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The map label for this gene is msrA [H]

Identifier: 78779228

GI number: 78779228

Start: 780335

End: 781063

Strand: Reverse

Name: msrA [H]

Synonym: PMT9312_0844

Alternate gene names: 78779228

Gene position: 781063-780335 (Counterclockwise)

Preceding gene: 78779229

Following gene: 78779221

Centisome position: 45.7

GC content: 29.77

Gene sequence:

>729_bases
ATGTTCAAATTTCTAAAAAATATCATGAATAATGAGGAACCAACTTTAAATAATGATATTAATTCAATTCATAGAATATT
AAAAACAGATATTACGAGAAATCCTAATCCACAAGAAGAAGAAATAATATTTGGATGTGGTTGTTTCTGGGGAGCTGAAA
AATGTTTTTGGAAACTTCCAGGAGTGGTCACAACCTCCGTAGGTTATGCTGGTGGAGATAAAAGCAACCCGACATATTAT
GAAGTATGTTCAGGTTTAACTGGTCATTCAGAAGTTGTGAGAGTGATTTGGAATAAAAGTGAAATAGACATAAGCGATTT
ATTAAAAATGTTTTGGGAATGTCATGACCCTACTCAAAAAAATAGACAAGGTAATGATATGGGTACTCAATATAGGTCAG
CAATATATTTTAAAAAAGAAAATAATAAAAAAATCATAATAGCGAGTAAAGAACAATATCAAAAAGAACTAAATAAAAAA
AATCTAGGTTTAATTGAAACCGAAATAAAAATGATTGATACCTATTTTTATGCAGAACAGTACCACCAACAATATCTTGC
ATCCCCAGGAAGTAGGCAGTATTGTTCTGCTTCGCCTACAAAAGTTAAGTTAGGAGATTTTCCTGGAAGTAAATATAAAT
TAAAAGAGCATATTTGGGAAAACTTTAATTGGCAAGTTGATAAATGTGTATTGAGATCTGATAACAATCCAATAAATAAT
AACATTTAA

Upstream 100 bases:

>100_bases
GAAGAAGGGTCTATACAAGCAACTTTGGGAAAGAGAACTAGCAACTAACATTGTTAAAAGCTAAAATATATTTTTGACTT
ATGATGTAAAAATTTAAATT

Downstream 100 bases:

>100_bases
ATCCATCTAATCTTTATAGTAATAAAACGGGGCGTAGCGCAGTTTGGTAGCGCACCACTTTGGGGTAGTGGGGGTCGTGG
GTTCAAATCCCGCCGTTCCG

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MFKFLKNIMNNEEPTLNNDINSIHRILKTDITRNPNPQEEEIIFGCGCFWGAEKCFWKLPGVVTTSVGYAGGDKSNPTYY
EVCSGLTGHSEVVRVIWNKSEIDISDLLKMFWECHDPTQKNRQGNDMGTQYRSAIYFKKENNKKIIIASKEQYQKELNKK
NLGLIETEIKMIDTYFYAEQYHQQYLASPGSRQYCSASPTKVKLGDFPGSKYKLKEHIWENFNWQVDKCVLRSDNNPINN
NI

Sequences:

>Translated_242_residues
MFKFLKNIMNNEEPTLNNDINSIHRILKTDITRNPNPQEEEIIFGCGCFWGAEKCFWKLPGVVTTSVGYAGGDKSNPTYY
EVCSGLTGHSEVVRVIWNKSEIDISDLLKMFWECHDPTQKNRQGNDMGTQYRSAIYFKKENNKKIIIASKEQYQKELNKK
NLGLIETEIKMIDTYFYAEQYHQQYLASPGSRQYCSASPTKVKLGDFPGSKYKLKEHIWENFNWQVDKCVLRSDNNPINN
NI
>Mature_242_residues
MFKFLKNIMNNEEPTLNNDINSIHRILKTDITRNPNPQEEEIIFGCGCFWGAEKCFWKLPGVVTTSVGYAGGDKSNPTYY
EVCSGLTGHSEVVRVIWNKSEIDISDLLKMFWECHDPTQKNRQGNDMGTQYRSAIYFKKENNKKIIIASKEQYQKELNKK
NLGLIETEIKMIDTYFYAEQYHQQYLASPGSRQYCSASPTKVKLGDFPGSKYKLKEHIWENFNWQVDKCVLRSDNNPINN
NI

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=172, Percent_Identity=52.9069767441861, Blast_Score=181, Evalue=4e-46,
Organism=Homo sapiens, GI208609995, Length=172, Percent_Identity=52.9069767441861, Blast_Score=180, Evalue=8e-46,
Organism=Homo sapiens, GI208609993, Length=116, Percent_Identity=50.8620689655172, Blast_Score=119, Evalue=3e-27,
Organism=Escherichia coli, GI1790665, Length=168, Percent_Identity=47.6190476190476, Blast_Score=161, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17533973, Length=146, Percent_Identity=36.3013698630137, Blast_Score=94, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6320881, Length=160, Percent_Identity=36.875, Blast_Score=101, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24664627, Length=184, Percent_Identity=32.0652173913043, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24664631, Length=184, Percent_Identity=31.5217391304348, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI45553131, Length=139, Percent_Identity=34.5323741007194, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 28105; Mature: 28105

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKFLKNIMNNEEPTLNNDINSIHRILKTDITRNPNPQEEEIIFGCGCFWGAEKCFWKLP
CHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEECCCHHCCHHHHHHCC
GVVTTSVGYAGGDKSNPTYYEVCSGLTGHSEVVRVIWNKSEIDISDLLKMFWECHDPTQK
CEEEECCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHC
NRQGNDMGTQYRSAIYFKKENNKKIIIASKEQYQKELNKKNLGLIETEIKMIDTYFYAEQ
CCCCCHHHHHHHHEEEEEECCCCEEEEECHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
YHQQYLASPGSRQYCSASPTKVKLGDFPGSKYKLKEHIWENFNWQVDKCVLRSDNNPINN
HHHHHHCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHCCCCCEEEEEEEECCCCCCCC
NI
CC
>Mature Secondary Structure
MFKFLKNIMNNEEPTLNNDINSIHRILKTDITRNPNPQEEEIIFGCGCFWGAEKCFWKLP
CHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEECCCHHCCHHHHHHCC
GVVTTSVGYAGGDKSNPTYYEVCSGLTGHSEVVRVIWNKSEIDISDLLKMFWECHDPTQK
CEEEECCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHC
NRQGNDMGTQYRSAIYFKKENNKKIIIASKEQYQKELNKKNLGLIETEIKMIDTYFYAEQ
CCCCCHHHHHHHHEEEEEECCCCEEEEECHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
YHQQYLASPGSRQYCSASPTKVKLGDFPGSKYKLKEHIWENFNWQVDKCVLRSDNNPINN
HHHHHHCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHCCCCCEEEEEEEECCCCCCCC
NI
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA