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The map label for this gene is folE [H]

Identifier: 78778921

GI number: 78778921

Start: 501991

End: 502731

Strand: Direct

Name: folE [H]

Synonym: PMT9312_0536

Alternate gene names: 78778921

Gene position: 501991-502731 (Clockwise)

Preceding gene: 78778920

Following gene: 78778923

Centisome position: 29.37

GC content: 33.87

Gene sequence:

>741_bases
ATGACCTCTACATTACCCAACGATAATATTAGAAACTTTGATGACCAGATTACTAATAAACTAATCTCTGAAATTATCAG
AGACAGAATTAAGAATTCTGGGACAAGATTCAGTGCAAATGATAACATTGCAGACTTTATAAATCCTGGAGAATTAGAAA
TTCTAGAAAAAGAAGTAGCCTCCAGAGTTAAAGACCTCCTTAAGTCCTTAGTAATAGATGTTGAAAATGATCATAATACT
CAAGAGACTGCAGAAAGAGTCTCAAAGATGTATTTAAATGAAGTTTTTAAAGGGAGATATCATGAACAACCCAAAGTTAC
AAGTTTTCCAAACGATAAGAATCTTGATGAGATTTATACTGTAGGCCCTATTTCAGTAAGATCTGCATGTTCACATCATT
TGGTCCCAATTCTTGGGGAGTGTTGGATAGGCATTAAACCTGGGAATAAAGTTATAGGGCTCTCAAAATTTGCAAGAGTC
GCTGATTGGGTTTTTTCAAGACCTCATATTCAAGAAGAAGCTGTAATGATACTCGCAGATGAAATTGAAAAATTGTGTGA
ACCTAAAGGTTTAGGTATTATTGTGAAGGCCCAACACTATTGTATGAAATGGAGGGGAGTTAAAGAACCAAATACAAGTA
TGATTAATTCTGTAGTAAGAGGCGACTTTAGGCATGACTTAAGTTTAAAACAAGAATTTTTTGAACTTGTAAAACAGCAA
TCTGCAACTAATAACTACTAA

Upstream 100 bases:

>100_bases
GAACCCGATTGAACAAGAGAATGTGATATAGTGTATAAGCAATTAAGCTTTTGGAAGATACAGTAAATTAAGTTGCATAC
AATTTTCTGTTTAAAATTTT

Downstream 100 bases:

>100_bases
TTCTTTTTTAAAAACTTAATTAGGGCCCCTGTTTTTTCTAGATCTTTCAAGCCTGGAGATATTTCAATACTGCTTGAAAT
GTCTAGTCCATCTGGTTTGA

Product: GTP cyclohydrolase

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MTSTLPNDNIRNFDDQITNKLISEIIRDRIKNSGTRFSANDNIADFINPGELEILEKEVASRVKDLLKSLVIDVENDHNT
QETAERVSKMYLNEVFKGRYHEQPKVTSFPNDKNLDEIYTVGPISVRSACSHHLVPILGECWIGIKPGNKVIGLSKFARV
ADWVFSRPHIQEEAVMILADEIEKLCEPKGLGIIVKAQHYCMKWRGVKEPNTSMINSVVRGDFRHDLSLKQEFFELVKQQ
SATNNY

Sequences:

>Translated_246_residues
MTSTLPNDNIRNFDDQITNKLISEIIRDRIKNSGTRFSANDNIADFINPGELEILEKEVASRVKDLLKSLVIDVENDHNT
QETAERVSKMYLNEVFKGRYHEQPKVTSFPNDKNLDEIYTVGPISVRSACSHHLVPILGECWIGIKPGNKVIGLSKFARV
ADWVFSRPHIQEEAVMILADEIEKLCEPKGLGIIVKAQHYCMKWRGVKEPNTSMINSVVRGDFRHDLSLKQEFFELVKQQ
SATNNY
>Mature_245_residues
TSTLPNDNIRNFDDQITNKLISEIIRDRIKNSGTRFSANDNIADFINPGELEILEKEVASRVKDLLKSLVIDVENDHNTQ
ETAERVSKMYLNEVFKGRYHEQPKVTSFPNDKNLDEIYTVGPISVRSACSHHLVPILGECWIGIKPGNKVIGLSKFARVA
DWVFSRPHIQEEAVMILADEIEKLCEPKGLGIIVKAQHYCMKWRGVKEPNTSMINSVVRGDFRHDLSLKQEFFELVKQQS
ATNNY

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=127, Percent_Identity=37.7952755905512, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4503949, Length=127, Percent_Identity=37.7952755905512, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI66932970, Length=86, Percent_Identity=38.3720930232558, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI66932972, Length=86, Percent_Identity=38.3720930232558, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1788476, Length=184, Percent_Identity=29.8913043478261, Blast_Score=109, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17560486, Length=178, Percent_Identity=33.1460674157303, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6321706, Length=188, Percent_Identity=31.3829787234043, Blast_Score=96, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24656782, Length=126, Percent_Identity=37.3015873015873, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24656796, Length=126, Percent_Identity=37.3015873015873, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24656791, Length=126, Percent_Identity=37.3015873015873, Blast_Score=89, Evalue=2e-18,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 28085; Mature: 27954

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSTLPNDNIRNFDDQITNKLISEIIRDRIKNSGTRFSANDNIADFINPGELEILEKEVA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHCCCCHHHHHHHHHH
SRVKDLLKSLVIDVENDHNTQETAERVSKMYLNEVFKGRYHEQPKVTSFPNDKNLDEIYT
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHEE
VGPISVRSACSHHLVPILGECWIGIKPGNKVIGLSKFARVADWVFSRPHIQEEAVMILAD
CCCHHHHHHHHHHHHHHHHCCEEEECCCCCEECHHHHHHHHHHHHCCCCCHHHHHHHHHH
EIEKLCEPKGLGIIVKAQHYCMKWRGVKEPNTSMINSVVRGDFRHDLSLKQEFFELVKQQ
HHHHHCCCCCCEEEEECHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SATNNY
HCCCCC
>Mature Secondary Structure 
TSTLPNDNIRNFDDQITNKLISEIIRDRIKNSGTRFSANDNIADFINPGELEILEKEVA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHCCCCHHHHHHHHHH
SRVKDLLKSLVIDVENDHNTQETAERVSKMYLNEVFKGRYHEQPKVTSFPNDKNLDEIYT
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHEE
VGPISVRSACSHHLVPILGECWIGIKPGNKVIGLSKFARVADWVFSRPHIQEEAVMILAD
CCCHHHHHHHHHHHHHHHHCCEEEECCCCCEECHHHHHHHHHHHHCCCCCHHHHHHHHHH
EIEKLCEPKGLGIIVKAQHYCMKWRGVKEPNTSMINSVVRGDFRHDLSLKQEFFELVKQQ
HHHHHCCCCCCEEEEECHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SATNNY
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA