Click here to switch to the map view.

The map label for this gene is pepA

Identifier: 78355615

GI number: 78355615

Start: 591949

End: 593493

Strand: Direct

Name: pepA

Synonym: Dde_0568

Alternate gene names: 78355615

Gene position: 591949-593493 (Clockwise)

Preceding gene: 78355608

Following gene: 78355617

Centisome position: 15.87

GC content: 60.39

Gene sequence:

>1545_bases
ATGGATCTCAGGTTTCAGAGAGGCCCTTCCGGAGAATGGAAAGCAAGCGTGGTGCTTGCTTTTGCCTTCAAGGGCGAAGA
CATACGCAAACAGGCACAGGCACTCATCGATGTGGCTCCGTGGCTGGACATCGCTCCGGCACTGAACGACTTTACGGGTG
CCGCGGGCGAAACAGGCGTTCTGTACGGCCATCCCAAAATAGCCATCCCGCGCATCATTCTGTGCGGCCTGGGCGAACGG
GAATCCTACACCGCTGAAACCCTGCGCAAGTCCGTGGCGGCCGCCATGCAGAAATGCCGCGAACTGAAGCTGGAAACAGT
GGGCATAGATGTGCAGACCCTTGCCGGTCTGCCCGGCGATGCCGCGCGCAATGTGGAAGAAGCCGTGGTTTCGGCGTATC
TGCCGCTGTATACATACGAAAGATTCCGCACCACGCGCAAAGAGCCGCTGTTCACCCCGTCGTGGATCAGCCTGTTTTTT
GCGGAAGATATAGACAGCACGCTGCGAGATGCCGCCCGCAGGGGCGAATCGGCCGCAGCCGGTATTTTTCTGACCCGTGA
TCTTGTCAACGGTCCGGCCAATCTGGTGACACCGTCATTTCTGGAAGAACAGGCCCGCAAGCTGGCGGCCCGCTATGGTT
TTACCGTGCGTTCCATGACCCGTCAGGAAATAGCCGCGGCGGGCATGGGGGCCTTTGAATCAGTTTTCAAGGGCGCTGTG
GAAGATGCACGGCTGCTTGCCATCGAGTATTGCCCCCGCGGGATGGAAAAGGAACAGCCTCTTGTGTTCGTGGGCAAGGG
CGTGACCTTTGATACCGGCGGCATCAGCCTGAAGCCTTCGGCCAACATGGGCGACATGAAAAGTGACATGGGCGGAGCGG
GTGCCATTTTCGGCCTGTTTGAAACCATCGGCCAGATGGGCGGACAGGCCGGCGCTGCATCGGCCGGATTCACCCGCAGG
GTCATCGGCGTGATGCCCTGCACCGAAAACATGCCCGACGGGCAGGCCACACGCCCCGGTGATGTGGTCACGTCACTTTC
CGGACAGACCATCGAAATCATCAATACCGATGCCGAGGGCCGTCTGATTCTGTGCGATGCCATGACATGGGCGCAGCGGG
AATACGATCCCGCGGTGATGGTCGATCTGGCCACGCTGACCGGCGCCTGCCTGATTGCGCTGGGAACCGATGTGGCAGCC
GTGTTTGCCACCGATGATGCACTGGCAGACACCGTGCGCACCCGGGGCGGCGACGTGGGAGACCTGTACTGGCGTCTGCC
GCTGTGGGACAGGTACTTTGAAGACCTGAAAAGCGATGTGGCCGACATGAAGAACGTGGGCGGCCGCGAAGGCGGCACCA
TTAACGCGGCACTGTTTCTGAAGCAGTTTGTGGATGAAGGACGTCGCTGGGCGCATCTGGACATTGCAGGTCCTGCCTAC
CGCAACAAAAAAAGTCCGCTGTGCCCGTTCGGCGCCACCGGATTTGCCGTACGTACCCTGATGCAGCTTGCACTGCACGG
CGTGCCTGAACCGTCCGGCGACTGA

Upstream 100 bases:

>100_bases
AAAGGCGGCCTATGTCTGCGGTCATGTCCCTGTCCCGCGCGGCAGGGACTGCTCATATCACGGCGTGCTGCGGCCCGCCG
CAGTCAGCGGAGGATTAGCA

Downstream 100 bases:

>100_bases
AGCCGACCGCAGGCTGTCGCGTCCCCCCGCTTTTGGCGCGGGCCGCAATAGTTTGCCGGTGCATATGATGCATGCATAAG
GGCGGCCCGCGGGCCGCCCT

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 514; Mature: 514

Protein sequence:

>514_residues
MDLRFQRGPSGEWKASVVLAFAFKGEDIRKQAQALIDVAPWLDIAPALNDFTGAAGETGVLYGHPKIAIPRIILCGLGER
ESYTAETLRKSVAAAMQKCRELKLETVGIDVQTLAGLPGDAARNVEEAVVSAYLPLYTYERFRTTRKEPLFTPSWISLFF
AEDIDSTLRDAARRGESAAAGIFLTRDLVNGPANLVTPSFLEEQARKLAARYGFTVRSMTRQEIAAAGMGAFESVFKGAV
EDARLLAIEYCPRGMEKEQPLVFVGKGVTFDTGGISLKPSANMGDMKSDMGGAGAIFGLFETIGQMGGQAGAASAGFTRR
VIGVMPCTENMPDGQATRPGDVVTSLSGQTIEIINTDAEGRLILCDAMTWAQREYDPAVMVDLATLTGACLIALGTDVAA
VFATDDALADTVRTRGGDVGDLYWRLPLWDRYFEDLKSDVADMKNVGGREGGTINAALFLKQFVDEGRRWAHLDIAGPAY
RNKKSPLCPFGATGFAVRTLMQLALHGVPEPSGD

Sequences:

>Translated_514_residues
MDLRFQRGPSGEWKASVVLAFAFKGEDIRKQAQALIDVAPWLDIAPALNDFTGAAGETGVLYGHPKIAIPRIILCGLGER
ESYTAETLRKSVAAAMQKCRELKLETVGIDVQTLAGLPGDAARNVEEAVVSAYLPLYTYERFRTTRKEPLFTPSWISLFF
AEDIDSTLRDAARRGESAAAGIFLTRDLVNGPANLVTPSFLEEQARKLAARYGFTVRSMTRQEIAAAGMGAFESVFKGAV
EDARLLAIEYCPRGMEKEQPLVFVGKGVTFDTGGISLKPSANMGDMKSDMGGAGAIFGLFETIGQMGGQAGAASAGFTRR
VIGVMPCTENMPDGQATRPGDVVTSLSGQTIEIINTDAEGRLILCDAMTWAQREYDPAVMVDLATLTGACLIALGTDVAA
VFATDDALADTVRTRGGDVGDLYWRLPLWDRYFEDLKSDVADMKNVGGREGGTINAALFLKQFVDEGRRWAHLDIAGPAY
RNKKSPLCPFGATGFAVRTLMQLALHGVPEPSGD
>Mature_514_residues
MDLRFQRGPSGEWKASVVLAFAFKGEDIRKQAQALIDVAPWLDIAPALNDFTGAAGETGVLYGHPKIAIPRIILCGLGER
ESYTAETLRKSVAAAMQKCRELKLETVGIDVQTLAGLPGDAARNVEEAVVSAYLPLYTYERFRTTRKEPLFTPSWISLFF
AEDIDSTLRDAARRGESAAAGIFLTRDLVNGPANLVTPSFLEEQARKLAARYGFTVRSMTRQEIAAAGMGAFESVFKGAV
EDARLLAIEYCPRGMEKEQPLVFVGKGVTFDTGGISLKPSANMGDMKSDMGGAGAIFGLFETIGQMGGQAGAASAGFTRR
VIGVMPCTENMPDGQATRPGDVVTSLSGQTIEIINTDAEGRLILCDAMTWAQREYDPAVMVDLATLTGACLIALGTDVAA
VFATDDALADTVRTRGGDVGDLYWRLPLWDRYFEDLKSDVADMKNVGGREGGTINAALFLKQFVDEGRRWAHLDIAGPAY
RNKKSPLCPFGATGFAVRTLMQLALHGVPEPSGD

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=466, Percent_Identity=36.480686695279, Blast_Score=245, Evalue=6e-65,
Organism=Homo sapiens, GI47155554, Length=333, Percent_Identity=34.8348348348348, Blast_Score=155, Evalue=1e-37,
Organism=Escherichia coli, GI1790710, Length=515, Percent_Identity=34.9514563106796, Blast_Score=285, Evalue=7e-78,
Organism=Escherichia coli, GI87082123, Length=330, Percent_Identity=36.6666666666667, Blast_Score=186, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17556903, Length=327, Percent_Identity=33.6391437308869, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17565172, Length=426, Percent_Identity=27.6995305164319, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21355725, Length=392, Percent_Identity=31.3775510204082, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24661038, Length=392, Percent_Identity=31.1224489795918, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI20129969, Length=397, Percent_Identity=29.4710327455919, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI161077148, Length=382, Percent_Identity=30.1047120418848, Blast_Score=159, Evalue=4e-39,
Organism=Drosophila melanogaster, GI20130057, Length=382, Percent_Identity=30.1047120418848, Blast_Score=159, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24662227, Length=389, Percent_Identity=28.2776349614396, Blast_Score=158, Evalue=1e-38,
Organism=Drosophila melanogaster, GI20129963, Length=390, Percent_Identity=29.4871794871795, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI21355645, Length=389, Percent_Identity=28.0205655526992, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI24662223, Length=389, Percent_Identity=28.0205655526992, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI21357381, Length=327, Percent_Identity=31.4984709480122, Blast_Score=145, Evalue=7e-35,
Organism=Drosophila melanogaster, GI221379063, Length=327, Percent_Identity=31.4984709480122, Blast_Score=145, Evalue=9e-35,
Organism=Drosophila melanogaster, GI221379062, Length=327, Percent_Identity=31.4984709480122, Blast_Score=145, Evalue=9e-35,
Organism=Drosophila melanogaster, GI19922386, Length=314, Percent_Identity=31.5286624203822, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24646701, Length=226, Percent_Identity=30.0884955752212, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24646703, Length=226, Percent_Identity=30.0884955752212, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21358201, Length=226, Percent_Identity=30.0884955752212, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_DESDG (Q315M7)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_387064.1
- HSSP:   P00727
- ProteinModelPortal:   Q315M7
- SMR:   Q315M7
- STRING:   Q315M7
- MEROPS:   M17.003
- GeneID:   3756477
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_0568
- NMPDR:   fig|207559.3.peg.242
- eggNOG:   COG0260
- HOGENOM:   HBG742580
- OMA:   RSIAMMK
- ProtClustDB:   CLSK704608
- BioCyc:   DDES207559:DDE_0568-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 55306; Mature: 55306

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 278-278 ACT_SITE 361-361

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLRFQRGPSGEWKASVVLAFAFKGEDIRKQAQALIDVAPWLDIAPALNDFTGAAGETGV
CCCCCCCCCCCCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
LYGHPKIAIPRIILCGLGERESYTAETLRKSVAAAMQKCRELKLETVGIDVQTLAGLPGD
EECCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHCCCCCH
AARNVEEAVVSAYLPLYTYERFRTTRKEPLFTPSWISLFFAEDIDSTLRDAARRGESAAA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHH
GIFLTRDLVNGPANLVTPSFLEEQARKLAARYGFTVRSMTRQEIAAAGMGAFESVFKGAV
HEEEEHHHHCCCHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHH
EDARLLAIEYCPRGMEKEQPLVFVGKGVTFDTGGISLKPSANMGDMKSDMGGAGAIFGLF
HHHHEEEEECCCCCCCCCCCEEEEECCEEECCCCEEECCCCCCCCHHHCCCCCHHHHHHH
ETIGQMGGQAGAASAGFTRRVIGVMPCTENMPDGQATRPGDVVTSLSGQTIEIINTDAEG
HHHHHHCCCCCCCCCCHHHHHHEEECCCCCCCCCCCCCCCHHHHCCCCCEEEEEECCCCC
RLILCDAMTWAQREYDPAVMVDLATLTGACLIALGTDVAAVFATDDALADTVRTRGGDVG
CEEEEECHHHHHHCCCCHHEEEHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCCCC
DLYWRLPLWDRYFEDLKSDVADMKNVGGREGGTINAALFLKQFVDEGRRWAHLDIAGPAY
CEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHCCCCEEEEEECCCCC
RNKKSPLCPFGATGFAVRTLMQLALHGVPEPSGD
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MDLRFQRGPSGEWKASVVLAFAFKGEDIRKQAQALIDVAPWLDIAPALNDFTGAAGETGV
CCCCCCCCCCCCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
LYGHPKIAIPRIILCGLGERESYTAETLRKSVAAAMQKCRELKLETVGIDVQTLAGLPGD
EECCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHCCCCCH
AARNVEEAVVSAYLPLYTYERFRTTRKEPLFTPSWISLFFAEDIDSTLRDAARRGESAAA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHH
GIFLTRDLVNGPANLVTPSFLEEQARKLAARYGFTVRSMTRQEIAAAGMGAFESVFKGAV
HEEEEHHHHCCCHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHH
EDARLLAIEYCPRGMEKEQPLVFVGKGVTFDTGGISLKPSANMGDMKSDMGGAGAIFGLF
HHHHEEEEECCCCCCCCCCCEEEEECCEEECCCCEEECCCCCCCCHHHCCCCCHHHHHHH
ETIGQMGGQAGAASAGFTRRVIGVMPCTENMPDGQATRPGDVVTSLSGQTIEIINTDAEG
HHHHHHCCCCCCCCCCHHHHHHEEECCCCCCCCCCCCCCCHHHHCCCCCEEEEEECCCCC
RLILCDAMTWAQREYDPAVMVDLATLTGACLIALGTDVAAVFATDDALADTVRTRGGDVG
CEEEEECHHHHHHCCCCHHEEEHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCCCC
DLYWRLPLWDRYFEDLKSDVADMKNVGGREGGTINAALFLKQFVDEGRRWAHLDIAGPAY
CEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHCCCCEEEEEECCCCC
RNKKSPLCPFGATGFAVRTLMQLALHGVPEPSGD
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA