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The map label for this gene is mutS [H]

Identifier: 82703400

GI number: 82703400

Start: 2595348

End: 2596991

Strand: Reverse

Name: mutS [H]

Synonym: Nmul_A2282

Alternate gene names: 82703400

Gene position: 2596991-2595348 (Counterclockwise)

Preceding gene: 82703401

Following gene: 82703399

Centisome position: 81.56

GC content: 53.77

Gene sequence:

>1644_bases
ATGAATTCGCCCTCTGCTCCCAATTCATACTGGAATCAAAAACCTGTTCTCTCCAGTGGACAGAAGCCCAGCGGTATTCG
AGACAGCCGGCCGAAGGAAGACGACTACAGTGTACTGGATGCGAAAACGTTCGATGCAATCGAAGCCGATGAGTTATTCG
ATTCGGTCAATCACGCTATTACTCATGCGGGGCAATCCGTGCTCTATCGCTCGCTTGCGCGACCAGAGACAGATGCGGCG
CTGATTCAGAAGAAACAGGAAGCAGTAAGGGAACTTGCGTCAAATTCAATGCTTCGTGAAGCGCTTCAGCACTTCGTCGA
TACGATGAAAGGGGGAGAACGGTCTCTTTATCATTTACTCTACGGTACTTTTACCGGGGGAATTGCCATAGACAATTCCA
GGGGCGGTAAAGATGAAATGGAATTCAGCGGTTACGGCTACCACCAGTTCATCGATGGCACGGGATTTGCAATCGACATG
GTCGAGACGATGGAAAATCTACCTCAGCCGCAAAGTGCTTATCTCCGGGAGCTATTTCAGGCTGTTCGCGACTTTGGCAA
ATCGAGGATTTATTCTCTGATGCGCGGCCCGGTCTATGTCTCGGAAGGAAAATTCAAGACCCGGGAAGAAAAACCGCACT
ATCTGCCGCTTTCGCGCTTCACGCCCTCCATGTTCAAGCCGATTCCGGTATTTTTCGCTGTGGCTGCGCTCGGTGCGGCG
CTTTATTTTTTTCAGGGGTTAATGGCGAGTTTCGGCATCGCTTATCTCGGCTATGGGATACTTGTGCTGGCAGTGCCGAT
TTTACCCGTTGTTCTGATCGCAATTGCCGCCTCCGATCGCGATACTGTCATCTATCCACTGCGCAAGCTGTTCAAGCACA
GCCCTGAACTGGCACGATTGGTGGATGTGCTGGGAATGCTCGACGAACTGCTATCCTTCCATCGCTATTCGGCAGCCTTC
GGCGGCAAGATGACTTTGCCGGAAATATCGGAAAGCGAGCGGCACACCCTGGAAGTCAGGGAAGCGCGGAATCCCGTACT
CGCGAGGACCAACTCCAATTATGTGCCGAATGATGTTTCGCTCGATGATGCCGGCCGCTTGCTGGTCATTACCGGACCCA
ACAGCGGCGGCAAAACTGCGTATTGCAAGACAGTCGTCCAGATTCAACTGCTGGGACAGATAGGTTGCTATATTCCCGCC
GCTGCCGGGTGGCTGGTGCTGGCTGAGCATGTTTTCTACCAGGTACCGGACCCCGGCCATCTGGATGAGGGCATGGGGCG
CTTTGGCCACGAGTTGAAACGCACGCGCGAAATTTTCTTCAATTCCACGCCGCGCAGTCTCGTCGTGCTGGATGAGCTTT
CGGAGGGAACGACATTCGAAGAGAAGATGGATCTCTCGGAGTACGTTCTCGCTGGTTTTTACAAGCTTGGCGCAAGCACC
TTGCTGGTTACCCATAACCACGAGCTATGCGAGCGCTTGCAGGACAAGGGGATAGGCCGCTATCTCCAGGGTGAATTTTC
GCTGCAGGGCCCGACCTATCGACTGATTCCGGGTGTTTCCCGGGTGAGTCATGCGGATCGGGTTGCGGCTGCCCTGGGTT
TCAGTAAGGAAGATGTGGAAAAGCACCTGGCCAGCCGCAGCTAG

Upstream 100 bases:

>100_bases
AACTGCTTTTCAGGCCCCTGCCTTCTCCTCCGGGCATCCCTCATTTCAGAAAGGCTGCCAATCTTATCCCGGAAATTGAT
CACTCCAACATAACCTGATC

Downstream 100 bases:

>100_bases
TTGAAGGGGATTGGCAGGTGGAGCGAAGAGAGATTTTATACTGTTGATCGCATTTTGTTCTTTGTAACGCTTCGTTTGTT
CTGGTTCAGACATAATGATC

Product: DNA mismatch repair protein MutS-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 547; Mature: 547

Protein sequence:

>547_residues
MNSPSAPNSYWNQKPVLSSGQKPSGIRDSRPKEDDYSVLDAKTFDAIEADELFDSVNHAITHAGQSVLYRSLARPETDAA
LIQKKQEAVRELASNSMLREALQHFVDTMKGGERSLYHLLYGTFTGGIAIDNSRGGKDEMEFSGYGYHQFIDGTGFAIDM
VETMENLPQPQSAYLRELFQAVRDFGKSRIYSLMRGPVYVSEGKFKTREEKPHYLPLSRFTPSMFKPIPVFFAVAALGAA
LYFFQGLMASFGIAYLGYGILVLAVPILPVVLIAIAASDRDTVIYPLRKLFKHSPELARLVDVLGMLDELLSFHRYSAAF
GGKMTLPEISESERHTLEVREARNPVLARTNSNYVPNDVSLDDAGRLLVITGPNSGGKTAYCKTVVQIQLLGQIGCYIPA
AAGWLVLAEHVFYQVPDPGHLDEGMGRFGHELKRTREIFFNSTPRSLVVLDELSEGTTFEEKMDLSEYVLAGFYKLGAST
LLVTHNHELCERLQDKGIGRYLQGEFSLQGPTYRLIPGVSRVSHADRVAAALGFSKEDVEKHLASRS

Sequences:

>Translated_547_residues
MNSPSAPNSYWNQKPVLSSGQKPSGIRDSRPKEDDYSVLDAKTFDAIEADELFDSVNHAITHAGQSVLYRSLARPETDAA
LIQKKQEAVRELASNSMLREALQHFVDTMKGGERSLYHLLYGTFTGGIAIDNSRGGKDEMEFSGYGYHQFIDGTGFAIDM
VETMENLPQPQSAYLRELFQAVRDFGKSRIYSLMRGPVYVSEGKFKTREEKPHYLPLSRFTPSMFKPIPVFFAVAALGAA
LYFFQGLMASFGIAYLGYGILVLAVPILPVVLIAIAASDRDTVIYPLRKLFKHSPELARLVDVLGMLDELLSFHRYSAAF
GGKMTLPEISESERHTLEVREARNPVLARTNSNYVPNDVSLDDAGRLLVITGPNSGGKTAYCKTVVQIQLLGQIGCYIPA
AAGWLVLAEHVFYQVPDPGHLDEGMGRFGHELKRTREIFFNSTPRSLVVLDELSEGTTFEEKMDLSEYVLAGFYKLGAST
LLVTHNHELCERLQDKGIGRYLQGEFSLQGPTYRLIPGVSRVSHADRVAAALGFSKEDVEKHLASRS
>Mature_547_residues
MNSPSAPNSYWNQKPVLSSGQKPSGIRDSRPKEDDYSVLDAKTFDAIEADELFDSVNHAITHAGQSVLYRSLARPETDAA
LIQKKQEAVRELASNSMLREALQHFVDTMKGGERSLYHLLYGTFTGGIAIDNSRGGKDEMEFSGYGYHQFIDGTGFAIDM
VETMENLPQPQSAYLRELFQAVRDFGKSRIYSLMRGPVYVSEGKFKTREEKPHYLPLSRFTPSMFKPIPVFFAVAALGAA
LYFFQGLMASFGIAYLGYGILVLAVPILPVVLIAIAASDRDTVIYPLRKLFKHSPELARLVDVLGMLDELLSFHRYSAAF
GGKMTLPEISESERHTLEVREARNPVLARTNSNYVPNDVSLDDAGRLLVITGPNSGGKTAYCKTVVQIQLLGQIGCYIPA
AAGWLVLAEHVFYQVPDPGHLDEGMGRFGHELKRTREIFFNSTPRSLVVLDELSEGTTFEEKMDLSEYVLAGFYKLGAST
LLVTHNHELCERLQDKGIGRYLQGEFSLQGPTYRLIPGVSRVSHADRVAAALGFSKEDVEKHLASRS

Specific function: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity [H]

COG id: COG0249

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutS family [H]

Homologues:

Organism=Homo sapiens, GI36949366, Length=205, Percent_Identity=30.7317073170732, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI284813531, Length=241, Percent_Identity=31.1203319502075, Blast_Score=109, Evalue=7e-24,
Organism=Homo sapiens, GI4504191, Length=222, Percent_Identity=29.7297297297297, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI4557761, Length=199, Percent_Identity=29.6482412060301, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI26638666, Length=275, Percent_Identity=26.9090909090909, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI4505253, Length=275, Percent_Identity=26.9090909090909, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI26638664, Length=276, Percent_Identity=26.8115942028986, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI262231786, Length=206, Percent_Identity=26.6990291262136, Blast_Score=73, Evalue=6e-13,
Organism=Escherichia coli, GI1789089, Length=204, Percent_Identity=29.9019607843137, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17508445, Length=252, Percent_Identity=26.1904761904762, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17534743, Length=231, Percent_Identity=27.2727272727273, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17508447, Length=504, Percent_Identity=20.2380952380952, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17539736, Length=225, Percent_Identity=24, Blast_Score=69, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6324482, Length=269, Percent_Identity=28.2527881040892, Blast_Score=98, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6321912, Length=312, Percent_Identity=28.2051282051282, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6319935, Length=149, Percent_Identity=30.8724832214765, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6320302, Length=262, Percent_Identity=25.9541984732824, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321109, Length=206, Percent_Identity=28.1553398058252, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24664545, Length=224, Percent_Identity=31.25, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24584320, Length=196, Percent_Identity=27.5510204081633, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005748
- InterPro:   IPR007695
- InterPro:   IPR000432
- InterPro:   IPR007861
- InterPro:   IPR007860
- InterPro:   IPR007696
- InterPro:   IPR016151 [H]

Pfam domain/function: PF01624 MutS_I; PF05188 MutS_II; PF05192 MutS_III; PF05190 MutS_IV; PF00488 MutS_V [H]

EC number: NA

Molecular weight: Translated: 60714; Mature: 60714

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSPSAPNSYWNQKPVLSSGQKPSGIRDSRPKEDDYSVLDAKTFDAIEADELFDSVNHAI
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHH
THAGQSVLYRSLARPETDAALIQKKQEAVRELASNSMLREALQHFVDTMKGGERSLYHLL
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
YGTFTGGIAIDNSRGGKDEMEFSGYGYHQFIDGTGFAIDMVETMENLPQPQSAYLRELFQ
HHHHCCCEEEECCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHH
AVRDFGKSRIYSLMRGPVYVSEGKFKTREEKPHYLPLSRFTPSMFKPIPVFFAVAALGAA
HHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHH
LYFFQGLMASFGIAYLGYGILVLAVPILPVVLIAIAASDRDTVIYPLRKLFKHSPELARL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHH
VDVLGMLDELLSFHRYSAAFGGKMTLPEISESERHTLEVREARNPVLARTNSNYVPNDVS
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCC
LDDAGRLLVITGPNSGGKTAYCKTVVQIQLLGQIGCYIPAAAGWLVLAEHVFYQVPDPGH
CCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCC
LDEGMGRFGHELKRTREIFFNSTPRSLVVLDELSEGTTFEEKMDLSEYVLAGFYKLGAST
CHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCE
LLVTHNHELCERLQDKGIGRYLQGEFSLQGPTYRLIPGVSRVSHADRVAAALGFSKEDVE
EEEECCHHHHHHHHHCCCCCEECCCEECCCCCEEECCCHHHHHHHHHHHHHHCCCHHHHH
KHLASRS
HHHHCCC
>Mature Secondary Structure
MNSPSAPNSYWNQKPVLSSGQKPSGIRDSRPKEDDYSVLDAKTFDAIEADELFDSVNHAI
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHH
THAGQSVLYRSLARPETDAALIQKKQEAVRELASNSMLREALQHFVDTMKGGERSLYHLL
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
YGTFTGGIAIDNSRGGKDEMEFSGYGYHQFIDGTGFAIDMVETMENLPQPQSAYLRELFQ
HHHHCCCEEEECCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHH
AVRDFGKSRIYSLMRGPVYVSEGKFKTREEKPHYLPLSRFTPSMFKPIPVFFAVAALGAA
HHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHH
LYFFQGLMASFGIAYLGYGILVLAVPILPVVLIAIAASDRDTVIYPLRKLFKHSPELARL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHH
VDVLGMLDELLSFHRYSAAFGGKMTLPEISESERHTLEVREARNPVLARTNSNYVPNDVS
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCC
LDDAGRLLVITGPNSGGKTAYCKTVVQIQLLGQIGCYIPAAAGWLVLAEHVFYQVPDPGH
CCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCC
LDEGMGRFGHELKRTREIFFNSTPRSLVVLDELSEGTTFEEKMDLSEYVLAGFYKLGAST
CHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCE
LLVTHNHELCERLQDKGIGRYLQGEFSLQGPTYRLIPGVSRVSHADRVAAALGFSKEDVE
EEEECCHHHHHHHHHCCCCCEECCCEECCCCCEEECCCHHHHHHHHHHHHHHCCCHHHHH
KHLASRS
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA