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The map label for this gene is ppiB [H]

Identifier: 82703006

GI number: 82703006

Start: 2171197

End: 2171691

Strand: Direct

Name: ppiB [H]

Synonym: Nmul_A1885

Alternate gene names: 82703006

Gene position: 2171197-2171691 (Clockwise)

Preceding gene: 82703005

Following gene: 82703007

Centisome position: 68.19

GC content: 46.46

Gene sequence:

>495_bases
ATGATCAGACTGCAAACGAACTACGGCGACATCATGCTCGAACTCGATCACGAAAAAGCACCGGTAACTGTCCAGAATTT
TATAGACTATGTAAATAGCGGATATTACGACAACACGATATTTCACCGCGTGATTGACGGATTCATGATTCAGGGAGGCG
GTTTCGAACCGGGCATGATCCAGAAAAAAACCCGTGCCCCGATTGCAAATGAAGCAGGCAACGGTCTCAAGAACGATAAA
TATACCATCGCCATGGCGCGCACCTCTGATCCTCATTCAGCAACCGGTCAATTCTTTATCAATGTCAAGGATAACGATTT
TCTGAATTACAAATCCCCCACAGCGCAAGGCTATGGCTACTGTGTGTTCGGCAAGGTGGTGGAAGGCATGGACGTAGTGG
ACAAGATCAAAAAGGTTAAAACGGGTACCCGCAGCGGCCATCAGGATGTACCTGTAGAAAATGCGATACTGGAAAAGGCA
GAGGTAATTCAATAA

Upstream 100 bases:

>100_bases
TCCACCGATGTGCCGAAGGAAACCATAGTAATCGAGGAAATGAGACTTATTGCAAACCCGTCTCTCGCCTCTCCCACCCA
TCCACAAAACAGGGATTGAT

Downstream 100 bases:

>100_bases
CGTTTGTCAACATCATGAGCATGTCAGCACCTAAAGCTTTTTTCTCGCTTGGATTTGCGATCGCGCTGTGGCTGCCGGCC
CCGGCTTTGCACGCTCTCCC

Product: peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MIRLQTNYGDIMLELDHEKAPVTVQNFIDYVNSGYYDNTIFHRVIDGFMIQGGGFEPGMIQKKTRAPIANEAGNGLKNDK
YTIAMARTSDPHSATGQFFINVKDNDFLNYKSPTAQGYGYCVFGKVVEGMDVVDKIKKVKTGTRSGHQDVPVENAILEKA
EVIQ

Sequences:

>Translated_164_residues
MIRLQTNYGDIMLELDHEKAPVTVQNFIDYVNSGYYDNTIFHRVIDGFMIQGGGFEPGMIQKKTRAPIANEAGNGLKNDK
YTIAMARTSDPHSATGQFFINVKDNDFLNYKSPTAQGYGYCVFGKVVEGMDVVDKIKKVKTGTRSGHQDVPVENAILEKA
EVIQ
>Mature_164_residues
MIRLQTNYGDIMLELDHEKAPVTVQNFIDYVNSGYYDNTIFHRVIDGFMIQGGGFEPGMIQKKTRAPIANEAGNGLKNDK
YTIAMARTSDPHSATGQFFINVKDNDFLNYKSPTAQGYGYCVFGKVVEGMDVVDKIKKVKTGTRSGHQDVPVENAILEKA
EVIQ

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=164, Percent_Identity=32.3170731707317, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI22547212, Length=164, Percent_Identity=32.3170731707317, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI7657473, Length=164, Percent_Identity=32.3170731707317, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI22547215, Length=164, Percent_Identity=32.3170731707317, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI24308049, Length=158, Percent_Identity=34.1772151898734, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI19557636, Length=148, Percent_Identity=29.7297297297297, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI64276486, Length=131, Percent_Identity=36.6412213740458, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1786736, Length=162, Percent_Identity=64.1975308641975, Blast_Score=222, Evalue=1e-59,
Organism=Escherichia coli, GI1789763, Length=162, Percent_Identity=58.641975308642, Blast_Score=189, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI17532641, Length=170, Percent_Identity=32.9411764705882, Blast_Score=85, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17506311, Length=148, Percent_Identity=34.4594594594595, Blast_Score=77, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71980594, Length=147, Percent_Identity=31.9727891156463, Blast_Score=73, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71980590, Length=147, Percent_Identity=31.9727891156463, Blast_Score=73, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17539496, Length=142, Percent_Identity=33.0985915492958, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17986117, Length=166, Percent_Identity=33.7349397590361, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI19922376, Length=171, Percent_Identity=30.9941520467836, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI19922912, Length=145, Percent_Identity=35.8620689655172, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18272; Mature: 18272

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRLQTNYGDIMLELDHEKAPVTVQNFIDYVNSGYYDNTIFHRVIDGFMIQGGGFEPGMI
CEEEECCCCEEEEEECCCCCCEEHHHHHHHHHCCCCCHHHHHHHHHCEEEECCCCCCCCC
QKKTRAPIANEAGNGLKNDKYTIAMARTSDPHSATGQFFINVKDNDFLNYKSPTAQGYGY
CHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEEECCCCEECCCCCCCCCCCE
CVFGKVVEGMDVVDKIKKVKTGTRSGHQDVPVENAILEKAEVIQ
EEHHHHHCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MIRLQTNYGDIMLELDHEKAPVTVQNFIDYVNSGYYDNTIFHRVIDGFMIQGGGFEPGMI
CEEEECCCCEEEEEECCCCCCEEHHHHHHHHHCCCCCHHHHHHHHHCEEEECCCCCCCCC
QKKTRAPIANEAGNGLKNDKYTIAMARTSDPHSATGQFFINVKDNDFLNYKSPTAQGYGY
CHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEEECCCCEECCCCCCCCCCCE
CVFGKVVEGMDVVDKIKKVKTGTRSGHQDVPVENAILEKAEVIQ
EEHHHHHCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]