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The map label for this gene is accC [H]

Identifier: 83593770

GI number: 83593770

Start: 2833362

End: 2834699

Strand: Direct

Name: accC [H]

Synonym: Rru_A2435

Alternate gene names: 83593770

Gene position: 2833362-2834699 (Clockwise)

Preceding gene: 83593769

Following gene: 83593771

Centisome position: 65.09

GC content: 64.5

Gene sequence:

>1338_bases
ATGTTCGACAAAATCCTCATCGCCAACCGGGGCGAGATCGCGCTACGCATCCATCGGGCCTGCCGGGAGATGGGCATCAA
GACCGTCGCGGTGCATTCCACCGCCGATTCCGAGGCCATGCATGTGCGTCTGGCCGACGAGTCGGTGTGCATCGGTCCGC
CCTCGGCCCGTGACAGCTATCTGTCCAAGGCGGCGATCATCTCGGCGGCGACCATCACCAATGCCGACGCCATCCACCCC
GGCTATGGCTTCTTGTCCGAAAACGCCGATTTCGCCGAGATGGTCCAGGACCACGGCTTCACCTTCATCGGCCCGTCGCC
GCGCCATATCCGCCTGATGGGCGACAAGATCACCGCCAAGCAGGCGGCCCTTGAAGCCGGGCTGCCCTGCGTGCCCGGGT
CGGCCGGGGCGGTGACCAGCGAAGAGGAAGGCTTGAAGGTCGCCGCGGCCTTTGGCTATCCCGTGCTGTTCAAGGCGACC
GCCGGCGGCGGCGGTCGCGGCATGAAGGTCGCCACCGGTCCCCATGACCTGGGCGAGGCCTTCCGCACGGCGCGGACGGA
AGCCCAGGCGGCCTTTGGCAATTCCGAAGTCTATATGGAGAAATATCTCCAGAACCCGCGCCATATCGAGGTGCAGGTGC
TTGGCGATAATTACGGCGGCGCGGTCTATCTTGGCGAACGCGATTGCTCGCTCCAGCGCAAGCACCAGAAGGTGCTTGAA
GAAGCCCGCTCGCCGGCGCTCAACGACGAGGCGCGCGCCCGCATCGGCGAAATCGCCCGACGCGCGGTCGAACGCCTAGG
CTACAGCAACGCCGGCACCATGGAGTTCCTTTACGAAGAGGGCGAGTTCTATTTCATCGAAATGAACACCCGCCTTCAGG
TGGAACACCCGGTCACCGAAATGATCACCGGCATCGATGTGGTGCGCGAGCAGATCCGCATCGCCGCCGGGGCGCCGCTG
GGTTATGACCAATCGGCGATCCGCTTCCATGGCCATGCCATCGAATGCCGGGTCAACGCCGAGGATCCGGTGACCTTCGC
CCCCTCCCCCGGGCGCGTGACCTATTTCCACCAGCCCGGCGGCATGGGCGTGCGCGTGGATTCCGGGCTGTACCAGGGGG
TGATGGTGCCTCCCCATTACGACAGCATGGTCGCCAAGCTGATCGTTCACGGGGCGACCCGCAACGAATGCCTGATGCGG
CTGCGCCGGGCCCTTGATGAATTCGTCATCGAGGGGATTCAAACCACCTTGCCGCTGCATCGCCGCATCGTCCGCGCCCC
CGAATTCGTCGATGGCGCCTATGACATCCGCTGGCTCGAGAACTTCGTGGACCAATAG

Upstream 100 bases:

>100_bases
CGCGCGCCGGTACGGTGGCGGCCATTCTGGTCGACGACGCCACTCCGGTGGAATTCGGCGAACCCCTGATCATCCTCGAG
TGAGGGAGGGCGGGCGCCCC

Downstream 100 bases:

>100_bases
GCCTTTCGCGCCGGAATTTTGATCCTATCTCCTTTGGGGACGGCCTCCCGCCGCGCGCGGGAAGCCGTCCCCGATTTCTT
GAGCGGAGCCGTTCCTACGC

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MFDKILIANRGEIALRIHRACREMGIKTVAVHSTADSEAMHVRLADESVCIGPPSARDSYLSKAAIISAATITNADAIHP
GYGFLSENADFAEMVQDHGFTFIGPSPRHIRLMGDKITAKQAALEAGLPCVPGSAGAVTSEEEGLKVAAAFGYPVLFKAT
AGGGGRGMKVATGPHDLGEAFRTARTEAQAAFGNSEVYMEKYLQNPRHIEVQVLGDNYGGAVYLGERDCSLQRKHQKVLE
EARSPALNDEARARIGEIARRAVERLGYSNAGTMEFLYEEGEFYFIEMNTRLQVEHPVTEMITGIDVVREQIRIAAGAPL
GYDQSAIRFHGHAIECRVNAEDPVTFAPSPGRVTYFHQPGGMGVRVDSGLYQGVMVPPHYDSMVAKLIVHGATRNECLMR
LRRALDEFVIEGIQTTLPLHRRIVRAPEFVDGAYDIRWLENFVDQ

Sequences:

>Translated_445_residues
MFDKILIANRGEIALRIHRACREMGIKTVAVHSTADSEAMHVRLADESVCIGPPSARDSYLSKAAIISAATITNADAIHP
GYGFLSENADFAEMVQDHGFTFIGPSPRHIRLMGDKITAKQAALEAGLPCVPGSAGAVTSEEEGLKVAAAFGYPVLFKAT
AGGGGRGMKVATGPHDLGEAFRTARTEAQAAFGNSEVYMEKYLQNPRHIEVQVLGDNYGGAVYLGERDCSLQRKHQKVLE
EARSPALNDEARARIGEIARRAVERLGYSNAGTMEFLYEEGEFYFIEMNTRLQVEHPVTEMITGIDVVREQIRIAAGAPL
GYDQSAIRFHGHAIECRVNAEDPVTFAPSPGRVTYFHQPGGMGVRVDSGLYQGVMVPPHYDSMVAKLIVHGATRNECLMR
LRRALDEFVIEGIQTTLPLHRRIVRAPEFVDGAYDIRWLENFVDQ
>Mature_445_residues
MFDKILIANRGEIALRIHRACREMGIKTVAVHSTADSEAMHVRLADESVCIGPPSARDSYLSKAAIISAATITNADAIHP
GYGFLSENADFAEMVQDHGFTFIGPSPRHIRLMGDKITAKQAALEAGLPCVPGSAGAVTSEEEGLKVAAAFGYPVLFKAT
AGGGGRGMKVATGPHDLGEAFRTARTEAQAAFGNSEVYMEKYLQNPRHIEVQVLGDNYGGAVYLGERDCSLQRKHQKVLE
EARSPALNDEARARIGEIARRAVERLGYSNAGTMEFLYEEGEFYFIEMNTRLQVEHPVTEMITGIDVVREQIRIAAGAPL
GYDQSAIRFHGHAIECRVNAEDPVTFAPSPGRVTYFHQPGGMGVRVDSGLYQGVMVPPHYDSMVAKLIVHGATRNECLMR
LRRALDEFVIEGIQTTLPLHRRIVRAPEFVDGAYDIRWLENFVDQ

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=444, Percent_Identity=48.8738738738739, Blast_Score=426, Evalue=1e-119,
Organism=Homo sapiens, GI65506442, Length=444, Percent_Identity=48.8738738738739, Blast_Score=425, Evalue=1e-119,
Organism=Homo sapiens, GI295821183, Length=444, Percent_Identity=48.8738738738739, Blast_Score=425, Evalue=1e-119,
Organism=Homo sapiens, GI116805327, Length=432, Percent_Identity=46.7592592592593, Blast_Score=394, Evalue=1e-109,
Organism=Homo sapiens, GI106049528, Length=444, Percent_Identity=46.1711711711712, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI106049295, Length=444, Percent_Identity=46.1711711711712, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI106049292, Length=444, Percent_Identity=46.1711711711712, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI38679974, Length=511, Percent_Identity=29.5499021526419, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI38679960, Length=511, Percent_Identity=29.5499021526419, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI38679977, Length=511, Percent_Identity=29.5499021526419, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI38679967, Length=511, Percent_Identity=29.5499021526419, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI38679971, Length=511, Percent_Identity=29.5499021526419, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI134142062, Length=512, Percent_Identity=29.4921875, Blast_Score=212, Evalue=7e-55,
Organism=Escherichia coli, GI1789654, Length=442, Percent_Identity=58.5972850678733, Blast_Score=516, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI17567343, Length=442, Percent_Identity=47.2850678733032, Blast_Score=400, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17562816, Length=448, Percent_Identity=46.2053571428571, Blast_Score=389, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI71987519, Length=432, Percent_Identity=47.9166666666667, Blast_Score=387, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI133931226, Length=487, Percent_Identity=29.5687885010267, Blast_Score=204, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI71997168, Length=503, Percent_Identity=27.6341948310139, Blast_Score=202, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI71997163, Length=503, Percent_Identity=27.6341948310139, Blast_Score=201, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6319685, Length=445, Percent_Identity=44.0449438202247, Blast_Score=376, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6319695, Length=451, Percent_Identity=44.7893569844789, Blast_Score=354, Evalue=1e-98,
Organism=Saccharomyces cerevisiae, GI6321376, Length=451, Percent_Identity=45.4545454545455, Blast_Score=344, Evalue=1e-95,
Organism=Saccharomyces cerevisiae, GI6323863, Length=460, Percent_Identity=30.6521739130435, Blast_Score=219, Evalue=6e-58,
Organism=Saccharomyces cerevisiae, GI6324343, Length=513, Percent_Identity=29.6296296296296, Blast_Score=213, Evalue=4e-56,
Organism=Drosophila melanogaster, GI281363050, Length=445, Percent_Identity=49.2134831460674, Blast_Score=407, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652224, Length=445, Percent_Identity=49.2134831460674, Blast_Score=407, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652222, Length=445, Percent_Identity=49.2134831460674, Blast_Score=407, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652220, Length=445, Percent_Identity=49.2134831460674, Blast_Score=407, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652218, Length=445, Percent_Identity=49.2134831460674, Blast_Score=407, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652212, Length=445, Percent_Identity=49.2134831460674, Blast_Score=407, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652210, Length=445, Percent_Identity=49.2134831460674, Blast_Score=407, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652214, Length=445, Percent_Identity=49.2134831460674, Blast_Score=407, Evalue=1e-114,
Organism=Drosophila melanogaster, GI19921944, Length=445, Percent_Identity=49.2134831460674, Blast_Score=407, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652216, Length=445, Percent_Identity=49.2134831460674, Blast_Score=407, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24651757, Length=430, Percent_Identity=48.1395348837209, Blast_Score=396, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24651759, Length=394, Percent_Identity=47.4619289340102, Blast_Score=355, Evalue=3e-98,
Organism=Drosophila melanogaster, GI24586458, Length=506, Percent_Identity=30.2371541501976, Blast_Score=223, Evalue=1e-58,
Organism=Drosophila melanogaster, GI161076407, Length=506, Percent_Identity=30.2371541501976, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24586460, Length=506, Percent_Identity=30.2371541501976, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI161076409, Length=506, Percent_Identity=30.2371541501976, Blast_Score=223, Evalue=2e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 48785; Mature: 48785

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS50975 ATP_GRASP ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDKILIANRGEIALRIHRACREMGIKTVAVHSTADSEAMHVRLADESVCIGPPSARDSY
CCCCEEEECCCCEEHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCEEEECCCCCHHHH
LSKAAIISAATITNADAIHPGYGFLSENADFAEMVQDHGFTFIGPSPRHIRLMGDKITAK
HHHHHHHEEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCEEECCCCCEEEEECCCHHHH
QAALEAGLPCVPGSAGAVTSEEEGLKVAAAFGYPVLFKATAGGGGRGMKVATGPHDLGEA
HHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCCCCEEECCCHHHHHH
FRTARTEAQAAFGNSEVYMEKYLQNPRHIEVQVLGDNYGGAVYLGERDCSLQRKHQKVLE
HHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
EARSPALNDEARARIGEIARRAVERLGYSNAGTMEFLYEEGEFYFIEMNTRLQVEHPVTE
HHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEECCEEEECCCHHH
MITGIDVVREQIRIAAGAPLGYDQSAIRFHGHAIECRVNAEDPVTFAPSPGRVTYFHQPG
HHHHHHHHHHHHHHHCCCCCCCCCCEEEECCEEEEEEECCCCCEEECCCCCEEEEEECCC
GMGVRVDSGLYQGVMVPPHYDSMVAKLIVHGATRNECLMRLRRALDEFVIEGIQTTLPLH
CCEEEECCCCCCCEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRIVRAPEFVDGAYDIRWLENFVDQ
HHHHCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MFDKILIANRGEIALRIHRACREMGIKTVAVHSTADSEAMHVRLADESVCIGPPSARDSY
CCCCEEEECCCCEEHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCEEEECCCCCHHHH
LSKAAIISAATITNADAIHPGYGFLSENADFAEMVQDHGFTFIGPSPRHIRLMGDKITAK
HHHHHHHEEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCEEECCCCCEEEEECCCHHHH
QAALEAGLPCVPGSAGAVTSEEEGLKVAAAFGYPVLFKATAGGGGRGMKVATGPHDLGEA
HHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCCCCEEECCCHHHHHH
FRTARTEAQAAFGNSEVYMEKYLQNPRHIEVQVLGDNYGGAVYLGERDCSLQRKHQKVLE
HHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
EARSPALNDEARARIGEIARRAVERLGYSNAGTMEFLYEEGEFYFIEMNTRLQVEHPVTE
HHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEECCEEEECCCHHH
MITGIDVVREQIRIAAGAPLGYDQSAIRFHGHAIECRVNAEDPVTFAPSPGRVTYFHQPG
HHHHHHHHHHHHHHHCCCCCCCCCCEEEECCEEEEEEECCCCCEEECCCCCEEEEEECCC
GMGVRVDSGLYQGVMVPPHYDSMVAKLIVHGATRNECLMRLRRALDEFVIEGIQTTLPLH
CCEEEECCCCCCCEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRIVRAPEFVDGAYDIRWLENFVDQ
HHHHCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]