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The map label for this gene is cpx [H]

Identifier: 78355748

GI number: 78355748

Start: 717621

End: 718928

Strand: Direct

Name: cpx [H]

Synonym: Dde_0701

Alternate gene names: 78355748

Gene position: 717621-718928 (Clockwise)

Preceding gene: 78355744

Following gene: 78355749

Centisome position: 19.24

GC content: 59.25

Gene sequence:

>1308_bases
ATGAGCCGCAATACCGAACTGCACCTTACGGTAGGTGTGGATGAGCCTGTTTCCCCCCTGAAAGCGTTTGCACTGGGCCT
GCAGCATGTGCTTGCCATGGATGTGTATATTGCTCCTTTTGTCATGGCCGGGCTGCTTTCGCTTTCCGTGCCGGAAACCG
CAACTTTCATTCAGATGACCTTTGTGGCTGCGGGGCTGGCCACACTTATCCAGGCGGGGTTCGGCATCCGCCTGCCTGTC
ATGCAGGGACCTTCCTATGTGCCCATCGGGGCGCTGGCCGCCATAGGCAATTCTCTGGGGCTGGGCGCCATGTTCGGTTC
TCTGCTGCCGGGGGCGCTTGTCATGACGTTGCTCGGCAAACCGCTGCGTGTGTTCAGCAGGATTGTGCGTTTTTTCATTC
CGCCGCTTGTGGGGGGCACTGTCATTGTCATTGTGGGCATTGCGCTTATGCCTGTGGCACTCAAGGGGTGCTACGGATAT
TTCGGCGATCCTGCGCATAATGCCGTCGTGGCGCTGGTGTCCGCTGCGGTGCTGGTGGTGCTCACTGTTGCCGGTTCGCG
TCCCGGCAGATTTAATCAGGTGGTGCGCATGGGGTCTGTTGTTTTCAGCATGGCAGCAGGAACCCTTACCGCCGCCGCCT
TCGGCATGGTGAATTTTGACAGCGTGGCCGCCGCCCCGTGGCTGGCGCTGCCTGTTATCTTTCCCTACGGTACTCCGCAT
ATCGACGTCTCCGCCGCGCTGACGCTGGTGTTCATATACCTTGTGGTGCTGGTGGAAACCACGGGAACGTGGTTTGCCGT
GGAGGCGGTGACAGGTTCGCGTCTGGATGATGAACGGATAAACGGCGGAACCTTCGGCGAAGGTGTGGGCTGTTTTCTGG
GTGCCATGCTGGGCGGCACGCCTGTGACAGGCTATTCCACCAATGCGGGCATCATTGCCATTACCGGCGTTGCCAGCCGA
TGGGCCATCATGGCGGGCGGAGGAATTCTGCTGGTGCTGGGCATGGTGCCCAAGCTGATGAACGTCATTGCCAGTATTCC
CGGACCGGTCATCAGCGGTGTTTTTGCCGTCATCTGCGTGGTCATTGCCATGAACGGTTTCCGCGTGGTGCGTACCGTCA
CGCTTTCCGAACGTAACATGCTGGTTATGGGGCTGCCCATTCTGCTTACGCTGGCCGCTGTTTTCATGCCTGCCGAACTG
CGTGACCGTCTGCCCGCGCTGGTCCGTTATCTTGTGGAATCCGGCATCGCCGTGGGCGCGGTTTCCGCTGTCGTTCTCAA
TCTCATCCTGCCTAAGGACGCAGAATAA

Upstream 100 bases:

>100_bases
CGCTGCAGCGCATGCGCTCTTTACATGCGCTGCGTGAAAGAGTACCGAAAGCCCCCTGCGTCACACTCAACTTTTTTTGC
ATCAGTACGGAGGGCCGCTG

Downstream 100 bases:

>100_bases
TCAAGGAAACGTCATGGGTACCATTCTTCTCCGCAATGCGACTATTCTTTCCATGGATTCGGAACGCCGTGTTTTTGAAA
ACGGCGATGTGCTGGTCAGA

Product: xanthine/uracil permease family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MSRNTELHLTVGVDEPVSPLKAFALGLQHVLAMDVYIAPFVMAGLLSLSVPETATFIQMTFVAAGLATLIQAGFGIRLPV
MQGPSYVPIGALAAIGNSLGLGAMFGSLLPGALVMTLLGKPLRVFSRIVRFFIPPLVGGTVIVIVGIALMPVALKGCYGY
FGDPAHNAVVALVSAAVLVVLTVAGSRPGRFNQVVRMGSVVFSMAAGTLTAAAFGMVNFDSVAAAPWLALPVIFPYGTPH
IDVSAALTLVFIYLVVLVETTGTWFAVEAVTGSRLDDERINGGTFGEGVGCFLGAMLGGTPVTGYSTNAGIIAITGVASR
WAIMAGGGILLVLGMVPKLMNVIASIPGPVISGVFAVICVVIAMNGFRVVRTVTLSERNMLVMGLPILLTLAAVFMPAEL
RDRLPALVRYLVESGIAVGAVSAVVLNLILPKDAE

Sequences:

>Translated_435_residues
MSRNTELHLTVGVDEPVSPLKAFALGLQHVLAMDVYIAPFVMAGLLSLSVPETATFIQMTFVAAGLATLIQAGFGIRLPV
MQGPSYVPIGALAAIGNSLGLGAMFGSLLPGALVMTLLGKPLRVFSRIVRFFIPPLVGGTVIVIVGIALMPVALKGCYGY
FGDPAHNAVVALVSAAVLVVLTVAGSRPGRFNQVVRMGSVVFSMAAGTLTAAAFGMVNFDSVAAAPWLALPVIFPYGTPH
IDVSAALTLVFIYLVVLVETTGTWFAVEAVTGSRLDDERINGGTFGEGVGCFLGAMLGGTPVTGYSTNAGIIAITGVASR
WAIMAGGGILLVLGMVPKLMNVIASIPGPVISGVFAVICVVIAMNGFRVVRTVTLSERNMLVMGLPILLTLAAVFMPAEL
RDRLPALVRYLVESGIAVGAVSAVVLNLILPKDAE
>Mature_434_residues
SRNTELHLTVGVDEPVSPLKAFALGLQHVLAMDVYIAPFVMAGLLSLSVPETATFIQMTFVAAGLATLIQAGFGIRLPVM
QGPSYVPIGALAAIGNSLGLGAMFGSLLPGALVMTLLGKPLRVFSRIVRFFIPPLVGGTVIVIVGIALMPVALKGCYGYF
GDPAHNAVVALVSAAVLVVLTVAGSRPGRFNQVVRMGSVVFSMAAGTLTAAAFGMVNFDSVAAAPWLALPVIFPYGTPHI
DVSAALTLVFIYLVVLVETTGTWFAVEAVTGSRLDDERINGGTFGEGVGCFLGAMLGGTPVTGYSTNAGIIAITGVASRW
AIMAGGGILLVLGMVPKLMNVIASIPGPVISGVFAVICVVIAMNGFRVVRTVTLSERNMLVMGLPILLTLAAVFMPAELR
DRLPALVRYLVESGIAVGAVSAVVLNLILPKDAE

Specific function: Unknown

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680145, Length=175, Percent_Identity=32, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI44680143, Length=175, Percent_Identity=32, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI44680148, Length=222, Percent_Identity=27.9279279279279, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI40316845, Length=222, Percent_Identity=27.9279279279279, Blast_Score=86, Evalue=1e-16,
Organism=Escherichia coli, GI87082181, Length=431, Percent_Identity=30.8584686774942, Blast_Score=161, Evalue=8e-41,
Organism=Escherichia coli, GI1790087, Length=458, Percent_Identity=30.1310043668122, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI87082178, Length=434, Percent_Identity=28.110599078341, Blast_Score=118, Evalue=8e-28,
Organism=Escherichia coli, GI87081818, Length=383, Percent_Identity=28.7206266318538, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788843, Length=368, Percent_Identity=27.445652173913, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87081750, Length=420, Percent_Identity=24.047619047619, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17541904, Length=453, Percent_Identity=25.60706401766, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17558856, Length=433, Percent_Identity=24.4803695150115, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17542262, Length=191, Percent_Identity=28.2722513089005, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21356175, Length=481, Percent_Identity=23.9085239085239, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017588
- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 44977; Mature: 44845

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHCCCCCC
>Mature Secondary Structure 
SRNTELHLTVGVDEPVSPLKAFALGLQHVLAMDVYIAPFVMAGLLSLSVPETATFIQMT
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
FVAAGLATLIQAGFGIRLPVMQGPSYVPIGALAAIGNSLGLGAMFGSLLPGALVMTLLGK
HHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC
PLRVFSRIVRFFIPPLVGGTVIVIVGIALMPVALKGCYGYFGDPAHNAVVALVSAAVLVV
HHHHHHHHHHHHHCHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
LTVAGSRPGRFNQVVRMGSVVFSMAAGTLTAAAFGMVNFDSVAAAPWLALPVIFPYGTPH
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHEEECCCCCC
IDVSAALTLVFIYLVVLVETTGTWFAVEAVTGSRLDDERINGGTFGEGVGCFLGAMLGGT
CCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCC
PVTGYSTNAGIIAITGVASRWAIMAGGGILLVLGMVPKLMNVIASIPGPVISGVFAVICV
CCCCCCCCCCEEEEECCCCCCCEEECCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
VIAMNGFRVVRTVTLSERNMLVMGLPILLTLAAVFMPAELRDRLPALVRYLVESGIAVGA
HHHHCCCEEEEEEEECCCCEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHH
VSAVVLNLILPKDAE
HHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11792842; 8162194 [H]