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The map label for this gene is ung

Identifier: 78355561

GI number: 78355561

Start: 522694

End: 523395

Strand: Direct

Name: ung

Synonym: Dde_0514

Alternate gene names: 78355561

Gene position: 522694-523395 (Clockwise)

Preceding gene: 78355560

Following gene: 78355564

Centisome position: 14.01

GC content: 64.25

Gene sequence:

>702_bases
ATGAGCCGCTCTGATGTTTTTGCCGATGCCCCGCCGGCTGACTGGGCACAGGCTGTGCCGTTGCTGCGCGAGGGGGCGCA
TCTGCCCCTGCTGCGTTCAGTCGCGCGTCTGCGTCGCAGCAAAACCGTCTATCCGCCGGAAGGACAGGTCTTTGCCGCGC
TGCACTGCACGCCGCTGCATACGGTGCGGGTTGTCATAGTGGGGCAGGACCCGTACCACGGCGCAGGTCAGGCCCACGGG
CTGGCGTTTTCCGTTCCGCAGGGGGTCAAGCCGCCGCCTTCACTGCGTAATGTGCTCAAAGAGGCCGCCGCGCAGAAGCC
TGAAGCTCCGGCTGCGGCGGGTATGCAGCATAACGGTGTGCAGACGGATCTCACTCCGTGGGCGGAACAGGGCGTGCTTT
TGCTTAACACCGCCCTCACGGTGGAGGCGGGCCGGGCGGGGTCTCATGCCGCGCTGGGCTGGCACGCGGTGACGGACGAT
ATTATCCGCACGGTTTCAGAGCGCTGTCCGGCCGTGGTATTCATGCTGTGGGGCAATCATGCCAGACAGAAGGCGGCTCT
GGTGGATACGGGGCGCCATCTGCTGCTGGAAAGTGTTCATCCTTCGCCGTTTTCCGCGCACAAAGGGTTTCTGGGCTGCG
GGCATTTTGTCACGGCCAACAGCTGGCTGGCTGCTAGAGGGCTTTTGCCTGTGCTGTGGTAG

Upstream 100 bases:

>100_bases
GCGGACGAGGCGGAGCTGACGGAATGTTTTGACCGGCTGCAACGCTGGGCGGAGCGGCAGTGAACAGGCATGCCGTCGGA
TTGCTGTCGCGGGGGTGCGC

Downstream 100 bases:

>100_bases
TGCAGGGGCTTTGCTGTTCCGCCCGCAGGCGGAGCCGCCGGACCGCGCTACCGCAGATTATGAGAGCAGGAAGAAAGATT
TGTCCCACCAGTGCACATTG

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG

Number of amino acids: Translated: 233; Mature: 232

Protein sequence:

>233_residues
MSRSDVFADAPPADWAQAVPLLREGAHLPLLRSVARLRRSKTVYPPEGQVFAALHCTPLHTVRVVIVGQDPYHGAGQAHG
LAFSVPQGVKPPPSLRNVLKEAAAQKPEAPAAAGMQHNGVQTDLTPWAEQGVLLLNTALTVEAGRAGSHAALGWHAVTDD
IIRTVSERCPAVVFMLWGNHARQKAALVDTGRHLLLESVHPSPFSAHKGFLGCGHFVTANSWLAARGLLPVLW

Sequences:

>Translated_233_residues
MSRSDVFADAPPADWAQAVPLLREGAHLPLLRSVARLRRSKTVYPPEGQVFAALHCTPLHTVRVVIVGQDPYHGAGQAHG
LAFSVPQGVKPPPSLRNVLKEAAAQKPEAPAAAGMQHNGVQTDLTPWAEQGVLLLNTALTVEAGRAGSHAALGWHAVTDD
IIRTVSERCPAVVFMLWGNHARQKAALVDTGRHLLLESVHPSPFSAHKGFLGCGHFVTANSWLAARGLLPVLW
>Mature_232_residues
SRSDVFADAPPADWAQAVPLLREGAHLPLLRSVARLRRSKTVYPPEGQVFAALHCTPLHTVRVVIVGQDPYHGAGQAHGL
AFSVPQGVKPPPSLRNVLKEAAAQKPEAPAAAGMQHNGVQTDLTPWAEQGVLLLNTALTVEAGRAGSHAALGWHAVTDDI
IRTVSERCPAVVFMLWGNHARQKAALVDTGRHLLLESVHPSPFSAHKGFLGCGHFVTANSWLAARGLLPVLW

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI19718751, Length=206, Percent_Identity=44.1747572815534, Blast_Score=180, Evalue=1e-45,
Organism=Homo sapiens, GI6224979, Length=206, Percent_Identity=44.1747572815534, Blast_Score=179, Evalue=2e-45,
Organism=Escherichia coli, GI1788934, Length=207, Percent_Identity=51.6908212560386, Blast_Score=207, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI17556304, Length=200, Percent_Identity=42, Blast_Score=173, Evalue=7e-44,
Organism=Saccharomyces cerevisiae, GI6323620, Length=227, Percent_Identity=39.2070484581498, Blast_Score=156, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UNG_DESDG (Q315T1)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_387010.1
- HSSP:   P10186
- ProteinModelPortal:   Q315T1
- SMR:   Q315T1
- STRING:   Q315T1
- GeneID:   3756537
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_0514
- NMPDR:   fig|207559.3.peg.2054
- eggNOG:   COG0692
- HOGENOM:   HBG605450
- OMA:   GAHAQKK
- ProtClustDB:   PRK05254
- BioCyc:   DDES207559:DDE_0514-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00148
- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR11264
- TIGRFAMs:   TIGR00628

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.27

Molecular weight: Translated: 24917; Mature: 24786

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: ACT_SITE 70-70

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRSDVFADAPPADWAQAVPLLREGAHLPLLRSVARLRRSKTVYPPEGQVFAALHCTPLH
CCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCC
TVRVVIVGQDPYHGAGQAHGLAFSVPQGVKPPPSLRNVLKEAAAQKPEAPAAAGMQHNGV
EEEEEEEECCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
QTDLTPWAEQGVLLLNTALTVEAGRAGSHAALGWHAVTDDIIRTVSERCPAVVFMLWGNH
CCCCCCHHHCCEEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEECCCC
ARQKAALVDTGRHLLLESVHPSPFSAHKGFLGCGHFVTANSWLAARGLLPVLW
CHHHHHHHHCCHHHHHHCCCCCCCCCCCCCEECCCEEECCCHHHHHCCCCCCC
>Mature Secondary Structure 
SRSDVFADAPPADWAQAVPLLREGAHLPLLRSVARLRRSKTVYPPEGQVFAALHCTPLH
CCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCC
TVRVVIVGQDPYHGAGQAHGLAFSVPQGVKPPPSLRNVLKEAAAQKPEAPAAAGMQHNGV
EEEEEEEECCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
QTDLTPWAEQGVLLLNTALTVEAGRAGSHAALGWHAVTDDIIRTVSERCPAVVFMLWGNH
CCCCCCHHHCCEEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEECCCC
ARQKAALVDTGRHLLLESVHPSPFSAHKGFLGCGHFVTANSWLAARGLLPVLW
CHHHHHHHHCCHHHHHHCCCCCCCCCCCCCEECCCEEECCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA