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The map label for this gene is hemE

Identifier: 78778968

GI number: 78778968

Start: 542445

End: 543485

Strand: Reverse

Name: hemE

Synonym: PMT9312_0583

Alternate gene names: 78778968

Gene position: 543485-542445 (Counterclockwise)

Preceding gene: 78778969

Following gene: 78778967

Centisome position: 31.8

GC content: 34.77

Gene sequence:

>1041_bases
ATGGGTGAAAATTTACCACTACTACTTTCTGCCGCATTAGGTAAAAAAGTAACTAGACCTCCAGTATGGATGATGAGGCA
AGCAGGAAGATATATGAAAATCTATAGAGATTTAAGGGAGCGTTACCCAAGCTTTAGAGAGAGGTCTGAAAATCCAGAAC
TATCATATGAGATATCAATGCAGCCTTTTCATGCTTTCAAACCGGATGGTGTGATCCTTTTTTCAGATATTCTCACACCT
CTTCCAGGAATGGGTATAAATTTTGAGATCATAGAAAGTAAAGGTCCAATAATTGAGGACCCAATAAGAACTCTTAGCCA
GATAGAAAGTTTAAAAGAATTAAATCCAAGTGAGAGTTTAAGTTTTGTTGGGCAAGTTCTATCTTCACTAAAAAAAGATG
TAAATAATGAGGCAACAGTTTTAGGTTTTGTTGGTGCACCTTGGACCCTGGCTGCATATGTAGTTGAAGGTAAAAGCAGT
AAAAACTATTCTTTAATAAAATCAATGGCTTTTAAAGAACCAGATTTACTTCACAAACTTCTTGATCATTTTGCAAAATC
TATTGGTGAATATCTTAAATTTCAAATAAAATCTGGAGCGCAAGTAGTACAAATTTTTGATTCATGGGCAGGTCAACTAA
GCCCACAAGATTATGATATCTTTGCTGGGCCTTATCAAAAAAAAGTTGTTGACATTGTAAAAGAGGAGTACCCTGACACA
CCTGTTATTCTCTATATTTCAGGAAGTGCAGGCGTAATAGAAAGAATGGCAAAAACTGGGGTAGATATAATTTCATTAGA
CTGGACAGTAGATATTGAAGAGGCTTGTAAAAGAATCCCTGATGAGATAGGCATCCAAGGTAATGTTGACCCTGGCATTT
TATTTGGAAATAAAGAATCAATAAAAGAAAGGATCGATGATACCTTTAATAAAATTAAAGATAGGAAATATATTCTTAAT
TTAGGTCATGGGATTTTACCTGGCACTCCAGAAGAAAATGCTCAAACATTTTTTGAGCATGGGAAAAAACTAACTTACTA
G

Upstream 100 bases:

>100_bases
TCATATAAATGTTCATATAACACTTTTGATCTGCTTTGCATTGTAAGATTTTTAAGTTGGAATTTTATTTTTTTTTAAAA
AAAACATATCGAATTGAAAA

Downstream 100 bases:

>100_bases
ACAAAGTCTTGGCATATAAAAACTTATTAATAACAGGTGCGAATGGATGTGTTGGCCAATATTTAGTTGATTGGTTTTTA
AAAAATACAAAATTCAAGCT

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MGENLPLLLSAALGKKVTRPPVWMMRQAGRYMKIYRDLRERYPSFRERSENPELSYEISMQPFHAFKPDGVILFSDILTP
LPGMGINFEIIESKGPIIEDPIRTLSQIESLKELNPSESLSFVGQVLSSLKKDVNNEATVLGFVGAPWTLAAYVVEGKSS
KNYSLIKSMAFKEPDLLHKLLDHFAKSIGEYLKFQIKSGAQVVQIFDSWAGQLSPQDYDIFAGPYQKKVVDIVKEEYPDT
PVILYISGSAGVIERMAKTGVDIISLDWTVDIEEACKRIPDEIGIQGNVDPGILFGNKESIKERIDDTFNKIKDRKYILN
LGHGILPGTPEENAQTFFEHGKKLTY

Sequences:

>Translated_346_residues
MGENLPLLLSAALGKKVTRPPVWMMRQAGRYMKIYRDLRERYPSFRERSENPELSYEISMQPFHAFKPDGVILFSDILTP
LPGMGINFEIIESKGPIIEDPIRTLSQIESLKELNPSESLSFVGQVLSSLKKDVNNEATVLGFVGAPWTLAAYVVEGKSS
KNYSLIKSMAFKEPDLLHKLLDHFAKSIGEYLKFQIKSGAQVVQIFDSWAGQLSPQDYDIFAGPYQKKVVDIVKEEYPDT
PVILYISGSAGVIERMAKTGVDIISLDWTVDIEEACKRIPDEIGIQGNVDPGILFGNKESIKERIDDTFNKIKDRKYILN
LGHGILPGTPEENAQTFFEHGKKLTY
>Mature_345_residues
GENLPLLLSAALGKKVTRPPVWMMRQAGRYMKIYRDLRERYPSFRERSENPELSYEISMQPFHAFKPDGVILFSDILTPL
PGMGINFEIIESKGPIIEDPIRTLSQIESLKELNPSESLSFVGQVLSSLKKDVNNEATVLGFVGAPWTLAAYVVEGKSSK
NYSLIKSMAFKEPDLLHKLLDHFAKSIGEYLKFQIKSGAQVVQIFDSWAGQLSPQDYDIFAGPYQKKVVDIVKEEYPDTP
VILYISGSAGVIERMAKTGVDIISLDWTVDIEEACKRIPDEIGIQGNVDPGILFGNKESIKERIDDTFNKIKDRKYILNL
GHGILPGTPEENAQTFFEHGKKLTY

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=339, Percent_Identity=33.0383480825959, Blast_Score=209, Evalue=4e-54,
Organism=Escherichia coli, GI2367337, Length=340, Percent_Identity=38.5294117647059, Blast_Score=258, Evalue=4e-70,
Organism=Saccharomyces cerevisiae, GI6320252, Length=351, Percent_Identity=33.048433048433, Blast_Score=221, Evalue=2e-58,
Organism=Drosophila melanogaster, GI19921920, Length=340, Percent_Identity=35.2941176470588, Blast_Score=221, Evalue=6e-58,
Organism=Drosophila melanogaster, GI221330099, Length=340, Percent_Identity=35.2941176470588, Blast_Score=221, Evalue=6e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 38922; Mature: 38791

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGENLPLLLSAALGKKVTRPPVWMMRQAGRYMKIYRDLRERYPSFRERSENPELSYEISM
CCCCCHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHHHHCCHHHHCCCCCCEEEEEEC
QPFHAFKPDGVILFSDILTPLPGMGINFEIIESKGPIIEDPIRTLSQIESLKELNPSESL
CCCCCCCCCCEEEEHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHH
SFVGQVLSSLKKDVNNEATVLGFVGAPWTLAAYVVEGKSSKNYSLIKSMAFKEPDLLHKL
HHHHHHHHHHHHCCCCCCEEEEECCCCHHHEEHEEECCCCCCHHHHHHHHCCCHHHHHHH
LDHFAKSIGEYLKFQIKSGAQVVQIFDSWAGQLSPQDYDIFAGPYQKKVVDIVKEEYPDT
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHCCCC
PVILYISGSAGVIERMAKTGVDIISLDWTVDIEEACKRIPDEIGIQGNVDPGILFGNKES
CEEEEECCCHHHHHHHHHCCCCEEEEEEEECHHHHHHHCHHHCCCCCCCCCCEEECCHHH
IKERIDDTFNKIKDRKYILNLGHGILPGTPEENAQTFFEHGKKLTY
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure 
GENLPLLLSAALGKKVTRPPVWMMRQAGRYMKIYRDLRERYPSFRERSENPELSYEISM
CCCCHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHHHHCCHHHHCCCCCCEEEEEEC
QPFHAFKPDGVILFSDILTPLPGMGINFEIIESKGPIIEDPIRTLSQIESLKELNPSESL
CCCCCCCCCCEEEEHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHH
SFVGQVLSSLKKDVNNEATVLGFVGAPWTLAAYVVEGKSSKNYSLIKSMAFKEPDLLHKL
HHHHHHHHHHHHCCCCCCEEEEECCCCHHHEEHEEECCCCCCHHHHHHHHCCCHHHHHHH
LDHFAKSIGEYLKFQIKSGAQVVQIFDSWAGQLSPQDYDIFAGPYQKKVVDIVKEEYPDT
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHCCCC
PVILYISGSAGVIERMAKTGVDIISLDWTVDIEEACKRIPDEIGIQGNVDPGILFGNKES
CEEEEECCCHHHHHHHHHCCCCEEEEEEEECHHHHHHHCHHHCCCCCCCCCCEEECCHHH
IKERIDDTFNKIKDRKYILNLGHGILPGTPEENAQTFFEHGKKLTY
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA