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The map label for this gene is prlC [H]

Identifier: 78778978

GI number: 78778978

Start: 555243

End: 557330

Strand: Reverse

Name: prlC [H]

Synonym: PMT9312_0593

Alternate gene names: 78778978

Gene position: 557330-555243 (Counterclockwise)

Preceding gene: 78778979

Following gene: 78778973

Centisome position: 32.61

GC content: 33.33

Gene sequence:

>2088_bases
ATGGAAACCACAATTTTTAAATATGGAGAATTACCAGAATTTAAAAAATTTACTCCAGAAAGTATCAGTAAACAATTTCC
AGAAGTATTAATAAAGATAGGCAATGATTTCAAAAATATAGAGGAAGATCTTTCTAATTATTTGATTCAGAAAAAGTTGG
ATTGGAATAAAGTTATAAACCCTTTAAATGAAGTTAATGAAGTCCTCAGGTGGAGTTGGGGGGTAATAAGCCACTTAAAT
GCCGTAAATAACTCTAAAAGTCTTAGAGATGTTTATTCAAAATTTCTTCCCGAGATTATTAGCTTGAGTAACAGATTTGG
ACAAAGTAAAGTAATTTACAATTCCTTAGTCAAGCTTAAAGAGACAAATAACTTTGATCGAATCAAAAATAGAATTCTAG
ATAAAGAAATACTTGAAATGCAACATAGGGGGATTTCTCTACAAAAAAATGATCAAAAATATTTCAATGAAATTTCAGAA
AAGCTTGGCAAGCTATCAACAGATTTCAGCAACAACGTTCTTGATGCTACAAAAAATTGGTTTTTAATTTTAAATAAAAA
ATCTGAAGTTGATGGTCTTCCTGATCGAGTACTAGAATTAATGGCAATATCAGCTCATAATCACTTAAAGAAAGATGGCG
AAGTTAACGTTATAAATGGTCCTTGGAAATTAAGCCTAGATATTCCAACTTATACAGCGTTTATGACATATGCCACTGAC
CGTAAACTCAGAGAAAAACTCTATAAGGCATTTGTGAGCAGGGCTTCAGATGGAGAAAAGAATAATTCTCAAATTATTGA
AGAGATATTATCTCTAAGGACTAAACAGGCCAATCTTCTTGGGTATAAAAGTTGGGCAGAACTGAGTTTGTCAACGAAAA
TGGCCAAAGAAATTAAAAATGTTGAAACCCTTTTAGAGGAATTAAGAGAACCAGCTTTTAAAACAGCAAAATTGGAATTA
CAATCACTAGAAAATTTTTCTAAAGATAATGGGTTTCCCCATTCCCAGACTATTGAGCCATGGGATATTAGTTATTGGTC
TGAGCTTCTTAGAAAGGAAAAGTTCAATTTAGATCAAGAGGCTTTGAGGCCTTGGTTCCCTCTAAATGATGTTTTAAAAG
GTTTGTTTAAACTAAGCGAAAAGTTATTTGAAATTAAAGTTGTCGAAGCAACTGATGAAGCACCCTCATGGAATAATGAC
GTCTTGTTTTTTAATATCCTCGATAAAAAAGAAAAAAAAATAGCATCTTTTTACCTCGATCCTTATTCTAGACCGGAATC
AAAAAGAGGAGGAGCTTGGATGGATGAATGTTTGAATAAAAATAATGTTGGGAAGAATACCCTACCGGTGGCTTATCTTG
TTTGTAATCAGACTCCACCATCAAAAGACAAACCTAGTTTGATGAGTTTCGAAGAAGTTCAGACACTTTTCCATGAATTT
GGTCACGGTCTTCAACATATGCTTACTACTGTAAATCTCCCTCAAGCTGCTGGCATTAATAATGTTGAATGGGATGCAGT
AGAACTTCCAAGTCAATTTATGGAGAACTGGTGCTTCCATAAAAATACACTCTTGAATATTGCTAAACACTATCAAACAG
GGGAAAAGTTATCCGATGAAAACTTTGAGAAACTCTTAAAGAACAGGACTTTTAATTGTGGAATGGACACACTTAGACAA
CTTCATTTTGCGATTACAGATCTCAGATTACACAGTAATATTGATAAAAACAAAGGTAAAACTGCAGACAAACTTAGAAG
AGAAATTGCAGAACAAACTACTGTAATTGCCCCAATTCAAGAAGATCAATTTCTTTGTTGTTTTAGTCATATATTTGCAG
GTGGATATTCTGCGGGATATTACTCATATAAATGGGCTGAGGTTCTAAGTGCTGATGCTTTTTCTATGTTTGAAGAAGCT
GATCTGGAAAATACTGAGGATTTAAAATTAATAGGAAAGAAATTTAAAGACACAATACTTAGCTTAGGAGGAAGCTTATC
TCCATTAGAAATATTCAAACTATTCAGAGGGAGAGAGCCACAAACAGATCCCCTAATAAGACACTTGGGCTTGTCTGGAA
CTACATAA

Upstream 100 bases:

>100_bases
TATATGAATCTTCAACCAATGCTCTCAGTCAGCAGCTAACTTTAGCTAAATTAGTAGGGCTAATTTCAAACATTAGTTAA
GTTTAATTTGTCTTAAATAA

Downstream 100 bases:

>100_bases
TAATTTTCTCAATTATTTTATTAACAGAAACTTTATTTCTTACTAAATTTCTATGTTTATATACTTTTACTGATATTTTT
TCTCCTAAATTTAAATTAGT

Product: peptidase family M3

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 695; Mature: 695

Protein sequence:

>695_residues
METTIFKYGELPEFKKFTPESISKQFPEVLIKIGNDFKNIEEDLSNYLIQKKLDWNKVINPLNEVNEVLRWSWGVISHLN
AVNNSKSLRDVYSKFLPEIISLSNRFGQSKVIYNSLVKLKETNNFDRIKNRILDKEILEMQHRGISLQKNDQKYFNEISE
KLGKLSTDFSNNVLDATKNWFLILNKKSEVDGLPDRVLELMAISAHNHLKKDGEVNVINGPWKLSLDIPTYTAFMTYATD
RKLREKLYKAFVSRASDGEKNNSQIIEEILSLRTKQANLLGYKSWAELSLSTKMAKEIKNVETLLEELREPAFKTAKLEL
QSLENFSKDNGFPHSQTIEPWDISYWSELLRKEKFNLDQEALRPWFPLNDVLKGLFKLSEKLFEIKVVEATDEAPSWNND
VLFFNILDKKEKKIASFYLDPYSRPESKRGGAWMDECLNKNNVGKNTLPVAYLVCNQTPPSKDKPSLMSFEEVQTLFHEF
GHGLQHMLTTVNLPQAAGINNVEWDAVELPSQFMENWCFHKNTLLNIAKHYQTGEKLSDENFEKLLKNRTFNCGMDTLRQ
LHFAITDLRLHSNIDKNKGKTADKLRREIAEQTTVIAPIQEDQFLCCFSHIFAGGYSAGYYSYKWAEVLSADAFSMFEEA
DLENTEDLKLIGKKFKDTILSLGGSLSPLEIFKLFRGREPQTDPLIRHLGLSGTT

Sequences:

>Translated_695_residues
METTIFKYGELPEFKKFTPESISKQFPEVLIKIGNDFKNIEEDLSNYLIQKKLDWNKVINPLNEVNEVLRWSWGVISHLN
AVNNSKSLRDVYSKFLPEIISLSNRFGQSKVIYNSLVKLKETNNFDRIKNRILDKEILEMQHRGISLQKNDQKYFNEISE
KLGKLSTDFSNNVLDATKNWFLILNKKSEVDGLPDRVLELMAISAHNHLKKDGEVNVINGPWKLSLDIPTYTAFMTYATD
RKLREKLYKAFVSRASDGEKNNSQIIEEILSLRTKQANLLGYKSWAELSLSTKMAKEIKNVETLLEELREPAFKTAKLEL
QSLENFSKDNGFPHSQTIEPWDISYWSELLRKEKFNLDQEALRPWFPLNDVLKGLFKLSEKLFEIKVVEATDEAPSWNND
VLFFNILDKKEKKIASFYLDPYSRPESKRGGAWMDECLNKNNVGKNTLPVAYLVCNQTPPSKDKPSLMSFEEVQTLFHEF
GHGLQHMLTTVNLPQAAGINNVEWDAVELPSQFMENWCFHKNTLLNIAKHYQTGEKLSDENFEKLLKNRTFNCGMDTLRQ
LHFAITDLRLHSNIDKNKGKTADKLRREIAEQTTVIAPIQEDQFLCCFSHIFAGGYSAGYYSYKWAEVLSADAFSMFEEA
DLENTEDLKLIGKKFKDTILSLGGSLSPLEIFKLFRGREPQTDPLIRHLGLSGTT
>Mature_695_residues
METTIFKYGELPEFKKFTPESISKQFPEVLIKIGNDFKNIEEDLSNYLIQKKLDWNKVINPLNEVNEVLRWSWGVISHLN
AVNNSKSLRDVYSKFLPEIISLSNRFGQSKVIYNSLVKLKETNNFDRIKNRILDKEILEMQHRGISLQKNDQKYFNEISE
KLGKLSTDFSNNVLDATKNWFLILNKKSEVDGLPDRVLELMAISAHNHLKKDGEVNVINGPWKLSLDIPTYTAFMTYATD
RKLREKLYKAFVSRASDGEKNNSQIIEEILSLRTKQANLLGYKSWAELSLSTKMAKEIKNVETLLEELREPAFKTAKLEL
QSLENFSKDNGFPHSQTIEPWDISYWSELLRKEKFNLDQEALRPWFPLNDVLKGLFKLSEKLFEIKVVEATDEAPSWNND
VLFFNILDKKEKKIASFYLDPYSRPESKRGGAWMDECLNKNNVGKNTLPVAYLVCNQTPPSKDKPSLMSFEEVQTLFHEF
GHGLQHMLTTVNLPQAAGINNVEWDAVELPSQFMENWCFHKNTLLNIAKHYQTGEKLSDENFEKLLKNRTFNCGMDTLRQ
LHFAITDLRLHSNIDKNKGKTADKLRREIAEQTTVIAPIQEDQFLCCFSHIFAGGYSAGYYSYKWAEVLSADAFSMFEEA
DLENTEDLKLIGKKFKDTILSLGGSLSPLEIFKLFRGREPQTDPLIRHLGLSGTT

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=654, Percent_Identity=28.1345565749235, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI14149738, Length=592, Percent_Identity=30.7432432432432, Blast_Score=243, Evalue=5e-64,
Organism=Homo sapiens, GI156105687, Length=600, Percent_Identity=24.1666666666667, Blast_Score=149, Evalue=8e-36,
Organism=Escherichia coli, GI1789913, Length=694, Percent_Identity=39.6253602305475, Blast_Score=496, Evalue=1e-141,
Organism=Escherichia coli, GI1787819, Length=650, Percent_Identity=30, Blast_Score=261, Evalue=8e-71,
Organism=Caenorhabditis elegans, GI71999758, Length=578, Percent_Identity=23.7024221453287, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI32565901, Length=595, Percent_Identity=21.8487394957983, Blast_Score=99, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6319793, Length=577, Percent_Identity=29.6360485268631, Blast_Score=238, Evalue=3e-63,
Organism=Saccharomyces cerevisiae, GI6322715, Length=490, Percent_Identity=26.9387755102041, Blast_Score=124, Evalue=5e-29,
Organism=Drosophila melanogaster, GI21356111, Length=701, Percent_Identity=29.243937232525, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI20129717, Length=458, Percent_Identity=23.3624454148472, Blast_Score=135, Evalue=9e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 80157; Mature: 80157

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METTIFKYGELPEFKKFTPESISKQFPEVLIKIGNDFKNIEEDLSNYLIQKKLDWNKVIN
CCCCEECCCCCCCHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHH
PLNEVNEVLRWSWGVISHLNAVNNSKSLRDVYSKFLPEIISLSNRFGQSKVIYNSLVKLK
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
ETNNFDRIKNRILDKEILEMQHRGISLQKNDQKYFNEISEKLGKLSTDFSNNVLDATKNW
HCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHCCCCE
FLILNKKSEVDGLPDRVLELMAISAHNHLKKDGEVNVINGPWKLSLDIPTYTAFMTYATD
EEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEEEECCHHHHHHHHHHH
RKLREKLYKAFVSRASDGEKNNSQIIEEILSLRTKQANLLGYKSWAELSLSTKMAKEIKN
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
VETLLEELREPAFKTAKLELQSLENFSKDNGFPHSQTIEPWDISYWSELLRKEKFNLDQE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHH
ALRPWFPLNDVLKGLFKLSEKLFEIKVVEATDEAPSWNNDVLFFNILDKKEKKIASFYLD
HCCCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCEEEEEECCHHHHHHHHHHCC
PYSRPESKRGGAWMDECLNKNNVGKNTLPVAYLVCNQTPPSKDKPSLMSFEEVQTLFHEF
CCCCCCCCCCCCHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHH
GHGLQHMLTTVNLPQAAGINNVEWDAVELPSQFMENWCFHKNTLLNIAKHYQTGEKLSDE
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCHH
NFEKLLKNRTFNCGMDTLRQLHFAITDLRLHSNIDKNKGKTADKLRREIAEQTTVIAPIQ
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCEEEEECC
EDQFLCCFSHIFAGGYSAGYYSYKWAEVLSADAFSMFEEADLENTEDLKLIGKKFKDTIL
CCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
SLGGSLSPLEIFKLFRGREPQTDPLIRHLGLSGTT
HHCCCCCHHHHHHHHCCCCCCCCHHHHHCCCCCCC
>Mature Secondary Structure
METTIFKYGELPEFKKFTPESISKQFPEVLIKIGNDFKNIEEDLSNYLIQKKLDWNKVIN
CCCCEECCCCCCCHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHH
PLNEVNEVLRWSWGVISHLNAVNNSKSLRDVYSKFLPEIISLSNRFGQSKVIYNSLVKLK
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
ETNNFDRIKNRILDKEILEMQHRGISLQKNDQKYFNEISEKLGKLSTDFSNNVLDATKNW
HCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHCCCCE
FLILNKKSEVDGLPDRVLELMAISAHNHLKKDGEVNVINGPWKLSLDIPTYTAFMTYATD
EEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEEEECCHHHHHHHHHHH
RKLREKLYKAFVSRASDGEKNNSQIIEEILSLRTKQANLLGYKSWAELSLSTKMAKEIKN
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
VETLLEELREPAFKTAKLELQSLENFSKDNGFPHSQTIEPWDISYWSELLRKEKFNLDQE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHH
ALRPWFPLNDVLKGLFKLSEKLFEIKVVEATDEAPSWNNDVLFFNILDKKEKKIASFYLD
HCCCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCEEEEEECCHHHHHHHHHHCC
PYSRPESKRGGAWMDECLNKNNVGKNTLPVAYLVCNQTPPSKDKPSLMSFEEVQTLFHEF
CCCCCCCCCCCCHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHH
GHGLQHMLTTVNLPQAAGINNVEWDAVELPSQFMENWCFHKNTLLNIAKHYQTGEKLSDE
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCHH
NFEKLLKNRTFNCGMDTLRQLHFAITDLRLHSNIDKNKGKTADKLRREIAEQTTVIAPIQ
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCEEEEECC
EDQFLCCFSHIFAGGYSAGYYSYKWAEVLSADAFSMFEEADLENTEDLKLIGKKFKDTIL
CCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
SLGGSLSPLEIFKLFRGREPQTDPLIRHLGLSGTT
HHCCCCCHHHHHHHHCCCCCCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]