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The map label for this gene is neuC [H]

Identifier: 78358295

GI number: 78358295

Start: 3253693

End: 3254862

Strand: Reverse

Name: neuC [H]

Synonym: Dde_3255

Alternate gene names: 78358295

Gene position: 3254862-3253693 (Counterclockwise)

Preceding gene: 78358296

Following gene: 78358294

Centisome position: 87.26

GC content: 49.15

Gene sequence:

>1170_bases
ATGGCTAAAAAAAAGATACTCTTTATTACGGGCACCCGCGCTGACTTTGGCAAGTTATGTAGCCTCATTGATAAAGTGAG
CGAGCATACCGAGTTTGAGTATTGTATTTTTGTCACGGGGATGCACACTCTTTCCCGTTACGGATACACAGTGGACGAGG
TGATGAAGAAATACAGCTCGTTCAGGCTGGAGGGAGGTTTTCGTAACGTTCACGTGTTTATGAATCAGGTCCATGGAGAA
TCCATGGATATGGTGCTTGGAAATACCATTTTTGGCCTCTCCCGTTATGTCAGCGAGTATCAGCCTGATATGATTGTAGT
GCACGGTGACAGAGTTGAAGCGTTGGCAGGATCAATAGTCGGTTCGTTGCGCAATATTCTGGTGGCACATGTCGAAGGCG
GTGAGCTGTCAGGCACCATAGACGAACTCATCCGTCATGCCGTATCCAAAATGGCTCACCTGCACTTTGTGGCAAACGGG
GATTCCCGCAGGAGACTGATGCAGATGGGCGAAGCGGAAGAGACTATCTATCCCATCGGATCACCGGACGTAGACCTGAT
GTTCTCCCCGAATCTACCCAGCAAGGAATCGGTGCTTGCATACTATAACATCCCGTTTACGGAGTATGCCATAACCCTGC
TGCACCCTGTGACAACAGATCTGGAGCAGACAAAGAAGATGGCCGGTGCCGTTGTGGACGCAATGCTGGATTCAGACGAT
AATTATATCGTTATCTATCCCAATAACGACCACGGAAGCGACATTATCCTGGATGAATATGACAGGTTGTCAGGAGAAGG
CAGGATAGCTGTTTACCCTTCTCTGCGGGTGGAGTCTTTTTTGGTCCTGTTGCGAGCTGCCAAATATCTGCTGGGCAATT
CCAGCGCGGGTATTCGTGAGACCCCTTGTTACGGTGTGCCGTCTATCAATATCGGCAGCCGGCAGGATGGACGGTTCTGC
TGTTCGTCAATCATTAATGTGCCGGGTTCATATGATGCCATTGTGAAGGCTTTGGCCGATGTCCGCAAAATGGTGCCACA
TCCTCCTCGGTTCGAGTTCGGGAGAGGTAACAGTGCAGAGCAGTTCATCAAAATTCTTATGGATGAAAAAACGTGGCTCA
CAAAGCCGCAAAAGCAGTTTGTTGATCATCATTTTGCACTCTGCCGCTGA

Upstream 100 bases:

>100_bases
GGAACCGGTGAGATTTTAGCCAGAGACTACGAGCGTGTTTTGGGAAGAGTGGCAAAACGACCATTACAAAAAAATGCCCA
GCTGGCATGGGATGATTTTG

Downstream 100 bases:

>100_bases
CGTATCTTTAGTTTTGGCACCTCTGTTATGAATTTTTCCGGAGTAAGACCTTATGTCCAACCTTGACCGCGACCGTGAAA
TATATTTGCAGGAGAACCGC

Product: UDP-N-acetylglucosamine 2-epimerase

Products: UDP-N-acetyl-D-mannosamine [C]

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MAKKKILFITGTRADFGKLCSLIDKVSEHTEFEYCIFVTGMHTLSRYGYTVDEVMKKYSSFRLEGGFRNVHVFMNQVHGE
SMDMVLGNTIFGLSRYVSEYQPDMIVVHGDRVEALAGSIVGSLRNILVAHVEGGELSGTIDELIRHAVSKMAHLHFVANG
DSRRRLMQMGEAEETIYPIGSPDVDLMFSPNLPSKESVLAYYNIPFTEYAITLLHPVTTDLEQTKKMAGAVVDAMLDSDD
NYIVIYPNNDHGSDIILDEYDRLSGEGRIAVYPSLRVESFLVLLRAAKYLLGNSSAGIRETPCYGVPSINIGSRQDGRFC
CSSIINVPGSYDAIVKALADVRKMVPHPPRFEFGRGNSAEQFIKILMDEKTWLTKPQKQFVDHHFALCR

Sequences:

>Translated_389_residues
MAKKKILFITGTRADFGKLCSLIDKVSEHTEFEYCIFVTGMHTLSRYGYTVDEVMKKYSSFRLEGGFRNVHVFMNQVHGE
SMDMVLGNTIFGLSRYVSEYQPDMIVVHGDRVEALAGSIVGSLRNILVAHVEGGELSGTIDELIRHAVSKMAHLHFVANG
DSRRRLMQMGEAEETIYPIGSPDVDLMFSPNLPSKESVLAYYNIPFTEYAITLLHPVTTDLEQTKKMAGAVVDAMLDSDD
NYIVIYPNNDHGSDIILDEYDRLSGEGRIAVYPSLRVESFLVLLRAAKYLLGNSSAGIRETPCYGVPSINIGSRQDGRFC
CSSIINVPGSYDAIVKALADVRKMVPHPPRFEFGRGNSAEQFIKILMDEKTWLTKPQKQFVDHHFALCR
>Mature_388_residues
AKKKILFITGTRADFGKLCSLIDKVSEHTEFEYCIFVTGMHTLSRYGYTVDEVMKKYSSFRLEGGFRNVHVFMNQVHGES
MDMVLGNTIFGLSRYVSEYQPDMIVVHGDRVEALAGSIVGSLRNILVAHVEGGELSGTIDELIRHAVSKMAHLHFVANGD
SRRRLMQMGEAEETIYPIGSPDVDLMFSPNLPSKESVLAYYNIPFTEYAITLLHPVTTDLEQTKKMAGAVVDAMLDSDDN
YIVIYPNNDHGSDIILDEYDRLSGEGRIAVYPSLRVESFLVLLRAAKYLLGNSSAGIRETPCYGVPSINIGSRQDGRFCC
SSIINVPGSYDAIVKALADVRKMVPHPPRFEFGRGNSAEQFIKILMDEKTWLTKPQKQFVDHHFALCR

Specific function: May be involved in the synthesis of polysialic acid (PSA) [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI298566312, Length=391, Percent_Identity=30.690537084399, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI4885285, Length=391, Percent_Identity=30.690537084399, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI190014632, Length=391, Percent_Identity=30.690537084399, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI298566325, Length=307, Percent_Identity=32.5732899022801, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI298566315, Length=298, Percent_Identity=27.1812080536913, Blast_Score=99, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020004
- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: 5.1.3.14 [C]

Molecular weight: Translated: 43555; Mature: 43423

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKKKILFITGTRADFGKLCSLIDKVSEHTEFEYCIFVTGMHTLSRYGYTVDEVMKKYSS
CCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECHHHHHHCCCCHHHHHHHHHH
FRLEGGFRNVHVFMNQVHGESMDMVLGNTIFGLSRYVSEYQPDMIVVHGDRVEALAGSIV
EEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHH
GSLRNILVAHVEGGELSGTIDELIRHAVSKMAHLHFVANGDSRRRLMQMGEAEETIYPIG
HHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHEEEEECCCHHHHHHHCCCCCCEEEECC
SPDVDLMFSPNLPSKESVLAYYNIPFTEYAITLLHPVTTDLEQTKKMAGAVVDAMLDSDD
CCCEEEEECCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCC
NYIVIYPNNDHGSDIILDEYDRLSGEGRIAVYPSLRVESFLVLLRAAKYLLGNSSAGIRE
CEEEEEECCCCCCCEEEECHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCC
TPCYGVPSINIGSRQDGRFCCSSIINVPGSYDAIVKALADVRKMVPHPPRFEFGRGNSAE
CCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
QFIKILMDEKTWLTKPQKQFVDHHFALCR
HHHHHHHCCCHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKKKILFITGTRADFGKLCSLIDKVSEHTEFEYCIFVTGMHTLSRYGYTVDEVMKKYSS
CCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECHHHHHHCCCCHHHHHHHHHH
FRLEGGFRNVHVFMNQVHGESMDMVLGNTIFGLSRYVSEYQPDMIVVHGDRVEALAGSIV
EEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHH
GSLRNILVAHVEGGELSGTIDELIRHAVSKMAHLHFVANGDSRRRLMQMGEAEETIYPIG
HHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHEEEEECCCHHHHHHHCCCCCCEEEECC
SPDVDLMFSPNLPSKESVLAYYNIPFTEYAITLLHPVTTDLEQTKKMAGAVVDAMLDSDD
CCCEEEEECCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCC
NYIVIYPNNDHGSDIILDEYDRLSGEGRIAVYPSLRVESFLVLLRAAKYLLGNSSAGIRE
CEEEEEECCCCCCCEEEECHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCC
TPCYGVPSINIGSRQDGRFCCSSIINVPGSYDAIVKALADVRKMVPHPPRFEFGRGNSAE
CCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
QFIKILMDEKTWLTKPQKQFVDHHFALCR
HHHHHHHCCCHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: UDP-N-acetylglucosamine [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.63 {UDP-N-acetylglucosamine}} 1 {UDP-N-acetylmannosamine}} 0.5 {UDP-N-acetylmannosamine}} [C]

Substrates: UDP-N-acetyl-D-glucosamine [C]

Specific reaction: UDP-N-acetyl-D-glucosamine --> UDP-N-acetyl-D-mannosamine [C]

General reaction: Epimerization [C]

Inhibitor: PCMB [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1729218 [H]