Click here to switch to the map view.

The map label for this gene is clpP1 [H]

Identifier: 78779134

GI number: 78779134

Start: 695388

End: 695975

Strand: Direct

Name: clpP1 [H]

Synonym: PMT9312_0750

Alternate gene names: 78779134

Gene position: 695388-695975 (Clockwise)

Preceding gene: 78779132

Following gene: 78779136

Centisome position: 40.68

GC content: 37.41

Gene sequence:

>588_bases
ATGATCCCATTAGTTTTAGAAGAATCTGGCGGTAGTGAAAGAGTCTTTGATATCTATTCAAGATTATTAAGAGAGAGAAT
AATCTTTTTGGGAGAACAAGTTACTAGTGAAACTGCTAATAGAATTGTTGCTCAATTATTATTCCTTGAAGCAGAGGATC
CAGACAAAGATATCTATATGTATATAAATTCCCCAGGAGGATCCGTCTATGATGGGCTAGGCATCTTTGACACAATGCAA
CATGTTAAGCCAGATATTCACACAGTTTGCGTGGGGTTGGCGGCTAGTATGGGTGCTTTTTTGTTGGCGGCAGGTACTAA
AGGCAAAAGAAGCAGCCTTAGACATTCAAGAATAATGATTCATCAACCACTTGGAGGGGCCAGAGGCCAAGCCAGTGACA
TAAGAATTCAGGCAGATGAAATTCTGTTTTTAAAGGAACGTCTTAATACTGAATTATCAGAAAGAACTGGTAAAGATTAT
GAAACTATTAAAGAGGATACTGATAGAGATTTTTATATGTCTCCGAGTGAGGCTGTGGAGTATGGGTTAATAGATCTAGT
ATTAGATAAGAAACCTGTTAAAGTTTAA

Upstream 100 bases:

>100_bases
ACAGTCAATTTTGCTTTCAATTTTTTATATGTAAACCTTAATAAGGTTAGCGTATGTTGACTCAATATCGTTAATATCTA
ATAAACAAATAAATATTATT

Downstream 100 bases:

>100_bases
TTTAATAATTGAGGTGTTCTCTCTTTCTCAGGAATGGTAGTGAATTCAGATAGAATTCTAGTAAATTCCTCACCATCTAA
CGTTTCTTTCTCTATTAGTA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 1 [H]

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MIPLVLEESGGSERVFDIYSRLLRERIIFLGEQVTSETANRIVAQLLFLEAEDPDKDIYMYINSPGGSVYDGLGIFDTMQ
HVKPDIHTVCVGLAASMGAFLLAAGTKGKRSSLRHSRIMIHQPLGGARGQASDIRIQADEILFLKERLNTELSERTGKDY
ETIKEDTDRDFYMSPSEAVEYGLIDLVLDKKPVKV

Sequences:

>Translated_195_residues
MIPLVLEESGGSERVFDIYSRLLRERIIFLGEQVTSETANRIVAQLLFLEAEDPDKDIYMYINSPGGSVYDGLGIFDTMQ
HVKPDIHTVCVGLAASMGAFLLAAGTKGKRSSLRHSRIMIHQPLGGARGQASDIRIQADEILFLKERLNTELSERTGKDY
ETIKEDTDRDFYMSPSEAVEYGLIDLVLDKKPVKV
>Mature_195_residues
MIPLVLEESGGSERVFDIYSRLLRERIIFLGEQVTSETANRIVAQLLFLEAEDPDKDIYMYINSPGGSVYDGLGIFDTMQ
HVKPDIHTVCVGLAASMGAFLLAAGTKGKRSSLRHSRIMIHQPLGGARGQASDIRIQADEILFLKERLNTELSERTGKDY
ETIKEDTDRDFYMSPSEAVEYGLIDLVLDKKPVKV

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=192, Percent_Identity=54.6875, Blast_Score=212, Evalue=2e-55,
Organism=Escherichia coli, GI1786641, Length=191, Percent_Identity=59.1623036649215, Blast_Score=241, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=51.6129032258064, Blast_Score=192, Evalue=9e-50,
Organism=Drosophila melanogaster, GI20129427, Length=195, Percent_Identity=51.7948717948718, Blast_Score=206, Evalue=5e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 21796; Mature: 21796

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00381 CLP_PROTEASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPLVLEESGGSERVFDIYSRLLRERIIFLGEQVTSETANRIVAQLLFLEAEDPDKDIYM
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
YINSPGGSVYDGLGIFDTMQHVKPDIHTVCVGLAASMGAFLLAAGTKGKRSSLRHSRIMI
EEECCCCCHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHCEEEE
HQPLGGARGQASDIRIQADEILFLKERLNTELSERTGKDYETIKEDTDRDFYMSPSEAVE
ECCCCCCCCCCCCEEEEHHHHHHHHHHHCCHHHHHCCCCHHHHHHCCCCCEEECHHHHHH
YGLIDLVLDKKPVKV
HHHHEEEECCCCCCC
>Mature Secondary Structure
MIPLVLEESGGSERVFDIYSRLLRERIIFLGEQVTSETANRIVAQLLFLEAEDPDKDIYM
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
YINSPGGSVYDGLGIFDTMQHVKPDIHTVCVGLAASMGAFLLAAGTKGKRSSLRHSRIMI
EEECCCCCHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHCEEEE
HQPLGGARGQASDIRIQADEILFLKERLNTELSERTGKDYETIKEDTDRDFYMSPSEAVE
ECCCCCCCCCCCCEEEEHHHHHHHHHHHCCHHHHHCCCCHHHHHHCCCCCEEECHHHHHH
YGLIDLVLDKKPVKV
HHHHEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]