Click here to switch to the map view.

The map label for this gene is ndk

Identifier: 78778432

GI number: 78778432

Start: 50772

End: 51230

Strand: Direct

Name: ndk

Synonym: PMT9312_0047

Alternate gene names: 78778432

Gene position: 50772-51230 (Clockwise)

Preceding gene: 78778430

Following gene: 78778434

Centisome position: 2.97

GC content: 35.73

Gene sequence:

>459_bases
ATGACCAAAGAGAGAACCTTTATTGCAATTAAACCAGATGGAGTTCAAAGGGGATATGTTTCTGAGATTATTGGCAGATT
TGAAAAAAAAGGATTTAAATTGGTTGGTTTAAAGCAATTAATTCCCTCAAAAGATCTTGCTCAAAATCATTATGGAGTAC
ATAGAGAAAGACCCTTTTTTGGTGATTTAGTAGACTTTATTTCAAGTGGGCCTGTTGTAGCAATGGTGTGGGAAGGCGAA
GGAGTTATTTTGAGTGCTAGAAAACTAATAGGTGCAACAAAACCTCTGGAAGCAGAGCCTGGAACAATTAGAGGTGATTT
AGCTATTGATATTGGGAGGAATATTATTCATGGTTCTGATGGAGAAGATACAGCAAAATTTGAAATTGATCTATGGTTTA
ACGAAGAGGAATTATGTGAGTGGTACACTTCTGATTCGAAATGGCGATCTGAAAATTAA

Upstream 100 bases:

>100_bases
ATGTTTTTGAAAATAACTCAAAACAATATCTTTTATTTTAATGATTACTTGCCAAGTTACCACCCAAAAGTTGAATATAC
ATAGAGTGATTATTAACTAA

Downstream 100 bases:

>100_bases
AATTTAAATCGCAAATCTATCTAAACTAAATTTTTCTAAAAAGCTTTTTTCTATTTCTTTGAGATTTTTATTTTGAACTA
TTTTCAAAAGAAGATCACTT

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 152; Mature: 151

Protein sequence:

>152_residues
MTKERTFIAIKPDGVQRGYVSEIIGRFEKKGFKLVGLKQLIPSKDLAQNHYGVHRERPFFGDLVDFISSGPVVAMVWEGE
GVILSARKLIGATKPLEAEPGTIRGDLAIDIGRNIIHGSDGEDTAKFEIDLWFNEEELCEWYTSDSKWRSEN

Sequences:

>Translated_152_residues
MTKERTFIAIKPDGVQRGYVSEIIGRFEKKGFKLVGLKQLIPSKDLAQNHYGVHRERPFFGDLVDFISSGPVVAMVWEGE
GVILSARKLIGATKPLEAEPGTIRGDLAIDIGRNIIHGSDGEDTAKFEIDLWFNEEELCEWYTSDSKWRSEN
>Mature_151_residues
TKERTFIAIKPDGVQRGYVSEIIGRFEKKGFKLVGLKQLIPSKDLAQNHYGVHRERPFFGDLVDFISSGPVVAMVWEGEG
VILSARKLIGATKPLEAEPGTIRGDLAIDIGRNIIHGSDGEDTAKFEIDLWFNEEELCEWYTSDSKWRSEN

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI37693993, Length=148, Percent_Identity=56.7567567567568, Blast_Score=178, Evalue=1e-45,
Organism=Homo sapiens, GI38045913, Length=148, Percent_Identity=57.4324324324324, Blast_Score=177, Evalue=4e-45,
Organism=Homo sapiens, GI4557797, Length=148, Percent_Identity=57.4324324324324, Blast_Score=177, Evalue=4e-45,
Organism=Homo sapiens, GI66392203, Length=148, Percent_Identity=55.4054054054054, Blast_Score=169, Evalue=9e-43,
Organism=Homo sapiens, GI66392227, Length=148, Percent_Identity=55.4054054054054, Blast_Score=169, Evalue=1e-42,
Organism=Homo sapiens, GI66392205, Length=148, Percent_Identity=55.4054054054054, Blast_Score=169, Evalue=1e-42,
Organism=Homo sapiens, GI4505409, Length=148, Percent_Identity=55.4054054054054, Blast_Score=169, Evalue=1e-42,
Organism=Homo sapiens, GI66392192, Length=148, Percent_Identity=55.4054054054054, Blast_Score=169, Evalue=1e-42,
Organism=Homo sapiens, GI4826862, Length=140, Percent_Identity=51.4285714285714, Blast_Score=157, Evalue=2e-39,
Organism=Homo sapiens, GI7019465, Length=134, Percent_Identity=33.5820895522388, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI37574614, Length=134, Percent_Identity=33.5820895522388, Blast_Score=75, Evalue=1e-14,
Organism=Homo sapiens, GI5031951, Length=141, Percent_Identity=31.9148936170213, Blast_Score=70, Evalue=6e-13,
Organism=Escherichia coli, GI1788866, Length=139, Percent_Identity=43.8848920863309, Blast_Score=120, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17506807, Length=138, Percent_Identity=55.7971014492754, Blast_Score=166, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17507605, Length=87, Percent_Identity=41.3793103448276, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322783, Length=145, Percent_Identity=55.1724137931034, Blast_Score=179, Evalue=2e-46,
Organism=Drosophila melanogaster, GI45549037, Length=150, Percent_Identity=56.6666666666667, Blast_Score=178, Evalue=1e-45,
Organism=Drosophila melanogaster, GI18860097, Length=135, Percent_Identity=32.5925925925926, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 17127; Mature: 16995

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKERTFIAIKPDGVQRGYVSEIIGRFEKKGFKLVGLKQLIPSKDLAQNHYGVHRERPFF
CCCCCEEEEECCCCCCCCHHHHHHHHHHHCCEEEECHHHHCCCCCHHHCCCCCCCCCCCH
GDLVDFISSGPVVAMVWEGEGVILSARKLIGATKPLEAEPGTIRGDLAIDIGRNIIHGSD
HHHHHHHCCCCEEEEEECCCCEEEECHHHHCCCCCCCCCCCEEECEEEEECCCCEEECCC
GEDTAKFEIDLWFNEEELCEWYTSDSKWRSEN
CCCEEEEEEEEEECHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TKERTFIAIKPDGVQRGYVSEIIGRFEKKGFKLVGLKQLIPSKDLAQNHYGVHRERPFF
CCCCEEEEECCCCCCCCHHHHHHHHHHHCCEEEECHHHHCCCCCHHHCCCCCCCCCCCH
GDLVDFISSGPVVAMVWEGEGVILSARKLIGATKPLEAEPGTIRGDLAIDIGRNIIHGSD
HHHHHHHCCCCEEEEEECCCCEEEECHHHHCCCCCCCCCCCEEECEEEEECCCCEEECCC
GEDTAKFEIDLWFNEEELCEWYTSDSKWRSEN
CCCEEEEEEEEEECHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA