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The map label for this gene is mtaD [H]

Identifier: 78355749

GI number: 78355749

Start: 718942

End: 720309

Strand: Direct

Name: mtaD [H]

Synonym: Dde_0702

Alternate gene names: 78355749

Gene position: 718942-720309 (Clockwise)

Preceding gene: 78355748

Following gene: 78355753

Centisome position: 19.27

GC content: 59.72

Gene sequence:

>1368_bases
ATGGGTACCATTCTTCTCCGCAATGCGACTATTCTTTCCATGGATTCGGAACGCCGTGTTTTTGAAAACGGCGATGTGCT
GGTCAGAGACGACCGTATAGCCGCTGTGGGGGCAGTTGACCCCGCAGAGGCGGATCAGGCGGACGAGGTGGTGGACCTGA
CAGGGCGCATGGTGCTGCCCGGTCTGGTTAACACGCATGTGCACACATCGCAGCAGCTTGAGCGAGGTCTTGCGGATGAC
GTGGATCTGCTTACCTGGCTGCACGACCGTACATGGCCCTTTGAAAGTGCACTTACAGAGGAAGACCAGTACCTTTCGAC
CCTTGCCTGCGGTTGCGAACTTATCCGCTCGGGCGTGACCACGTTTGCAGAGGCGGGCGGGCAGCATATGGACGCCACCG
GCCGCGCTGTGGAAAATCTGGGGCTGCGCGCCCGTCTGTGCATTTCAAGCATGGACTGCGGCGAAGGGCTGCCTGAAGGG
TGGGTGCGCCCCATACAGGAGGTGCTGGCAGAGCAGAAGGGATTGTATGACCGCTGGCACGGCAAGGCCGGCGGCCGTAT
CGGAGTATGGTTCGGCCTGCGTACCATTTTCAACTGCTCCGATGAACTGATTGTGGCCACCAAGGATATGGCAGACACCC
TGCAGACCGGTGTGCATATGCATGTGGCCGAAATTCAGGAAGAAGTCCGTTTTGCCCGGCAGACCCGCGGTGCCTCGACA
GTGGAACATCTGGGTGCGCTGGGCGCGCTGGGACCCAATCTGCTGGCCGTGCATCATGTATGGCTTACCGCAAAAGAAGT
GGACCTGCTGGCGCTGCATGATGTGAAAACATCGCACAACGCCGCTGCCGCCATGCGGTATCTGGGCTTTGCTCCGGTGC
CGGAAATGCTGCGCAAGGGCGTGGCCGTTTCCATAGGCACGGACGGGGCACCCAGCAACAACCATATGGACATGATGAGT
GAAATGTACCTTGTTTCGCTGATTCATAAAGGACGGCACCTTGACCCGTGTGCCGTAACGGCGGACAAGGTGCTTGAAAT
GGCCACCGTCATGGGGGCCCGCTGTATGCTGATGGATGATTCCATAGGCTCGCTGAGCGAAGGCATGAAGGCCGACCTGA
TGGTGGTGAATCCGCGCGACTTCGGGTCATTGCCGGTGCACGACCCTGTGTCGGCGCTGGTGGGCGCCATGTATTCCGCC
AATGTGGAATCGTCCATGTGTGACGGCCGCTGGCTGATGCGTGACAGAAAGGTGCTGACCGTGGATATGGAAGGGCTGCT
GGACGAAATACAGTCCAGAGCCGATGCCGTGCGCAGACGGGCCGGCATTGAGCTGCCGCCCCGTTTTCCCGTGGTCAGAG
TGCGGTAG

Upstream 100 bases:

>100_bases
GTCCGTTATCTTGTGGAATCCGGCATCGCCGTGGGCGCGGTTTCCGCTGTCGTTCTCAATCTCATCCTGCCTAAGGACGC
AGAATAATCAAGGAAACGTC

Downstream 100 bases:

>100_bases
TTTTTTGCACGGAATAAACCGGCCGGTGCATGCACCGGCCGGTTTTTTTTATTCAGTTTGCGCAGCGTGTTGCCGGAGTC
AGCTTTTGGACAGCATGTCC

Product: chlorohydrolase family protein

Products: NA

Alternate protein names: MTA/SAH deaminase [H]

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MGTILLRNATILSMDSERRVFENGDVLVRDDRIAAVGAVDPAEADQADEVVDLTGRMVLPGLVNTHVHTSQQLERGLADD
VDLLTWLHDRTWPFESALTEEDQYLSTLACGCELIRSGVTTFAEAGGQHMDATGRAVENLGLRARLCISSMDCGEGLPEG
WVRPIQEVLAEQKGLYDRWHGKAGGRIGVWFGLRTIFNCSDELIVATKDMADTLQTGVHMHVAEIQEEVRFARQTRGAST
VEHLGALGALGPNLLAVHHVWLTAKEVDLLALHDVKTSHNAAAAMRYLGFAPVPEMLRKGVAVSIGTDGAPSNNHMDMMS
EMYLVSLIHKGRHLDPCAVTADKVLEMATVMGARCMLMDDSIGSLSEGMKADLMVVNPRDFGSLPVHDPVSALVGAMYSA
NVESSMCDGRWLMRDRKVLTVDMEGLLDEIQSRADAVRRRAGIELPPRFPVVRVR

Sequences:

>Translated_455_residues
MGTILLRNATILSMDSERRVFENGDVLVRDDRIAAVGAVDPAEADQADEVVDLTGRMVLPGLVNTHVHTSQQLERGLADD
VDLLTWLHDRTWPFESALTEEDQYLSTLACGCELIRSGVTTFAEAGGQHMDATGRAVENLGLRARLCISSMDCGEGLPEG
WVRPIQEVLAEQKGLYDRWHGKAGGRIGVWFGLRTIFNCSDELIVATKDMADTLQTGVHMHVAEIQEEVRFARQTRGAST
VEHLGALGALGPNLLAVHHVWLTAKEVDLLALHDVKTSHNAAAAMRYLGFAPVPEMLRKGVAVSIGTDGAPSNNHMDMMS
EMYLVSLIHKGRHLDPCAVTADKVLEMATVMGARCMLMDDSIGSLSEGMKADLMVVNPRDFGSLPVHDPVSALVGAMYSA
NVESSMCDGRWLMRDRKVLTVDMEGLLDEIQSRADAVRRRAGIELPPRFPVVRVR
>Mature_454_residues
GTILLRNATILSMDSERRVFENGDVLVRDDRIAAVGAVDPAEADQADEVVDLTGRMVLPGLVNTHVHTSQQLERGLADDV
DLLTWLHDRTWPFESALTEEDQYLSTLACGCELIRSGVTTFAEAGGQHMDATGRAVENLGLRARLCISSMDCGEGLPEGW
VRPIQEVLAEQKGLYDRWHGKAGGRIGVWFGLRTIFNCSDELIVATKDMADTLQTGVHMHVAEIQEEVRFARQTRGASTV
EHLGALGALGPNLLAVHHVWLTAKEVDLLALHDVKTSHNAAAAMRYLGFAPVPEMLRKGVAVSIGTDGAPSNNHMDMMSE
MYLVSLIHKGRHLDPCAVTADKVLEMATVMGARCMLMDDSIGSLSEGMKADLMVVNPRDFGSLPVHDPVSALVGAMYSAN
VESSMCDGRWLMRDRKVLTVDMEGLLDEIQSRADAVRRRAGIELPPRFPVVRVR

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=384, Percent_Identity=23.4375, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI87082177, Length=461, Percent_Identity=25.3796095444685, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1789249, Length=380, Percent_Identity=26.5789473684211, Blast_Score=96, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24643849, Length=407, Percent_Identity=23.5872235872236, Blast_Score=96, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 49740; Mature: 49608

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTILLRNATILSMDSERRVFENGDVLVRDDRIAAVGAVDPAEADQADEVVDLTGRMVLP
CCEEEEECEEEEECCCCCHHHCCCCEEEECCCEEEECCCCCCCCCCHHHHHHHCCCEECC
GLVNTHVHTSQQLERGLADDVDLLTWLHDRTWPFESALTEEDQYLSTLACGCELIRSGVT
CHHHCCCCCHHHHHCCCCCHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHH
TFAEAGGQHMDATGRAVENLGLRARLCISSMDCGEGLPEGWVRPIQEVLAEQKGLYDRWH
HHHHCCCCCCCHHHHHHHHCCCEEEHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHC
GKAGGRIGVWFGLRTIFNCSDELIVATKDMADTLQTGVHMHVAEIQEEVRFARQTRGAST
CCCCCEEEEHHHHHHHHCCCCCEEEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHH
VEHLGALGALGPNLLAVHHVWLTAKEVDLLALHDVKTSHNAAAAMRYLGFAPVPEMLRKG
HHHHHHHHCCCCHHHHHHHHHEECCCCCEEEEECCCCCCHHHHHHHHHCCCCHHHHHHCC
VAVSIGTDGAPSNNHMDMMSEMYLVSLIHKGRHLDPCAVTADKVLEMATVMGARCMLMDD
EEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEC
SIGSLSEGMKADLMVVNPRDFGSLPVHDPVSALVGAMYSANVESSMCDGRWLMRDRKVLT
CCCHHHCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCHHHCCCHHHHCCCEEEE
VDMEGLLDEIQSRADAVRRRAGIELPPRFPVVRVR
EEHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEC
>Mature Secondary Structure 
GTILLRNATILSMDSERRVFENGDVLVRDDRIAAVGAVDPAEADQADEVVDLTGRMVLP
CEEEEECEEEEECCCCCHHHCCCCEEEECCCEEEECCCCCCCCCCHHHHHHHCCCEECC
GLVNTHVHTSQQLERGLADDVDLLTWLHDRTWPFESALTEEDQYLSTLACGCELIRSGVT
CHHHCCCCCHHHHHCCCCCHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHH
TFAEAGGQHMDATGRAVENLGLRARLCISSMDCGEGLPEGWVRPIQEVLAEQKGLYDRWH
HHHHCCCCCCCHHHHHHHHCCCEEEHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHC
GKAGGRIGVWFGLRTIFNCSDELIVATKDMADTLQTGVHMHVAEIQEEVRFARQTRGAST
CCCCCEEEEHHHHHHHHCCCCCEEEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHH
VEHLGALGALGPNLLAVHHVWLTAKEVDLLALHDVKTSHNAAAAMRYLGFAPVPEMLRKG
HHHHHHHHCCCCHHHHHHHHHEECCCCCEEEEECCCCCCHHHHHHHHHCCCCHHHHHHCC
VAVSIGTDGAPSNNHMDMMSEMYLVSLIHKGRHLDPCAVTADKVLEMATVMGARCMLMDD
EEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEC
SIGSLSEGMKADLMVVNPRDFGSLPVHDPVSALVGAMYSANVESSMCDGRWLMRDRKVLT
CCCHHHCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCHHHCCCHHHHCCCEEEE
VDMEGLLDEIQSRADAVRRRAGIELPPRFPVVRVR
EEHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA