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The map label for this gene is hemB [H]

Identifier: 78778603

GI number: 78778603

Start: 209697

End: 210698

Strand: Direct

Name: hemB [H]

Synonym: PMT9312_0217

Alternate gene names: 78778603

Gene position: 209697-210698 (Clockwise)

Preceding gene: 78778599

Following gene: 78778604

Centisome position: 12.27

GC content: 34.73

Gene sequence:

>1002_bases
ATGAATTCGATTATTCGCCCAAGAAGATTAAGAAGGACTGAGGCAATTAGAGAAATGGTAAGAGAAAACCATCTAAAGGC
TTCGGACTTTATATATCCATTATTTATTCATGAAAAAGATTTTAAAGAGGAAATTTCGGCAATGCCGGGAACTTTTAGAT
GGGATATGAATGGCTTAATAAAGGAGGTTACTAGGGCATGGGAATTAGGAATAAGGTGTGTGGTCCTTTTCCCAAAAATA
AACGATAGCTTAAAGACTGAAGATGGATCAGAGTGTTTTAATGAAGACGGTTTAATACCTAAAGCTATTCGAATATTAAA
AAAAGAGATTCCAGAAATGGCAATAATGACAGATGTTGCCTTGGACCCATACTCGTGTGATGGACATGATGGATTAGTTG
ATGAAACTGGAAAAATATTGAATGATGAAACAATCGAAGTTTTAACAAAACAAGCCTTAACACAAGCTAGAGCTGGAGCA
GATTTTATTGGCCCTAGTGACATGATGGATGGGAGAGTTGGAGCAATAAGAACTGCTCTTGATAGTCAAGGATTTAGTGA
TATAGGTATTATTAGTTATACAGCAAAATATTCATCTGCTTATTATGGTCCATTTAGAACTGCTTTAGATTCGGCTCCTA
GAGAAAATAGTAAAAAAATAATTCCAGATAATAAGTCTACATATCAAATGGATCCCGCCAATTCAAAAGAGGCTTTAATT
GAATCTGCATTAGATCAGTATGAAGGAGCTGATATTTTAATGGTAAAACCAGGAATTGCATATTTGGATATTGTTTATAG
ACTAAGCACTTTTTCAAATAAACCCATAGCTGCATATAACGTTAGTGGGGAGTATTCCATGGTCAAGTCTGCTGCTATGA
AGAACTGGATTAATGAAAAAGATATTGTTTTAGAAACGTTGCTTAGTTTTAAAAGAGCAGGAGCAAAATTAATACTCACT
TATCATGCTTGTGATGCATCTCAATGGTTGCAGGATACTTAA

Upstream 100 bases:

>100_bases
AAGTTAATTTTCCTCAACAAAAGGAGTCTCTGATTGATTTATGTGCGAGGCAAGCGACTAATGTATTAGATAAATATTTT
TCAACTTAAAAAATATTCAA

Downstream 100 bases:

>100_bases
AAACTCATTAATTAACAAAAATTTGGTTTATTCTTAGATTAATAATAAATTCACTGCTTTGTTTTGAAGTTTTCACAAGG
AGTAAATAGGATTGGTCACA

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MNSIIRPRRLRRTEAIREMVRENHLKASDFIYPLFIHEKDFKEEISAMPGTFRWDMNGLIKEVTRAWELGIRCVVLFPKI
NDSLKTEDGSECFNEDGLIPKAIRILKKEIPEMAIMTDVALDPYSCDGHDGLVDETGKILNDETIEVLTKQALTQARAGA
DFIGPSDMMDGRVGAIRTALDSQGFSDIGIISYTAKYSSAYYGPFRTALDSAPRENSKKIIPDNKSTYQMDPANSKEALI
ESALDQYEGADILMVKPGIAYLDIVYRLSTFSNKPIAAYNVSGEYSMVKSAAMKNWINEKDIVLETLLSFKRAGAKLILT
YHACDASQWLQDT

Sequences:

>Translated_333_residues
MNSIIRPRRLRRTEAIREMVRENHLKASDFIYPLFIHEKDFKEEISAMPGTFRWDMNGLIKEVTRAWELGIRCVVLFPKI
NDSLKTEDGSECFNEDGLIPKAIRILKKEIPEMAIMTDVALDPYSCDGHDGLVDETGKILNDETIEVLTKQALTQARAGA
DFIGPSDMMDGRVGAIRTALDSQGFSDIGIISYTAKYSSAYYGPFRTALDSAPRENSKKIIPDNKSTYQMDPANSKEALI
ESALDQYEGADILMVKPGIAYLDIVYRLSTFSNKPIAAYNVSGEYSMVKSAAMKNWINEKDIVLETLLSFKRAGAKLILT
YHACDASQWLQDT
>Mature_333_residues
MNSIIRPRRLRRTEAIREMVRENHLKASDFIYPLFIHEKDFKEEISAMPGTFRWDMNGLIKEVTRAWELGIRCVVLFPKI
NDSLKTEDGSECFNEDGLIPKAIRILKKEIPEMAIMTDVALDPYSCDGHDGLVDETGKILNDETIEVLTKQALTQARAGA
DFIGPSDMMDGRVGAIRTALDSQGFSDIGIISYTAKYSSAYYGPFRTALDSAPRENSKKIIPDNKSTYQMDPANSKEALI
ESALDQYEGADILMVKPGIAYLDIVYRLSTFSNKPIAAYNVSGEYSMVKSAAMKNWINEKDIVLETLLSFKRAGAKLILT
YHACDASQWLQDT

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=311, Percent_Identity=38.2636655948553, Blast_Score=214, Evalue=9e-56,
Organism=Escherichia coli, GI87081728, Length=327, Percent_Identity=46.177370030581, Blast_Score=269, Evalue=1e-73,
Organism=Saccharomyces cerevisiae, GI6321398, Length=323, Percent_Identity=35.6037151702786, Blast_Score=172, Evalue=5e-44,
Organism=Drosophila melanogaster, GI21358291, Length=296, Percent_Identity=35.8108108108108, Blast_Score=183, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 37377; Mature: 37377

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSIIRPRRLRRTEAIREMVRENHLKASDFIYPLFIHEKDFKEEISAMPGTFRWDMNGLI
CCCCCCHHHHHHHHHHHHHHHHCCCCHHHCEEEEEEECHHHHHHHHCCCCCEEECHHHHH
KEVTRAWELGIRCVVLFPKINDSLKTEDGSECFNEDGLIPKAIRILKKEIPEMAIMTDVA
HHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHC
LDPYSCDGHDGLVDETGKILNDETIEVLTKQALTQARAGADFIGPSDMMDGRVGAIRTAL
CCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHH
DSQGFSDIGIISYTAKYSSAYYGPFRTALDSAPRENSKKIIPDNKSTYQMDPANSKEALI
HCCCCCCCEEEEEEHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCHHHHH
ESALDQYEGADILMVKPGIAYLDIVYRLSTFSNKPIAAYNVSGEYSMVKSAAMKNWINEK
HHHHHHHCCCCEEEECCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCHH
DIVLETLLSFKRAGAKLILTYHACDASQWLQDT
HHHHHHHHHHHHCCCEEEEEEECCCHHHHHCCC
>Mature Secondary Structure
MNSIIRPRRLRRTEAIREMVRENHLKASDFIYPLFIHEKDFKEEISAMPGTFRWDMNGLI
CCCCCCHHHHHHHHHHHHHHHHCCCCHHHCEEEEEEECHHHHHHHHCCCCCEEECHHHHH
KEVTRAWELGIRCVVLFPKINDSLKTEDGSECFNEDGLIPKAIRILKKEIPEMAIMTDVA
HHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHC
LDPYSCDGHDGLVDETGKILNDETIEVLTKQALTQARAGADFIGPSDMMDGRVGAIRTAL
CCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHH
DSQGFSDIGIISYTAKYSSAYYGPFRTALDSAPRENSKKIIPDNKSTYQMDPANSKEALI
HCCCCCCCEEEEEEHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCHHHHH
ESALDQYEGADILMVKPGIAYLDIVYRLSTFSNKPIAAYNVSGEYSMVKSAAMKNWINEK
HHHHHHHCCCCEEEECCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCHH
DIVLETLLSFKRAGAKLILTYHACDASQWLQDT
HHHHHHHHHHHHCCCEEEEEEECCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8626508 [H]