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The map label for this gene is cobC [C]

Identifier: 78355558

GI number: 78355558

Start: 519401

End: 520633

Strand: Direct

Name: cobC [C]

Synonym: Dde_0511

Alternate gene names: 78355558

Gene position: 519401-520633 (Clockwise)

Preceding gene: 78355557

Following gene: 78355560

Centisome position: 13.92

GC content: 57.42

Gene sequence:

>1233_bases
ATGAGCGGGCTGTTCATTGTAATGGTGGGGCTGCCCGCCAGAGGCAAATCCACTGTGGCATCCAAGCTGCGCGAAGGGCT
GGAAAGTGAAGGCCTGCGGGTGGAGATATTCAATAACGGTGAACTGCGACGGGAAAGGCTGGGGCAGGATTCATCAGCGC
CTTCATTTTATGAGCCCGGCAATGAAGAAGGGCGTATGCGGCGTGAAGAGCTGGCGCGGATAAATATACGCCGTGCACTG
GCATTTTTGCATGCCGGGGGCGATGTGGCAGTGCTGGATGCCACCAACGCCAGCCGCGCCCGCAGGGCCATGATAGAAGA
ATCCGCGCGCGGGCTGCCGACGTTGTTTGTGGAATGCTTCAACGACGACCCCGACCTGCTGGAAGCCTCGGTCCAGCGCA
AGACGCGCCTGCCGGAATTTGCCGGTCTGACGCCGGAAGCGGCAGCCGAAAGCTTCAACCGGCGTATCGAATACTACAGG
CGGATTTATGTGCCGCTGGGTGAGGAAAGCTGTTTTCTGCGGGTGGATACGCTGAACAACCGTATCGTGGAGGAACGGCT
GGGGTACAGGGTGCCACATTACATCCGCATCCGCGATATTCTGGTTTCCGACTGGGTGCGCAACCTGTATCTGGTCCGCC
ACGGCGAGACCGTTTACAACGTCGAAGGGCGTATCGGCGGTGACGCGCCCCTGACGGAAAAAGGGCTGGCACAGGCCAAT
GCACTGGGGCGTCACTTCAGCAATATGGTCATCCCCTATATTTTTACCAGCACGCGGCAGCGCTCGGCGCAGACTGCGGC
TCCGGTGCTGGCAGGGCAGGAACGTCAGGGGTTTGCCGCAACACGCATGGCCCTGACCGAGTTTGACGAGATAAACGCCG
GAGTATGTGAAGGCATGCGCTATGATGAGATACGCAGCCGCATGCCGGAAATTTTTGATGCGCGCGCCCGCGACAAGTAT
AACTATGTGTATCCCCGCGGTGAAGGGTACTCCACGCTTAAAGCCCGCGTGGACAGGGGGCTGAAAAAGGCTCTGTTTCT
GTCGGGCAATGCGCCTGCCATCATGATAGTGGGGCATCAGGCCATAAACCGTATGATACTTTCACACTTTCTGTTCCGCA
GAACAGAGGACGTGCCGTATATCTATATCCCGCAGGATCAGTATTTCCATATTGTATCCACGCAGAAGAAAAAACTTTTC
GAACTGGTCCGCTTTACGGGGCAGACTGCCTAG

Upstream 100 bases:

>100_bases
TGGCGCATGAATGCGGATCAGCTGGAAGCGTATCATTACGAACGCTTTGCGGCCATGACCCGTTTTTTTGGAAGGCAGAG
CTAACGGCAAAGGAGCACGC

Downstream 100 bases:

>100_bases
CGGGCAGTGCCGCCGCGATGCCGACAGAGCCGGCGGCCAGCAGAGCCGAAGGACAGCAACGGCCCGTTTTGCGGGCCGTT
TTTGCGTGTACTTTGCGGCA

Product: 6-phosphofructo-2-kinase

Products: NA

Alternate protein names: Phosphoglycerate Mutase Family Protein; Fructose-2 6-Bisphosphatase; Alpha-Ribazole Phosphatase; 6-Phosphofructo-2-Kinase/Fructose-2 6-Biphosphatase; Phosphoglycerate Mutase Protein; Fructose-2 6-Bisphosphate 2-Phosphatase; 6-Phosphofructo-2-Kinase; 6-Phosphofructo-2-Kinase/Fructose-2 6- Biphosphatase; Phosphoglycerate Mutase Family; Phosphatase PhoE

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MSGLFIVMVGLPARGKSTVASKLREGLESEGLRVEIFNNGELRRERLGQDSSAPSFYEPGNEEGRMRREELARINIRRAL
AFLHAGGDVAVLDATNASRARRAMIEESARGLPTLFVECFNDDPDLLEASVQRKTRLPEFAGLTPEAAAESFNRRIEYYR
RIYVPLGEESCFLRVDTLNNRIVEERLGYRVPHYIRIRDILVSDWVRNLYLVRHGETVYNVEGRIGGDAPLTEKGLAQAN
ALGRHFSNMVIPYIFTSTRQRSAQTAAPVLAGQERQGFAATRMALTEFDEINAGVCEGMRYDEIRSRMPEIFDARARDKY
NYVYPRGEGYSTLKARVDRGLKKALFLSGNAPAIMIVGHQAINRMILSHFLFRRTEDVPYIYIPQDQYFHIVSTQKKKLF
ELVRFTGQTA

Sequences:

>Translated_410_residues
MSGLFIVMVGLPARGKSTVASKLREGLESEGLRVEIFNNGELRRERLGQDSSAPSFYEPGNEEGRMRREELARINIRRAL
AFLHAGGDVAVLDATNASRARRAMIEESARGLPTLFVECFNDDPDLLEASVQRKTRLPEFAGLTPEAAAESFNRRIEYYR
RIYVPLGEESCFLRVDTLNNRIVEERLGYRVPHYIRIRDILVSDWVRNLYLVRHGETVYNVEGRIGGDAPLTEKGLAQAN
ALGRHFSNMVIPYIFTSTRQRSAQTAAPVLAGQERQGFAATRMALTEFDEINAGVCEGMRYDEIRSRMPEIFDARARDKY
NYVYPRGEGYSTLKARVDRGLKKALFLSGNAPAIMIVGHQAINRMILSHFLFRRTEDVPYIYIPQDQYFHIVSTQKKKLF
ELVRFTGQTA
>Mature_409_residues
SGLFIVMVGLPARGKSTVASKLREGLESEGLRVEIFNNGELRRERLGQDSSAPSFYEPGNEEGRMRREELARINIRRALA
FLHAGGDVAVLDATNASRARRAMIEESARGLPTLFVECFNDDPDLLEASVQRKTRLPEFAGLTPEAAAESFNRRIEYYRR
IYVPLGEESCFLRVDTLNNRIVEERLGYRVPHYIRIRDILVSDWVRNLYLVRHGETVYNVEGRIGGDAPLTEKGLAQANA
LGRHFSNMVIPYIFTSTRQRSAQTAAPVLAGQERQGFAATRMALTEFDEINAGVCEGMRYDEIRSRMPEIFDARARDKYN
YVYPRGEGYSTLKARVDRGLKKALFLSGNAPAIMIVGHQAINRMILSHFLFRRTEDVPYIYIPQDQYFHIVSTQKKKLFE
LVRFTGQTA

Specific function: Converts N1-(5-Phospho-Alpha-D-Ribosyl)-5,6- Dimethylbenzimidazole Into N1-Alpha-D-Ribosyl-5,6- Dimethylbenzimidazole; Involved In The Assembly Of The Nucleotide Loop Of Cobalamin. [C]

COG id: COG0406

COG function: function code G; Fructose-2,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI224282149, Length=398, Percent_Identity=33.9195979899498, Blast_Score=205, Evalue=5e-53,
Organism=Homo sapiens, GI4758900, Length=398, Percent_Identity=33.9195979899498, Blast_Score=205, Evalue=6e-53,
Organism=Homo sapiens, GI118582286, Length=397, Percent_Identity=33.2493702770781, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI4758902, Length=390, Percent_Identity=34.8717948717949, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI64762445, Length=402, Percent_Identity=33.5820895522388, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI64762406, Length=402, Percent_Identity=33.5820895522388, Blast_Score=196, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI71993390, Length=426, Percent_Identity=33.8028169014084, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17510917, Length=405, Percent_Identity=34.8148148148148, Blast_Score=212, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI25145314, Length=398, Percent_Identity=34.9246231155779, Blast_Score=211, Evalue=6e-55,
Organism=Saccharomyces cerevisiae, GI6322306, Length=394, Percent_Identity=30.4568527918782, Blast_Score=179, Evalue=8e-46,
Organism=Saccharomyces cerevisiae, GI6322084, Length=413, Percent_Identity=28.8135593220339, Blast_Score=140, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6324436, Length=191, Percent_Identity=26.7015706806283, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24643264, Length=394, Percent_Identity=34.7715736040609, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24643254, Length=394, Percent_Identity=34.7715736040609, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24643260, Length=394, Percent_Identity=34.7715736040609, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24643258, Length=394, Percent_Identity=34.7715736040609, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24643256, Length=394, Percent_Identity=34.7715736040609, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24643262, Length=394, Percent_Identity=34.7715736040609, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24643252, Length=394, Percent_Identity=34.7715736040609, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI17137706, Length=394, Percent_Identity=34.7715736040609, Blast_Score=209, Evalue=3e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.1.3.73 [C]

Molecular weight: Translated: 46613; Mature: 46482

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: PS00175 PG_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGLFIVMVGLPARGKSTVASKLREGLESEGLRVEIFNNGELRRERLGQDSSAPSFYEPG
CCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHCCCCCCCCCCCCCC
NEEGRMRREELARINIRRALAFLHAGGDVAVLDATNASRARRAMIEESARGLPTLFVECF
CHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEHEEC
NDDPDLLEASVQRKTRLPEFAGLTPEAAAESFNRRIEYYRRIYVPLGEESCFLRVDTLNN
CCCHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEECHHH
RIVEERLGYRVPHYIRIRDILVSDWVRNLYLVRHGETVYNVEGRIGGDAPLTEKGLAQAN
HHHHHHHCCCCCCEEHHHHHHHHHHHHHEEEEECCCEEEEECCCCCCCCCCCHHHHHHHH
ALGRHFSNMVIPYIFTSTRQRSAQTAAPVLAGQERQGFAATRMALTEFDEINAGVCEGMR
HHHHHHHCCHHHHEEECCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHCCCC
YDEIRSRMPEIFDARARDKYNYVYPRGEGYSTLKARVDRGLKKALFLSGNAPAIMIVGHQ
HHHHHHHCHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHCHHHEEEECCCCCEEEEECHH
AINRMILSHFLFRRTEDVPYIYIPQDQYFHIVSTQKKKLFELVRFTGQTA
HHHHHHHHHHHHHCCCCCCEEEECCCCEEEEEHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SGLFIVMVGLPARGKSTVASKLREGLESEGLRVEIFNNGELRRERLGQDSSAPSFYEPG
CCEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHCCCCCCCCCCCCCC
NEEGRMRREELARINIRRALAFLHAGGDVAVLDATNASRARRAMIEESARGLPTLFVECF
CHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEHEEC
NDDPDLLEASVQRKTRLPEFAGLTPEAAAESFNRRIEYYRRIYVPLGEESCFLRVDTLNN
CCCHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEECHHH
RIVEERLGYRVPHYIRIRDILVSDWVRNLYLVRHGETVYNVEGRIGGDAPLTEKGLAQAN
HHHHHHHCCCCCCEEHHHHHHHHHHHHHEEEEECCCEEEEECCCCCCCCCCCHHHHHHHH
ALGRHFSNMVIPYIFTSTRQRSAQTAAPVLAGQERQGFAATRMALTEFDEINAGVCEGMR
HHHHHHHCCHHHHEEECCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHCCCC
YDEIRSRMPEIFDARARDKYNYVYPRGEGYSTLKARVDRGLKKALFLSGNAPAIMIVGHQ
HHHHHHHCHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHCHHHEEEECCCCCEEEEECHH
AINRMILSHFLFRRTEDVPYIYIPQDQYFHIVSTQKKKLFELVRFTGQTA
HHHHHHHHHHHHHCCCCCCEEEECCCCEEEEEHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA