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The map label for this gene is lpxD

Identifier: 78779179

GI number: 78779179

Start: 740879

End: 741913

Strand: Reverse

Name: lpxD

Synonym: PMT9312_0795

Alternate gene names: 78779179

Gene position: 741913-740879 (Counterclockwise)

Preceding gene: 78779180

Following gene: 78779178

Centisome position: 43.41

GC content: 31.3

Gene sequence:

>1035_bases
ATGCTTTTAAGTGATTTAGTTGATCTAATTAAAAAAGGAAATTCAAATTTTATTAGTTCCAATATTTTTGAAGATTTAAA
TATAGAGGATGCTGCCTCTTTAGATGAAGCAGTTAATCATCAAATATCTTTTTTAGAAGAAAACAATATCCTTAAAGAAA
AATTAGATAAATCCAACGCATCAGCAATAATAACTTCCAACAATAACGAAATTATTAGTGCTCTAAAGAAACTCAATATT
TCAAACATAATTGTTAAAAATCCAAGAATTGCATTTGCAGAAGTATTGAATCATTTATATAAAACTATCAACTTTAATCC
AGGAATTCACGCTTCAGCCGTTATAGATAAAACAGCAATAATTGGAGCGGATTGCCATATAGGACCTAATGTCTATATAG
GAGAAAATACTGTAATTGGTAACAATAATGATATTCTTACTGGCTCATCAATTTTAGGAAATGTTCGAATAGGAGATAAT
AATATAATTCATCCCAATTGTGTAGTTTACGAAAACACCACCTTAAAAAATAATTGTGTAATCAATTCAAATTCTGTTAT
TGGATCAGAAGGATTTGGTTTTATTCCTAAAGATGACAAATGGGTAAAGATGCCTCAAAAAGGTGGTGTAAAAATAATGA
GTTTTGTTGAAATTGGAACGAATTGTTGCATTGATAGACCGGCAGTAGGGATTACTTTTATTGATGAGGGAACAAAGTTG
GATAATTTAGTACAAATAGGTCATGGAGTTAAAATTGGTAAGAATTGTGCATTCGCCGCTCAAGTTGGTATTGCTGGAGG
AGCAAAAATTGGAGATAGAGTTATTTTGGCAGGGCAAGTAGGGGTCAATAATAGAGTAAAAGTTGGGAACAATGTCATAG
CGAGTTCAAAATGCGGAATCCATTGTGACATAGAAGATGGCAAGGTAATTAGTGGTTTCCCCGCTATGGAGAATAAATCA
TGGCTAAGGAGTTCAAGTATTTTTAAAAAATTACCAGAATTAGCAAAAAAACTTAGACAATTAGACAAGCAATAA

Upstream 100 bases:

>100_bases
TAAGAAGTATCTTAAATAATAAAGACAATAACAACTCCTCTATAATTGTCGTACACAGAGATGTTCTAGCTCTCTCTTAG
AAAAAAATTAAAACTCAAAA

Downstream 100 bases:

>100_bases
TTTATTGTTCTATTAAACAAAAATTTTAATGAAGAATTATAAGATTGTTTTATTGTCAGGCGACGGAATTGGACCAGAGA
TTTCAGAAGTTTCAAAGAAA

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MLLSDLVDLIKKGNSNFISSNIFEDLNIEDAASLDEAVNHQISFLEENNILKEKLDKSNASAIITSNNNEIISALKKLNI
SNIIVKNPRIAFAEVLNHLYKTINFNPGIHASAVIDKTAIIGADCHIGPNVYIGENTVIGNNNDILTGSSILGNVRIGDN
NIIHPNCVVYENTTLKNNCVINSNSVIGSEGFGFIPKDDKWVKMPQKGGVKIMSFVEIGTNCCIDRPAVGITFIDEGTKL
DNLVQIGHGVKIGKNCAFAAQVGIAGGAKIGDRVILAGQVGVNNRVKVGNNVIASSKCGIHCDIEDGKVISGFPAMENKS
WLRSSSIFKKLPELAKKLRQLDKQ

Sequences:

