Click here to switch to the map view.

The map label for this gene is bisC [H]

Identifier: 82545916

GI number: 82545916

Start: 3560935

End: 3563154

Strand: Reverse

Name: bisC [H]

Synonym: SBO_3553

Alternate gene names: 82545916

Gene position: 3563154-3560935 (Counterclockwise)

Preceding gene: 82545919

Following gene: 82545913

Centisome position: 78.83

GC content: 53.83

Gene sequence:

>2220_bases
ATGGAAAACTCCTTGCAGAGCGCGGTTCGCGACCAGGTTCACAGCAATACGCGGGTACGATTTCCAATGGTGCGCAAAGG
CTTTCTCGCGTCACCGGAAAACCCGCAAGGCATTCGTGGGCAGGATGAATTTGTTCACGTGAGTTGGGATGAGGCGCTGG
ATCTTATTCACCAACAACATAAACGCATTCGTGAGGCTTATGGTCCGGCATCGATTTTTGCTGGTTCCTACGGCTGGCGT
TCAAACGGCGTGCTGCATAAGGCCTCGACATTATTACAACGCTATATGGCGCTGGCAGGCGGTTATACCGGGCATCTGGG
GGATTATTCGACCGGTGCGGCACAGGCGATCATGCCGTATGTCGTGGGTGGCAGCGAAGTTTATCAACAGCAAACCAGTT
GGCCGCTGGTGCTGGAACATAGCGATGTCGTGGTGTTGTGGAGTGCTAACCCACTCAATACGCTGAAAATTGCGTGGAAT
GCATCTGATGAGCAGGGGCTTTCTTACTTTTCCGCACTGCGTGACAGCGGGAAAAAGCTGATCTGTATTGATCCAATGCG
ATCGGAAACCGTCGATTTCTTTGGCGATAAAATGGAGTGGGTGGCACCGCACATGGGCACCGATGTTGCGCTGATGCTGG
GGATCGCCCATACGCTGGTGGAAAATGGTTGGCACGACGAAGCGTTTCTGGCGCGTTGCACCACAGGTTATGCCGTCTTC
GCCTCTTATTTGCTGGGCGAGAGTGACGGAATAGCCAAAACCGCCGAATGGGCGGCAGGGATTTGTGGGGTTCACGCAGC
GAAAATTCGCGAGTTGGCGGCTCTTTTCCACCAAAACACGACCATGCTGATGGCTGGCTGGGGAATGCAGCGCCAACAGC
TTGGTGAGCAAAAACACTGGATGATCGTCACGCTGGCGGCAATGTTGGGGCAAATCGGCACACCCGGCGGCGGTTTTGGT
CTTTCTTATCATTTTGCCAATGGTGGTAATCCCACGCGGTGTTCTGCGGTGCTCTCTTCCATGCAGGGTAGCTTGCCGGG
TGGCAGCGATGCGGTAGATAAAATCCCTGTTGCCCGTATTGTTGAAGCACTGGAAAACCCTGGCTGCGCATACCAACACA
ATGGCATGAATCGCCTCTTCCCGGATATTCGCTTTATCTGGTGGGCGGGTGGCGCCAACTTCACCCATCATCAGGACACT
AATCGCCTGATACGAGCTTGGCAAAAACCGGAGCTGGTAGTTATCTCCGAATGCTTCTGGACGGCGGCGGCAAAACACGC
GGATATCGTTCTGCCTGCGACTACCTCTTTTGAGCGTAATGATCTCACCATGACCGGCGATTACAGTAATCAGCATCTGG
TGCCGATGAAGCAAGTGGTGCCGCCACGCTATGAAGCGCGTAATGATTTTGATGTTTTTGCCGAGTTAAGTGAACGCTGG
GAGAAGGGCGGTTATGCACGTTTTACGGAAGGAAAAAGTGAGTTGCAATGGCTGGAAACGTTTTATAACGTTGCCCGACA
GCGCGGGGCAAGCCAGCAGGTTGAATTGCCGCCATTTGCTGAGTTCTGGCAAGCCAATCAGTTAATTGAGATGCCGGAAA
ACCCGGACAGCGAGCGGTTTATTCGCTTCGCTGATTTTTGCCGCGATCCGCAGGCGCATCCATTAAAAACCGCCAGCGGT
AAGATTGAAATCTTCTCGCAGCGTATTGCCGATTACGCTTATCCGGATTGCCCGGGGCATCCAATGTGGCTGGAGCCGGA
CGAATGGCAGGGCAATGCCGAACCGGAACAGTTACAGGTACTTTCTGCTCATCCGGCGCATCGTCTGCACAGCCAGCTGA
ATTACAGTTCTCTGCGCGAATTGTATGCGGTGGCAAATCGTGAGCCTGTCACCATTCATCCTGACGATGCCCTGGCGCGC
GGCATTCAAGATGGCGATACTGTTCGGCTGTGGAACGCACGCGGGCAAATTCTTGCCGGAGTGGTCATTAGCGAGGGAAT
TAAACCTGGCGTGATTTGTATTCACGAAGGGGCATGGCCGGATTTGGATTTAACCGCTGACGGTATTTGTAAAAACGGCG
CAGTCAACGTGCTGACCAAAGATCTCCCCAGCTCGCGGCTGGGGAATGGCTGTGCGGGTAATACGGCGCTGGCATGGCTG
GAAAAATACAACGGTCCGGAACTGACACTTACAGCGTTTGAACCACCGGCCAGCTCATAA

Upstream 100 bases:

>100_bases
CTCACGATATTCCGTTCTGACTGCCGCCCACTGGGGGCCCATGCTGGTTGAAACCGACGGCGAAACCGTGTTTAGCTCGC
GTGGCGCGTTAGCCACAGGA

Downstream 100 bases:

>100_bases
TCCAGGTGGGTAGTTGGGTTTCATCCTGCCATGCGCAATCGACAATGTGAAAACCCTGCGCCTGGTAAAAATTTATCGCC
GGTTGATTTTTTTGATAAAC

Product: biotin sulfoxide reductase

Products: Biotin. [C]

Alternate protein names: BDS reductase; BSO reductase [H]

Number of amino acids: Translated: 739; Mature: 739

Protein sequence:

>739_residues
MENSLQSAVRDQVHSNTRVRFPMVRKGFLASPENPQGIRGQDEFVHVSWDEALDLIHQQHKRIREAYGPASIFAGSYGWR
SNGVLHKASTLLQRYMALAGGYTGHLGDYSTGAAQAIMPYVVGGSEVYQQQTSWPLVLEHSDVVVLWSANPLNTLKIAWN
ASDEQGLSYFSALRDSGKKLICIDPMRSETVDFFGDKMEWVAPHMGTDVALMLGIAHTLVENGWHDEAFLARCTTGYAVF
ASYLLGESDGIAKTAEWAAGICGVHAAKIRELAALFHQNTTMLMAGWGMQRQQLGEQKHWMIVTLAAMLGQIGTPGGGFG
LSYHFANGGNPTRCSAVLSSMQGSLPGGSDAVDKIPVARIVEALENPGCAYQHNGMNRLFPDIRFIWWAGGANFTHHQDT
NRLIRAWQKPELVVISECFWTAAAKHADIVLPATTSFERNDLTMTGDYSNQHLVPMKQVVPPRYEARNDFDVFAELSERW
EKGGYARFTEGKSELQWLETFYNVARQRGASQQVELPPFAEFWQANQLIEMPENPDSERFIRFADFCRDPQAHPLKTASG
KIEIFSQRIADYAYPDCPGHPMWLEPDEWQGNAEPEQLQVLSAHPAHRLHSQLNYSSLRELYAVANREPVTIHPDDALAR
GIQDGDTVRLWNARGQILAGVVISEGIKPGVICIHEGAWPDLDLTADGICKNGAVNVLTKDLPSSRLGNGCAGNTALAWL
EKYNGPELTLTAFEPPASS

Sequences:

>Translated_739_residues
MENSLQSAVRDQVHSNTRVRFPMVRKGFLASPENPQGIRGQDEFVHVSWDEALDLIHQQHKRIREAYGPASIFAGSYGWR
SNGVLHKASTLLQRYMALAGGYTGHLGDYSTGAAQAIMPYVVGGSEVYQQQTSWPLVLEHSDVVVLWSANPLNTLKIAWN
ASDEQGLSYFSALRDSGKKLICIDPMRSETVDFFGDKMEWVAPHMGTDVALMLGIAHTLVENGWHDEAFLARCTTGYAVF
ASYLLGESDGIAKTAEWAAGICGVHAAKIRELAALFHQNTTMLMAGWGMQRQQLGEQKHWMIVTLAAMLGQIGTPGGGFG
LSYHFANGGNPTRCSAVLSSMQGSLPGGSDAVDKIPVARIVEALENPGCAYQHNGMNRLFPDIRFIWWAGGANFTHHQDT
NRLIRAWQKPELVVISECFWTAAAKHADIVLPATTSFERNDLTMTGDYSNQHLVPMKQVVPPRYEARNDFDVFAELSERW
EKGGYARFTEGKSELQWLETFYNVARQRGASQQVELPPFAEFWQANQLIEMPENPDSERFIRFADFCRDPQAHPLKTASG
KIEIFSQRIADYAYPDCPGHPMWLEPDEWQGNAEPEQLQVLSAHPAHRLHSQLNYSSLRELYAVANREPVTIHPDDALAR
GIQDGDTVRLWNARGQILAGVVISEGIKPGVICIHEGAWPDLDLTADGICKNGAVNVLTKDLPSSRLGNGCAGNTALAWL
EKYNGPELTLTAFEPPASS
>Mature_739_residues
MENSLQSAVRDQVHSNTRVRFPMVRKGFLASPENPQGIRGQDEFVHVSWDEALDLIHQQHKRIREAYGPASIFAGSYGWR
SNGVLHKASTLLQRYMALAGGYTGHLGDYSTGAAQAIMPYVVGGSEVYQQQTSWPLVLEHSDVVVLWSANPLNTLKIAWN
ASDEQGLSYFSALRDSGKKLICIDPMRSETVDFFGDKMEWVAPHMGTDVALMLGIAHTLVENGWHDEAFLARCTTGYAVF
ASYLLGESDGIAKTAEWAAGICGVHAAKIRELAALFHQNTTMLMAGWGMQRQQLGEQKHWMIVTLAAMLGQIGTPGGGFG
LSYHFANGGNPTRCSAVLSSMQGSLPGGSDAVDKIPVARIVEALENPGCAYQHNGMNRLFPDIRFIWWAGGANFTHHQDT
NRLIRAWQKPELVVISECFWTAAAKHADIVLPATTSFERNDLTMTGDYSNQHLVPMKQVVPPRYEARNDFDVFAELSERW
EKGGYARFTEGKSELQWLETFYNVARQRGASQQVELPPFAEFWQANQLIEMPENPDSERFIRFADFCRDPQAHPLKTASG
KIEIFSQRIADYAYPDCPGHPMWLEPDEWQGNAEPEQLQVLSAHPAHRLHSQLNYSSLRELYAVANREPVTIHPDDALAR
GIQDGDTVRLWNARGQILAGVVISEGIKPGVICIHEGAWPDLDLTADGICKNGAVNVLTKDLPSSRLGNGCAGNTALAWL
EKYNGPELTLTAFEPPASS

Specific function: This enzyme may serve as a scavenger, allowing the cell to utilize biotin sulfoxide as a biotin source. It reduces a spontaneous oxidation product of biotin, D-biotin D-sulfoxide (BSO or BDS), back to biotin [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI145693196, Length=739, Percent_Identity=98.105548037889, Blast_Score=1507, Evalue=0.0,
Organism=Escherichia coli, GI87081994, Length=741, Percent_Identity=64.2375168690958, Blast_Score=1025, Evalue=0.0,
Organism=Escherichia coli, GI1787231, Length=747, Percent_Identity=44.3105756358768, Blast_Score=584, Evalue=1e-168,
Organism=Escherichia coli, GI87081797, Length=757, Percent_Identity=31.9682959048877, Blast_Score=301, Evalue=9e-83,
Organism=Escherichia coli, GI1787870, Length=753, Percent_Identity=30.1460823373174, Blast_Score=285, Evalue=6e-78,
Organism=Escherichia coli, GI171474008, Length=753, Percent_Identity=30.1460823373174, Blast_Score=273, Evalue=3e-74,
Organism=Escherichia coli, GI3868721, Length=473, Percent_Identity=23.2558139534884, Blast_Score=103, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006658
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006655 [H]

Pfam domain/function: PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 81803; Mature: 81803

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00490 MOLYBDOPTERIN_PROK_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENSLQSAVRDQVHSNTRVRFPMVRKGFLASPENPQGIRGQDEFVHVSWDEALDLIHQQH
CCHHHHHHHHHHHHCCCEEEEHHHHCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHH
KRIREAYGPASIFAGSYGWRSNGVLHKASTLLQRYMALAGGYTGHLGDYSTGAAQAIMPY
HHHHHHCCCHHHEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
VVGGSEVYQQQTSWPLVLEHSDVVVLWSANPLNTLKIAWNASDEQGLSYFSALRDSGKKL
EECCHHHHHHCCCCCEEEECCCEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEE
ICIDPMRSETVDFFGDKMEWVAPHMGTDVALMLGIAHTLVENGWHDEAFLARCTTGYAVF
EEECCCCHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
ASYLLGESDGIAKTAEWAAGICGVHAAKIRELAALFHQNTTMLMAGWGMQRQQLGEQKHW
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHCCCCCC
MIVTLAAMLGQIGTPGGGFGLSYHFANGGNPTRCSAVLSSMQGSLPGGSDAVDKIPVARI
HHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCCHHHHCCHHHH
VEALENPGCAYQHNGMNRLFPDIRFIWWAGGANFTHHQDTNRLIRAWQKPELVVISECFW
HHHHCCCCCCEEECCCHHHCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCCEEEEEHHHH
TAAAKHADIVLPATTSFERNDLTMTGDYSNQHLVPMKQVVPPRYEARNDFDVFAELSERW
HHHCCCCCEEEECCCCCCCCCCEEECCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHH
EKGGYARFTEGKSELQWLETFYNVARQRGASQQVELPPFAEFWQANQLIEMPENPDSERF
HCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCEEECCCCCCHHHH
IRFADFCRDPQAHPLKTASGKIEIFSQRIADYAYPDCPGHPMWLEPDEWQGNAEPEQLQV
HHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHEEE
LSAHPAHRLHSQLNYSSLRELYAVANREPVTIHPDDALARGIQDGDTVRLWNARGQILAG
ECCCCHHHHHHHCCHHHHHHHHHHCCCCCEEECCCHHHHCCCCCCCEEEEECCCCCEEEH
VVISEGIKPGVICIHEGAWPDLDLTADGICKNGAVNVLTKDLPSSRLGNGCAGNTALAWL
HHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCHHCCCCCCCCHHHHHH
EKYNGPELTLTAFEPPASS
HHCCCCEEEEEECCCCCCC
>Mature Secondary Structure
MENSLQSAVRDQVHSNTRVRFPMVRKGFLASPENPQGIRGQDEFVHVSWDEALDLIHQQH
CCHHHHHHHHHHHHCCCEEEEHHHHCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHH
KRIREAYGPASIFAGSYGWRSNGVLHKASTLLQRYMALAGGYTGHLGDYSTGAAQAIMPY
HHHHHHCCCHHHEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
VVGGSEVYQQQTSWPLVLEHSDVVVLWSANPLNTLKIAWNASDEQGLSYFSALRDSGKKL
EECCHHHHHHCCCCCEEEECCCEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEE
ICIDPMRSETVDFFGDKMEWVAPHMGTDVALMLGIAHTLVENGWHDEAFLARCTTGYAVF
EEECCCCHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
ASYLLGESDGIAKTAEWAAGICGVHAAKIRELAALFHQNTTMLMAGWGMQRQQLGEQKHW
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHCCCCCC
MIVTLAAMLGQIGTPGGGFGLSYHFANGGNPTRCSAVLSSMQGSLPGGSDAVDKIPVARI
HHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCCHHHHCCHHHH
VEALENPGCAYQHNGMNRLFPDIRFIWWAGGANFTHHQDTNRLIRAWQKPELVVISECFW
HHHHCCCCCCEEECCCHHHCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCCEEEEEHHHH
TAAAKHADIVLPATTSFERNDLTMTGDYSNQHLVPMKQVVPPRYEARNDFDVFAELSERW
HHHCCCCCEEEECCCCCCCCCCEEECCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHH
EKGGYARFTEGKSELQWLETFYNVARQRGASQQVELPPFAEFWQANQLIEMPENPDSERF
HCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCEEECCCCCCHHHH
IRFADFCRDPQAHPLKTASGKIEIFSQRIADYAYPDCPGHPMWLEPDEWQGNAEPEQLQV
HHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHEEE
LSAHPAHRLHSQLNYSSLRELYAVANREPVTIHPDDALARGIQDGDTVRLWNARGQILAG
ECCCCHHHHHHHCCHHHHHHHHHHCCCCCEEECCCHHHHCCCCCCCEEEEECCCCCEEEH
VVISEGIKPGVICIHEGAWPDLDLTADGICKNGAVNVLTKDLPSSRLGNGCAGNTALAWL
HHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCHHCCCCCCCCHHHHHH
EKYNGPELTLTAFEPPASS
HHCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Spontaneous Oxidation Product Of Biotin, D-Biotin D-Sulfoxide (Bso Or Bds), [C]

Specific reaction: Reduces A Spontaneous Oxidation Product Of Biotin, D-Biotin D-Sulfoxide (Bso Or Bds), Back To Biotin. [C]

General reaction: Reduction [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2180922; 8041620; 9278503 [H]