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The map label for this gene is gloA [H]

Identifier: 78779037

GI number: 78779037

Start: 615906

End: 616295

Strand: Reverse

Name: gloA [H]

Synonym: PMT9312_0652

Alternate gene names: 78779037

Gene position: 616295-615906 (Counterclockwise)

Preceding gene: 78779039

Following gene: 78779036

Centisome position: 36.06

GC content: 32.56

Gene sequence:

>390_bases
ATGCGCATCCTTCATACAATGCTGAGAGTTGGAGATTTAGATAAATCCATTAATTTTTACGTTAATAGATTAGGAATGAA
TTTATTAAGAAAAAAGGATTACCCTCACGGAAAATTCACTTTGGCATTTGTTGGTTATGGTTCAGAAAAAGAGAATGCAG
TGATTGAATTAACCTATAACTGGGATAAGAAGTCAGACGACTATGAGCTCGGAGATAAGTATGGTCATATAGCTATTGGA
GTAAAAGATATTCATCTTATTTGCCAAGGACTAGAAAATAATGGTTGTAAAGTAACAACCAAACCTAAGACAATGAAAAA
CAGTACAACTGTCTTGGCTTTTATTGAGGATCCTGATGGATATAAAATTGAACTTATTGAAAGAGATTAA

Upstream 100 bases:

>100_bases
CCTAATTTTCTGTACGTATTTAAAGACTTAACCTCGAAACATCAACTTTGGCAGATGGTTGTTAAATATTAGATAATTAA
TTTAAGTTCATAATTCAAAA

Downstream 100 bases:

>100_bases
AAGCTCGGAAGTTTTTATTTAATAAACAAATTATTAAAAATAAAAATAACTTAAAAGATTTAATTATCTAATAAATAATT
TCCAATTACCAAAAAAAATA

Product: glyoxalase I

Products: NA

Alternate protein names: Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase [H]

Number of amino acids: Translated: 129; Mature: 129

Protein sequence:

>129_residues
MRILHTMLRVGDLDKSINFYVNRLGMNLLRKKDYPHGKFTLAFVGYGSEKENAVIELTYNWDKKSDDYELGDKYGHIAIG
VKDIHLICQGLENNGCKVTTKPKTMKNSTTVLAFIEDPDGYKIELIERD

Sequences:

>Translated_129_residues
MRILHTMLRVGDLDKSINFYVNRLGMNLLRKKDYPHGKFTLAFVGYGSEKENAVIELTYNWDKKSDDYELGDKYGHIAIG
VKDIHLICQGLENNGCKVTTKPKTMKNSTTVLAFIEDPDGYKIELIERD
>Mature_129_residues
MRILHTMLRVGDLDKSINFYVNRLGMNLLRKKDYPHGKFTLAFVGYGSEKENAVIELTYNWDKKSDDYELGDKYGHIAIG
VKDIHLICQGLENNGCKVTTKPKTMKNSTTVLAFIEDPDGYKIELIERD

Specific function: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione [H]

COG id: COG0346

COG function: function code E; Lactoylglutathione lyase and related lyases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyoxalase I family [H]

Homologues:

Organism=Homo sapiens, GI118402586, Length=146, Percent_Identity=37.6712328767123, Blast_Score=91, Evalue=4e-19,
Organism=Escherichia coli, GI1787940, Length=127, Percent_Identity=59.8425196850394, Blast_Score=154, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6323639, Length=136, Percent_Identity=38.9705882352941, Blast_Score=93, Evalue=1e-20,
Organism=Drosophila melanogaster, GI20129743, Length=146, Percent_Identity=38.3561643835616, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI19920404, Length=138, Percent_Identity=31.8840579710145, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004360
- InterPro:   IPR004361
- InterPro:   IPR018146 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =4.4.1.5 [H]

Molecular weight: Translated: 14787; Mature: 14787

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: PS00934 GLYOXALASE_I_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILHTMLRVGDLDKSINFYVNRLGMNLLRKKDYPHGKFTLAFVGYGSEKENAVIELTYN
CHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCEEEEEEEC
WDKKSDDYELGDKYGHIAIGVKDIHLICQGLENNGCKVTTKPKTMKNSTTVLAFIEDPDG
CCCCCCCCCCCCCCCEEEEEHEEEEEEEECCCCCCCEEEECCCCCCCCEEEEEEEECCCC
YKIELIERD
CEEEEEECC
>Mature Secondary Structure
MRILHTMLRVGDLDKSINFYVNRLGMNLLRKKDYPHGKFTLAFVGYGSEKENAVIELTYN
CHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCEEEEEEEC
WDKKSDDYELGDKYGHIAIGVKDIHLICQGLENNGCKVTTKPKTMKNSTTVLAFIEDPDG
CCCCCCCCCCCCCCCEEEEEHEEEEEEEECCCCCCCEEEECCCCCCCCEEEEEEEECCCC
YKIELIERD
CEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]