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The map label for this gene is hemD [H]

Identifier: 78778502

GI number: 78778502

Start: 115259

End: 116056

Strand: Direct

Name: hemD [H]

Synonym: PMT9312_0116

Alternate gene names: 78778502

Gene position: 115259-116056 (Clockwise)

Preceding gene: 78778501

Following gene: 78778505

Centisome position: 6.74

GC content: 33.21

Gene sequence:

>798_bases
ATGCCAATAGTTGATCGACCCCTTGATCAAAGAAATATAATTATCACTCGATCAAAAGAGGGGATATTGGATATCAAAAA
GATATTCACAAGCAAAGGCGCTAATATATATGAGTTTCCTGCAATAAGTATTGGAGATCCTGATGATTTAGATCCTCTTG
ACGAAGCGTTAAATCAAATAAATGATTTTCATTGGATTATTTTTTCTAGTAGTAATGGGATCAAATTTGTTGATAAAAGA
CTTAGATATTTTCAAAGTTCATTAAAGGAGTGTTCTAAAAAAACAAAAATCGCTGTAGTCGGAGAAAAAACTGCACAAAC
TCTTGATGATTTTGGGATTAAGGCTGATTTCATACCCCCAGAATATGTTGCCGAAAGTTTAATTGATAATTTTCCAATAT
CTGGATATGGACTTCGAGTATTTTTGCCAAGAGTCCAAACAGGAGGAAGGGATCTAATTGCAGATCAATTTAGAAAGGCT
GGTTCGCGTGTATTTGAGGTTGCTGCGTATGAAACTAGATGTCCGGATTCAATCCCAGAAGAGACAATTGATATTATTGT
TAATCGAAAAGTCGATGCATTTATTTTCTCAAGTGGCAAAACTGTATCAAATTCTGCTGTTTTACTAGAAAAAGCCTTTG
GTAAAGAATGGTTAAAATATTTAGATCAAACTAGGTTCTTAACTATTGGACCTCAAACAACAAAAATATGTAAAAAGATT
TTTGGCAGAGTTGATAGTCAGGCACAAAAATATACTTTTGATGGACTACTGGATGTAGCAATTAGTATTTTTAGTTAG

Upstream 100 bases:

>100_bases
ATTTTTAAAGAAGATATTGTTCTTGACAAAGGATTATCAGTCTTGAAACTTCTTGATGAATTAAAAAATAAACATCAAGA
CAAGAATTATGAGGATAAGG

Downstream 100 bases:

>100_bases
AAAAATCTTTTTTATAATTCTTTTCCACTAATTCTTTAAATCTATCAATATTAGCCTGTAATTCGTTAGTGACCATTTTG
CCTAAAATATTCTCTTCCAT

Product: putative uroporphyrinogen III synthase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MPIVDRPLDQRNIIITRSKEGILDIKKIFTSKGANIYEFPAISIGDPDDLDPLDEALNQINDFHWIIFSSSNGIKFVDKR
LRYFQSSLKECSKKTKIAVVGEKTAQTLDDFGIKADFIPPEYVAESLIDNFPISGYGLRVFLPRVQTGGRDLIADQFRKA
GSRVFEVAAYETRCPDSIPEETIDIIVNRKVDAFIFSSGKTVSNSAVLLEKAFGKEWLKYLDQTRFLTIGPQTTKICKKI
FGRVDSQAQKYTFDGLLDVAISIFS

Sequences:

>Translated_265_residues
MPIVDRPLDQRNIIITRSKEGILDIKKIFTSKGANIYEFPAISIGDPDDLDPLDEALNQINDFHWIIFSSSNGIKFVDKR
LRYFQSSLKECSKKTKIAVVGEKTAQTLDDFGIKADFIPPEYVAESLIDNFPISGYGLRVFLPRVQTGGRDLIADQFRKA
GSRVFEVAAYETRCPDSIPEETIDIIVNRKVDAFIFSSGKTVSNSAVLLEKAFGKEWLKYLDQTRFLTIGPQTTKICKKI
FGRVDSQAQKYTFDGLLDVAISIFS
>Mature_264_residues
PIVDRPLDQRNIIITRSKEGILDIKKIFTSKGANIYEFPAISIGDPDDLDPLDEALNQINDFHWIIFSSSNGIKFVDKRL
RYFQSSLKECSKKTKIAVVGEKTAQTLDDFGIKADFIPPEYVAESLIDNFPISGYGLRVFLPRVQTGGRDLIADQFRKAG
SRVFEVAAYETRCPDSIPEETIDIIVNRKVDAFIFSSGKTVSNSAVLLEKAFGKEWLKYLDQTRFLTIGPQTTKICKKIF
GRVDSQAQKYTFDGLLDVAISIFS

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 29837; Mature: 29706

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIVDRPLDQRNIIITRSKEGILDIKKIFTSKGANIYEFPAISIGDPDDLDPLDEALNQI
CCCCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCEEECCEEECCCCCCCCHHHHHHHHC
NDFHWIIFSSSNGIKFVDKRLRYFQSSLKECSKKTKIAVVGEKTAQTLDDFGIKADFIPP
CCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCEEEEEECHHHHHHHHCCCEECCCCH
EYVAESLIDNFPISGYGLRVFLPRVQTGGRDLIADQFRKAGSRVFEVAAYETRCPDSIPE
HHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
ETIDIIVNRKVDAFIFSSGKTVSNSAVLLEKAFGKEWLKYLDQTRFLTIGPQTTKICKKI
HHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHH
FGRVDSQAQKYTFDGLLDVAISIFS
HHHCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PIVDRPLDQRNIIITRSKEGILDIKKIFTSKGANIYEFPAISIGDPDDLDPLDEALNQI
CCCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCEEECCEEECCCCCCCCHHHHHHHHC
NDFHWIIFSSSNGIKFVDKRLRYFQSSLKECSKKTKIAVVGEKTAQTLDDFGIKADFIPP
CCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCEEEEEECHHHHHHHHCCCEECCCCH
EYVAESLIDNFPISGYGLRVFLPRVQTGGRDLIADQFRKAGSRVFEVAAYETRCPDSIPE
HHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
ETIDIIVNRKVDAFIFSSGKTVSNSAVLLEKAFGKEWLKYLDQTRFLTIGPQTTKICKKI
HHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHH
FGRVDSQAQKYTFDGLLDVAISIFS
HHHCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8123787 [H]