>Translated_344_residues
MLLSDLVDLIKKGNSNFISSNIFEDLNIEDAASLDEAVNHQISFLEENNILKEKLDKSNASAIITSNNNEIISALKKLNI
SNIIVKNPRIAFAEVLNHLYKTINFNPGIHASAVIDKTAIIGADCHIGPNVYIGENTVIGNNNDILTGSSILGNVRIGDN
NIIHPNCVVYENTTLKNNCVINSNSVIGSEGFGFIPKDDKWVKMPQKGGVKIMSFVEIGTNCCIDRPAVGITFIDEGTKL
DNLVQIGHGVKIGKNCAFAAQVGIAGGAKIGDRVILAGQVGVNNRVKVGNNVIASSKCGIHCDIEDGKVISGFPAMENKS
WLRSSSIFKKLPELAKKLRQLDKQ
>Mature_344_residues
MLLSDLVDLIKKGNSNFISSNIFEDLNIEDAASLDEAVNHQISFLEENNILKEKLDKSNASAIITSNNNEIISALKKLNI
SNIIVKNPRIAFAEVLNHLYKTINFNPGIHASAVIDKTAIIGADCHIGPNVYIGENTVIGNNNDILTGSSILGNVRIGDN
NIIHPNCVVYENTTLKNNCVINSNSVIGSEGFGFIPKDDKWVKMPQKGGVKIMSFVEIGTNCCIDRPAVGITFIDEGTKL
DNLVQIGHGVKIGKNCAFAAQVGIAGGAKIGDRVILAGQVGVNNRVKVGNNVIASSKCGIHCDIEDGKVISGFPAMENKS
WLRSSSIFKKLPELAKKLRQLDKQ

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=321, Percent_Identity=32.0872274143302, Blast_Score=152, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_PROM9 (Q31B90)

Other databases:

- EMBL:   CP000111
- RefSeq:   YP_397291.1
- ProteinModelPortal:   Q31B90
- SMR:   Q31B90
- STRING:   Q31B90
- GeneID:   3765595
- GenomeReviews:   CP000111_GR
- KEGG:   pmi:PMT9312_0795
- eggNOG:   COG1044
- HOGENOM:   HBG469615
- OMA:   PRLLFAK
- ProtClustDB:   PRK00892
- BioCyc:   PMAR74546:PMT9312_0795-MONOMER
- HAMAP:   MF_00523
- InterPro:   IPR001451
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 37089; Mature: 37089

Theoretical pI: Translated: 7.75; Mature: 7.75

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLSDLVDLIKKGNSNFISSNIFEDLNIEDAASLDEAVNHQISFLEENNILKEKLDKSNA
CCHHHHHHHHHCCCCCEEHHHHHCCCCCHHHHHHHHHHHHHEEEECCCCHHHHHHCCCCC
SAIITSNNNEIISALKKLNISNIIVKNPRIAFAEVLNHLYKTINFNPGIHASAVIDKTAI
CEEEECCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCHHHEECCEEE
IGADCHIGPNVYIGENTVIGNNNDILTGSSILGNVRIGDNNIIHPNCVVYENTTLKNNCV
EECCCCCCCEEEECCEEEECCCCCEEECCCEEEEEEECCCCEECCCEEEEECCEECCCEE
INSNSVIGSEGFGFIPKDDKWVKMPQKGGVKIMSFVEIGTNCCIDRPAVGITFIDEGTKL
EECCCEECCCCCCCCCCCCCEEECCCCCCEEEEEEEHHCCCCCCCCCCEEEEEECCCCCH
DNLVQIGHGVKIGKNCAFAAQVGIAGGAKIGDRVILAGQVGVNNRVKVGNNVIASSKCGI
HHHHHHCCCEEECCCEEEEEEECCCCCCCCCCEEEEEECCCCCCEEEECCCEEECCCCCE
HCDIEDGKVISGFPAMENKSWLRSSSIFKKLPELAKKLRQLDKQ
EEECCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLLSDLVDLIKKGNSNFISSNIFEDLNIEDAASLDEAVNHQISFLEENNILKEKLDKSNA
CCHHHHHHHHHCCCCCEEHHHHHCCCCCHHHHHHHHHHHHHEEEECCCCHHHHHHCCCCC
SAIITSNNNEIISALKKLNISNIIVKNPRIAFAEVLNHLYKTINFNPGIHASAVIDKTAI
CEEEECCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCHHHEECCEEE
IGADCHIGPNVYIGENTVIGNNNDILTGSSILGNVRIGDNNIIHPNCVVYENTTLKNNCV
EECCCCCCCEEEECCEEEECCCCCEEECCCEEEEEEECCCCEECCCEEEEECCEECCCEE
INSNSVIGSEGFGFIPKDDKWVKMPQKGGVKIMSFVEIGTNCCIDRPAVGITFIDEGTKL
EECCCEECCCCCCCCCCCCCEEECCCCCCEEEEEEEHHCCCCCCCCCCEEEEEECCCCCH
DNLVQIGHGVKIGKNCAFAAQVGIAGGAKIGDRVILAGQVGVNNRVKVGNNVIASSKCGI
HHHHHHCCCEEECCCEEEEEEECCCCCCCCCCEEEEEECCCCCCEEEECCCEEECCCCCE
HCDIEDGKVISGFPAMENKSWLRSSSIFKKLPELAKKLRQLDKQ
EEECCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA