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The map label for this gene is pth

Identifier: 78778637

GI number: 78778637

Start: 241734

End: 242336

Strand: Reverse

Name: pth

Synonym: PMT9312_0252

Alternate gene names: 78778637

Gene position: 242336-241734 (Counterclockwise)

Preceding gene: 78778638

Following gene: 78778636

Centisome position: 14.18

GC content: 27.36

Gene sequence:

>603_bases
ATGAATGAAATATATTTAATTGGGTTGGGTAATCCTGGCAAAAAATACTCAAACAGTAGACATAATATAGGATTTTTGCT
GCTTGAAAATTTATCGAAAAAATATAATTCAAGTTTTTTATTAAAGGATAAACTTAAAAGTTTCTACTCAGAATTCAAAG
CGAATGATTCCACTTACAGGTTGTTTTTGCCCAATACGTTTATGAATAACAGTGGTGAGGCTGTCCTAGCGATATTAGAT
TGGTACAAAATTAATTTAAATCAGATTTTTGTAATAGTAGATGATAAAGATCTTCCCCTTGGAAAAATAAGATTCAGAAA
AAAAGGGAGTTCAGGAGGACATAATGGTCTTAAAAGTATTATTGAAAAATTGCAAACTCATGACTTTAATAGAATAAGAA
TTGGTATTGGTTCTCCTCCATCAACTAAAGAAACCAATAATTTCAATACTATTTCTCATGTATTAGGAAACATTTCTAGA
GAGGAAAAATCAATATTGGATAAAGTATATGTCAGGGTAATAGAATCCCTTGAACAGTTAAATACTAAAAAAGAAGAATA
TATAATAAATAAATTAAATTCTTTTGATATAGAACAAATATAA

Upstream 100 bases:

>100_bases
ATTACTGGATAAATTTTTATTGGAATTTTTGTTTTAATTTCTAAGTATAGTTTGTTTATATATTAATAATTCTCAATGAA
AAGAGATTTAGAGTTACCTC

Downstream 100 bases:

>100_bases
CAAATGCGTTCAAAACCAGAAACAATAGCAAATGTAAGTGTTAAAGAATATTGCTTCTCAAAAAAACAAATTAAGGGAGT
TGTAGAAGCTAGTCAATTTA

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 200; Mature: 200

Protein sequence:

>200_residues
MNEIYLIGLGNPGKKYSNSRHNIGFLLLENLSKKYNSSFLLKDKLKSFYSEFKANDSTYRLFLPNTFMNNSGEAVLAILD
WYKINLNQIFVIVDDKDLPLGKIRFRKKGSSGGHNGLKSIIEKLQTHDFNRIRIGIGSPPSTKETNNFNTISHVLGNISR
EEKSILDKVYVRVIESLEQLNTKKEEYIINKLNSFDIEQI

Sequences:

>Translated_200_residues
MNEIYLIGLGNPGKKYSNSRHNIGFLLLENLSKKYNSSFLLKDKLKSFYSEFKANDSTYRLFLPNTFMNNSGEAVLAILD
WYKINLNQIFVIVDDKDLPLGKIRFRKKGSSGGHNGLKSIIEKLQTHDFNRIRIGIGSPPSTKETNNFNTISHVLGNISR
EEKSILDKVYVRVIESLEQLNTKKEEYIINKLNSFDIEQI
>Mature_200_residues
MNEIYLIGLGNPGKKYSNSRHNIGFLLLENLSKKYNSSFLLKDKLKSFYSEFKANDSTYRLFLPNTFMNNSGEAVLAILD
WYKINLNQIFVIVDDKDLPLGKIRFRKKGSSGGHNGLKSIIEKLQTHDFNRIRIGIGSPPSTKETNNFNTISHVLGNISR
EEKSILDKVYVRVIESLEQLNTKKEEYIINKLNSFDIEQI

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=173, Percent_Identity=27.1676300578035, Blast_Score=87, Evalue=1e-17,
Organism=Escherichia coli, GI1787455, Length=194, Percent_Identity=34.020618556701, Blast_Score=100, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6321983, Length=171, Percent_Identity=29.2397660818713, Blast_Score=68, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_PROM9 (Q31CT2)

Other databases:

- EMBL:   CP000111
- RefSeq:   YP_396749.1
- ProteinModelPortal:   Q31CT2
- SMR:   Q31CT2
- STRING:   Q31CT2
- GeneID:   3765038
- GenomeReviews:   CP000111_GR
- KEGG:   pmi:PMT9312_0252
- eggNOG:   COG0193
- HOGENOM:   HBG610927
- OMA:   AMHRLHS
- ProtClustDB:   PRK05426
- BioCyc:   PMAR74546:PMT9312_0252-MONOMER
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 22980; Mature: 22980

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEIYLIGLGNPGKKYSNSRHNIGFLLLENLSKKYNSSFLLKDKLKSFYSEFKANDSTYR
CCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEHHHHHHHHHHHHCCCCCEEE
LFLPNTFMNNSGEAVLAILDWYKINLNQIFVIVDDKDLPLGKIRFRKKGSSGGHNGLKSI
EEECCHHCCCCCCEEEEEEEEEEECCEEEEEEECCCCCCCCCEEEEECCCCCCHHHHHHH
IEKLQTHDFNRIRIGIGSPPSTKETNNFNTISHVLGNISREEKSILDKVYVRVIESLEQL
HHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
NTKKEEYIINKLNSFDIEQI
CCHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNEIYLIGLGNPGKKYSNSRHNIGFLLLENLSKKYNSSFLLKDKLKSFYSEFKANDSTYR
CCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEHHHHHHHHHHHHCCCCCEEE
LFLPNTFMNNSGEAVLAILDWYKINLNQIFVIVDDKDLPLGKIRFRKKGSSGGHNGLKSI
EEECCHHCCCCCCEEEEEEEEEEECCEEEEEEECCCCCCCCCEEEEECCCCCCHHHHHHH
IEKLQTHDFNRIRIGIGSPPSTKETNNFNTISHVLGNISREEKSILDKVYVRVIESLEQL
HHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
NTKKEEYIINKLNSFDIEQI
CCHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA