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The map label for this gene is folD

Identifier: 83590359

GI number: 83590359

Start: 1561840

End: 1562682

Strand: Reverse

Name: folD

Synonym: Moth_1516

Alternate gene names: 83590359

Gene position: 1562682-1561840 (Counterclockwise)

Preceding gene: 83590360

Following gene: 83590358

Centisome position: 59.45

GC content: 57.89

Gene sequence:

>843_bases
ATGCCAGCCCAGATCCTCGACGGGAAAAAGATTGCTGCCGAAGTAAGGGCTGAAGTAAAGGAGGAGGTATCCCGGTTAAA
GGCGGAAGGTATTAACCCAGGCCTGGCCGTAGTCCTGGTGGGCGAAGACCCGGCTTCCCAGGTGTACGTCCGTAACAAGC
ACCGCGCCTGTGAGGAGGTCGGTATCTACTCCGAGGTTCACCGCCTGCCGGCGGCGACCAGCCAGGCCGAACTCTTAAAG
CTGATCGACCAGCTCAATAAAGATCCCAAGATTCACGGCATCCTGGTCCAGTTGCCGTTGCCTGATCATATTGATGAGAA
GAAAGTCATCGATGCCATCGCCCTGGAAAAGGATGTTGACGGGTTCAGCCCGGCCAACGTCGGCAACCTGGTTATCGGCG
ATAAATGCTTCTATCCATGCACACCCCACGGCTGTATGGTTTTGCTGGAAAAAGCCGGTATTGATCCCAAGGGTAAAAAG
GCAGTGGTCGTCGGCCGGAGCAATATCGTCGGCAAGCCAGTAGCAATGATGCTCCTGGCCCGCCACGCCACGGTGACCAT
CTGTCACTCCCGCACCAGGGACCTGGCAGCCGAATGCCGGCAGGCCGACATTCTCATTGCGGCCGTAGGGAAGCCGGAGT
TGATTACCGGGGATATGATTAAAGAGGGCGCGGTAGTTATCGACGTAGGTATCAACCGGGTCGGCGAGAAAAAGCTGGTG
GGCGACGTCCACTTCGAGAGTGCGGCCCAGAAGGCCGGTTGGATCACTCCCGTACCCGGCGGGGTAGGTCCCATGACCAT
TGCCATGCTCTTGAAGAATACAGTCGAGGCGGCCCGGCGCTAG

Upstream 100 bases:

>100_bases
GGCGGCTACCGTCATCCTGGCCATGGGAGCCGGTAAAGCGGCCGCCCGGGCCATTGACGCCTATCTACGGGAAAAATAAT
ATATAAAGGAGGGTATTTTT

Downstream 100 bases:

>100_bases
TGCCGGAGGTTAAAGTCCTGGCGGTGAGGGAACTCACCGCCTATTTGCAGCGCCTCCTGGCCAACGACGGCCGCCTGGCC
AATGTCTGGGTAAAGGGCGA

Product: methenyltetrahydrofolate cyclohydrolase

Products: NA

Alternate protein names: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MPAQILDGKKIAAEVRAEVKEEVSRLKAEGINPGLAVVLVGEDPASQVYVRNKHRACEEVGIYSEVHRLPAATSQAELLK
LIDQLNKDPKIHGILVQLPLPDHIDEKKVIDAIALEKDVDGFSPANVGNLVIGDKCFYPCTPHGCMVLLEKAGIDPKGKK
AVVVGRSNIVGKPVAMMLLARHATVTICHSRTRDLAAECRQADILIAAVGKPELITGDMIKEGAVVIDVGINRVGEKKLV
GDVHFESAAQKAGWITPVPGGVGPMTIAMLLKNTVEAARR

Sequences:

>Translated_280_residues
MPAQILDGKKIAAEVRAEVKEEVSRLKAEGINPGLAVVLVGEDPASQVYVRNKHRACEEVGIYSEVHRLPAATSQAELLK
LIDQLNKDPKIHGILVQLPLPDHIDEKKVIDAIALEKDVDGFSPANVGNLVIGDKCFYPCTPHGCMVLLEKAGIDPKGKK
AVVVGRSNIVGKPVAMMLLARHATVTICHSRTRDLAAECRQADILIAAVGKPELITGDMIKEGAVVIDVGINRVGEKKLV
GDVHFESAAQKAGWITPVPGGVGPMTIAMLLKNTVEAARR
>Mature_279_residues
PAQILDGKKIAAEVRAEVKEEVSRLKAEGINPGLAVVLVGEDPASQVYVRNKHRACEEVGIYSEVHRLPAATSQAELLKL
IDQLNKDPKIHGILVQLPLPDHIDEKKVIDAIALEKDVDGFSPANVGNLVIGDKCFYPCTPHGCMVLLEKAGIDPKGKKA
VVVGRSNIVGKPVAMMLLARHATVTICHSRTRDLAAECRQADILIAAVGKPELITGDMIKEGAVVIDVGINRVGEKKLVG
DVHFESAAQKAGWITPVPGGVGPMTIAMLLKNTVEAARR

Specific function: Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate

COG id: COG0190

COG function: function code H; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=291, Percent_Identity=48.7972508591065, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI222418558, Length=294, Percent_Identity=49.6598639455782, Blast_Score=258, Evalue=4e-69,
Organism=Homo sapiens, GI94721354, Length=294, Percent_Identity=50.6802721088435, Blast_Score=251, Evalue=4e-67,
Organism=Homo sapiens, GI36796743, Length=276, Percent_Identity=28.9855072463768, Blast_Score=98, Evalue=8e-21,
Organism=Escherichia coli, GI1786741, Length=278, Percent_Identity=57.1942446043165, Blast_Score=300, Evalue=6e-83,
Organism=Caenorhabditis elegans, GI17568735, Length=293, Percent_Identity=43.3447098976109, Blast_Score=223, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6319558, Length=287, Percent_Identity=49.1289198606272, Blast_Score=273, Evalue=2e-74,
Organism=Saccharomyces cerevisiae, GI6321643, Length=298, Percent_Identity=45.6375838926174, Blast_Score=263, Evalue=2e-71,
Organism=Saccharomyces cerevisiae, GI6322933, Length=325, Percent_Identity=26.1538461538462, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17136816, Length=294, Percent_Identity=55.1020408163265, Blast_Score=297, Evalue=5e-81,
Organism=Drosophila melanogaster, GI17136818, Length=294, Percent_Identity=55.1020408163265, Blast_Score=296, Evalue=9e-81,
Organism=Drosophila melanogaster, GI62472483, Length=289, Percent_Identity=47.4048442906574, Blast_Score=254, Evalue=5e-68,
Organism=Drosophila melanogaster, GI45551871, Length=289, Percent_Identity=47.4048442906574, Blast_Score=254, Evalue=5e-68,
Organism=Drosophila melanogaster, GI24645718, Length=289, Percent_Identity=47.4048442906574, Blast_Score=254, Evalue=5e-68,
Organism=Drosophila melanogaster, GI17137370, Length=289, Percent_Identity=47.4048442906574, Blast_Score=254, Evalue=5e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FOLD_MOOTA (Q2RIB4)

Other databases:

- EMBL:   CP000232
- RefSeq:   YP_430368.1
- ProteinModelPortal:   Q2RIB4
- SMR:   Q2RIB4
- STRING:   Q2RIB4
- GeneID:   3831981
- GenomeReviews:   CP000232_GR
- KEGG:   mta:Moth_1516
- NMPDR:   fig|264732.9.peg.1521
- eggNOG:   COG0190
- HOGENOM:   HBG328751
- OMA:   GINHIHD
- PhylomeDB:   Q2RIB4
- BioCyc:   MTHE264732:MOTH_1516-MONOMER
- GO:   GO:0005488
- HAMAP:   MF_01576
- InterPro:   IPR016040
- InterPro:   IPR000672
- InterPro:   IPR020630
- InterPro:   IPR020867
- InterPro:   IPR020631
- Gene3D:   G3DSA:3.40.50.720
- PRINTS:   PR00085

Pfam domain/function: PF00763 THF_DHG_CYH; PF02882 THF_DHG_CYH_C

EC number: =1.5.1.5; =3.5.4.9

Molecular weight: Translated: 29964; Mature: 29832

Theoretical pI: Translated: 7.87; Mature: 7.87

Prosite motif: PS00766 THF_DHG_CYH_1; PS00767 THF_DHG_CYH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAQILDGKKIAAEVRAEVKEEVSRLKAEGINPGLAVVLVGEDPASQVYVRNKHRACEEV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEECCHHHHHHHH
GIYSEVHRLPAATSQAELLKLIDQLNKDPKIHGILVQLPLPDHIDEKKVIDAIALEKDVD
HHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCC
GFSPANVGNLVIGDKCFYPCTPHGCMVLLEKAGIDPKGKKAVVVGRSNIVGKPVAMMLLA
CCCCCCCCCEEECCCCCCCCCCHHHEEEEECCCCCCCCCEEEEEECCCCCCCHHHHHHHH
RHATVTICHSRTRDLAAECRQADILIAAVGKPELITGDMIKEGAVVIDVGINRVGEKKLV
HCCEEEEECCCHHHHHHHHHHCCEEEEECCCCCEEECCHHHCCCEEEEECCCCCCCHHHC
GDVHFESAAQKAGWITPVPGGVGPMTIAMLLKNTVEAARR
CHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PAQILDGKKIAAEVRAEVKEEVSRLKAEGINPGLAVVLVGEDPASQVYVRNKHRACEEV
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEECCHHHHHHHH
GIYSEVHRLPAATSQAELLKLIDQLNKDPKIHGILVQLPLPDHIDEKKVIDAIALEKDVD
HHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCC
GFSPANVGNLVIGDKCFYPCTPHGCMVLLEKAGIDPKGKKAVVVGRSNIVGKPVAMMLLA
CCCCCCCCCEEECCCCCCCCCCHHHEEEEECCCCCCCCCEEEEEECCCCCCCHHHHHHHH
RHATVTICHSRTRDLAAECRQADILIAAVGKPELITGDMIKEGAVVIDVGINRVGEKKLV
HCCEEEEECCCHHHHHHHHHHCCEEEEECCCCCEEECCHHHCCCEEEEECCCCCCCHHHC
GDVHFESAAQKAGWITPVPGGVGPMTIAMLLKNTVEAARR
CHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA