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The map label for this gene is coaBC [H]

Identifier: 78778617

GI number: 78778617

Start: 224709

End: 225965

Strand: Reverse

Name: coaBC [H]

Synonym: PMT9312_0231

Alternate gene names: 78778617

Gene position: 225965-224709 (Counterclockwise)

Preceding gene: 78778618

Following gene: 78778616

Centisome position: 13.22

GC content: 30.39

Gene sequence:

>1257_bases
ATGAAAACTAAAAGTACAGACTCCAAAATAAAGGTTCTTTTATTAATAACGGGGAGTATTGCAGCTGTAAGAATTCCATT
ATTAGTTAGCCAATTAGCAAAAGAAAATTATGAAATAAGGTGCGTTTTATCTAAAAATGCAGAAAAATTAATAAAACCGC
TTTCTCTTTCTATCTTAAGTAGAAACCCTTGCATTTTAGAAAATGATCAATGGTTAAATAGTCAATCAACACCTCTTCAT
ATAGAACTAACCAAATGGGCTGATATTTTAATCATTGCCCCTTTAACAGCTACAACATTATCAAAATGGGTAACTGGAAA
TGCAGAAGGATTGATTCCAAGCATATTAATTGCAAATATTAAGCCAATTGTTGTTGCACCAGCAATGAATACACAAATGT
GGCTAAATAAAGCTGTCCAAGAAAATTATGAGAATTTACAGAATTACGAAAATGTTTTGTCTTTGCATCCAAGTGAAGGT
CTCTTAGCATGCGATGCTATTGGCATAGGTAAGATACCTCCAAATGATCTAATTCAATTAGCTCTTGAATTTATAACTTC
ACATAATCAAAATATTTATCGCAAAGATTTACTAAACAAAGAAATTTTAATAACTGGAGGTTGTACCTCAGAAAAAATTG
ACGCAGCAAGAAATATTACTAACAAAAGTTCTGGAGCTATGGGCTTACTTCTTTCTCAAGTAGCAAGGTTCAGAGGAGCA
CAAGTAAAATATATCCATGGGCCTCTGAAAATTGATAAAGATCTTACTGATGGAATAAAAAGATATGAAATCGAGACAAG
TGTTGATTTAATTAGGTCACTTCAAAATGAAATTTCAAATTGTGATTATTTTTTCATGAATGCAGCAGTATCTGATTTCA
AGATAACCTCTGATACTTCTGCTAAAATTCCCAAACATAAAATTAATGATCATTTGAATAAAAATTTTGAGCTAGTGCCA
GATATTTTAAAAACAATAAGTGAATCAAAAAAAGATAACCAAGTTTTTGTAGGCTTTTGCGCTTTTACAGGATCTATTGG
AGAAGCAAGAACAATAATTAAAAAAAAGATTATTCAAAAAGGTTGCGATTATCTATTCGCAAATCCAATTGATCTTGAAG
GGCAAGGATTTGGCTTTTTGGCGCAAAATGAAGGTTGGCTATTCGATACAAAAAATATGGAACATCATATACATAAAACA
TCAAAAATTGATTTAGCAAATAAATTAATCACTCAAATTATTTCAGTAAAAAATTAA

Upstream 100 bases:

>100_bases
TTTGATGGTTTAAAAGACTGGCACTTACTGAGGGCCCTTGCAATCAATAGACCTGAATTAACAACTGATTATATCCATCT
ACTCGATCAGGAACCTTTCG

Downstream 100 bases:

>100_bases
AAAAAAATTTCTAATTTGTATTTTTTTGTAATCTTAATCATTAAAAATAATGTGATAGCTTACAATAATTCCAGTTTTTA
AAAATCTCAAAAAACTACGG

Product: phosphopantothenate-cysteine ligase / phosphopantothenoylcysteine decarboxylase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MKTKSTDSKIKVLLLITGSIAAVRIPLLVSQLAKENYEIRCVLSKNAEKLIKPLSLSILSRNPCILENDQWLNSQSTPLH
IELTKWADILIIAPLTATTLSKWVTGNAEGLIPSILIANIKPIVVAPAMNTQMWLNKAVQENYENLQNYENVLSLHPSEG
LLACDAIGIGKIPPNDLIQLALEFITSHNQNIYRKDLLNKEILITGGCTSEKIDAARNITNKSSGAMGLLLSQVARFRGA
QVKYIHGPLKIDKDLTDGIKRYEIETSVDLIRSLQNEISNCDYFFMNAAVSDFKITSDTSAKIPKHKINDHLNKNFELVP
DILKTISESKKDNQVFVGFCAFTGSIGEARTIIKKKIIQKGCDYLFANPIDLEGQGFGFLAQNEGWLFDTKNMEHHIHKT
SKIDLANKLITQIISVKN

Sequences:

>Translated_418_residues
MKTKSTDSKIKVLLLITGSIAAVRIPLLVSQLAKENYEIRCVLSKNAEKLIKPLSLSILSRNPCILENDQWLNSQSTPLH
IELTKWADILIIAPLTATTLSKWVTGNAEGLIPSILIANIKPIVVAPAMNTQMWLNKAVQENYENLQNYENVLSLHPSEG
LLACDAIGIGKIPPNDLIQLALEFITSHNQNIYRKDLLNKEILITGGCTSEKIDAARNITNKSSGAMGLLLSQVARFRGA
QVKYIHGPLKIDKDLTDGIKRYEIETSVDLIRSLQNEISNCDYFFMNAAVSDFKITSDTSAKIPKHKINDHLNKNFELVP
DILKTISESKKDNQVFVGFCAFTGSIGEARTIIKKKIIQKGCDYLFANPIDLEGQGFGFLAQNEGWLFDTKNMEHHIHKT
SKIDLANKLITQIISVKN
>Mature_418_residues
MKTKSTDSKIKVLLLITGSIAAVRIPLLVSQLAKENYEIRCVLSKNAEKLIKPLSLSILSRNPCILENDQWLNSQSTPLH
IELTKWADILIIAPLTATTLSKWVTGNAEGLIPSILIANIKPIVVAPAMNTQMWLNKAVQENYENLQNYENVLSLHPSEG
LLACDAIGIGKIPPNDLIQLALEFITSHNQNIYRKDLLNKEILITGGCTSEKIDAARNITNKSSGAMGLLLSQVARFRGA
QVKYIHGPLKIDKDLTDGIKRYEIETSVDLIRSLQNEISNCDYFFMNAAVSDFKITSDTSAKIPKHKINDHLNKNFELVP
DILKTISESKKDNQVFVGFCAFTGSIGEARTIIKKKIIQKGCDYLFANPIDLEGQGFGFLAQNEGWLFDTKNMEHHIHKT
SKIDLANKLITQIISVKN

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=152, Percent_Identity=34.2105263157895, Blast_Score=87, Evalue=4e-17,
Organism=Escherichia coli, GI87082301, Length=371, Percent_Identity=32.0754716981132, Blast_Score=168, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17560194, Length=179, Percent_Identity=32.9608938547486, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322762, Length=184, Percent_Identity=35.3260869565217, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24657262, Length=148, Percent_Identity=32.4324324324324, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 46535; Mature: 46535

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTKSTDSKIKVLLLITGSIAAVRIPLLVSQLAKENYEIRCVLSKNAEKLIKPLSLSILS
CCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHEEC
RNPCILENDQWLNSQSTPLHIELTKWADILIIAPLTATTLSKWVTGNAEGLIPSILIANI
CCCEEECCCCCCCCCCCEEEEEEECCCCEEEECCCHHHHHHHHHCCCCCCCHHHHHHHCC
KPIVVAPAMNTQMWLNKAVQENYENLQNYENVLSLHPSEGLLACDAIGIGKIPPNDLIQL
CCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEECCCCCCCCCHHHHHHH
ALEFITSHNQNIYRKDLLNKEILITGGCTSEKIDAARNITNKSSGAMGLLLSQVARFRGA
HHHHHHCCCCCHHHHHHCCCEEEEECCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHCCC
QVKYIHGPLKIDKDLTDGIKRYEIETSVDLIRSLQNEISNCDYFFMNAAVSDFKITSDTS
EEEEEECCEEECCHHHCCHHHEEHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCC
AKIPKHKINDHLNKNFELVPDILKTISESKKDNQVFVGFCAFTGSIGEARTIIKKKIIQK
CCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHH
GCDYLFANPIDLEGQGFGFLAQNEGWLFDTKNMEHHIHKTSKIDLANKLITQIISVKN
CCCEEECCCCCCCCCCCEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKTKSTDSKIKVLLLITGSIAAVRIPLLVSQLAKENYEIRCVLSKNAEKLIKPLSLSILS
CCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHEEC
RNPCILENDQWLNSQSTPLHIELTKWADILIIAPLTATTLSKWVTGNAEGLIPSILIANI
CCCEEECCCCCCCCCCCEEEEEEECCCCEEEECCCHHHHHHHHHCCCCCCCHHHHHHHCC
KPIVVAPAMNTQMWLNKAVQENYENLQNYENVLSLHPSEGLLACDAIGIGKIPPNDLIQL
CCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEECCCCCCCCCHHHHHHH
ALEFITSHNQNIYRKDLLNKEILITGGCTSEKIDAARNITNKSSGAMGLLLSQVARFRGA
HHHHHHCCCCCHHHHHHCCCEEEEECCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHCCC
QVKYIHGPLKIDKDLTDGIKRYEIETSVDLIRSLQNEISNCDYFFMNAAVSDFKITSDTS
EEEEEECCEEECCHHHCCHHHEEHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCC
AKIPKHKINDHLNKNFELVPDILKTISESKKDNQVFVGFCAFTGSIGEARTIIKKKIIQK
CCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHH
GCDYLFANPIDLEGQGFGFLAQNEGWLFDTKNMEHHIHKTSKIDLANKLITQIISVKN
CCCEEECCCCCCCCCCCEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]