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The map label for this gene is glmU

Identifier: 78778996

GI number: 78778996

Start: 576122

End: 577471

Strand: Reverse

Name: glmU

Synonym: PMT9312_0611

Alternate gene names: 78778996

Gene position: 577471-576122 (Counterclockwise)

Preceding gene: 78778997

Following gene: 78778991

Centisome position: 33.79

GC content: 31.85

Gene sequence:

>1350_bases
ATGTTAAGTGTTGCGATACTGGCTGCAGGTAAGGGCACTAGAATGGAAAGCTCAATACCAAAGGTTTTACATAAAATTTC
TGGCAAAAGTCTTTTGCAGAGAGTAATTGATTCATGTGTTGAATTAAATCCCGATCAAATTTTTGTAATTACTGGACACA
AATCCAAAGAGGTACAAGAGTCAATACCAGATAATAAAAAAATCCATTTTGTCATTCAAGAACCTCAATCAGGGACTGGT
CATGCTATCCAGATACTTTGTAGAGAAGTAAAAAAAAATGAAGGAAAACTTTTAGTGCTTAATGGTGATGTTCCTCTTAT
AACGCCTGAGACTCTAAAAAATCTTTTAAATTTACATGATTCAAAAAACGCCGATGTTTCTTTAATAACAACAAAGAAAA
AAAATCCTCATGGGTATGGAAGAGTTTTTTTGAAGGGGGATTTTATAGAGAGAATTGTTGAAGAAAAAGATTGCAATAAT
CAAGAACGACTTAATTTATTAATAAATGCAGGAGTTTACTGTTTCAACTGGGAAAATTTGTCAGAGATAATAAGTACTTT
ACAAAGTAATAATAACCAGAATGAAATTTACCTAACTGATACAGTATCTATGCTAAAGAATGCCTTAAGCCTAGAGATAG
AGGATAATGGAGAGCTTCAAGGAATAAATAATAGAATACAACTTTCAAAATGCGAAGAAATTATTCAGAATTCAATTAAA
GAAAAGCATATGCTTAATGGAGTAACATTTATAAATCAAGCAAGTTGTTCAATTAGTGAAGAAGCCGAGATTGGCAAAGA
TGTGATCATTGAGGCTAACACTCATATAAGAGGAAGTACCAAAATATTTAATAGTTGCGTTATTGGGCCAAATACTTTTA
TTGAAAATTCTAATATTGGATTACATTGTGAAATCTCAAATTCCACTGTTTATGATTCTCAGATAATGGATCATATAAAA
GTTGGTCCCTACAGTCATATAAGACCTAAATCCAAGATTTATTCTTACAGTAAAATAGGTAATTTTGTTGAAATAAAAAA
TAGTCAACTAGAGGAAGAATCTAAAGTAAACCATCTAAGTTATATTGGCGATTCTATTATTGGAAGATCAACAAATATAG
GGGCAGGTACTATTACTGCAAATTTTGATGGTCAGAAAAAACATCAAACAAAAATTGGCAAGAATTCCAGCATTGGAGCA
AATACAGTTCTTGTTGCGCCTATTAATCTCGGGGAATCAGTGACAACTGGTGCTGGTTCAGTGATAACAAAAGACTCCAA
AGATAATTCATTAGCAATCTCAAGAACTAAGCAAGTTAATATAGATAATTGGGAAAGGAAGAAACCTTGA

Upstream 100 bases:

>100_bases
ATTATGCTCAAATCTATTACCTACAAAGAAATGGAGAAAAAAGTGGGGAATGACGAAGTCGGCCTTCAAGAGTTAGATTT
ATATATATATTCAAAAAAAC

Downstream 100 bases:

>100_bases
TCTAATTAATTAATTCAATAATTTTTTCAAGCTGCCAACATCTGCTCCCTTTTATAAGAATTGAATCACCTTTTTTTGTA
GATTTATTAATCTCTTTAGG

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MLSVAILAAGKGTRMESSIPKVLHKISGKSLLQRVIDSCVELNPDQIFVITGHKSKEVQESIPDNKKIHFVIQEPQSGTG
HAIQILCREVKKNEGKLLVLNGDVPLITPETLKNLLNLHDSKNADVSLITTKKKNPHGYGRVFLKGDFIERIVEEKDCNN
QERLNLLINAGVYCFNWENLSEIISTLQSNNNQNEIYLTDTVSMLKNALSLEIEDNGELQGINNRIQLSKCEEIIQNSIK
EKHMLNGVTFINQASCSISEEAEIGKDVIIEANTHIRGSTKIFNSCVIGPNTFIENSNIGLHCEISNSTVYDSQIMDHIK
VGPYSHIRPKSKIYSYSKIGNFVEIKNSQLEEESKVNHLSYIGDSIIGRSTNIGAGTITANFDGQKKHQTKIGKNSSIGA
NTVLVAPINLGESVTTGAGSVITKDSKDNSLAISRTKQVNIDNWERKKP

Sequences:

>Translated_449_residues
MLSVAILAAGKGTRMESSIPKVLHKISGKSLLQRVIDSCVELNPDQIFVITGHKSKEVQESIPDNKKIHFVIQEPQSGTG
HAIQILCREVKKNEGKLLVLNGDVPLITPETLKNLLNLHDSKNADVSLITTKKKNPHGYGRVFLKGDFIERIVEEKDCNN
QERLNLLINAGVYCFNWENLSEIISTLQSNNNQNEIYLTDTVSMLKNALSLEIEDNGELQGINNRIQLSKCEEIIQNSIK
EKHMLNGVTFINQASCSISEEAEIGKDVIIEANTHIRGSTKIFNSCVIGPNTFIENSNIGLHCEISNSTVYDSQIMDHIK
VGPYSHIRPKSKIYSYSKIGNFVEIKNSQLEEESKVNHLSYIGDSIIGRSTNIGAGTITANFDGQKKHQTKIGKNSSIGA
NTVLVAPINLGESVTTGAGSVITKDSKDNSLAISRTKQVNIDNWERKKP
>Mature_449_residues
MLSVAILAAGKGTRMESSIPKVLHKISGKSLLQRVIDSCVELNPDQIFVITGHKSKEVQESIPDNKKIHFVIQEPQSGTG
HAIQILCREVKKNEGKLLVLNGDVPLITPETLKNLLNLHDSKNADVSLITTKKKNPHGYGRVFLKGDFIERIVEEKDCNN
QERLNLLINAGVYCFNWENLSEIISTLQSNNNQNEIYLTDTVSMLKNALSLEIEDNGELQGINNRIQLSKCEEIIQNSIK
EKHMLNGVTFINQASCSISEEAEIGKDVIIEANTHIRGSTKIFNSCVIGPNTFIENSNIGLHCEISNSTVYDSQIMDHIK
VGPYSHIRPKSKIYSYSKIGNFVEIKNSQLEEESKVNHLSYIGDSIIGRSTNIGAGTITANFDGQKKHQTKIGKNSSIGA
NTVLVAPINLGESVTTGAGSVITKDSKDNSLAISRTKQVNIDNWERKKP

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=451, Percent_Identity=37.9157427937916, Blast_Score=316, Evalue=2e-87,
Organism=Saccharomyces cerevisiae, GI6320148, Length=351, Percent_Identity=23.3618233618234, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_PROM9 (Q31BS3)

Other databases:

- EMBL:   CP000111
- RefSeq:   YP_397108.1
- ProteinModelPortal:   Q31BS3
- SMR:   Q31BS3
- STRING:   Q31BS3
- GeneID:   3765411
- GenomeReviews:   CP000111_GR
- KEGG:   pmi:PMT9312_0611
- eggNOG:   COG1207
- HOGENOM:   HBG688195
- OMA:   GSKVNHL
- ProtClustDB:   PRK14360
- BioCyc:   PMAR74546:PMT9312_0611-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 49613; Mature: 49613

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 358-358 BINDING 73-73 BINDING 140-140 BINDING 154-154 BINDING 169-169 BINDING 418-418 BINDING 435-435

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSVAILAAGKGTRMESSIPKVLHKISGKSLLQRVIDSCVELNPDQIFVITGHKSKEVQE
CEEEEEEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHH
SIPDNKKIHFVIQEPQSGTGHAIQILCREVKKNEGKLLVLNGDVPLITPETLKNLLNLHD
HCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCEECHHHHHHHHHCCC
SKNADVSLITTKKKNPHGYGRVFLKGDFIERIVEEKDCNNQERLNLLINAGVYCFNWENL
CCCCCEEEEEECCCCCCCCEEEEEECHHHHHHHHHCCCCCHHHEEEEEECCEEEEECCCH
SEIISTLQSNNNQNEIYLTDTVSMLKNALSLEIEDNGELQGINNRIQLSKCEEIIQNSIK
HHHHHHHHCCCCCCEEEEEHHHHHHHHHEEEEECCCCCEECCCCEEEHHHHHHHHHHHHH
EKHMLNGVTFINQASCSISEEAEIGKDVIIEANTHIRGSTKIFNSCVIGPNTFIENSNIG
HHHHHCCEEEEECCCCCCCCHHHCCCEEEEECCCCCCCCHHHHHEEEECCCCEEECCCCE
LHCEISNSTVYDSQIMDHIKVGPYSHIRPKSKIYSYSKIGNFVEIKNSQLEEESKVNHLS
EEEEECCCEEEHHHHHHHHCCCCCCCCCCHHHHEEHHHCCCEEEECCCCCCHHHHHHHHH
YIGDSIIGRSTNIGAGTITANFDGQKKHQTKIGKNSSIGANTVLVAPINLGESVTTGAGS
HHHHHHCCCCCCCCCEEEEECCCCCHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCC
VITKDSKDNSLAISRTKQVNIDNWERKKP
EEECCCCCCCEEEEEEEEECCCCCCCCCC
>Mature Secondary Structure
MLSVAILAAGKGTRMESSIPKVLHKISGKSLLQRVIDSCVELNPDQIFVITGHKSKEVQE
CEEEEEEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHH
SIPDNKKIHFVIQEPQSGTGHAIQILCREVKKNEGKLLVLNGDVPLITPETLKNLLNLHD
HCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCEECHHHHHHHHHCCC
SKNADVSLITTKKKNPHGYGRVFLKGDFIERIVEEKDCNNQERLNLLINAGVYCFNWENL
CCCCCEEEEEECCCCCCCCEEEEEECHHHHHHHHHCCCCCHHHEEEEEECCEEEEECCCH
SEIISTLQSNNNQNEIYLTDTVSMLKNALSLEIEDNGELQGINNRIQLSKCEEIIQNSIK
HHHHHHHHCCCCCCEEEEEHHHHHHHHHEEEEECCCCCEECCCCEEEHHHHHHHHHHHHH
EKHMLNGVTFINQASCSISEEAEIGKDVIIEANTHIRGSTKIFNSCVIGPNTFIENSNIG
HHHHHCCEEEEECCCCCCCCHHHCCCEEEEECCCCCCCCHHHHHEEEECCCCEEECCCCE
LHCEISNSTVYDSQIMDHIKVGPYSHIRPKSKIYSYSKIGNFVEIKNSQLEEESKVNHLS
EEEEECCCEEEHHHHHHHHCCCCCCCCCCHHHHEEHHHCCCEEEECCCCCCHHHHHHHHH
YIGDSIIGRSTNIGAGTITANFDGQKKHQTKIGKNSSIGANTVLVAPINLGESVTTGAGS
HHHHHHCCCCCCCCCEEEEECCCCCHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCC
VITKDSKDNSLAISRTKQVNIDNWERKKP
EEECCCCCCCEEEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA