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The map label for this gene is mco [H]

Identifier: 82702803

GI number: 82702803

Start: 1920152

End: 1921780

Strand: Reverse

Name: mco [H]

Synonym: Nmul_A1679

Alternate gene names: 82702803

Gene position: 1921780-1920152 (Counterclockwise)

Preceding gene: 82702804

Following gene: 82702802

Centisome position: 60.35

GC content: 53.78

Gene sequence:

>1629_bases
ATGTTTCCAGGGTGGGCATGGAGCCAGCATGGCGCGGGCGCGGGTATATTGAATACGAAACCCAACTCTGCCTTCAAGCC
GGATGTAGAAATTGAGTTCATCGCGCAAATAGCGGAGATTCAAATCCTGCCAGGTCCCCGTACGAGCGTTTTCAAATACG
ATGGGAAGGTATTGAGAGGGCCTGAAACGGCCTTGTTGAAGAGCACAAGCTATCTGGGGCCAATCATGAACCTTGCCCAT
GGGCAAAAAGTGCGAATTTTTTACTACAACAAATTGCCTGAACCCTCGATCATGCATTGGCATGGTATGCACGTGCCGCA
GAAGATGGATGGACATCCCATGTATGCGATAGAGCCGGGTGAAAGGTACGTGTACGAGTTCGAGGTAAAGAACCCGGCCG
GCACAAACTGGTATCACGCACACCCGCATGAAATGACAGGGCCGCAGGTCTATCGCGGCCAGGCCGGATTGATCACGATT
ACGGATGAGCAGGAGCAAAAATTGAATCTGCCCGATGGCGAGTACGATCTTCCCCTCGTCATTCAGGACCGTCGCTTCAC
CGCGGGAAATCAGTTGCAATACATTTTCGGGATGCATGAGCGGATGACGGGTTTCCTGGGAGATACCATCCTGGTTAACG
GGCAGGTAAACGCTACTATTCCGGTAAAAAGCCGCGCTTATCGAATACGCGTTTTCAACGGCTCGAATTCGAGGATTTAC
AAGCTGGGATGGGAAGACGGCATGCCCCTGACAGCAATCGGCACCGACGGAGGCCTGCTGGAAGCGCCGGAAACCTTTCC
ATATATCATACTGGCACCTGCAGAGCGGGTCGAGCTTTGGGTCGACTTCAGCGGCCGCAAGCCTGGAACGGATTTGACGC
TGCAGAGCCTCGAATACGACTTTCCCCAGATGGGAATGGGAATGGGGATGGGTGGCGGCATGGGAATGCACGGTGGCATG
GGCCGCGGGAGAATGGGAGGCAGGGGCGGCATGGGCATGGGAACAGCAAGACTGGCCCAAGGTGAAGACTTTCCGATTGT
GAAATTCAGCGTTGTTGAAAAAGTCAGCGAGTCTCCCCGGCTGCCGGAGAGGCTGGTCAGGATGCGCAATCTGCCAGAAA
GCGATATTGCAAATCCGGATCAGCCTGTACCAATCGCCGCCTCCATGGAGCATATGTCGCCCCTCTTAAACGGCGCGTCT
TTCGAAATGCATGAAGCAATGGATATCGAACGCATCCCGCTCAATACCATCCGAAAGGTCCGTATAACCAACGAGCATGG
GTCGATGATGGGTGGGCGGGATGGAATGGGCGGCATGGGAGGAGGGGGTCGTGGAATGAGAGGGGGAATGGGCGGCATGG
GCATGATGATGTTGCCGCATCCCATCCATATGCACGGTCAACAGTTCCGGATCATTTCACGTAGATTAAAGGGCGCAGAC
ACGGATAGCTATGCCAGTGTCCGCGAAGGTTTCATTAACAGCGGCTGGAAAGATACTGTGTTGGTCATGCCGAACGAGGA
AATTGATGTGATCAAACCGTTCGAGGATTACACCGGCCTGTTTCTCTATCACTGCCACAATCTGGAGCATGAAGATCTGG
GCATGATGCGGAATTTTTATGTAAGCTGA

Upstream 100 bases:

>100_bases
GTCCCCAGTCCCATGGAAAAAAACGGAGAAAATCATGAAAAATCAAGATTATAAGCGACGCCAATTCATGCAATATGCCT
TGGCGGGTGCAGCCTCGGCT

Downstream 100 bases:

>100_bases
CATGCTTAGAAACCTTTGAAGGAAAACCCCTTTATGTTGCCTATAAAGCGAATAGTAGTCGGTACCGACATGTCCCCGCT
TGCGAGTTGGGCGGCGGCAC

Product: Bilirubin oxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 542; Mature: 542

Protein sequence:

>542_residues
MFPGWAWSQHGAGAGILNTKPNSAFKPDVEIEFIAQIAEIQILPGPRTSVFKYDGKVLRGPETALLKSTSYLGPIMNLAH
GQKVRIFYYNKLPEPSIMHWHGMHVPQKMDGHPMYAIEPGERYVYEFEVKNPAGTNWYHAHPHEMTGPQVYRGQAGLITI
TDEQEQKLNLPDGEYDLPLVIQDRRFTAGNQLQYIFGMHERMTGFLGDTILVNGQVNATIPVKSRAYRIRVFNGSNSRIY
KLGWEDGMPLTAIGTDGGLLEAPETFPYIILAPAERVELWVDFSGRKPGTDLTLQSLEYDFPQMGMGMGMGGGMGMHGGM
GRGRMGGRGGMGMGTARLAQGEDFPIVKFSVVEKVSESPRLPERLVRMRNLPESDIANPDQPVPIAASMEHMSPLLNGAS
FEMHEAMDIERIPLNTIRKVRITNEHGSMMGGRDGMGGMGGGGRGMRGGMGGMGMMMLPHPIHMHGQQFRIISRRLKGAD
TDSYASVREGFINSGWKDTVLVMPNEEIDVIKPFEDYTGLFLYHCHNLEHEDLGMMRNFYVS

Sequences:

>Translated_542_residues
MFPGWAWSQHGAGAGILNTKPNSAFKPDVEIEFIAQIAEIQILPGPRTSVFKYDGKVLRGPETALLKSTSYLGPIMNLAH
GQKVRIFYYNKLPEPSIMHWHGMHVPQKMDGHPMYAIEPGERYVYEFEVKNPAGTNWYHAHPHEMTGPQVYRGQAGLITI
TDEQEQKLNLPDGEYDLPLVIQDRRFTAGNQLQYIFGMHERMTGFLGDTILVNGQVNATIPVKSRAYRIRVFNGSNSRIY
KLGWEDGMPLTAIGTDGGLLEAPETFPYIILAPAERVELWVDFSGRKPGTDLTLQSLEYDFPQMGMGMGMGGGMGMHGGM
GRGRMGGRGGMGMGTARLAQGEDFPIVKFSVVEKVSESPRLPERLVRMRNLPESDIANPDQPVPIAASMEHMSPLLNGAS
FEMHEAMDIERIPLNTIRKVRITNEHGSMMGGRDGMGGMGGGGRGMRGGMGGMGMMMLPHPIHMHGQQFRIISRRLKGAD
TDSYASVREGFINSGWKDTVLVMPNEEIDVIKPFEDYTGLFLYHCHNLEHEDLGMMRNFYVS
>Mature_542_residues
MFPGWAWSQHGAGAGILNTKPNSAFKPDVEIEFIAQIAEIQILPGPRTSVFKYDGKVLRGPETALLKSTSYLGPIMNLAH
GQKVRIFYYNKLPEPSIMHWHGMHVPQKMDGHPMYAIEPGERYVYEFEVKNPAGTNWYHAHPHEMTGPQVYRGQAGLITI
TDEQEQKLNLPDGEYDLPLVIQDRRFTAGNQLQYIFGMHERMTGFLGDTILVNGQVNATIPVKSRAYRIRVFNGSNSRIY
KLGWEDGMPLTAIGTDGGLLEAPETFPYIILAPAERVELWVDFSGRKPGTDLTLQSLEYDFPQMGMGMGMGGGMGMHGGM
GRGRMGGRGGMGMGTARLAQGEDFPIVKFSVVEKVSESPRLPERLVRMRNLPESDIANPDQPVPIAASMEHMSPLLNGAS
FEMHEAMDIERIPLNTIRKVRITNEHGSMMGGRDGMGGMGGGGRGMRGGMGGMGMMMLPHPIHMHGQQFRIISRRLKGAD
TDSYASVREGFINSGWKDTVLVMPNEEIDVIKPFEDYTGLFLYHCHNLEHEDLGMMRNFYVS

Specific function: May be involved in copper homeostasis and oxidative stress response [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=487, Percent_Identity=31.6221765913758, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1789394, Length=252, Percent_Identity=34.9206349206349, Blast_Score=138, Evalue=9e-34,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR002355
- InterPro:   IPR008972 [H]

Pfam domain/function: PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 60293; Mature: 60293

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
7.2 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
7.2 %Met     (Mature Protein)
7.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPGWAWSQHGAGAGILNTKPNSAFKPDVEIEFIAQIAEIQILPGPRTSVFKYDGKVLRG
CCCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHEEEEEEEEEECCCCCEEEEECCEEEEC
PETALLKSTSYLGPIMNLAHGQKVRIFYYNKLPEPSIMHWHGMHVPQKMDGHPMYAIEPG
CCHHHHCCCHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCEEEEECCC
ERYVYEFEVKNPAGTNWYHAHPHEMTGPQVYRGQAGLITITDEQEQKLNLPDGEYDLPLV
CEEEEEEEECCCCCCCCEECCCCCCCCCEEECCCCCEEEEECCHHHCCCCCCCCCCCCEE
IQDRRFTAGNQLQYIFGMHERMTGFLGDTILVNGQVNATIPVKSRAYRIRVFNGSNSRIY
EECCCCCCCCCEEEEECHHHHHHHHCCCEEEECCEEEEEEEECCCEEEEEEEECCCCEEE
KLGWEDGMPLTAIGTDGGLLEAPETFPYIILAPAERVELWVDFSGRKPGTDLTLQSLEYD
EEECCCCCEEEEECCCCCCCCCCCCCCEEEECCCCEEEEEEEECCCCCCCCEEEEHHCCC
FPQMGMGMGMGGGMGMHGGMGRGRMGGRGGMGMGTARLAQGEDFPIVKFSVVEKVSESPR
CCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCEEEHHHHHHHHCCCC
LPERLVRMRNLPESDIANPDQPVPIAASMEHMSPLLNGASFEMHEAMDIERIPLNTIRKV
CHHHHHHHHCCCHHHCCCCCCCCCHHHCHHHHHHHHCCCCEEHHHHCCCCCCCCCCEEEE
RITNEHGSMMGGRDGMGGMGGGGRGMRGGMGGMGMMMLPHPIHMHGQQFRIISRRLKGAD
EEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHCCCC
TDSYASVREGFINSGWKDTVLVMPNEEIDVIKPFEDYTGLFLYHCHNLEHEDLGMMRNFY
CCHHHHHHHHHHCCCCCCEEEEECCCCCEEECCCHHHCCEEEEEECCCCHHHHHHHHHHC
VS
CC
>Mature Secondary Structure
MFPGWAWSQHGAGAGILNTKPNSAFKPDVEIEFIAQIAEIQILPGPRTSVFKYDGKVLRG
CCCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHEEEEEEEEEECCCCCEEEEECCEEEEC
PETALLKSTSYLGPIMNLAHGQKVRIFYYNKLPEPSIMHWHGMHVPQKMDGHPMYAIEPG
CCHHHHCCCHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCEEEEECCC
ERYVYEFEVKNPAGTNWYHAHPHEMTGPQVYRGQAGLITITDEQEQKLNLPDGEYDLPLV
CEEEEEEEECCCCCCCCEECCCCCCCCCEEECCCCCEEEEECCHHHCCCCCCCCCCCCEE
IQDRRFTAGNQLQYIFGMHERMTGFLGDTILVNGQVNATIPVKSRAYRIRVFNGSNSRIY
EECCCCCCCCCEEEEECHHHHHHHHCCCEEEECCEEEEEEEECCCEEEEEEEECCCCEEE
KLGWEDGMPLTAIGTDGGLLEAPETFPYIILAPAERVELWVDFSGRKPGTDLTLQSLEYD
EEECCCCCEEEEECCCCCCCCCCCCCCEEEECCCCEEEEEEEECCCCCCCCEEEEHHCCC
FPQMGMGMGMGGGMGMHGGMGRGRMGGRGGMGMGTARLAQGEDFPIVKFSVVEKVSESPR
CCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCEEEHHHHHHHHCCCC
LPERLVRMRNLPESDIANPDQPVPIAASMEHMSPLLNGASFEMHEAMDIERIPLNTIRKV
CHHHHHHHHCCCHHHCCCCCCCCCHHHCHHHHHHHHCCCCEEHHHHCCCCCCCCCCEEEE
RITNEHGSMMGGRDGMGGMGGGGRGMRGGMGGMGMMMLPHPIHMHGQQFRIISRRLKGAD
EEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHCCCC
TDSYASVREGFINSGWKDTVLVMPNEEIDVIKPFEDYTGLFLYHCHNLEHEDLGMMRNFY
CCHHHHHHHHHHCCCCCCEEEEECCCCCEEECCCHHHCCEEEEEECCCCHHHHHHHHHHC
VS
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA