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The map label for this gene is relA [H]

Identifier: 78356612

GI number: 78356612

Start: 1591070

End: 1593217

Strand: Direct

Name: relA [H]

Synonym: Dde_1569

Alternate gene names: 78356612

Gene position: 1591070-1593217 (Clockwise)

Preceding gene: 78356611

Following gene: 78356614

Centisome position: 42.65

GC content: 55.45

Gene sequence:

>2148_bases
ATGATCCGCATTCAGGACATACTCGATACCATTGCCGAATACAGGCAGGACGCCGACATTGCGCTTATCCAGAAAGCGTA
TGTCTTTTCTGCCGCCGCGCATGCCGGACAGACGCGTCTTTCCGGTGAACCGTACCTGATGCATCCGCTTGCCGTGGCGC
ACAGTCTGGCAAAGATGCGTCTTGACGAGGCTTCCATCGCTGCCGGTCTTTTGCACGACACGGTGGAGGATACCAGCACC
GGCATTGAAGAGATCGATTCGCTTTTCGGCGAAGAAGTGGCTGATATCGTGGACGGTGTCACTAAAATCAGCCAGATGAC
GTTTGAAAGCAAGGAAGAGGCGCAGGCCGAAAACATCCGCAAGATGGTTCTGGCTATGGCGGAAGATATCCGCGTGCTCA
TCGTCAAACTGGCGGACCGGCTGCATAACATGAGCACTCTGGACTTTCAGAAACCGCACAAGCAGAAGCTCATCGCGCAG
GAAACCATGGACATTTATGCCCCGCTGGCAAACAGGCTGGGGCTGCACCGCATTAAACTGCAGCTGGAAGACCTTTCGCT
GCGGTATCTGCGTCCTGATGTGTGGAGTCAGCTGTCTGACTGGCTGGAAAAAAAGCGGGTTGCAGACAGCGACTACATTG
ACAATGTCATCAGTCTGCTGCGCGGCATGCTGGATGAAAACGATATTCCCGGCAAGGTTAAAGGGCGTATCAAACATATC
AACAGCATCTACCGCAAGATGGTGCATCAGAACCTTGCTCTGGACGAGGTGCCCGATGTCATCGCGTTCCGCGTTATCGT
GGATGACGTAAAAAACTGCTACGCCATGCTGGGGCTTGTACACGCCGCATGGAAGCCCATTCACGGACGGTTCAAAGATT
ACATTTCCATGCCCAAAGCCAACATGTATCAGAGCCTGCACACCACTGTTGTGGGCCCCGGGGGCGAGCGCATAGAAATA
CAGATACGTACCGAGGAAATGGACAGAATGGCGGAGCACGGGGTTGCTTCGCACTGGCTGTACAAAGAGGGACAGCGCGT
AAAATCCAAGGACGTCAGGCAGTTTGCCTGGCTGCGTGAAATGCTGGACTGGCAGAAGATGGAAAGCGACTCGCGCGAAT
TCATGCGGTCGCTGAAATTCGATCTTTTCAAGGAAGAAGTTTATGTCTTCACCCCGCGCGGCGAGGTGAAGGAACTGCCC
GAAGGCGCAAGCCCCATCGACTTTGCCTATCTGATACATACCAAGGTGGGAGACCACTGTTCCGGCGCCAAGGTCAACGG
CAAGCTGGTTCCGCTTTCGACCAAGCTGCATAATGGCGACACCGTTGAGATAATAACCGATGCCAACCGCCATCCCAGCC
GCGACTGGCTCCGGTTTGTCAAAACAGCCAAGGCACGTACCCGTATCAACAACTATATCCGTACGGAAGAACGCAGCCGC
AGCATTGCACTGGGCCGGGAAATGCTGGAAAAGCAGGGCCGGCGCATGGGGCTGAATGTGCCCAAGCTGCTTAAGGAAGG
CGGTCTGATGCCTGTGGCGGAGGAATTTTCTTACCGCGAGGTTGAAGAGCTGCTTTCTGCCGTGGGGTATGCCCGCCTTA
CTCCGCGCAAGGTGCTGCGCAAGCTGCTGCCCAAAGAAGAGGAACCCGCACGTCAGCCGGAGGTAAAAGCTCCGGAACCA
CAGAAGTCGCGTCGTGAGTCTGACAGTGTGAGCATCAAGGGCGTTGACGATGTGCTGGTGCGTTTCGGCAAATGCTGCAA
TCCGGTGCCCGGTGATGCCATTGTGGGGTATATCAGCCGCGGGCGTGGGGTGACCGTGCATACGTCGGACTGTGTCAACG
TGCAGGCCATGGAACCGGAACGCCTTATCAGTGTGTTCTGGGACGGCACCGAAGGCAAACCCTATCCGGCACGCATCCAC
ATGCTTTGCCATAATGAAATAGGCGGTTTTGCCAAGATTACCACACTGCTGGCGGAAGAGCAGGTGAATATCGATGCATG
CCACATGCGGTCCAATGTTGACGGACGTTCGGAGCTGGATGTGACCGTGGAGGTACGCGATGTGGCTCATCTGTACCGTA
CCATCGACAGGCTGCGTCATCTTGATGCCGTCATCGAAGTGACAAGGCACTCCTCGCACAGCGAATAG

Upstream 100 bases:

>100_bases
GCCCAAGGGCATAATGCATAATTTCATCCGCTGGTGGGTTCCTGCCGGGCTGCAGCGTTATTCCTCATCCGGACCAGAAG
ACGGGACAAAGAAGAAATAA

Downstream 100 bases:

>100_bases
TTTTATCCGGATGCCATTTAAAAGGGCCGCCCTTTGCGGGGCGGCCCTTTTTTCTGGCGCTTTGAGTGAGGAGGATGGTC
TTTCCCTGAAGTAATGACTT

Product: metal dependent phosphohydrolase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 715; Mature: 715

Protein sequence:

>715_residues
MIRIQDILDTIAEYRQDADIALIQKAYVFSAAAHAGQTRLSGEPYLMHPLAVAHSLAKMRLDEASIAAGLLHDTVEDTST
GIEEIDSLFGEEVADIVDGVTKISQMTFESKEEAQAENIRKMVLAMAEDIRVLIVKLADRLHNMSTLDFQKPHKQKLIAQ
ETMDIYAPLANRLGLHRIKLQLEDLSLRYLRPDVWSQLSDWLEKKRVADSDYIDNVISLLRGMLDENDIPGKVKGRIKHI
NSIYRKMVHQNLALDEVPDVIAFRVIVDDVKNCYAMLGLVHAAWKPIHGRFKDYISMPKANMYQSLHTTVVGPGGERIEI
QIRTEEMDRMAEHGVASHWLYKEGQRVKSKDVRQFAWLREMLDWQKMESDSREFMRSLKFDLFKEEVYVFTPRGEVKELP
EGASPIDFAYLIHTKVGDHCSGAKVNGKLVPLSTKLHNGDTVEIITDANRHPSRDWLRFVKTAKARTRINNYIRTEERSR
SIALGREMLEKQGRRMGLNVPKLLKEGGLMPVAEEFSYREVEELLSAVGYARLTPRKVLRKLLPKEEEPARQPEVKAPEP
QKSRRESDSVSIKGVDDVLVRFGKCCNPVPGDAIVGYISRGRGVTVHTSDCVNVQAMEPERLISVFWDGTEGKPYPARIH
MLCHNEIGGFAKITTLLAEEQVNIDACHMRSNVDGRSELDVTVEVRDVAHLYRTIDRLRHLDAVIEVTRHSSHSE

Sequences:

>Translated_715_residues
MIRIQDILDTIAEYRQDADIALIQKAYVFSAAAHAGQTRLSGEPYLMHPLAVAHSLAKMRLDEASIAAGLLHDTVEDTST
GIEEIDSLFGEEVADIVDGVTKISQMTFESKEEAQAENIRKMVLAMAEDIRVLIVKLADRLHNMSTLDFQKPHKQKLIAQ
ETMDIYAPLANRLGLHRIKLQLEDLSLRYLRPDVWSQLSDWLEKKRVADSDYIDNVISLLRGMLDENDIPGKVKGRIKHI
NSIYRKMVHQNLALDEVPDVIAFRVIVDDVKNCYAMLGLVHAAWKPIHGRFKDYISMPKANMYQSLHTTVVGPGGERIEI
QIRTEEMDRMAEHGVASHWLYKEGQRVKSKDVRQFAWLREMLDWQKMESDSREFMRSLKFDLFKEEVYVFTPRGEVKELP
EGASPIDFAYLIHTKVGDHCSGAKVNGKLVPLSTKLHNGDTVEIITDANRHPSRDWLRFVKTAKARTRINNYIRTEERSR
SIALGREMLEKQGRRMGLNVPKLLKEGGLMPVAEEFSYREVEELLSAVGYARLTPRKVLRKLLPKEEEPARQPEVKAPEP
QKSRRESDSVSIKGVDDVLVRFGKCCNPVPGDAIVGYISRGRGVTVHTSDCVNVQAMEPERLISVFWDGTEGKPYPARIH
MLCHNEIGGFAKITTLLAEEQVNIDACHMRSNVDGRSELDVTVEVRDVAHLYRTIDRLRHLDAVIEVTRHSSHSE
>Mature_715_residues
MIRIQDILDTIAEYRQDADIALIQKAYVFSAAAHAGQTRLSGEPYLMHPLAVAHSLAKMRLDEASIAAGLLHDTVEDTST
GIEEIDSLFGEEVADIVDGVTKISQMTFESKEEAQAENIRKMVLAMAEDIRVLIVKLADRLHNMSTLDFQKPHKQKLIAQ
ETMDIYAPLANRLGLHRIKLQLEDLSLRYLRPDVWSQLSDWLEKKRVADSDYIDNVISLLRGMLDENDIPGKVKGRIKHI
NSIYRKMVHQNLALDEVPDVIAFRVIVDDVKNCYAMLGLVHAAWKPIHGRFKDYISMPKANMYQSLHTTVVGPGGERIEI
QIRTEEMDRMAEHGVASHWLYKEGQRVKSKDVRQFAWLREMLDWQKMESDSREFMRSLKFDLFKEEVYVFTPRGEVKELP
EGASPIDFAYLIHTKVGDHCSGAKVNGKLVPLSTKLHNGDTVEIITDANRHPSRDWLRFVKTAKARTRINNYIRTEERSR
SIALGREMLEKQGRRMGLNVPKLLKEGGLMPVAEEFSYREVEELLSAVGYARLTPRKVLRKLLPKEEEPARQPEVKAPEP
QKSRRESDSVSIKGVDDVLVRFGKCCNPVPGDAIVGYISRGRGVTVHTSDCVNVQAMEPERLISVFWDGTEGKPYPARIH
MLCHNEIGGFAKITTLLAEEQVNIDACHMRSNVDGRSELDVTVEVRDVAHLYRTIDRLRHLDAVIEVTRHSSHSE

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Escherichia coli, GI1790082, Length=720, Percent_Identity=40.2777777777778, Blast_Score=548, Evalue=1e-157,
Organism=Escherichia coli, GI1789147, Length=680, Percent_Identity=34.1176470588235, Blast_Score=451, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI25143118, Length=139, Percent_Identity=35.9712230215827, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 81314; Mature: 81314

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRIQDILDTIAEYRQDADIALIQKAYVFSAAAHAGQTRLSGEPYLMHPLAVAHSLAKMR
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHH
LDEASIAAGLLHDTVEDTSTGIEEIDSLFGEEVADIVDGVTKISQMTFESKEEAQAENIR
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
KMVLAMAEDIRVLIVKLADRLHNMSTLDFQKPHKQKLIAQETMDIYAPLANRLGLHRIKL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEE
QLEDLSLRYLRPDVWSQLSDWLEKKRVADSDYIDNVISLLRGMLDENDIPGKVKGRIKHI
EEECCHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
NSIYRKMVHQNLALDEVPDVIAFRVIVDDVKNCYAMLGLVHAAWKPIHGRFKDYISMPKA
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
NMYQSLHTTVVGPGGERIEIQIRTEEMDRMAEHGVASHWLYKEGQRVKSKDVRQFAWLRE
HHHHHHHHEEECCCCCEEEEEEEHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHH
MLDWQKMESDSREFMRSLKFDLFKEEVYVFTPRGEVKELPEGASPIDFAYLIHTKVGDHC
HHHHHHHCCHHHHHHHHHHHHHHHCCEEEECCCCHHHHCCCCCCCCEEEEEEECCCCCCC
SGAKVNGKLVPLSTKLHNGDTVEIITDANRHPSRDWLRFVKTAKARTRINNYIRTEERSR
CCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SIALGREMLEKQGRRMGLNVPKLLKEGGLMPVAEEFSYREVEELLSAVGYARLTPRKVLR
HHHHHHHHHHHCCHHCCCCHHHHHHCCCCCCHHHHCCHHHHHHHHHHHCHHCCCHHHHHH
KLLPKEEEPARQPEVKAPEPQKSRRESDSVSIKGVDDVLVRFGKCCNPVPGDAIVGYISR
HHCCCCCCCCCCCCCCCCCCHHHHCCCCCEEECCHHHHHHHHHHCCCCCCCHHHHHHHHC
GRGVTVHTSDCVNVQAMEPERLISVFWDGTEGKPYPARIHMLCHNEIGGFAKITTLLAEE
CCCEEEECCCCCEEEECCHHHHHHHEECCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHH
QVNIDACHMRSNVDGRSELDVTVEVRDVAHLYRTIDRLRHLDAVIEVTRHSSHSE
CCCCHHHHHCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MIRIQDILDTIAEYRQDADIALIQKAYVFSAAAHAGQTRLSGEPYLMHPLAVAHSLAKMR
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHH
LDEASIAAGLLHDTVEDTSTGIEEIDSLFGEEVADIVDGVTKISQMTFESKEEAQAENIR
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
KMVLAMAEDIRVLIVKLADRLHNMSTLDFQKPHKQKLIAQETMDIYAPLANRLGLHRIKL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEE
QLEDLSLRYLRPDVWSQLSDWLEKKRVADSDYIDNVISLLRGMLDENDIPGKVKGRIKHI
EEECCHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
NSIYRKMVHQNLALDEVPDVIAFRVIVDDVKNCYAMLGLVHAAWKPIHGRFKDYISMPKA
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
NMYQSLHTTVVGPGGERIEIQIRTEEMDRMAEHGVASHWLYKEGQRVKSKDVRQFAWLRE
HHHHHHHHEEECCCCCEEEEEEEHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHH
MLDWQKMESDSREFMRSLKFDLFKEEVYVFTPRGEVKELPEGASPIDFAYLIHTKVGDHC
HHHHHHHCCHHHHHHHHHHHHHHHCCEEEECCCCHHHHCCCCCCCCEEEEEEECCCCCCC
SGAKVNGKLVPLSTKLHNGDTVEIITDANRHPSRDWLRFVKTAKARTRINNYIRTEERSR
CCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SIALGREMLEKQGRRMGLNVPKLLKEGGLMPVAEEFSYREVEELLSAVGYARLTPRKVLR
HHHHHHHHHHHCCHHCCCCHHHHHHCCCCCCHHHHCCHHHHHHHHHHHCHHCCCHHHHHH
KLLPKEEEPARQPEVKAPEPQKSRRESDSVSIKGVDDVLVRFGKCCNPVPGDAIVGYISR
HHCCCCCCCCCCCCCCCCCCHHHHCCCCCEEECCHHHHHHHHHHCCCCCCCHHHHHHHHC
GRGVTVHTSDCVNVQAMEPERLISVFWDGTEGKPYPARIHMLCHNEIGGFAKITTLLAEE
CCCEEEECCCCCEEEECCHHHHHHHEECCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHH
QVNIDACHMRSNVDGRSELDVTVEVRDVAHLYRTIDRLRHLDAVIEVTRHSSHSE
CCCCHHHHHCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA