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The map label for this gene is fruA

Identifier: 82750402

GI number: 82750402

Start: 713255

End: 715219

Strand: Direct

Name: fruA

Synonym: SAB0649

Alternate gene names: 82750402

Gene position: 713255-715219 (Clockwise)

Preceding gene: 82750401

Following gene: 82750403

Centisome position: 26.01

GC content: 37.15

Gene sequence:

>1965_bases
ATGAGAGTAACAGAGTTATTAACAAAAGATACAATAGCAATGGATTTAATGGCAAATGATAAAAATGGTGTTATTGATGA
GTTAGTAAATCAATTAGACAAAGCAGGTAAATTAAGTGATGTAGCGTCATTTAAGGAAGCGATTCACAATCGAGAATCAC
AAAGTACAACTGGTATCGGAGAAGGTATTGCTATTCCACATGCGAAAGTAGCCGCAGTTAAGTCTCCAGCTATCGCATTC
GGTAAATCTAAAGAAGGTGTAGATTACCAAAGTTTAGATATGCAACCAGCTCATTTATTCTTTATGATTGCAGCGCCAGA
AGGTGGTGCCCAAACACATTTAGATGCTTTAGCTAAACTATCTGGTATTTTAATGGATGAAAATGTACGTGAAAAATTAT
TACATGCATCGTCTCCAGAAGAAGTGTTAGCAATTATTGATCATGCTGATGATGAAGCGACAAAAGAAGAAGAGGCAGAA
GCTGAAGCACAACAAGTTGCTACTGTAGAAGCAAATCAAGACACTAATGGATCAAACGAGCCATATGTATTAGCTGTAAC
TGCTTGTCCAACAGGTATTGCACACACATATATGGCGCGTGATGCATTGAAAAAGCAAGCGGATAATATGGGCATTAAAA
TTAAAGTTGAAACGAACGGTTCAAGTGGTATTAAAAACCATTTAACGGAACAAGATATTAAAAATGCAACAGGTATCATT
GTTGCTGCTGATGTTCATGTTGAGACGGATCGCTTCGATGGTAAAAATGTCGTAGAAGTACCAGTAGCAGATGGTATTAA
ACGCCCAGAAGAATTAATTAATAAAGCATTAGATACAAGTCGTAAACCTTTTGTTGTCCGTGATGGTCAAAGAAAAGGTA
ACTCAAATGACAGTCAAGAAAAATTAAGCCCAGGTAAAGCTTTCTATAAACACTTAATGAACGGTGTTTCTAACATGTTG
CCACTTGTAATATCTGGTGGTATTTTAATGGCAATTGTATTTTTATTTGGAGCAAATTCATTTAATCCAAAAAGCTCAGA
GTACAATGCGTTTGCAGAGCAGCTTTGGAACATTGGTAGTAAAAGTGCATTCGCGTTAATCATTCCAATTTTATCTGGAT
TCATTGCTCGTAGTATTGCGGATAAACCTGGATTCGCTTCAGGTCTTGTAGGTGGTATGTTAGCAATTTCAGGTGGTTCA
GGATTTATTGGTGGTATTATTGCAGGTTTCTTAGCAGGTTACTTAACACAAGGTGTTAAAGCCATGACACGTAAGTTACC
ACAAGCATTAGAAGGATTAAAGCCAACATTAATTTACCCACTATTAACAGTGACAGCTACAGGCTTATTGATGATTTATG
TCTTTAATCCACCAGCATCTTGGTTAAATCATTTGTTATTAGATGGATTAAATAACTTATCAGGTTCTAATATTGTATTA
TTAGGTTTAGTTATTGGCGCTATGATGGCGATTGATATGGGCGGTCCATTCAACAAAGCGGCATATGTTTTTGCAACAGG
TGCGTTGATTGAAGGTAATGCAGCACCAATTACAGCTGCAATGATTGGTGGTATGATTCCACCGTTAGCAATTGCGACAG
CGATGTTAATTTTCAGACGTAAATTTACAAAAGAACAACGTGGTTCAATTATCCCTAACTATGTGATGGGTATGTCGTTT
ATTACAGAAGGTGCGATTCCATTTGCGGCTGCCGATCCATTACGTGTTATTCCTTCAATGATGATTGGATCAGGTATAGG
TGGCGCAATCGCTTTAGGTTTAGGTTCTCGAATTACTGCGCCACACGGTGGTATTATCGTAATTGTTGGTACGGATGGTG
CACATTTACTACAAACACTTATTGCACTTGTAGTAGGTACATTAGTTTCTGCATTAATTTATGGACTTATTAAACCAAAG
TTAACTGAAACAGAAATCGAAGCTTCAAAATCAATGGACGAATAG

Upstream 100 bases:

>100_bases
GTACTGCCACGGCATTTGATGAGGACTTAGCAACACGGGACGCTATAGAAAAAATAAAATCACAAGTTACGATTAGCGTA
CTTGATGGGGAGTGAAAATA

Downstream 100 bases:

>100_bases
TTTTAATGATTTAAAGTGATTGTTAGCAAAGAGCTTCATATTAAGTTGTAAGTTCAATGAATATATGTTAGTTTTATATA
TCGTGTTAACGGTAGCTTAT

Product: fructose specific permease

Products: NA

Alternate protein names: EIIABC-Fru; Fructose-specific phosphotransferase enzyme IIA component; EII-Fru; PTS system fructose-specific EIIA component; Fructose-specific phosphotransferase enzyme IIB component; EIII-Fru; PTS system fructose-specific EIIB component; Fructose permease IIC component; PTS system fructose-specific EIIC component [H]

Number of amino acids: Translated: 654; Mature: 654

Protein sequence:

>654_residues
MRVTELLTKDTIAMDLMANDKNGVIDELVNQLDKAGKLSDVASFKEAIHNRESQSTTGIGEGIAIPHAKVAAVKSPAIAF
GKSKEGVDYQSLDMQPAHLFFMIAAPEGGAQTHLDALAKLSGILMDENVREKLLHASSPEEVLAIIDHADDEATKEEEAE
AEAQQVATVEANQDTNGSNEPYVLAVTACPTGIAHTYMARDALKKQADNMGIKIKVETNGSSGIKNHLTEQDIKNATGII
VAADVHVETDRFDGKNVVEVPVADGIKRPEELINKALDTSRKPFVVRDGQRKGNSNDSQEKLSPGKAFYKHLMNGVSNML
PLVISGGILMAIVFLFGANSFNPKSSEYNAFAEQLWNIGSKSAFALIIPILSGFIARSIADKPGFASGLVGGMLAISGGS
GFIGGIIAGFLAGYLTQGVKAMTRKLPQALEGLKPTLIYPLLTVTATGLLMIYVFNPPASWLNHLLLDGLNNLSGSNIVL
LGLVIGAMMAIDMGGPFNKAAYVFATGALIEGNAAPITAAMIGGMIPPLAIATAMLIFRRKFTKEQRGSIIPNYVMGMSF
ITEGAIPFAAADPLRVIPSMMIGSGIGGAIALGLGSRITAPHGGIIVIVGTDGAHLLQTLIALVVGTLVSALIYGLIKPK
LTETEIEASKSMDE

Sequences:

>Translated_654_residues
MRVTELLTKDTIAMDLMANDKNGVIDELVNQLDKAGKLSDVASFKEAIHNRESQSTTGIGEGIAIPHAKVAAVKSPAIAF
GKSKEGVDYQSLDMQPAHLFFMIAAPEGGAQTHLDALAKLSGILMDENVREKLLHASSPEEVLAIIDHADDEATKEEEAE
AEAQQVATVEANQDTNGSNEPYVLAVTACPTGIAHTYMARDALKKQADNMGIKIKVETNGSSGIKNHLTEQDIKNATGII
VAADVHVETDRFDGKNVVEVPVADGIKRPEELINKALDTSRKPFVVRDGQRKGNSNDSQEKLSPGKAFYKHLMNGVSNML
PLVISGGILMAIVFLFGANSFNPKSSEYNAFAEQLWNIGSKSAFALIIPILSGFIARSIADKPGFASGLVGGMLAISGGS
GFIGGIIAGFLAGYLTQGVKAMTRKLPQALEGLKPTLIYPLLTVTATGLLMIYVFNPPASWLNHLLLDGLNNLSGSNIVL
LGLVIGAMMAIDMGGPFNKAAYVFATGALIEGNAAPITAAMIGGMIPPLAIATAMLIFRRKFTKEQRGSIIPNYVMGMSF
ITEGAIPFAAADPLRVIPSMMIGSGIGGAIALGLGSRITAPHGGIIVIVGTDGAHLLQTLIALVVGTLVSALIYGLIKPK
LTETEIEASKSMDE
>Mature_654_residues
MRVTELLTKDTIAMDLMANDKNGVIDELVNQLDKAGKLSDVASFKEAIHNRESQSTTGIGEGIAIPHAKVAAVKSPAIAF
GKSKEGVDYQSLDMQPAHLFFMIAAPEGGAQTHLDALAKLSGILMDENVREKLLHASSPEEVLAIIDHADDEATKEEEAE
AEAQQVATVEANQDTNGSNEPYVLAVTACPTGIAHTYMARDALKKQADNMGIKIKVETNGSSGIKNHLTEQDIKNATGII
VAADVHVETDRFDGKNVVEVPVADGIKRPEELINKALDTSRKPFVVRDGQRKGNSNDSQEKLSPGKAFYKHLMNGVSNML
PLVISGGILMAIVFLFGANSFNPKSSEYNAFAEQLWNIGSKSAFALIIPILSGFIARSIADKPGFASGLVGGMLAISGGS
GFIGGIIAGFLAGYLTQGVKAMTRKLPQALEGLKPTLIYPLLTVTATGLLMIYVFNPPASWLNHLLLDGLNNLSGSNIVL
LGLVIGAMMAIDMGGPFNKAAYVFATGALIEGNAAPITAAMIGGMIPPLAIATAMLIFRRKFTKEQRGSIIPNYVMGMSF
ITEGAIPFAAADPLRVIPSMMIGSGIGGAIALGLGSRITAPHGGIIVIVGTDGAHLLQTLIALVVGTLVSALIYGLIKPK
LTETEIEASKSMDE

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1299

COG function: function code G; Phosphotransferase system, fructose-specific IIC component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=38, Percent_Identity=86.8421052631579, Blast_Score=73, Evalue=8e-13,
Organism=Escherichia coli, GI1788492, Length=463, Percent_Identity=43.8444924406048, Blast_Score=374, Evalue=1e-105,
Organism=Escherichia coli, GI1786951, Length=614, Percent_Identity=33.8762214983713, Blast_Score=336, Evalue=3e-93,
Organism=Escherichia coli, GI87082348, Length=440, Percent_Identity=32.9545454545455, Blast_Score=211, Evalue=1e-55,
Organism=Escherichia coli, GI1790386, Length=307, Percent_Identity=37.785016286645, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI1788729, Length=360, Percent_Identity=30, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1790387, Length=94, Percent_Identity=43.6170212765958, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1788730, Length=86, Percent_Identity=45.3488372093023, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1789597, Length=113, Percent_Identity=36.283185840708, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI2367327, Length=145, Percent_Identity=24.1379310344828, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR004715
- InterPro:   IPR003353
- InterPro:   IPR006327 [H]

Pfam domain/function: PF00359 PTS_EIIA_2; PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 68950; Mature: 68950

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00372 PTS_EIIA_TYPE_2_HIS ; PS51094 PTS_EIIA_TYPE_2 ; PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVTELLTKDTIAMDLMANDKNGVIDELVNQLDKAGKLSDVASFKEAIHNRESQSTTGIG
CCHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCC
EGIAIPHAKVAAVKSPAIAFGKSKEGVDYQSLDMQPAHLFFMIAAPEGGAQTHLDALAKL
CCCCCCCHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHH
SGILMDENVREKLLHASSPEEVLAIIDHADDEATKEEEAEAEAQQVATVEANQDTNGSNE
HHHHCCCHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHEEECCCCCCCCCC
PYVLAVTACPTGIAHTYMARDALKKQADNMGIKIKVETNGSSGIKNHLTEQDIKNATGII
CEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHCCHHHHCCCCCEE
VAADVHVETDRFDGKNVVEVPVADGIKRPEELINKALDTSRKPFVVRDGQRKGNSNDSQE
EEEEEEEECCCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCCCHH
KLSPGKAFYKHLMNGVSNMLPLVISGGILMAIVFLFGANSFNPKSSEYNAFAEQLWNIGS
HCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCC
KSAFALIIPILSGFIARSIADKPGFASGLVGGMLAISGGSGFIGGIIAGFLAGYLTQGVK
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCEEEECCCCCHHHHHHHHHHHHHHHHHHH
AMTRKLPQALEGLKPTLIYPLLTVTATGLLMIYVFNPPASWLNHLLLDGLNNLSGSNIVL
HHHHHHHHHHHCCCHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHCCCCCCCCHH
LGLVIGAMMAIDMGGPFNKAAYVFATGALIEGNAAPITAAMIGGMIPPLAIATAMLIFRR
HHHHHHHHHHHCCCCCCCCCEEEEEECEEEECCCCCHHHHHHCCCCCHHHHHHHHHHHHH
KFTKEQRGSIIPNYVMGMSFITEGAIPFAAADPLRVIPSMMIGSGIGGAIALGLGSRITA
HHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHCCCCCCCC
PHGGIIVIVGTDGAHLLQTLIALVVGTLVSALIYGLIKPKLTETEIEASKSMDE
CCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCC
>Mature Secondary Structure
MRVTELLTKDTIAMDLMANDKNGVIDELVNQLDKAGKLSDVASFKEAIHNRESQSTTGIG
CCHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCC
EGIAIPHAKVAAVKSPAIAFGKSKEGVDYQSLDMQPAHLFFMIAAPEGGAQTHLDALAKL
CCCCCCCHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHH
SGILMDENVREKLLHASSPEEVLAIIDHADDEATKEEEAEAEAQQVATVEANQDTNGSNE
HHHHCCCHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHEEECCCCCCCCCC
PYVLAVTACPTGIAHTYMARDALKKQADNMGIKIKVETNGSSGIKNHLTEQDIKNATGII
CEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHCCHHHHCCCCCEE
VAADVHVETDRFDGKNVVEVPVADGIKRPEELINKALDTSRKPFVVRDGQRKGNSNDSQE
EEEEEEEECCCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCCCHH
KLSPGKAFYKHLMNGVSNMLPLVISGGILMAIVFLFGANSFNPKSSEYNAFAEQLWNIGS
HCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCC
KSAFALIIPILSGFIARSIADKPGFASGLVGGMLAISGGSGFIGGIIAGFLAGYLTQGVK
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCEEEECCCCCHHHHHHHHHHHHHHHHHHH
AMTRKLPQALEGLKPTLIYPLLTVTATGLLMIYVFNPPASWLNHLLLDGLNNLSGSNIVL
HHHHHHHHHHHCCCHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHCCCCCCCCHH
LGLVIGAMMAIDMGGPFNKAAYVFATGALIEGNAAPITAAMIGGMIPPLAIATAMLIFRR
HHHHHHHHHHHCCCCCCCCCEEEEEECEEEECCCCCHHHHHHCCCCCHHHHHHHHHHHHH
KFTKEQRGSIIPNYVMGMSFITEGAIPFAAADPLRVIPSMMIGSGIGGAIALGLGSRITA
HHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHCCCCCCCC
PHGGIIVIVGTDGAHLLQTLIALVVGTLVSALIYGLIKPKLTETEIEASKSMDE
CCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]