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The map label for this gene is aroE

Identifier: 83590401

GI number: 83590401

Start: 1601250

End: 1602137

Strand: Reverse

Name: aroE

Synonym: Moth_1558

Alternate gene names: 83590401

Gene position: 1602137-1601250 (Counterclockwise)

Preceding gene: 83590402

Following gene: 83590400

Centisome position: 60.95

GC content: 65.43

Gene sequence:

>888_bases
ATGATACAGGTTAAAGCTTCCACCGGGCTGGTTGCCCTCCTGGGACACCCGGTGCAACACTCCCTTTCGCCTCTTATGCA
TAATGCCGCCTTTGCGGCCGGCGGCCAGAACCTGGTCTACCTGGCCTTTGATGTTAAACCGGGTGATTTAGCTGCCGCCC
TGGCCGGATTAAAGGCCCTGGGTTTCCGCGGGGCCAACGTCACCGTACCCCATAAGGAAGCGATAATCCCCTACCTGGAT
GCAGTCGACCCGGTAGCAGCCAGGATCGGGGCCGTGAATACTATCGTCAATGAGGACCGGTGCCTGAAAGGCTACAACAC
CGACGGCAGCGGTTTTTTGCGTTCCCTGGAGGAGGCCGGTTTTGACCCGGCCGGGAAGAGGGCAGTAATCCTGGGTGCAG
GTGGCGCCGCCAGGGCGGTGGCCTTCGCCCTGGCGACGGCCGGCTGTGGGAGCCTGGTCCTGGCCAACCGGACCCCGGAA
CGGGCCACGGAACTGGCCGGTGCCCTGGCAGGAGCCGGCCTGCCGGCGCCCGTAGTTTACCGGCTGGGAGATGCCGGGAT
GCGGTCCGAAGTGGAGGCCGCCGACCTGGTACTCAATACCACCAGCCTGGGTATGTGGCCCCGGGTCGAAGAAACGCCGC
TGCCACCGGACTGGTTCCGGCCCGGACAATGGGTCTACGACCTGGTTTACAACCCCCTGGAAACCAAATTCCTGGCAGGT
GCCCGGCGCCGGGGCTGCCGGGTGATCTCCGGCCTGGATATGCTCCTCTACCAGGGGGCCGCGGCCTTTACTCTCTGGAC
GGGCCGCGAAGCCCCGGTAGCAGTCATGGACAGGGTCCTCCGGGAGGCCATGGGGGCGAGTTCAGGCGGGCCTGCTGCCG
GCCGGTGA

Upstream 100 bases:

>100_bases
ACCCCTGCGTGTGCCCCCACGGCAAAATAAGGACTTCCCCGGCCCGGGAGTAACAACCCGGGTGCGAGGCGAACTTCAAT
AAAGGATGGTAGGATGGCAG

Downstream 100 bases:

>100_bases
AAGCTTGAGAAAGGATGGATACATATGCTGCGCTATCTGACTGCCGGGGAATCCCACGGCCGGGGCCTGAGCGTCATTGT
CGAAGGGCTGCCGGCCGGGG

Product: shikimate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MIQVKASTGLVALLGHPVQHSLSPLMHNAAFAAGGQNLVYLAFDVKPGDLAAALAGLKALGFRGANVTVPHKEAIIPYLD
AVDPVAARIGAVNTIVNEDRCLKGYNTDGSGFLRSLEEAGFDPAGKRAVILGAGGAARAVAFALATAGCGSLVLANRTPE
RATELAGALAGAGLPAPVVYRLGDAGMRSEVEAADLVLNTTSLGMWPRVEETPLPPDWFRPGQWVYDLVYNPLETKFLAG
ARRRGCRVISGLDMLLYQGAAAFTLWTGREAPVAVMDRVLREAMGASSGGPAAGR

Sequences:

>Translated_295_residues
MIQVKASTGLVALLGHPVQHSLSPLMHNAAFAAGGQNLVYLAFDVKPGDLAAALAGLKALGFRGANVTVPHKEAIIPYLD
AVDPVAARIGAVNTIVNEDRCLKGYNTDGSGFLRSLEEAGFDPAGKRAVILGAGGAARAVAFALATAGCGSLVLANRTPE
RATELAGALAGAGLPAPVVYRLGDAGMRSEVEAADLVLNTTSLGMWPRVEETPLPPDWFRPGQWVYDLVYNPLETKFLAG
ARRRGCRVISGLDMLLYQGAAAFTLWTGREAPVAVMDRVLREAMGASSGGPAAGR
>Mature_295_residues
MIQVKASTGLVALLGHPVQHSLSPLMHNAAFAAGGQNLVYLAFDVKPGDLAAALAGLKALGFRGANVTVPHKEAIIPYLD
AVDPVAARIGAVNTIVNEDRCLKGYNTDGSGFLRSLEEAGFDPAGKRAVILGAGGAARAVAFALATAGCGSLVLANRTPE
RATELAGALAGAGLPAPVVYRLGDAGMRSEVEAADLVLNTTSLGMWPRVEETPLPPDWFRPGQWVYDLVYNPLETKFLAG
ARRRGCRVISGLDMLLYQGAAAFTLWTGREAPVAVMDRVLREAMGASSGGPAAGR

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1787983, Length=285, Percent_Identity=40.3508771929825, Blast_Score=204, Evalue=6e-54,
Organism=Escherichia coli, GI1789675, Length=278, Percent_Identity=35.9712230215827, Blast_Score=129, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6320332, Length=287, Percent_Identity=28.9198606271777, Blast_Score=90, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_MOOTA (Q2RI72)

Other databases:

- EMBL:   CP000232
- RefSeq:   YP_430410.1
- HSSP:   Q9SQT8
- ProteinModelPortal:   Q2RI72
- SMR:   Q2RI72
- STRING:   Q2RI72
- GeneID:   3832191
- GenomeReviews:   CP000232_GR
- KEGG:   mta:Moth_1558
- NMPDR:   fig|264732.9.peg.1562
- eggNOG:   COG0169
- HOGENOM:   HBG553408
- OMA:   RVEVANR
- PhylomeDB:   Q2RI72
- BioCyc:   MTHE264732:MOTH_1558-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 30672; Mature: 30672

Theoretical pI: Translated: 8.06; Mature: 8.06

Prosite motif: NA

Important sites: ACT_SITE 72-72

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQVKASTGLVALLGHPVQHSLSPLMHNAAFAAGGQNLVYLAFDVKPGDLAAALAGLKAL
CEEEECCCCEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHH
GFRGANVTVPHKEAIIPYLDAVDPVAARIGAVNTIVNEDRCLKGYNTDGSGFLRSLEEAG
CCCCCCEECCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHCC
FDPAGKRAVILGAGGAARAVAFALATAGCGSLVLANRTPERATELAGALAGAGLPAPVVY
CCCCCCEEEEEECCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCCHHHHE
RLGDAGMRSEVEAADLVLNTTSLGMWPRVEETPLPPDWFRPGQWVYDLVYNPLETKFLAG
ECCCCCCCCCCCHHHEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHH
ARRRGCRVISGLDMLLYQGAAAFTLWTGREAPVAVMDRVLREAMGASSGGPAAGR
HHHCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MIQVKASTGLVALLGHPVQHSLSPLMHNAAFAAGGQNLVYLAFDVKPGDLAAALAGLKAL
CEEEECCCCEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHH
GFRGANVTVPHKEAIIPYLDAVDPVAARIGAVNTIVNEDRCLKGYNTDGSGFLRSLEEAG
CCCCCCEECCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHCC
FDPAGKRAVILGAGGAARAVAFALATAGCGSLVLANRTPERATELAGALAGAGLPAPVVY
CCCCCCEEEEEECCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCCHHHHE
RLGDAGMRSEVEAADLVLNTTSLGMWPRVEETPLPPDWFRPGQWVYDLVYNPLETKFLAG
ECCCCCCCCCCCHHHEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHH
ARRRGCRVISGLDMLLYQGAAAFTLWTGREAPVAVMDRVLREAMGASSGGPAAGR
HHHCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA