Click here to switch to the map view.

The map label for this gene is pip [H]

Identifier: 82750322

GI number: 82750322

Start: 632288

End: 633076

Strand: Direct

Name: pip [H]

Synonym: SAB0568

Alternate gene names: 82750322

Gene position: 632288-633076 (Clockwise)

Preceding gene: 82750321

Following gene: 82750325

Centisome position: 23.05

GC content: 30.16

Gene sequence:

>789_bases
ATGAATAAAGTCACAATTAATCCTCAAATCCAATTAACTTATCAAATTGAAGGTAAAGGGGATCCTATAATATTACTTCA
TGGATTGGATGGTAATTTAGCTGGATTTGAAGATTTGCAACATCAACTAGCATCATCATATAAAGTACTTACTTACGATT
TAAGAGGTCATGGCAAGTCTTCTAAAAGTGAATCATACGATTTAAACGATCACGTTGAGGATTTAAAAATTCTAATGGAG
AAGTTAAATATTCATGAGGCACATATTCTAGGACATGATTTAGGTGGGGTAGTTGCTAAGTTATTTACAGATAAATATGC
TTATCGTGTAAAATCATTAACTACCATTGCATCGAAGAAAGATGACTTAATACACAGCTTTACTCAATTGTTAATTCAAT
ATCAAGATGATATAGCGGGTTTTAATAAGTCTGAAGCGTATATTCTTTTATTTTCTAAATTGTTTAGAAATCAAGAGAAG
ACGATGAAATGGTATCAAAAACAAAGAATATATAGCATTAAGTCTGAGGATGATAGTGCGGTGGCAATTCGTTCATTAAT
TTTGCATAAAGATGAACCTATGTATTTGAAAAAACGTACATGTGTACCTACTTTGTTAATTAATGGGGAACATGATCCTT
TGATTAAAGATAAGAATCATTTTAAATTGGAAGCGCATTTTTTAAATGCTACGAAAAAAATCTTCGAACATTCAGGACAT
GCACCGCATATTGAAGAACCAGAAGCATTTATGAATTATTATTTAAATTTTTTAAAAAGCGTATCATAA

Upstream 100 bases:

>100_bases
AACTTTTTGTAATTTATAAATAATTTAAAAAAATGTTTATAAAATGGAAGCGTATATAGAATGAAGGTTGGGTATATAGT
TTATTGAGGGAGGTGTCACA

Downstream 100 bases:

>100_bases
TATTTGATATATAAACCTAGGGCATAAAGTCCTTAGGCAACGTGAAAAAGCTGATTACTATTCATTATTTGATAGAAATC
AGCTTTTTTTGAAATGTATT

Product: esterase or lipase

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP [H]

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MNKVTINPQIQLTYQIEGKGDPIILLHGLDGNLAGFEDLQHQLASSYKVLTYDLRGHGKSSKSESYDLNDHVEDLKILME
KLNIHEAHILGHDLGGVVAKLFTDKYAYRVKSLTTIASKKDDLIHSFTQLLIQYQDDIAGFNKSEAYILLFSKLFRNQEK
TMKWYQKQRIYSIKSEDDSAVAIRSLILHKDEPMYLKKRTCVPTLLINGEHDPLIKDKNHFKLEAHFLNATKKIFEHSGH
APHIEEPEAFMNYYLNFLKSVS

Sequences:

>Translated_262_residues
MNKVTINPQIQLTYQIEGKGDPIILLHGLDGNLAGFEDLQHQLASSYKVLTYDLRGHGKSSKSESYDLNDHVEDLKILME
KLNIHEAHILGHDLGGVVAKLFTDKYAYRVKSLTTIASKKDDLIHSFTQLLIQYQDDIAGFNKSEAYILLFSKLFRNQEK
TMKWYQKQRIYSIKSEDDSAVAIRSLILHKDEPMYLKKRTCVPTLLINGEHDPLIKDKNHFKLEAHFLNATKKIFEHSGH
APHIEEPEAFMNYYLNFLKSVS
>Mature_262_residues
MNKVTINPQIQLTYQIEGKGDPIILLHGLDGNLAGFEDLQHQLASSYKVLTYDLRGHGKSSKSESYDLNDHVEDLKILME
KLNIHEAHILGHDLGGVVAKLFTDKYAYRVKSLTTIASKKDDLIHSFTQLLIQYQDDIAGFNKSEAYILLFSKLFRNQEK
TMKWYQKQRIYSIKSEDDSAVAIRSLILHKDEPMYLKKRTCVPTLLINGEHDPLIKDKNHFKLEAHFLNATKKIFEHSGH
APHIEEPEAFMNYYLNFLKSVS

Specific function: Releases the N-terminal proline from the dipeptides, Pro-Pro, Pro-Gln, Pro-Trp and Pro-Tyr. Also from amides (Pro-beta NA) and oligopeptides, Pro-Leu-GlyNH2, Pro-Leu-Gly and Pro-Phe- Gly-Lys. Higher activity toward small peptides (up to three residues), b

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR005945
- InterPro:   IPR002410 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.4.11.5 [H]

Molecular weight: Translated: 30174; Mature: 30174

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKVTINPQIQLTYQIEGKGDPIILLHGLDGNLAGFEDLQHQLASSYKVLTYDLRGHGKS
CCEEEECCEEEEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCC
SKSESYDLNDHVEDLKILMEKLNIHEAHILGHDLGGVVAKLFTDKYAYRVKSLTTIASKK
CCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCH
DDLIHSFTQLLIQYQDDIAGFNKSEAYILLFSKLFRNQEKTMKWYQKQRIYSIKSEDDSA
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHEEECCCCCHH
VAIRSLILHKDEPMYLKKRTCVPTLLINGEHDPLIKDKNHFKLEAHFLNATKKIFEHSGH
HHHHHHHHCCCCCCEEECCCCCEEEEECCCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCC
APHIEEPEAFMNYYLNFLKSVS
CCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNKVTINPQIQLTYQIEGKGDPIILLHGLDGNLAGFEDLQHQLASSYKVLTYDLRGHGKS
CCEEEECCEEEEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCC
SKSESYDLNDHVEDLKILMEKLNIHEAHILGHDLGGVVAKLFTDKYAYRVKSLTTIASKK
CCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCH
DDLIHSFTQLLIQYQDDIAGFNKSEAYILLFSKLFRNQEKTMKWYQKQRIYSIKSEDDSA
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHEEECCCCCHH
VAIRSLILHKDEPMYLKKRTCVPTLLINGEHDPLIKDKNHFKLEAHFLNATKKIFEHSGH
HHHHHHHHCCCCCCEEECCCCCEEEEECCCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCC
APHIEEPEAFMNYYLNFLKSVS
CCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1459939 [H]