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The map label for this gene is pyrE [H]

Identifier: 78778662

GI number: 78778662

Start: 265116

End: 265676

Strand: Direct

Name: pyrE [H]

Synonym: PMT9312_0277

Alternate gene names: 78778662

Gene position: 265116-265676 (Clockwise)

Preceding gene: 78778659

Following gene: 78778663

Centisome position: 15.51

GC content: 32.09

Gene sequence:

>561_bases
ATGGGCAATTTTTCTGATAAGTATGATTTAAATAAAGCAAAATTGTTAAAACAGTTAATTGAAAAATCTTATAAGAAAGG
AAACTTCACTTTAGCTTCAGGTAAAAAAAGCAGTCATTACTTGAACTGTAAACCGGTATCTTTAAATGGCGAAGGTCTAA
ACTTAATAAGTGATTTATTTTTAGAGTTAATTGACTCAAGGTCAAAAGCAGTGGCAGGAATGACATTAGGTGCAGATCCT
CTTGTAAGTGGATTAATCGTCTCAGCTGCTTCGCAAGGCCTATTCATTAATGGTTTAATAATTAGGAAAGAAATCAAAAA
TTATGGCACAAAAGCTGGAATAGAGGGCCCTTCGTTAGAAAAAGGAACTTTGGTAACTGTGTTAGAGGATGTAGTCACTA
CTGCTGGTTCAGTAATAAAGGCAATAAAAAAGTTACGTGAAAATAATTATGTTGTTAAGGAGGTTTTGTCTATTGTTGAT
AGACAAGAAGGAGGATATGAAGCTCTTGATGATGAAAATGTTAAATTAAAGAGTCTTTTTACAATAAACGACTTTTTATA
A

Upstream 100 bases:

>100_bases
ACAATATAAAAATAATATTTCAAAAAACACCTTATTAGGAAGTTTTTGTGAGATTTCTTTTTTTTCTTCTAATCTTTAAA
TATAAATTTAACTTTTACTA

Downstream 100 bases:

>100_bases
TTTTTTTTAAGATGCAAGATTTAGAAAAAAATTTTTGGCTTGAAACATTTGATTGTTTTTCTGTTTCTGGAAAAGATGCT
AAAAAATTTTTAAATGGAAT

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 186; Mature: 185

Protein sequence:

>186_residues
MGNFSDKYDLNKAKLLKQLIEKSYKKGNFTLASGKKSSHYLNCKPVSLNGEGLNLISDLFLELIDSRSKAVAGMTLGADP
LVSGLIVSAASQGLFINGLIIRKEIKNYGTKAGIEGPSLEKGTLVTVLEDVVTTAGSVIKAIKKLRENNYVVKEVLSIVD
RQEGGYEALDDENVKLKSLFTINDFL

Sequences:

>Translated_186_residues
MGNFSDKYDLNKAKLLKQLIEKSYKKGNFTLASGKKSSHYLNCKPVSLNGEGLNLISDLFLELIDSRSKAVAGMTLGADP
LVSGLIVSAASQGLFINGLIIRKEIKNYGTKAGIEGPSLEKGTLVTVLEDVVTTAGSVIKAIKKLRENNYVVKEVLSIVD
RQEGGYEALDDENVKLKSLFTINDFL
>Mature_185_residues
GNFSDKYDLNKAKLLKQLIEKSYKKGNFTLASGKKSSHYLNCKPVSLNGEGLNLISDLFLELIDSRSKAVAGMTLGADPL
VSGLIVSAASQGLFINGLIIRKEIKNYGTKAGIEGPSLEKGTLVTVLEDVVTTAGSVIKAIKKLRENNYVVKEVLSIVDR
QEGGYEALDDENVKLKSLFTINDFL

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=168, Percent_Identity=28.5714285714286, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17554964, Length=179, Percent_Identity=36.3128491620112, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17508631, Length=168, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17933654, Length=181, Percent_Identity=32.0441988950276, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031 [H]

Pfam domain/function: NA

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 20200; Mature: 20068

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNFSDKYDLNKAKLLKQLIEKSYKKGNFTLASGKKSSHYLNCKPVSLNGEGLNLISDLF
CCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEEEEECCCCHHHHHHHH
LELIDSRSKAVAGMTLGADPLVSGLIVSAASQGLFINGLIIRKEIKNYGTKAGIEGPSLE
HHHHHCHHHHHHCEECCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHCCCCCCCCCCCCC
KGTLVTVLEDVVTTAGSVIKAIKKLRENNYVVKEVLSIVDRQEGGYEALDDENVKLKSLF
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEE
TINDFL
EHHHCC
>Mature Secondary Structure 
GNFSDKYDLNKAKLLKQLIEKSYKKGNFTLASGKKSSHYLNCKPVSLNGEGLNLISDLF
CCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEEEEECCCCHHHHHHHH
LELIDSRSKAVAGMTLGADPLVSGLIVSAASQGLFINGLIIRKEIKNYGTKAGIEGPSLE
HHHHHCHHHHHHCEECCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHCCCCCCCCCCCCC
KGTLVTVLEDVVTTAGSVIKAIKKLRENNYVVKEVLSIVDRQEGGYEALDDENVKLKSLF
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEE
TINDFL
EHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA