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The map label for this gene is frvB [H]

Identifier: 82546247

GI number: 82546247

Start: 3943955

End: 3945412

Strand: Reverse

Name: frvB [H]

Synonym: SBO_3915

Alternate gene names: 82546247

Gene position: 3945412-3943955 (Counterclockwise)

Preceding gene: 82546248

Following gene: 82546246

Centisome position: 87.29

GC content: 55.69

Gene sequence:

>1458_bases
GTGGCGATGGAGTCATCCTTACGTATTGTCGCGATCACCAACTGCCCCGCCGGGATCGCTCACACCTACATGGTGGCGGA
AGCCCTGGAACAGAAAGCCCGTTCTCTCGGCCATACCATAAAAGTGGAAACTCAAGGGTCCAGTGGCGTTGAAAACCGCT
TATCCAGCGAAGAGATTGCCGCTGCCGATTACGTCATTCTCGCTACCGGGCGTGGCCTGAGCGGTGATGATCGCGCGCGG
TTTACCGGGAAGAAAGTTTATGAGATTGCCATCTCCCAGGCGTTGAAAAATATCGACCAGATTTTCAGCGAATTACCGAC
AAACTCGCAGCTTTTTGCCGCAGATAGTGGCGTGAAGCTTGGCAAACAGGAAATGCAAAGCGGCAGCGTGATGAGCCACC
TGATGGCGGGCGTCTCTGCGGCGCTGCCGTTTGTCATCGGCGGTGGTATCCTGGTGGCGCTTGCCAACATGCTGGTGCAG
TTCGGTTTGCCGTATACCGATATGTCGAAAGGCGCGCCGTCGTTTACCTGGGTAGTTGAATCCATCGGTTACCTTGGCTT
CACCTTTATGATCCCCATCATGGGCGCTTATATTGCCTCGTCGATTGCCGATAAACCGGCTTTCGCTCCGGCGTTTCTGG
TTTGCTATCTGGCGAACGACAAAGCGCTGCTCGGCACCCAGTCGGGTGCGGGATTCCTCGGCGCGGTGGTGCTGGGGCTG
GCGATTGGCTATTTCGTCTTCTGGTTCCGCAAAGTGCGCCTTGGCAAAGCATTACAACCGCTGCTCGGTTCAATGCTGAT
CCCGTTCGTTACTCTGCTGGTTTTCGGCGTGCTCACTTACTACGTTATCGGGCCGGTGATGTCCGACCTCATGGGCGGGC
TGCTCCACTTCCTGAATACCATTCCTCCATCAATGAAGTTTGCAGCAGCGTTTCTGGTCGGTGCGATGCTGGCGTTCGAT
ATGGGCGGCCCCATCAATAAAACCGCCTGGTTCTTCTGCTTCTCACTGCTGGAAAAACACATTTATGACTGGTACGCCAT
CGTCGGCGTTGTCGCGTTGATGCCGCCCGTTGCGGCGGGTCTTGCGACGTTCATTGCGCCCAAACTGTTTACCCGACAGG
AAAAAGAGGCTGCCAGTAGTGCCATTGTGGTCGGTGCCACAGTCGCAACCGAACCGGCTATACCTTACGCTCTGGCAGCT
CCGTTGCCGATGATTACCGCCAATACGCTGGCGGGTGGCATTACCGGCGTGCTGGTGATCGCTTTCGGAATCAAACGTCT
GGCACCTGGTTTGGGTATCTTTGACCCGCTGATCGGCCTGATGTCGCCGGTGGGTTCGTTTTATCTGGTGCTGGCGATTG
GCCTCGCGCTGAACATTTCATTCATTATCGTCCTGAAAGGATTGTGGTTACGCCGCAAAGCGAAAGCCGCGCAACAGGAG
CTTGTCCATGAACATTGA

Upstream 100 bases:

>100_bases
TGTCGCAAAATTATTCACAAGGAATTTATTCATCAACTGCAACAGGGCGATACCGACCAAGTGCTTGCCTTGTTAAATCA
AACCCTCAGCTCATAAGGAA

Downstream 100 bases:

>100_bases
GTTACTGCAACAGTTGTGCGAAGCCAGCGCCGTCAGCGGCGATGAACAGGAAGTTCGCGACATTCTGATAAACACGCTGG
AACCTTGCGTTAATGAGATC

Product: PTS system transporter subunits IIBC

Products: NA

Alternate protein names: Fructose-like phosphotransferase enzyme IIB component; PTS system fructose-like EIIB component; Fructose-like permease IIC component; PTS system fructose-like EIIC component [H]

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MAMESSLRIVAITNCPAGIAHTYMVAEALEQKARSLGHTIKVETQGSSGVENRLSSEEIAAADYVILATGRGLSGDDRAR
FTGKKVYEIAISQALKNIDQIFSELPTNSQLFAADSGVKLGKQEMQSGSVMSHLMAGVSAALPFVIGGGILVALANMLVQ
FGLPYTDMSKGAPSFTWVVESIGYLGFTFMIPIMGAYIASSIADKPAFAPAFLVCYLANDKALLGTQSGAGFLGAVVLGL
AIGYFVFWFRKVRLGKALQPLLGSMLIPFVTLLVFGVLTYYVIGPVMSDLMGGLLHFLNTIPPSMKFAAAFLVGAMLAFD
MGGPINKTAWFFCFSLLEKHIYDWYAIVGVVALMPPVAAGLATFIAPKLFTRQEKEAASSAIVVGATVATEPAIPYALAA
PLPMITANTLAGGITGVLVIAFGIKRLAPGLGIFDPLIGLMSPVGSFYLVLAIGLALNISFIIVLKGLWLRRKAKAAQQE
LVHEH

Sequences:

>Translated_485_residues
MAMESSLRIVAITNCPAGIAHTYMVAEALEQKARSLGHTIKVETQGSSGVENRLSSEEIAAADYVILATGRGLSGDDRAR
FTGKKVYEIAISQALKNIDQIFSELPTNSQLFAADSGVKLGKQEMQSGSVMSHLMAGVSAALPFVIGGGILVALANMLVQ
FGLPYTDMSKGAPSFTWVVESIGYLGFTFMIPIMGAYIASSIADKPAFAPAFLVCYLANDKALLGTQSGAGFLGAVVLGL
AIGYFVFWFRKVRLGKALQPLLGSMLIPFVTLLVFGVLTYYVIGPVMSDLMGGLLHFLNTIPPSMKFAAAFLVGAMLAFD
MGGPINKTAWFFCFSLLEKHIYDWYAIVGVVALMPPVAAGLATFIAPKLFTRQEKEAASSAIVVGATVATEPAIPYALAA
PLPMITANTLAGGITGVLVIAFGIKRLAPGLGIFDPLIGLMSPVGSFYLVLAIGLALNISFIIVLKGLWLRRKAKAAQQE
LVHEH
>Mature_484_residues
AMESSLRIVAITNCPAGIAHTYMVAEALEQKARSLGHTIKVETQGSSGVENRLSSEEIAAADYVILATGRGLSGDDRARF
TGKKVYEIAISQALKNIDQIFSELPTNSQLFAADSGVKLGKQEMQSGSVMSHLMAGVSAALPFVIGGGILVALANMLVQF
GLPYTDMSKGAPSFTWVVESIGYLGFTFMIPIMGAYIASSIADKPAFAPAFLVCYLANDKALLGTQSGAGFLGAVVLGLA
IGYFVFWFRKVRLGKALQPLLGSMLIPFVTLLVFGVLTYYVIGPVMSDLMGGLLHFLNTIPPSMKFAAAFLVGAMLAFDM
GGPINKTAWFFCFSLLEKHIYDWYAIVGVVALMPPVAAGLATFIAPKLFTRQEKEAASSAIVVGATVATEPAIPYALAAP
LPMITANTLAGGITGVLVIAFGIKRLAPGLGIFDPLIGLMSPVGSFYLVLAIGLALNISFIIVLKGLWLRRKAKAAQQEL
VHEH

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane [H]

COG id: COG1299

COG function: function code G; Phosphotransferase system, fructose-specific IIC component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI87082348, Length=483, Percent_Identity=99.5859213250518, Blast_Score=963, Evalue=0.0,
Organism=Escherichia coli, GI1788492, Length=442, Percent_Identity=33.2579185520362, Blast_Score=234, Evalue=7e-63,
Organism=Escherichia coli, GI1786951, Length=483, Percent_Identity=32.5051759834368, Blast_Score=218, Evalue=1e-57,
Organism=Escherichia coli, GI1790386, Length=291, Percent_Identity=35.7388316151203, Blast_Score=155, Evalue=7e-39,
Organism=Escherichia coli, GI1788729, Length=322, Percent_Identity=27.3291925465839, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790387, Length=98, Percent_Identity=48.9795918367347, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1788730, Length=100, Percent_Identity=40, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1790390, Length=70, Percent_Identity=45.7142857142857, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR003353
- InterPro:   IPR006327 [H]

Pfam domain/function: PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 51385; Mature: 51254

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMESSLRIVAITNCPAGIAHTYMVAEALEQKARSLGHTIKVETQGSSGVENRLSSEEIA
CCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHCCHHHHH
AADYVILATGRGLSGDDRARFTGKKVYEIAISQALKNIDQIFSELPTNSQLFAADSGVKL
HCCEEEEEECCCCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHH
GKQEMQSGSVMSHLMAGVSAALPFVIGGGILVALANMLVQFGLPYTDMSKGAPSFTWVVE
CHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
SIGYLGFTFMIPIMGAYIASSIADKPAFAPAFLVCYLANDKALLGTQSGAGFLGAVVLGL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHEECCCCEEEECCCCCHHHHHHHHHH
AIGYFVFWFRKVRLGKALQPLLGSMLIPFVTLLVFGVLTYYVIGPVMSDLMGGLLHFLNT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IPPSMKFAAAFLVGAMLAFDMGGPINKTAWFFCFSLLEKHIYDWYAIVGVVALMPPVAAG
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LATFIAPKLFTRQEKEAASSAIVVGATVATEPAIPYALAAPLPMITANTLAGGITGVLVI
HHHHHHHHHHHHHHHHHHCCEEEEEEEHHCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHH
AFGIKRLAPGLGIFDPLIGLMSPVGSFYLVLAIGLALNISFIIVLKGLWLRRKAKAAQQE
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVHEH
HHCCC
>Mature Secondary Structure 
AMESSLRIVAITNCPAGIAHTYMVAEALEQKARSLGHTIKVETQGSSGVENRLSSEEIA
CCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHCCHHHHH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HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8346018; 9278503; 8019415 [H]