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The map label for this gene is atoS [H]

Identifier: 78358754

GI number: 78358754

Start: 3674500

End: 3676461

Strand: Direct

Name: atoS [H]

Synonym: Dde_3715

Alternate gene names: 78358754

Gene position: 3674500-3676461 (Clockwise)

Preceding gene: 78358753

Following gene: 78358760

Centisome position: 98.51

GC content: 57.95

Gene sequence:

>1962_bases
ATGAGCCATTCCATCCTGCTGGTAGATGACGAGGAAGGTATACGCACCGTCCTCGGGCTTTCGCTGGCCGATGCCGGGTA
CAATGTATCCGTGGCCGCCACCGGAGAAGAGGCCCTGCGACTGTTCGACCAGTCGCGTCCGGACATCATTCTTACAGATA
TCAAGATGCCCGGACTTTCCGGTCTTGATCTGCTCAAACGCGTCAAAAACATCGCCCCCGATGTGGAAGTCATCATGATC
ACCGGCCATGGTGACATGCAGCTGGCCATCCAGAGCCTGAAACAGGACGCCACGGACTTCATCACCAAACCCATCAACGA
CGACGTGCTGGAAATTGCCCTGAACAGGGCTCATGAACGCATCTCCATGCGCAACCAGCTGCGCGAATACACTGAAAACC
TGGAAAACAAAGTACGCGAGCAGTCCGCACGACTGGTGGAGGCCGAACGGCAGCTGGCCGCCCAGCAGATGATGGACGGG
TTTTCCGTGGGTCTCAAAGCGCTGCTTAACGCCATGGACAGCACGCTGGGCGGCGTGTTCAACGAACTGCCCTGCTTTGT
GGCTGTGCACAGCCGCTATCTGGAAATCATCGCCGCAAACGATCTGTACAGAGAAAAACTGGGCAATCTGGTGGGCCACC
AGAGCTGGGAAGCCTACTACGGGCGGGATAAAGACAGTAACGGCTGCCCCGTGCTGACCGCCATACGCGAAGGACGCGGC
AGCCGCACCGAAGAAATGCTGGTGGACAAGACCGGCAAAGGTATTCCCGTGCTGGTGCACACCGCCCCCATTCTCGACAA
TGACGGCGAAGTGGAACTGGTGCTGGAAATTTCGGTCGATACATCTGAAGCACGCCGGCTGCACGAAGAACTGCGCCTTA
CCCGCCACCGCTACGGCCAGCTTTTCGACGAAGCCCCCTGCTACATCACCGTTCAGGACAAACAGTTCAGAGTGGTGGAG
GCCAACCGCAGGTTCCGTGAAGATTTCGGAGACGCCGTGGGAGGTTTCTGCCACGAAGTATTTGTACACCGCCAGACGCC
CTGTACCGGCTGCCCAGTGCAACGCACCTTTAACGACGGCCAGCCGCATCAGTATGAAACCGTGGTCACGTCACGCTCCG
GCGAGCAGTACAACGTGCTTGTCTGGACGGCCCCCCTGCGCGATGCCGCAGGCAACATCACGGAAGTGATGGAAATGTCG
ACCAACATCACGGAGCTGCGCAAGCTGCAGGACAGACTTTCCAACCTCGGCCTGCTGCTCGGTTCAACCGCACACGGCAT
CAAAGGGCTGCTTACCGCTCTGGACGGGGGCATATACAGGCTTGGTTCCGGGCTGGAACGCAACAATACCGAGCGGGTAC
ACGACAGCTACGAAGATATCAGACACCTGACAGACCGGCTGCGCAAAATGGTGCTCGACCTGCTGTACTATGCAAAAAAA
CGTGAGCTGAACTGGGAAGTCGTTCTGGCTTCGCATTTTGCTCCTGAAGTGGCCGCACTTGTCAGACCCAAGGCTGAAGC
GCAGAAAGTACGCTTTACCATCGAAGTTGCTCCCGATGCAGGAACATTTGAAGCCGATGCCGGCGCACTTTCCTCCGCAT
TTGTAAACCTGCTGGAAAATGCCGTGGAAGCCTGTACGGCAGACCGGACTCCGGACAAAAAACATGCAGTACACATGGCC
GTCAGCGGCCTGCCGGATAGGGTGGAATTCTGTATCACCGACAACGGGGTGGGCATGGACAGAGAAACGCGCGAAAAGCT
GTTCACGCTCTTCTTCTCCTCCAAAGGTGCCGCAGGTACCGGCATAGGCCTTTTCGTGGCATCACAGACCGTACAGCAGC
ACGGGGGCTCCATCTCCGTGGGGTCCGAACCGGGCAAAGGTACAACCTTTGTCATCACACTGCCCCGCACGCTGCCGGAT
TCCGCCAAGTCAGAACCCCGTCATCCGGCACCCGCCACCTAG

Upstream 100 bases:

>100_bases
CACGCCGGGACGCGCTCCGCGGGGGGGGCGTCCCGACGCAACTGCCGGTCCTGTTCTGCGGAACAGGCCGGAACGCGCTG
CTATGCGCCGAGGAGAACCC

Downstream 100 bases:

>100_bases
ACTCCATAACCCCTTCCTGCCCGTCGGAGACATAAACAATCATATCTGAAGAGCCTCCGGCGGGCAGGGAGATGATCTCC
CTGCACCCTCAACACGCACG

Product: multi-sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 653; Mature: 652

Protein sequence:

>653_residues
MSHSILLVDDEEGIRTVLGLSLADAGYNVSVAATGEEALRLFDQSRPDIILTDIKMPGLSGLDLLKRVKNIAPDVEVIMI
TGHGDMQLAIQSLKQDATDFITKPINDDVLEIALNRAHERISMRNQLREYTENLENKVREQSARLVEAERQLAAQQMMDG
FSVGLKALLNAMDSTLGGVFNELPCFVAVHSRYLEIIAANDLYREKLGNLVGHQSWEAYYGRDKDSNGCPVLTAIREGRG
SRTEEMLVDKTGKGIPVLVHTAPILDNDGEVELVLEISVDTSEARRLHEELRLTRHRYGQLFDEAPCYITVQDKQFRVVE
ANRRFREDFGDAVGGFCHEVFVHRQTPCTGCPVQRTFNDGQPHQYETVVTSRSGEQYNVLVWTAPLRDAAGNITEVMEMS
TNITELRKLQDRLSNLGLLLGSTAHGIKGLLTALDGGIYRLGSGLERNNTERVHDSYEDIRHLTDRLRKMVLDLLYYAKK
RELNWEVVLASHFAPEVAALVRPKAEAQKVRFTIEVAPDAGTFEADAGALSSAFVNLLENAVEACTADRTPDKKHAVHMA
VSGLPDRVEFCITDNGVGMDRETREKLFTLFFSSKGAAGTGIGLFVASQTVQQHGGSISVGSEPGKGTTFVITLPRTLPD
SAKSEPRHPAPAT

Sequences:

>Translated_653_residues
MSHSILLVDDEEGIRTVLGLSLADAGYNVSVAATGEEALRLFDQSRPDIILTDIKMPGLSGLDLLKRVKNIAPDVEVIMI
TGHGDMQLAIQSLKQDATDFITKPINDDVLEIALNRAHERISMRNQLREYTENLENKVREQSARLVEAERQLAAQQMMDG
FSVGLKALLNAMDSTLGGVFNELPCFVAVHSRYLEIIAANDLYREKLGNLVGHQSWEAYYGRDKDSNGCPVLTAIREGRG
SRTEEMLVDKTGKGIPVLVHTAPILDNDGEVELVLEISVDTSEARRLHEELRLTRHRYGQLFDEAPCYITVQDKQFRVVE
ANRRFREDFGDAVGGFCHEVFVHRQTPCTGCPVQRTFNDGQPHQYETVVTSRSGEQYNVLVWTAPLRDAAGNITEVMEMS
TNITELRKLQDRLSNLGLLLGSTAHGIKGLLTALDGGIYRLGSGLERNNTERVHDSYEDIRHLTDRLRKMVLDLLYYAKK
RELNWEVVLASHFAPEVAALVRPKAEAQKVRFTIEVAPDAGTFEADAGALSSAFVNLLENAVEACTADRTPDKKHAVHMA
VSGLPDRVEFCITDNGVGMDRETREKLFTLFFSSKGAAGTGIGLFVASQTVQQHGGSISVGSEPGKGTTFVITLPRTLPD
SAKSEPRHPAPAT
>Mature_652_residues
SHSILLVDDEEGIRTVLGLSLADAGYNVSVAATGEEALRLFDQSRPDIILTDIKMPGLSGLDLLKRVKNIAPDVEVIMIT
GHGDMQLAIQSLKQDATDFITKPINDDVLEIALNRAHERISMRNQLREYTENLENKVREQSARLVEAERQLAAQQMMDGF
SVGLKALLNAMDSTLGGVFNELPCFVAVHSRYLEIIAANDLYREKLGNLVGHQSWEAYYGRDKDSNGCPVLTAIREGRGS
RTEEMLVDKTGKGIPVLVHTAPILDNDGEVELVLEISVDTSEARRLHEELRLTRHRYGQLFDEAPCYITVQDKQFRVVEA
NRRFREDFGDAVGGFCHEVFVHRQTPCTGCPVQRTFNDGQPHQYETVVTSRSGEQYNVLVWTAPLRDAAGNITEVMEMST
NITELRKLQDRLSNLGLLLGSTAHGIKGLLTALDGGIYRLGSGLERNNTERVHDSYEDIRHLTDRLRKMVLDLLYYAKKR
ELNWEVVLASHFAPEVAALVRPKAEAQKVRFTIEVAPDAGTFEADAGALSSAFVNLLENAVEACTADRTPDKKHAVHMAV
SGLPDRVEFCITDNGVGMDRETREKLFTLFFSSKGAAGTGIGLFVASQTVQQHGGSISVGSEPGKGTTFVITLPRTLPDS
AKSEPRHPAPAT

Specific function: Member of the two-component regulatory system AtoS/AtoC; may activate AtoC by phosphorylation [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=293, Percent_Identity=26.2798634812287, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1790299, Length=125, Percent_Identity=36.8, Blast_Score=89, Evalue=9e-19,
Organism=Escherichia coli, GI1788550, Length=130, Percent_Identity=33.0769230769231, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1790436, Length=314, Percent_Identity=26.7515923566879, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1788905, Length=123, Percent_Identity=34.9593495934959, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1790437, Length=120, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=5e-15,
Organism=Escherichia coli, GI1790346, Length=225, Percent_Identity=28, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1786599, Length=124, Percent_Identity=31.4516129032258, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI48994928, Length=319, Percent_Identity=24.7648902821317, Blast_Score=66, Evalue=7e-12,
Organism=Escherichia coli, GI1787487, Length=117, Percent_Identity=31.6239316239316, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 72133; Mature: 72001

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS50113 PAC ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHSILLVDDEEGIRTVLGLSLADAGYNVSVAATGEEALRLFDQSRPDIILTDIKMPGLS
CCCCEEEEECCCCHHHHHHHHEECCCCEEEEEECCHHHHHHHHCCCCCEEEEECCCCCCC
GLDLLKRVKNIAPDVEVIMITGHGDMQLAIQSLKQDATDFITKPINDDVLEIALNRAHER
HHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
ISMRNQLREYTENLENKVREQSARLVEAERQLAAQQMMDGFSVGLKALLNAMDSTLGGVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NELPCFVAVHSRYLEIIAANDLYREKLGNLVGHQSWEAYYGRDKDSNGCPVLTAIREGRG
HHCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCEEHEECCCCC
SRTEEMLVDKTGKGIPVLVHTAPILDNDGEVELVLEISVDTSEARRLHEELRLTRHRYGQ
CCCHHHHHHCCCCCCEEEEEECCEECCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHH
LFDEAPCYITVQDKQFRVVEANRRFREDFGDAVGGFCHEVFVHRQTPCTGCPVQRTFNDG
HHCCCCCEEEEECCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
QPHQYETVVTSRSGEQYNVLVWTAPLRDAAGNITEVMEMSTNITELRKLQDRLSNLGLLL
CCCEEEEEEECCCCCEEEEEEEECCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCEEE
GSTAHGIKGLLTALDGGIYRLGSGLERNNTERVHDSYEDIRHLTDRLRKMVLDLLYYAKK
CCCHHHHHHHHHHHCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RELNWEVVLASHFAPEVAALVRPKAEAQKVRFTIEVAPDAGTFEADAGALSSAFVNLLEN
CCCCEEEEEECCCCHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHH
AVEACTADRTPDKKHAVHMAVSGLPDRVEFCITDNGVGMDRETREKLFTLFFSSKGAAGT
HHHHHCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCC
GIGLFVASQTVQQHGGSISVGSEPGKGTTFVITLPRTLPDSAKSEPRHPAPAT
CHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SHSILLVDDEEGIRTVLGLSLADAGYNVSVAATGEEALRLFDQSRPDIILTDIKMPGLS
CCCEEEEECCCCHHHHHHHHEECCCCEEEEEECCHHHHHHHHCCCCCEEEEECCCCCCC
GLDLLKRVKNIAPDVEVIMITGHGDMQLAIQSLKQDATDFITKPINDDVLEIALNRAHER
HHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
ISMRNQLREYTENLENKVREQSARLVEAERQLAAQQMMDGFSVGLKALLNAMDSTLGGVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NELPCFVAVHSRYLEIIAANDLYREKLGNLVGHQSWEAYYGRDKDSNGCPVLTAIREGRG
HHCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCEEHEECCCCC
SRTEEMLVDKTGKGIPVLVHTAPILDNDGEVELVLEISVDTSEARRLHEELRLTRHRYGQ
CCCHHHHHHCCCCCCEEEEEECCEECCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHH
LFDEAPCYITVQDKQFRVVEANRRFREDFGDAVGGFCHEVFVHRQTPCTGCPVQRTFNDG
HHCCCCCEEEEECCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
QPHQYETVVTSRSGEQYNVLVWTAPLRDAAGNITEVMEMSTNITELRKLQDRLSNLGLLL
CCCEEEEEEECCCCCEEEEEEEECCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCEEE
GSTAHGIKGLLTALDGGIYRLGSGLERNNTERVHDSYEDIRHLTDRLRKMVLDLLYYAKK
CCCHHHHHHHHHHHCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RELNWEVVLASHFAPEVAALVRPKAEAQKVRFTIEVAPDAGTFEADAGALSSAFVNLLEN
CCCCEEEEEECCCCHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHH
AVEACTADRTPDKKHAVHMAVSGLPDRVEFCITDNGVGMDRETREKLFTLFFSSKGAAGT
HHHHHCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCC
GIGLFVASQTVQQHGGSISVGSEPGKGTTFVITLPRTLPDSAKSEPRHPAPAT
CHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8346225; 9097040; 9278503 [H]