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The map label for this gene is atoC [H]

Identifier: 78355897

GI number: 78355897

Start: 881877

End: 883265

Strand: Direct

Name: atoC [H]

Synonym: Dde_0850

Alternate gene names: 78355897

Gene position: 881877-883265 (Clockwise)

Preceding gene: 78355896

Following gene: 78355898

Centisome position: 23.64

GC content: 58.46

Gene sequence:

>1389_bases
ATGCCGAAATTGCTGATTGTTGATGACAACGAGGATGTGCGCCGCCAACTGCGCTGGGGGCTGTCGCGGGAACCGTATGA
TCTGTTGCTGGCGGCAGACGGGCAGGAGGCACTGAAGCTGTTCCGTGAACATCGTCCCGGAGCCGTCACTCTTGACCTCG
GGCTGCCGCCCGACCCTGAAGGTACGGATGAAGGGTTCCGTTGTCTGGATGCCATGTTGCGCCATGACCCCAATGCCCAG
ATTGTGGTGGTGACCGGTCATCACGACAAGGAAAATGCGCTCCGTGCCATTCGTGCGGGTGCTTTCGACTTCTGCCGCAA
GCCTGTGGACCTTGCCGAGCTCAAGGTCATTATCAACAGGGCTTTTTATCTGAGCGAGCTTAAAGCAGCAGACCAGCCTC
TGCAGGAAGACCTGCCGCCTGAGCCGGAAGTGCCTCACTTCAACGGTCTGGTGGGAGACTGCGAAGCCATGCGGCGGGTG
TATGCCACCATCGAAAAAGTGGCCGGAGCAGATGCTCCGGTGCTGGTGACCGGCGAATCGGGCACAGGCAAGGAACTGGT
GGCGCGCGCGGTGCACAGGCTCAGTTCGCGGCGCAGCGGTGCCATGGTTGCCGTAAACTGCGGTGCCATTCCTGAAACGC
TTATTGAATCAGAGCTGTTCGGACATGAGAAAGGGGCATTTACCGGTGCCACCAGCCGGGTGCAGGGCAAGGTGGAATAT
GCCGACGGAGGCACGCTTTTTCTGGACGAGATAGGTGAACTTCCGGCAAGCATGCAGGTGAAGTTTTTGCGTTTTTTGCA
GGAAATGGTGATGCAGCGGGTTGGCGGACGCAAGGATATTCCGGTCAACTGCCGTATCATTGCCGCTACCAATGTGGACA
TCGAACAGGCCATGCGCGAAGGAGCCTTCCGCGAAGATCTGTATTTCCGTATCGGGGTGGTTACCATCAACCTGCCCCCG
TTGCGTGAACGCGGGGCAGATGTGCTGCTGCTGGCCCGTCATTTTCTGAGCAGTATCGGCGTGCAGCAGAAAACAAAAGT
GCAGGGTTTTTCTGCCGCGGCGGAGAAAGCCATGCTGCATTACCCGTGGCCCGGCAATGTGCGTGAACTGGAAAACAAGG
TGCGCAGAGCGGTCATTCTGACCAGCGGACAGCGTATCGGTCCCGAAGATCTGGGCATAGAGCCGGAGCCGGTGCAGCCT
GCTCCGGAGGGGGCTGTTCCGTCTGCGGGGCGGAAGACTTTGAAGGAAGCCCGTAATGAGGTGGAGCGCGACATGGTGGA
GCAGGCGCTGAGAACTTTTTCCGGTAATATAGTGCAGGCTGCCAAATCCATCGGCGTGAGCCGGCCCACGTTTTATGATC
TGCTGAAAAAACACGGTCTGGACGGCTGA

Upstream 100 bases:

>100_bases
GGCGGTGCAAAGGGCGCTTCTGTCTGATGCCGCATGGTTTTCTGCATATCCGCAGCCACAGAGCACGGTGCGGCAGAAAA
CCGGACCACAGGGGATTACC

Downstream 100 bases:

>100_bases
TGCCGTACGATCCGTTGTTGTATGCGCACTTCCTGCCCGAAGGATGCTGCCGCGGAGGTTGCCATTTCGGGCTGAACCCA
ACGATGAAGAGGCGTACTGA

Product: two component Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MPKLLIVDDNEDVRRQLRWGLSREPYDLLLAADGQEALKLFREHRPGAVTLDLGLPPDPEGTDEGFRCLDAMLRHDPNAQ
IVVVTGHHDKENALRAIRAGAFDFCRKPVDLAELKVIINRAFYLSELKAADQPLQEDLPPEPEVPHFNGLVGDCEAMRRV
YATIEKVAGADAPVLVTGESGTGKELVARAVHRLSSRRSGAMVAVNCGAIPETLIESELFGHEKGAFTGATSRVQGKVEY
ADGGTLFLDEIGELPASMQVKFLRFLQEMVMQRVGGRKDIPVNCRIIAATNVDIEQAMREGAFREDLYFRIGVVTINLPP
LRERGADVLLLARHFLSSIGVQQKTKVQGFSAAAEKAMLHYPWPGNVRELENKVRRAVILTSGQRIGPEDLGIEPEPVQP
APEGAVPSAGRKTLKEARNEVERDMVEQALRTFSGNIVQAAKSIGVSRPTFYDLLKKHGLDG

Sequences:

>Translated_462_residues
MPKLLIVDDNEDVRRQLRWGLSREPYDLLLAADGQEALKLFREHRPGAVTLDLGLPPDPEGTDEGFRCLDAMLRHDPNAQ
IVVVTGHHDKENALRAIRAGAFDFCRKPVDLAELKVIINRAFYLSELKAADQPLQEDLPPEPEVPHFNGLVGDCEAMRRV
YATIEKVAGADAPVLVTGESGTGKELVARAVHRLSSRRSGAMVAVNCGAIPETLIESELFGHEKGAFTGATSRVQGKVEY
ADGGTLFLDEIGELPASMQVKFLRFLQEMVMQRVGGRKDIPVNCRIIAATNVDIEQAMREGAFREDLYFRIGVVTINLPP
LRERGADVLLLARHFLSSIGVQQKTKVQGFSAAAEKAMLHYPWPGNVRELENKVRRAVILTSGQRIGPEDLGIEPEPVQP
APEGAVPSAGRKTLKEARNEVERDMVEQALRTFSGNIVQAAKSIGVSRPTFYDLLKKHGLDG
>Mature_461_residues
PKLLIVDDNEDVRRQLRWGLSREPYDLLLAADGQEALKLFREHRPGAVTLDLGLPPDPEGTDEGFRCLDAMLRHDPNAQI
VVVTGHHDKENALRAIRAGAFDFCRKPVDLAELKVIINRAFYLSELKAADQPLQEDLPPEPEVPHFNGLVGDCEAMRRVY
ATIEKVAGADAPVLVTGESGTGKELVARAVHRLSSRRSGAMVAVNCGAIPETLIESELFGHEKGAFTGATSRVQGKVEYA
DGGTLFLDEIGELPASMQVKFLRFLQEMVMQRVGGRKDIPVNCRIIAATNVDIEQAMREGAFREDLYFRIGVVTINLPPL
RERGADVLLLARHFLSSIGVQQKTKVQGFSAAAEKAMLHYPWPGNVRELENKVRRAVILTSGQRIGPEDLGIEPEPVQPA
PEGAVPSAGRKTLKEARNEVERDMVEQALRTFSGNIVQAAKSIGVSRPTFYDLLKKHGLDG

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=460, Percent_Identity=40.2173913043478, Blast_Score=346, Evalue=2e-96,
Organism=Escherichia coli, GI1790437, Length=454, Percent_Identity=38.9867841409692, Blast_Score=299, Evalue=3e-82,
Organism=Escherichia coli, GI1788905, Length=459, Percent_Identity=38.3442265795207, Blast_Score=292, Evalue=4e-80,
Organism=Escherichia coli, GI1790299, Length=480, Percent_Identity=36.875, Blast_Score=290, Evalue=2e-79,
Organism=Escherichia coli, GI87082117, Length=452, Percent_Identity=36.5044247787611, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI87082152, Length=317, Percent_Identity=43.5331230283912, Blast_Score=247, Evalue=9e-67,
Organism=Escherichia coli, GI1789087, Length=318, Percent_Identity=42.4528301886792, Blast_Score=245, Evalue=4e-66,
Organism=Escherichia coli, GI87081872, Length=321, Percent_Identity=39.2523364485981, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI1786524, Length=329, Percent_Identity=41.9452887537994, Blast_Score=228, Evalue=5e-61,
Organism=Escherichia coli, GI1789233, Length=331, Percent_Identity=40.1812688821752, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI1787583, Length=322, Percent_Identity=35.0931677018634, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI1789828, Length=332, Percent_Identity=34.0361445783133, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI87081858, Length=305, Percent_Identity=28.5245901639344, Blast_Score=135, Evalue=7e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50810; Mature: 50679

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKLLIVDDNEDVRRQLRWGLSREPYDLLLAADGQEALKLFREHRPGAVTLDLGLPPDPE
CCCEEEEECCHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHCCCCEEEEECCCCCCCC
GTDEGFRCLDAMLRHDPNAQIVVVTGHHDKENALRAIRAGAFDFCRKPVDLAELKVIINR
CCCHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCHHHHHCCCCHHHHHHHHHHH
AFYLSELKAADQPLQEDLPPEPEVPHFNGLVGDCEAMRRVYATIEKVAGADAPVLVTGES
HHHHHHHHHCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCC
GTGKELVARAVHRLSSRRSGAMVAVNCGAIPETLIESELFGHEKGAFTGATSRVQGKVEY
CCCHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCHHHCCEEEE
ADGGTLFLDEIGELPASMQVKFLRFLQEMVMQRVGGRKDIPVNCRIIAATNVDIEQAMRE
CCCCEEEHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHC
GAFREDLYFRIGVVTINLPPLRERGADVLLLARHFLSSIGVQQKTKVQGFSAAAEKAMLH
CCCHHCCEEEEEEEEEECCCHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEEE
YPWPGNVRELENKVRRAVILTSGQRIGPEDLGIEPEPVQPAPEGAVPSAGRKTLKEARNE
CCCCCCHHHHHHHHHHEEEEECCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
VERDMVEQALRTFSGNIVQAAKSIGVSRPTFYDLLKKHGLDG
HHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
PKLLIVDDNEDVRRQLRWGLSREPYDLLLAADGQEALKLFREHRPGAVTLDLGLPPDPE
CCEEEEECCHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHCCCCEEEEECCCCCCCC
GTDEGFRCLDAMLRHDPNAQIVVVTGHHDKENALRAIRAGAFDFCRKPVDLAELKVIINR
CCCHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCHHHHHCCCCHHHHHHHHHHH
AFYLSELKAADQPLQEDLPPEPEVPHFNGLVGDCEAMRRVYATIEKVAGADAPVLVTGES
HHHHHHHHHCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCC
GTGKELVARAVHRLSSRRSGAMVAVNCGAIPETLIESELFGHEKGAFTGATSRVQGKVEY
CCCHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCHHHCCEEEE
ADGGTLFLDEIGELPASMQVKFLRFLQEMVMQRVGGRKDIPVNCRIIAATNVDIEQAMRE
CCCCEEEHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHC
GAFREDLYFRIGVVTINLPPLRERGADVLLLARHFLSSIGVQQKTKVQGFSAAAEKAMLH
CCCHHCCEEEEEEEEEECCCHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEEE
YPWPGNVRELENKVRRAVILTSGQRIGPEDLGIEPEPVQPAPEGAVPSAGRKTLKEARNE
CCCCCCHHHHHHHHHHEEEEECCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
VERDMVEQALRTFSGNIVQAAKSIGVSRPTFYDLLKKHGLDG
HHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]