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The map label for this gene is argH

Identifier: 78778397

GI number: 78778397

Start: 14583

End: 15962

Strand: Direct

Name: argH

Synonym: PMT9312_0012

Alternate gene names: 78778397

Gene position: 14583-15962 (Clockwise)

Preceding gene: 78778396

Following gene: 78778398

Centisome position: 0.85

GC content: 32.17

Gene sequence:

>1380_bases
ATGGCAAAAGTTTGGAGTAAAAGATTCGATAATACACTTAACCCTTTCATTGAAAAGTTTAACGCTTCTATTAGTTTTGA
TAAAAAGCTTATTTTAGAAGATTTAGAGTGCTCAATTGCCCATGCAAAAATGCTTGGTAAGACAAAAGTATTATCCTCTT
CTGAAACTTTGCTTATTATTAATGGGCTAGAGAAAATAAAAGTTGAGTATCTGGAAGATAAATTTTCTCCAAGCCTCCCT
TCCGAAGATATTCACTATTGTATTGAAGAAAAATTAATTAGTTTAATTGGTGAAACTGGAAAAAAATTACATACAGGTAG
AAGCAGAAATGATCAAGTTGGTACAGATTTACGATTGTGGCTCAGAAAGGAGATAGACAATCTTGAAATTTTAATAACTG
ATTTGCAAAAATCTTTCTTAAATCTTGCGAAATCTAATATTCATACCTTAATTCCTGGATATACACATATGCAAAGAGCC
CAACCATTATCTTTAGCTCATCATTTATTAGCTTATCTAGAAATGTTCCAAAGAGACCGTGAAAGGTTTCAAGAAGTAAG
ATCACGAGTGAATATTTCCCCATTAGGAGCTGCAGCATTAGCTGGTACAAAAATAAAAATAGATAGGAACTTTACAGCTG
AAGAATTGGGTTTTGACAAGATTTATAAAAATAGTATTGATGCTGTGAGTGATAGGGATTTTTGTATAGAGTTTGTTTCT
GCATCTGCTTTGGCAATGTCTCATTTGAGTAAAATATCGGAGGAAATAATTTTATGGGTAACAGATGAATTTTCTTTTGC
CAAATTAACAGACAAATGTGCGACGGGTAGTAGTTTAATGCCGCAGAAAAAAAATCCAGATGTTCCAGAATTGATAAGAG
GTAAAACGGGAAGAGTTTATGGAAATCTCCAAGCATTATTAACGATGGTTAAAGGTGTACCACTTGCATATAATAAGGAT
TTTCAAGAGGATAAAGAGCCAATATTTGATACTGCAGAGACTATATCTTCTTCCATTAAAGCAATGACTATTTTAATTAC
TGAGGGCATAGAATTTAATATTAAAAATTTATCTGAATCGGTACAAAATGACTTCTCTAATGCCACTGATTTGGCAGATT
ACTTAGTTTGTAAACAGGTTCCTTTTAGGACTGCTTATCATGTAGTGGGTGAAATTGTTAAGTATTGCTTAGAGAGAGAA
ATTTTGTTTAAAGATCTTAAAATTAGTGAAATTAAAAAATTTCATCCCGAATTTGATGAGGATGTTTTTGTGGATCTTGA
ACCTTTTAATGTTGTTAAGTCAAGAACAAGTGAGGGTGGAACAGGTTTTACTCAAGTAGAAAAGGAGGTCAATAATTGGC
AAAAAAAATTGTTACTCTGA

Upstream 100 bases:

>100_bases
AAGATGATGCATCAATGGTTATTTTTCAAATTAATTAGATATTTTTTGTCACTAATATAAAAAAATGCTTTATTAGAGAT
ATCTAAAGTTACTAATTGAT

Downstream 100 bases:

>100_bases
ATCCGAATGATTTTTCTACAACAAGGGTATGCTTTGAAGTAGAATAATAAGGTAATGTTATAAAACTACCTTAAGTAGTT
TTTTAATTAGGTTTTTCTTT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MAKVWSKRFDNTLNPFIEKFNASISFDKKLILEDLECSIAHAKMLGKTKVLSSSETLLIINGLEKIKVEYLEDKFSPSLP
SEDIHYCIEEKLISLIGETGKKLHTGRSRNDQVGTDLRLWLRKEIDNLEILITDLQKSFLNLAKSNIHTLIPGYTHMQRA
QPLSLAHHLLAYLEMFQRDRERFQEVRSRVNISPLGAAALAGTKIKIDRNFTAEELGFDKIYKNSIDAVSDRDFCIEFVS
ASALAMSHLSKISEEIILWVTDEFSFAKLTDKCATGSSLMPQKKNPDVPELIRGKTGRVYGNLQALLTMVKGVPLAYNKD
FQEDKEPIFDTAETISSSIKAMTILITEGIEFNIKNLSESVQNDFSNATDLADYLVCKQVPFRTAYHVVGEIVKYCLERE
ILFKDLKISEIKKFHPEFDEDVFVDLEPFNVVKSRTSEGGTGFTQVEKEVNNWQKKLLL

Sequences:

>Translated_459_residues
MAKVWSKRFDNTLNPFIEKFNASISFDKKLILEDLECSIAHAKMLGKTKVLSSSETLLIINGLEKIKVEYLEDKFSPSLP
SEDIHYCIEEKLISLIGETGKKLHTGRSRNDQVGTDLRLWLRKEIDNLEILITDLQKSFLNLAKSNIHTLIPGYTHMQRA
QPLSLAHHLLAYLEMFQRDRERFQEVRSRVNISPLGAAALAGTKIKIDRNFTAEELGFDKIYKNSIDAVSDRDFCIEFVS
ASALAMSHLSKISEEIILWVTDEFSFAKLTDKCATGSSLMPQKKNPDVPELIRGKTGRVYGNLQALLTMVKGVPLAYNKD
FQEDKEPIFDTAETISSSIKAMTILITEGIEFNIKNLSESVQNDFSNATDLADYLVCKQVPFRTAYHVVGEIVKYCLERE
ILFKDLKISEIKKFHPEFDEDVFVDLEPFNVVKSRTSEGGTGFTQVEKEVNNWQKKLLL
>Mature_458_residues
AKVWSKRFDNTLNPFIEKFNASISFDKKLILEDLECSIAHAKMLGKTKVLSSSETLLIINGLEKIKVEYLEDKFSPSLPS
EDIHYCIEEKLISLIGETGKKLHTGRSRNDQVGTDLRLWLRKEIDNLEILITDLQKSFLNLAKSNIHTLIPGYTHMQRAQ
PLSLAHHLLAYLEMFQRDRERFQEVRSRVNISPLGAAALAGTKIKIDRNFTAEELGFDKIYKNSIDAVSDRDFCIEFVSA
SALAMSHLSKISEEIILWVTDEFSFAKLTDKCATGSSLMPQKKNPDVPELIRGKTGRVYGNLQALLTMVKGVPLAYNKDF
QEDKEPIFDTAETISSSIKAMTILITEGIEFNIKNLSESVQNDFSNATDLADYLVCKQVPFRTAYHVVGEIVKYCLEREI
LFKDLKISEIKKFHPEFDEDVFVDLEPFNVVKSRTSEGGTGFTQVEKEVNNWQKKLLL

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=451, Percent_Identity=41.6851441241685, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI68303542, Length=451, Percent_Identity=41.6851441241685, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI68303547, Length=451, Percent_Identity=39.4678492239468, Blast_Score=343, Evalue=3e-94,
Organism=Homo sapiens, GI68303549, Length=451, Percent_Identity=39.0243902439024, Blast_Score=335, Evalue=4e-92,
Organism=Escherichia coli, GI1790398, Length=456, Percent_Identity=43.640350877193, Blast_Score=387, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6321806, Length=462, Percent_Identity=42.4242424242424, Blast_Score=344, Evalue=1e-95,
Organism=Drosophila melanogaster, GI221473854, Length=451, Percent_Identity=37.2505543237251, Blast_Score=331, Evalue=5e-91,
Organism=Drosophila melanogaster, GI78706858, Length=451, Percent_Identity=37.2505543237251, Blast_Score=331, Evalue=5e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_PROM9 (Q31DH2)

Other databases:

- EMBL:   CP000111
- RefSeq:   YP_396509.1
- ProteinModelPortal:   Q31DH2
- SMR:   Q31DH2
- STRING:   Q31DH2
- GeneID:   3764793
- GenomeReviews:   CP000111_GR
- KEGG:   pmi:PMT9312_0012
- eggNOG:   COG0165
- HOGENOM:   HBG539632
- OMA:   MAEDLIF
- ProtClustDB:   PRK00855
- BioCyc:   PMAR74546:PMT9312_0012-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 52190; Mature: 52058

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKVWSKRFDNTLNPFIEKFNASISFDKKLILEDLECSIAHAKMLGKTKVLSSSETLLII
CCCHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEE
NGLEKIKVEYLEDKFSPSLPSEDIHYCIEEKLISLIGETGKKLHTGRSRNDQVGTDLRLW
ECHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
LRKEIDNLEILITDLQKSFLNLAKSNIHTLIPGYTHMQRAQPLSLAHHLLAYLEMFQRDR
HHHCCCCHHHHHHHHHHHHHHHHHHCHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHH
ERFQEVRSRVNISPLGAAALAGTKIKIDRNFTAEELGFDKIYKNSIDAVSDRDFCIEFVS
HHHHHHHHHCCCCCCCHHHHCCCEEEEECCCCHHHHCHHHHHHCCCCCCCCHHHHHHHHH
ASALAMSHLSKISEEIILWVTDEFSFAKLTDKCATGSSLMPQKKNPDVPELIRGKTGRVY
HHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCHH
GNLQALLTMVKGVPLAYNKDFQEDKEPIFDTAETISSSIKAMTILITEGIEFNIKNLSES
HHHHHHHHHHCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHEEEEEEECCCEEEHHHHHHH
VQNDFSNATDLADYLVCKQVPFRTAYHVVGEIVKYCLEREILFKDLKISEIKKFHPEFDE
HHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCC
DVFVDLEPFNVVKSRTSEGGTGFTQVEKEVNNWQKKLLL
CEEEECCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKVWSKRFDNTLNPFIEKFNASISFDKKLILEDLECSIAHAKMLGKTKVLSSSETLLII
CCHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEE
NGLEKIKVEYLEDKFSPSLPSEDIHYCIEEKLISLIGETGKKLHTGRSRNDQVGTDLRLW
ECHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
LRKEIDNLEILITDLQKSFLNLAKSNIHTLIPGYTHMQRAQPLSLAHHLLAYLEMFQRDR
HHHCCCCHHHHHHHHHHHHHHHHHHCHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHH
ERFQEVRSRVNISPLGAAALAGTKIKIDRNFTAEELGFDKIYKNSIDAVSDRDFCIEFVS
HHHHHHHHHCCCCCCCHHHHCCCEEEEECCCCHHHHCHHHHHHCCCCCCCCHHHHHHHHH
ASALAMSHLSKISEEIILWVTDEFSFAKLTDKCATGSSLMPQKKNPDVPELIRGKTGRVY
HHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCHH
GNLQALLTMVKGVPLAYNKDFQEDKEPIFDTAETISSSIKAMTILITEGIEFNIKNLSES
HHHHHHHHHHCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHEEEEEEECCCEEEHHHHHHH
VQNDFSNATDLADYLVCKQVPFRTAYHVVGEIVKYCLEREILFKDLKISEIKKFHPEFDE
HHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCC
DVFVDLEPFNVVKSRTSEGGTGFTQVEKEVNNWQKKLLL
CEEEECCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA