LEPGSPASLYLHVAYCAEMCWFCGCHTRVTKRYDPVADYLDALLSESAMVAKRLSGPLKV
HCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEE
THVHFGGGTPTILTADDFVRTIDTLRADFGLADVAEIAVEMDPRTATLDYVKAMARAGVT
EEEEECCCCCEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
RASIGVQDFKDDVQKAINRIQPIELVAQVIDWLRDNGISDINMDLVYGLPHQTTSSVLHT
HHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHH
IDQAIAMAPRRVSLFGYAHVPWMKKHMRLIDEASLPDVPERWSQYLAATAHFQALGYVAV
HHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GLDHFAAPDDEMARALSEGILHRNFQGYTTDTAPALIGLGASGIGYLPQGYVANEGEIGA
HHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHH
YKELIRGGSFATKRGIAVSTDDMVRRSVIERLMCDLAVDLGAVAREYGLPDDTFATELAA
HHHHHCCCCCHHCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
MDSLEGDGVLVREGGVVHITELGRPLVRAVCAKFDRYLKMGEQRHSRAV
HHCCCCCCEEEECCCEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDGETNTLHPEASQASAISAKTQALASKYDLRLPRYTSYPTAPHFHGGVGAETYGQWLEA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
LEPGSPASLYLHVAYCAEMCWFCGCHTRVTKRYDPVADYLDALLSESAMVAKRLSGPLKV
HCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEE
THVHFGGGTPTILTADDFVRTIDTLRADFGLADVAEIAVEMDPRTATLDYVKAMARAGVT
EEEEECCCCCEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
RASIGVQDFKDDVQKAINRIQPIELVAQVIDWLRDNGISDINMDLVYGLPHQTTSSVLHT
HHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHH
IDQAIAMAPRRVSLFGYAHVPWMKKHMRLIDEASLPDVPERWSQYLAATAHFQALGYVAV
HHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GLDHFAAPDDEMARALSEGILHRNFQGYTTDTAPALIGLGASGIGYLPQGYVANEGEIGA
HHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHH
YKELIRGGSFATKRGIAVSTDDMVRRSVIERLMCDLAVDLGAVAREYGLPDDTFATELAA
HHHHHCCCCCHHCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
MDSLEGDGVLVREGGVVHITELGRPLVRAVCAKFDRYLKMGEQRHSRAV
HHCCCCCCEEEECCCEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11157943; 12597275 [H]